P41161 (ETV5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ETS translocation variant 5

Alternative name(s):
Ets-related protein ERM

Gene names

Name:	ETV5
Synonyms:	ERM

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to DNA sequences containing the consensus nucleotide core sequence GGAA.
Subcellular location	Nucleus.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the ETS family. Contains 1 ETS DNA-binding domain.
Mass spectrometry	Molecular mass is 57837.98 Da from positions 1 - 510. Determined by MALDI. Ref.8

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	behavior Inferred from electronic annotation. Source: Compara cellular response to oxidative stress Inferred from direct assay PubMed 19443906. Source: UniProtKB male germ-line stem cell division Inferred from electronic annotation. Source: Compara neuromuscular synaptic transmission Inferred from electronic annotation. Source: Compara positive regulation of glial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara regulation of branching involved in mammary gland duct morphogenesis Inferred from electronic annotation. Source: Compara regulation of synapse organization Inferred from electronic annotation. Source: Compara skeletal muscle acetylcholine-gated channel clustering Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from direct assay PubMed 19443906. Source: UniProtKB
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 19443906. Source: UniProtKB transcription regulatory region DNA binding Inferred from direct assay PubMed 19443906. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 510	510	ETS translocation variant 5		PRO_0000204118
Regions
	DNA binding	368 – 448	81	ETS
Natural variations
	Natural variant	348	1	K → R. Corresponds to variant rs2228269 [ dbSNP | Ensembl ].		VAR_048951

Sequences

	Sequence		Length	Mass (Da)
	P41161 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: B7CE40A33927F46E	FASTA	510	57,838
	10 20 30 40 50 60 MDGFYDQQVP FMVPGKSRSE ECRGRPVIDR KRKFLDTDLA HDSEELFQDL SQLQEAWLAE 70 80 90 100 110 120 AQVPDDEQFV PDFQSDNLVL HAPPPTKIKR ELHSPSSELS SCSHEQALGA NYGEKCLYNY 130 140 150 160 170 180 CAYDRKPPSG FKPLTPPTTP LSPTHQNPLF PPPQATLPTS GHAPAAGPVQ GVGPAPAPHS 190 200 210 220 230 240 LPEPGPQQQT FAVPRPPHQP LQMPKMMPEN QYPSEQRFQR QLSEPCHPFP PQPGVPGDNR 250 260 270 280 290 300 PSYHRQMSEP IVPAAPPPPQ GFKQEYHDPL YEHGVPGMPG PPAHGFQSPM GIKQEPRDYC 310 320 330 340 350 360 VDSEVPNCQS SYMRGGYFSS SHEGFSYEKD PRLYFDDTCV VPERLEGKVK QEPTMYREGP 370 380 390 400 410 420 PYQRRGSLQL WQFLVTLLDD PANAHFIAWT GRGMEFKLIE PEEVARRWGI QKNRPAMNYD 430 440 450 460 470 480 KLSRSLRYYY EKGIMQKVAG ERYVYKFVCD PDALFSMAFP DNQRPFLKAE SECHLSEEDT 490 500 510 LPLTHFEDSP AYLLDMDRCS SLPYAEGFAY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors." Monte D., Baert J.-L., Defossez P.-A., de Launoit Y., Stehelin D. Oncogene 9:1397-1406(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors." Monte D., Coutte L., Dewitte F., Defossez P.-A., le Coniat D., Stehelin R., Berger Y., de Launoit Y. Genomics 35:236-240(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[8]	"Cluster analysis of an extensive human breast cancer cell line protein expression map database." Harris R.A., Yang A., Stein R.C., Lucy K., Brusten L., Herath A., Parekh R., Waterfield M.D., O'Hare M.J., Neville M.A., Page M.J., Zvelebil M.J. Proteomics 2:212-223(2002) [PubMed] [Europe PMC] [Abstract] Cited for: MASS SPECTROMETRY. Tissue: Mammary cancer.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X76184 mRNA. Translation: CAA53778.1. X96381 , X96380, X96382, X96379, X96378, X96377, X96376, X96375 Genomic DNA. Translation: CAA65246.1. CR456767 mRNA. Translation: CAG33048.1. BT006713 mRNA. Translation: AAP35359.1. AC108671 Genomic DNA. No translation available. AC112649 Genomic DNA. No translation available. AC131156 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW78200.1. BC007333 mRNA. Translation: AAH07333.1.
IPI	IPI01010250.
PIR	S43692.
RefSeq	NP_004445.1. NM_004454.2.
UniGene	Hs.43697.
3D structure databases
ProteinModelPortal	P41161.
ModBase	Search...
Protein-protein interaction databases
IntAct	P41161. 8 interactions.
STRING	9606.ENSP00000306894.
PTM databases
PhosphoSite	P41161.
Polymorphism databases
DMDM	729441.
Proteomic databases
PaxDb	P41161.
PRIDE	P41161.
Protocols and materials databases
DNASU	2119.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306376; ENSP00000306894; ENSG00000244405. ENST00000434744; ENSP00000413755; ENSG00000244405.
GeneID	2119.
KEGG	hsa:2119.
UCSC	uc003fpz.3. human.
Organism-specific databases
CTD	2119.
GeneCards	GC03M185764.
HGNC	HGNC:3494. ETV5.
HPA	CAB009590.
MIM	601600. gene.
neXtProt	NX_P41161.
PharmGKB	PA27908.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG258471.
HOVERGEN	HBG000231.
InParanoid	P41161.
KO	K15593.
OrthoDB	EOG49GKGC.
Enzyme and pathway databases
Pathway_Interaction_DB	foxm1pathway. FOXM1 transcription factor network. il12_stat4pathway. IL12 signaling mediated by STAT4.
Gene expression databases
ArrayExpress	P41161.
Bgee	P41161.
CleanEx	HS_ETV5.
Genevestigator	P41161.
GermOnline	ENSG00000171656. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR000418. Ets_dom. IPR006715. ETS_PEA3_N. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00178. Ets. 1 hit. PF04621. ETS_PEA3_N. 1 hit. [Graphical view]
PRINTS	PR00454. ETSDOMAIN.
SMART	SM00413. ETS. 1 hit. [Graphical view]
PROSITE	PS00345. ETS_DOMAIN_1. 1 hit. PS00346. ETS_DOMAIN_2. 1 hit. PS50061. ETS_DOMAIN_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ETV5. human.
GenomeRNAi	2119.
NextBio	8565.
SOURCE	Search...

Entry information

Entry name

ETV5_HUMAN

Accession

Primary (citable) accession number: P41161
Secondary accession number(s): A6NH46, Q6IBN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.