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P41162

- ETV3_HUMAN

UniProt

P41162 - ETV3_HUMAN

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Protein

ETS translocation variant 3

Gene

ETV3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi35 – 11682ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

GO - Biological processi

  1. cell differentiation Source: RefGenome
  2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  4. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS translocation variant 3
Alternative name(s):
ETS domain transcriptional repressor PE1
Short name:
PE-1
Mitogenic Ets transcriptional suppressor
Gene namesi
Name:ETV3
Synonyms:METS, PE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3492. ETV3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: RefGenome
  2. transcriptional repressor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27906.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512ETS translocation variant 3PRO_0000204114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei139 – 1391Phosphoserine1 Publication
Modified residuei388 – 3881N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP41162.
PaxDbiP41162.
PRIDEiP41162.

PTM databases

PhosphoSiteiP41162.

Expressioni

Gene expression databases

BgeeiP41162.
CleanExiHS_ETV3.
GenevestigatoriP41162.

Organism-specific databases

HPAiHPA004794.

Interactioni

Protein-protein interaction databases

BioGridi108418. 9 interactions.
IntActiP41162. 2 interactions.
MINTiMINT-8417661.
STRINGi9606.ENSP00000357175.

Structurei

3D structure databases

ProteinModelPortaliP41162.
SMRiP41162. Positions 30-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG331846.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000070246.
HOVERGENiHBG005183.
InParanoidiP41162.
KOiK09433.
OMAiLMVPPLQ.
OrthoDBiEOG70ZZN1.
PhylomeDBiP41162.
TreeFamiTF351065.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P41162-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAGCSIVEK PEGGGGYQFP DWAYKTESSP GSRQIQLWHF ILELLQKEEF
60 70 80 90 100
RHVIAWQQGE YGEFVIKDPD EVARLWGRRK CKPQMNYDKL SRALRYYYNK
110 120 130 140 150
RILHKTKGKR FTYKFNFNKL VMPNYPFINI RSSGVVPQSA PPVPTASSRF
160 170 180 190 200
HFPPLDTHSP TNDVQPGRFS ASSLTASGQE SSNGTDRKTE LSELEDGSAA
210 220 230 240 250
DWRRGVDPVS SRNAIGGGGI GHQKRKPDIM LPLFARPGMY PDPHSPFAVS
260 270 280 290 300
PIPGRGGVLN VPISPALSLT PTIFSYSPSP GLSPFTSSSC FSFNPEEMKH
310 320 330 340 350
YLHSQACSVF NYHLSPRTFP RYPGLMVPPL QCQMHPEEST QFSIKLQPPP
360 370 380 390 400
VGRKNRERVE SSEESAPVTT PTMASIPPRI KVEPASEKDP ESLRQSAREK
410 420 430 440 450
EEHTQEEGTV PSRTIEEEKG TIFARPAAPP IWPSVPISTP SGEPLEVTED
460 470 480 490 500
SEDRPGKEPS APEKKEDALM PPKLRLKRRW NDDPEARELS KSGKFLWNGS
510
GPQGLATAAA DA
Length:512
Mass (Da):57,001
Last modified:April 12, 2005 - v2
Checksum:i3E50323BF9910062
GO
Isoform 2 (identifier: P41162-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     135-143: VVPQSAPPV → KIQTLLVGN
     144-512: Missing.

Show »
Length:143
Mass (Da):16,943
Checksum:iDFA61901E0891AEF
GO

Sequence cautioni

The sequence AAA60949.1 differs from that shown. Reason: Frameshift at position 174.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei135 – 1439VVPQSAPPV → KIQTLLVGN in isoform 2. 2 PublicationsVSP_013351
Alternative sequencei144 – 512369Missing in isoform 2. 2 PublicationsVSP_013352Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF218540 mRNA. Translation: AAK56846.1.
AK304789 mRNA. Translation: BAG65539.1.
AK316274 mRNA. Translation: BAH14645.1.
AL157713 Genomic DNA. Translation: CAH70131.1.
AL157713 Genomic DNA. Translation: CAC36082.1.
CH471121 Genomic DNA. Translation: EAW52888.1.
BC022868 mRNA. Translation: AAH22868.1.
L16464 mRNA. Translation: AAA60949.1. Frameshift.
CCDSiCCDS1164.1. [P41162-2]
CCDS44250.1. [P41162-1]
PIRiA54308.
RefSeqiNP_001138784.1. NM_001145312.1. [P41162-1]
NP_005231.1. NM_005240.1. [P41162-2]
XP_006711273.1. XM_006711210.1. [P41162-1]
UniGeneiHs.105636.

