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P41160

- LEP_MOUSE

UniProt

P41160 - LEP_MOUSE

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Protein

Leptin

Gene
Lep, Ob
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.

GO - Molecular functioni

  1. growth factor activity Source: MGI
  2. protein binding Source: MGI

GO - Biological processi

  1. adipose tissue development Source: MGI
  2. adult feeding behavior Source: HGNC
  3. bile acid metabolic process Source: MGI
  4. bone mineralization involved in bone maturation Source: Ensembl
  5. cellular response to L-ascorbic acid Source: Ensembl
  6. cellular response to retinoic acid Source: Ensembl
  7. central nervous system neuron development Source: MGI
  8. cholesterol metabolic process Source: MGI
  9. circadian rhythm Source: Ensembl
  10. eating behavior Source: MGI
  11. energy reserve metabolic process Source: Ensembl
  12. fatty acid beta-oxidation Source: MGI
  13. female pregnancy Source: Ensembl
  14. glucose homeostasis Source: MGI
  15. glucose metabolic process Source: MGI
  16. glycerol biosynthetic process Source: Ensembl
  17. hormone metabolic process Source: MGI
  18. insulin secretion Source: MGI
  19. leptin-mediated signaling pathway Source: Ensembl
  20. leukocyte tethering or rolling Source: Ensembl
  21. lipid metabolic process Source: MGI
  22. negative regulation of apoptotic process Source: Ensembl
  23. negative regulation of appetite Source: HGNC
  24. negative regulation of cartilage development Source: Ensembl
  25. negative regulation of glucagon secretion Source: BHF-UCL
  26. negative regulation of glutamine transport Source: Ensembl
  27. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  28. negative regulation of vasoconstriction Source: Ensembl
  29. ovulation from ovarian follicle Source: Ensembl
  30. placenta development Source: Ensembl
  31. positive regulation of cell proliferation Source: Ensembl
  32. positive regulation of cytokine production Source: Ensembl
  33. positive regulation of developmental growth Source: Ensembl
  34. positive regulation of follicle-stimulating hormone secretion Source: Ensembl
  35. positive regulation of hepatic stellate cell activation Source: Ensembl
  36. positive regulation of insulin receptor signaling pathway Source: Ensembl
  37. positive regulation of ion transport Source: Ensembl
  38. positive regulation of JAK-STAT cascade Source: BHF-UCL
  39. positive regulation of luteinizing hormone secretion Source: Ensembl
  40. positive regulation of MAPK cascade Source: Ensembl
  41. positive regulation of myeloid cell differentiation Source: MGI
  42. positive regulation of protein import into nucleus Source: BHF-UCL
  43. positive regulation of STAT protein import into nucleus Source: BHF-UCL
  44. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
  45. regulation of blood pressure Source: Ensembl
  46. regulation of fat cell differentiation Source: MGI
  47. regulation of gluconeogenesis Source: MGI
  48. regulation of insulin secretion Source: MGI
  49. regulation of intestinal cholesterol absorption Source: MGI
  50. regulation of lipoprotein lipid oxidation Source: Ensembl
  51. regulation of metabolic process Source: MGI
  52. regulation of protein phosphorylation Source: BHF-UCL
  53. regulation of steroid biosynthetic process Source: MGI
  54. response to dietary excess Source: MGI
  55. response to hypoxia Source: Ensembl
  56. response to insulin Source: MGI
  57. response to vitamin E Source: Ensembl
  58. tyrosine phosphorylation of STAT protein Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_169390. Signaling by Leptin.
REACT_188529. Signaling by Leptin.

Names & Taxonomyi

Protein namesi
Recommended name:
Leptin
Alternative name(s):
Obesity factor
Gene namesi
Name:Lep
Synonyms:Ob
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:104663. Lep.

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. extracellular region Source: Reactome
  3. extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Defects in Lep are the cause of profound obesity and type II diabetes.

Keywords - Diseasei

Diabetes mellitus, Obesity

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 167146LeptinPRO_0000017687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi117 ↔ 167 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP41160.

PTM databases

PhosphoSiteiP41160.

