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P41162

- ETV3_HUMAN

UniProt

P41162 - ETV3_HUMAN

Protein

ETS translocation variant 3

Gene

ETV3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (12 Apr 2005)
      Previous versions | rss
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    Functioni

    Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi35 – 11682ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. cell differentiation Source: RefGenome
    2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    4. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS translocation variant 3
    Alternative name(s):
    ETS domain transcriptional repressor PE1
    Short name:
    PE-1
    Mitogenic Ets transcriptional suppressor
    Gene namesi
    Name:ETV3
    Synonyms:METS, PE1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:3492. ETV3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: RefGenome
    2. transcriptional repressor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27906.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512ETS translocation variant 3PRO_0000204114Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei139 – 1391Phosphoserine1 Publication
    Modified residuei388 – 3881N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP41162.
    PaxDbiP41162.
    PRIDEiP41162.

    PTM databases

    PhosphoSiteiP41162.

    Expressioni

    Gene expression databases

    BgeeiP41162.
    CleanExiHS_ETV3.
    GenevestigatoriP41162.

    Organism-specific databases

    HPAiHPA004794.

    Interactioni

    Protein-protein interaction databases

    BioGridi108418. 5 interactions.
    IntActiP41162. 2 interactions.
    MINTiMINT-8417661.
    STRINGi9606.ENSP00000357175.

    Structurei

    3D structure databases

    ProteinModelPortaliP41162.
    SMRiP41162. Positions 30-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG331846.
    HOGENOMiHOG000070246.
    HOVERGENiHBG005183.
    InParanoidiP41162.
    KOiK09433.
    OMAiLMVPPLQ.
    OrthoDBiEOG70ZZN1.
    PhylomeDBiP41162.
    TreeFamiTF351065.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    [Graphical view]
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P41162-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKAGCSIVEK PEGGGGYQFP DWAYKTESSP GSRQIQLWHF ILELLQKEEF    50
    RHVIAWQQGE YGEFVIKDPD EVARLWGRRK CKPQMNYDKL SRALRYYYNK 100
    RILHKTKGKR FTYKFNFNKL VMPNYPFINI RSSGVVPQSA PPVPTASSRF 150
    HFPPLDTHSP TNDVQPGRFS ASSLTASGQE SSNGTDRKTE LSELEDGSAA 200
    DWRRGVDPVS SRNAIGGGGI GHQKRKPDIM LPLFARPGMY PDPHSPFAVS 250
    PIPGRGGVLN VPISPALSLT PTIFSYSPSP GLSPFTSSSC FSFNPEEMKH 300
    YLHSQACSVF NYHLSPRTFP RYPGLMVPPL QCQMHPEEST QFSIKLQPPP 350
    VGRKNRERVE SSEESAPVTT PTMASIPPRI KVEPASEKDP ESLRQSAREK 400
    EEHTQEEGTV PSRTIEEEKG TIFARPAAPP IWPSVPISTP SGEPLEVTED 450
    SEDRPGKEPS APEKKEDALM PPKLRLKRRW NDDPEARELS KSGKFLWNGS 500
    GPQGLATAAA DA 512
    Length:512
    Mass (Da):57,001
    Last modified:April 12, 2005 - v2
    Checksum:i3E50323BF9910062
    GO
    Isoform 2 (identifier: P41162-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         135-143: VVPQSAPPV → KIQTLLVGN
         144-512: Missing.

    Show »
    Length:143
    Mass (Da):16,943
    Checksum:iDFA61901E0891AEF
    GO

    Sequence cautioni

    The sequence AAA60949.1 differs from that shown. Reason: Frameshift at position 174.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei135 – 1439VVPQSAPPV → KIQTLLVGN in isoform 2. 2 PublicationsVSP_013351
    Alternative sequencei144 – 512369Missing in isoform 2. 2 PublicationsVSP_013352Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218540 mRNA. Translation: AAK56846.1.
    AK304789 mRNA. Translation: BAG65539.1.
    AK316274 mRNA. Translation: BAH14645.1.
    AL157713 Genomic DNA. Translation: CAH70131.1.
    AL157713 Genomic DNA. Translation: CAC36082.1.
    CH471121 Genomic DNA. Translation: EAW52888.1.
    BC022868 mRNA. Translation: AAH22868.1.
    L16464 mRNA. Translation: AAA60949.1. Frameshift.
    CCDSiCCDS1164.1. [P41162-2]
    CCDS44250.1. [P41162-1]
    PIRiA54308.
    RefSeqiNP_001138784.1. NM_001145312.1. [P41162-1]
    NP_005231.1. NM_005240.1. [P41162-2]
    XP_006711273.1. XM_006711210.1. [P41162-1]
    UniGeneiHs.105636.