Genome annotation databases

EnsembliENST00000326786; ENSP00000327316; ENSG00000117036. [P41162-2]
ENST00000368192; ENSP00000357175; ENSG00000117036. [P41162-1]
GeneIDi2117.
KEGGihsa:2117.
UCSCiuc001fqr.2. human. [P41162-1]
uc001fqt.3. human. [P41162-2]

Polymorphism databases

DMDMi62512143.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF218540 mRNA. Translation: AAK56846.1 .
AK304789 mRNA. Translation: BAG65539.1 .
AK316274 mRNA. Translation: BAH14645.1 .
AL157713 Genomic DNA. Translation: CAH70131.1 .
AL157713 Genomic DNA. Translation: CAC36082.1 .
CH471121 Genomic DNA. Translation: EAW52888.1 .
BC022868 mRNA. Translation: AAH22868.1 .
L16464 mRNA. Translation: AAA60949.1 . Frameshift.
CCDSi CCDS1164.1. [P41162-2 ]
CCDS44250.1. [P41162-1 ]
PIRi A54308.
RefSeqi NP_001138784.1. NM_001145312.1. [P41162-1 ]
NP_005231.1. NM_005240.1. [P41162-2 ]
XP_006711273.1. XM_006711210.1. [P41162-1 ]
UniGenei Hs.105636.

3D structure databases

ProteinModelPortali P41162.
SMRi P41162. Positions 30-118.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108418. 9 interactions.
IntActi P41162. 2 interactions.
MINTi MINT-8417661.
STRINGi 9606.ENSP00000357175.

PTM databases

PhosphoSitei P41162.

Polymorphism databases

DMDMi 62512143.

Proteomic databases

MaxQBi P41162.
PaxDbi P41162.
PRIDEi P41162.

Protocols and materials databases

DNASUi 2117.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000326786 ; ENSP00000327316 ; ENSG00000117036 . [P41162-2 ]
ENST00000368192 ; ENSP00000357175 ; ENSG00000117036 . [P41162-1 ]
GeneIDi 2117.
KEGGi hsa:2117.
UCSCi uc001fqr.2. human. [P41162-1 ]
uc001fqt.3. human. [P41162-2 ]

Organism-specific databases

CTDi 2117.
GeneCardsi GC01M157090.
HGNCi HGNC:3492. ETV3.
HPAi HPA004794.
MIMi 164873. gene.
neXtProti NX_P41162.
PharmGKBi PA27906.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG331846.
GeneTreei ENSGT00760000118907.
HOGENOMi HOG000070246.
HOVERGENi HBG005183.
InParanoidi P41162.
KOi K09433.
OMAi LMVPPLQ.
OrthoDBi EOG70ZZN1.
PhylomeDBi P41162.
TreeFami TF351065.

Miscellaneous databases

GenomeRNAii 2117.
NextBioi 8555.
PROi P41162.
SOURCEi Search...

Gene expression databases

Bgeei P41162.
CleanExi HS_ETV3.
Genevestigatori P41162.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
[Graphical view ]
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation."
    Klappacher G.W., Lunyak V.V., Sykes D.B., Sawka-Verhelle D., Sage J., Brard G., Ngo S.D., Gangadharan D., Jacks T., Kamps M.P., Rose D.W., Rosenfeld M.G., Glass C.K.
    Cell 109:169-180(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Uterus.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Bone marrow.
  6. "PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23."
    Klemsz M., Hromas R., Raskind W., Bruno E., Hoffman R.
    Genomics 20:291-294(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-262 (ISOFORM 1).
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-388, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiETV3_HUMAN
AccessioniPrimary (citable) accession number: P41162
Secondary accession number(s): B4E3M7, Q8TAC8, Q9BX30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: April 12, 2005
Last modified: October 29, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3