Expressioni

Gene expression databases

BgeeiP41160.
CleanExiMM_LEP.
GenevestigatoriP41160.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067046.

Structurei

3D structure databases

ProteinModelPortaliP41160.
SMRiP41160. Positions 24-167.

Family & Domainsi

Sequence similaritiesi

Belongs to the leptin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45133.
HOGENOMiHOG000252923.
HOVERGENiHBG007860.
InParanoidiP41160.
KOiK05424.
OMAiTIVTRIN.
OrthoDBiEOG77Q4Z3.
PhylomeDBiP41160.
TreeFamiTF105086.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000065. Leptin.
[Graphical view]
PANTHERiPTHR11724. PTHR11724. 1 hit.
PfamiPF02024. Leptin. 1 hit.
[Graphical view]
PIRSFiPIRSF001837. Leptin. 1 hit.
PRINTSiPR00495. LEPTIN.
ProDomiPD005698. Leptin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41160-1 [UniParc]FASTAAdd to Basket

« Hide

MCWRPLCRFL WLWSYLSYVQ AVPIQKVQDD TKTLIKTIVT RINDISHTQS    50
VSAKQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND 100
LENLRDLLHL LAFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL 150
QGSLQDILQQ LDVSPEC 167
Length:167
Mass (Da):18,709
Last modified:February 1, 1995 - v1
Checksum:iD6783E6C76FD7116
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491Missing in 30% the clones.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18812 mRNA. Translation: AAA64564.1.
U22421 Genomic DNA. Translation: AAA64213.1.
CCDSiCCDS19955.1.
PIRiS50863. LTMS.
RefSeqiNP_032519.1. NM_008493.3.
UniGeneiMm.277072.

Genome annotation databases

EnsembliENSMUST00000069789; ENSMUSP00000067046; ENSMUSG00000059201.
GeneIDi16846.
KEGGimmu:16846.
UCSCiuc009bcv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18812 mRNA. Translation: AAA64564.1 .
U22421 Genomic DNA. Translation: AAA64213.1 .
CCDSi CCDS19955.1.
PIRi S50863. LTMS.
RefSeqi NP_032519.1. NM_008493.3.
UniGenei Mm.277072.

3D structure databases

ProteinModelPortali P41160.
SMRi P41160. Positions 24-167.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000067046.

PTM databases

PhosphoSitei P41160.

Proteomic databases

PRIDEi P41160.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000069789 ; ENSMUSP00000067046 ; ENSMUSG00000059201 .
GeneIDi 16846.
KEGGi mmu:16846.
UCSCi uc009bcv.1. mouse.

Organism-specific databases

CTDi 3952.
MGIi MGI:104663. Lep.

Phylogenomic databases

eggNOGi NOG45133.
HOGENOMi HOG000252923.
HOVERGENi HBG007860.
InParanoidi P41160.
KOi K05424.
OMAi TIVTRIN.
OrthoDBi EOG77Q4Z3.
PhylomeDBi P41160.
TreeFami TF105086.

Enzyme and pathway databases

Reactomei REACT_169390. Signaling by Leptin.
REACT_188529. Signaling by Leptin.

Miscellaneous databases

NextBioi 290772.
PROi P41160.
SOURCEi Search...

Gene expression databases

Bgeei P41160.
CleanExi MM_LEP.
Genevestigatori P41160.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000065. Leptin.
[Graphical view ]
PANTHERi PTHR11724. PTHR11724. 1 hit.
Pfami PF02024. Leptin. 1 hit.
[Graphical view ]
PIRSFi PIRSF001837. Leptin. 1 hit.
PRINTSi PR00495. LEPTIN.
ProDomi PD005698. Leptin. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Positional cloning of the mouse obese gene and its human homologue."
    Zhang Y., Proenca P., Maffei M., Barone M., Leopold L., Friedman J.M.
    Nature 372:425-432(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Erratum
    Zhang Y., Proenca P., Maffei M., Barone M., Leopold L., Friedman J.M.
    Nature 374:479-479(1995)
  3. Chehab F.F., Lim M.E.
    Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiLEP_MOUSE
AccessioniPrimary (citable) accession number: P41160
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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