    Genome annotation databases

    EnsembliENST00000326786; ENSP00000327316; ENSG00000117036. [P41162-2]
    ENST00000368192; ENSP00000357175; ENSG00000117036. [P41162-1]
    GeneIDi2117.
    KEGGihsa:2117.
    UCSCiuc001fqr.2. human. [P41162-1]
    uc001fqt.3. human. [P41162-2]

    Polymorphism databases

    DMDMi62512143.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218540 mRNA. Translation: AAK56846.1 .
    AK304789 mRNA. Translation: BAG65539.1 .
    AK316274 mRNA. Translation: BAH14645.1 .
    AL157713 Genomic DNA. Translation: CAH70131.1 .
    AL157713 Genomic DNA. Translation: CAC36082.1 .
    CH471121 Genomic DNA. Translation: EAW52888.1 .
    BC022868 mRNA. Translation: AAH22868.1 .
    L16464 mRNA. Translation: AAA60949.1 . Frameshift.
    CCDSi CCDS1164.1. [P41162-2 ]
    CCDS44250.1. [P41162-1 ]
    PIRi A54308.
    RefSeqi NP_001138784.1. NM_001145312.1. [P41162-1 ]
    NP_005231.1. NM_005240.1. [P41162-2 ]
    XP_006711273.1. XM_006711210.1. [P41162-1 ]
    UniGenei Hs.105636.

    3D structure databases

    ProteinModelPortali P41162.
    SMRi P41162. Positions 30-118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108418. 5 interactions.
    IntActi P41162. 2 interactions.
    MINTi MINT-8417661.
    STRINGi 9606.ENSP00000357175.

    PTM databases

    PhosphoSitei P41162.

    Polymorphism databases

    DMDMi 62512143.

    Proteomic databases

    MaxQBi P41162.
    PaxDbi P41162.
    PRIDEi P41162.

    Protocols and materials databases

    DNASUi 2117.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326786 ; ENSP00000327316 ; ENSG00000117036 . [P41162-2 ]
    ENST00000368192 ; ENSP00000357175 ; ENSG00000117036 . [P41162-1 ]
    GeneIDi 2117.
    KEGGi hsa:2117.
    UCSCi uc001fqr.2. human. [P41162-1 ]
    uc001fqt.3. human. [P41162-2 ]

    Organism-specific databases

    CTDi 2117.
    GeneCardsi GC01M157090.
    HGNCi HGNC:3492. ETV3.
    HPAi HPA004794.
    MIMi 164873. gene.
    neXtProti NX_P41162.
    PharmGKBi PA27906.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG331846.
    HOGENOMi HOG000070246.
    HOVERGENi HBG005183.
    InParanoidi P41162.
    KOi K09433.
    OMAi LMVPPLQ.
    OrthoDBi EOG70ZZN1.
    PhylomeDBi P41162.
    TreeFami TF351065.

    Miscellaneous databases

    GenomeRNAii 2117.
    NextBioi 8555.
    PROi P41162.
    SOURCEi Search...

    Gene expression databases

    Bgeei P41162.
    CleanExi HS_ETV3.
    Genevestigatori P41162.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    [Graphical view ]
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation."
      Klappacher G.W., Lunyak V.V., Sykes D.B., Sawka-Verhelle D., Sage J., Brard G., Ngo S.D., Gangadharan D., Jacks T., Kamps M.P., Rose D.W., Rosenfeld M.G., Glass C.K.
      Cell 109:169-180(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Uterus.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Bone marrow.
    6. "PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23."
      Klemsz M., Hromas R., Raskind W., Bruno E., Hoffman R.
      Genomics 20:291-294(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-262 (ISOFORM 1).
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-388, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiETV3_HUMAN
    AccessioniPrimary (citable) accession number: P41162
    Secondary accession number(s): B4E3M7, Q8TAC8, Q9BX30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: April 12, 2005
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3