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Protein

ETS translocation variant 3

Gene

ETV3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi35 – 116ETSPROSITE-ProRule annotationAdd BLAST82

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
ETS translocation variant 3
Alternative name(s):
ETS domain transcriptional repressor PE1
Short name:
PE-1
Mitogenic Ets transcriptional suppressor
Gene namesi
Name:ETV3
Synonyms:METS, PE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117036.11
HGNCiHGNC:3492 ETV3
MIMi164873 gene
neXtProtiNX_P41162

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2117
OpenTargetsiENSG00000117036
PharmGKBiPA27906

Polymorphism and mutation databases

BioMutaiETV3
DMDMi62512143

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041141 – 512ETS translocation variant 3Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei139PhosphoserineCombined sources1
Modified residuei159PhosphoserineCombined sources1
Modified residuei315PhosphoserineBy similarity1
Cross-linki381Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei388N6-acetyllysine; alternateCombined sources1
Cross-linki388Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP41162
MaxQBiP41162
PaxDbiP41162
PeptideAtlasiP41162
PRIDEiP41162

PTM databases

iPTMnetiP41162
PhosphoSitePlusiP41162

Expressioni

Gene expression databases

BgeeiENSG00000117036
CleanExiHS_ETV3
GenevisibleiP41162 HS

Organism-specific databases

HPAiHPA004794

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108418, 17 interactors
IntActiP41162, 3 interactors
MINTiP41162
STRINGi9606.ENSP00000357175

Structurei

3D structure databases

ProteinModelPortaliP41162
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000070246
HOVERGENiHBG005183
InParanoidiP41162
KOiK09433
OMAiVPPLQCQ
OrthoDBiEOG091G05C7
PhylomeDBiP41162
TreeFamiTF351065

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR032929 ETV3
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11849:SF264 PTHR11849:SF264, 1 hit
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P41162-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAGCSIVEK PEGGGGYQFP DWAYKTESSP GSRQIQLWHF ILELLQKEEF
60 70 80 90 100
RHVIAWQQGE YGEFVIKDPD EVARLWGRRK CKPQMNYDKL SRALRYYYNK
110 120 130 140 150
RILHKTKGKR FTYKFNFNKL VMPNYPFINI RSSGVVPQSA PPVPTASSRF
160 170 180 190 200
HFPPLDTHSP TNDVQPGRFS ASSLTASGQE SSNGTDRKTE LSELEDGSAA
210 220 230 240 250
DWRRGVDPVS SRNAIGGGGI GHQKRKPDIM LPLFARPGMY PDPHSPFAVS
260 270 280 290 300
PIPGRGGVLN VPISPALSLT PTIFSYSPSP GLSPFTSSSC FSFNPEEMKH
310 320 330 340 350
YLHSQACSVF NYHLSPRTFP RYPGLMVPPL QCQMHPEEST QFSIKLQPPP
360 370 380 390 400
VGRKNRERVE SSEESAPVTT PTMASIPPRI KVEPASEKDP ESLRQSAREK
410 420 430 440 450
EEHTQEEGTV PSRTIEEEKG TIFARPAAPP IWPSVPISTP SGEPLEVTED
460 470 480 490 500
SEDRPGKEPS APEKKEDALM PPKLRLKRRW NDDPEARELS KSGKFLWNGS
510
GPQGLATAAA DA
Length:512
Mass (Da):57,001
Last modified:April 12, 2005 - v2
Checksum:i3E50323BF9910062
GO
Isoform 2 (identifier: P41162-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     135-143: VVPQSAPPV → KIQTLLVGN
     144-512: Missing.

Show »
Length:143
Mass (Da):16,943
Checksum:iDFA61901E0891AEF
GO

Sequence cautioni

The sequence AAA60949 differs from that shown. Reason: Frameshift at position 174.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013351135 – 143VVPQSAPPV → KIQTLLVGN in isoform 2. 2 Publications9
Alternative sequenceiVSP_013352144 – 512Missing in isoform 2. 2 PublicationsAdd BLAST369

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218540 mRNA Translation: AAK56846.1
AK304789 mRNA Translation: BAG65539.1
AK316274 mRNA Translation: BAH14645.1
AL157713 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52888.1
BC022868 mRNA Translation: AAH22868.1
L16464 mRNA Translation: AAA60949.1 Frameshift.
CCDSiCCDS1164.1 [P41162-2]
CCDS44250.1 [P41162-1]
PIRiA54308
RefSeqiNP_001138784.1, NM_001145312.1 [P41162-1]
NP_005231.1, NM_005240.1 [P41162-2]
XP_006711273.1, XM_006711210.2 [P41162-1]
UniGeneiHs.105636
Hs.709764

Genome annotation databases

EnsembliENST00000326786; ENSP00000327316; ENSG00000117036 [P41162-2]
ENST00000368192; ENSP00000357175; ENSG00000117036 [P41162-1]
GeneIDi2117
KEGGihsa:2117
UCSCiuc001fqr.3 human [P41162-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiETV3_HUMAN
AccessioniPrimary (citable) accession number: P41162
Secondary accession number(s): B4E3M7, Q8TAC8, Q9BX30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: April 12, 2005
Last modified: May 23, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health