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Protein

Leptin

Gene

Lep

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.

GO - Molecular functioni

  • growth factor activity Source: MGI

GO - Biological processi

  • adipose tissue development Source: MGI
  • adult feeding behavior Source: HGNC
  • bile acid metabolic process Source: MGI
  • bone mineralization involved in bone maturation Source: Ensembl
  • cellular response to L-ascorbic acid Source: Ensembl
  • cellular response to retinoic acid Source: Ensembl
  • central nervous system neuron development Source: MGI
  • cholesterol metabolic process Source: MGI
  • circadian rhythm Source: Ensembl
  • eating behavior Source: MGI
  • energy reserve metabolic process Source: Ensembl
  • fatty acid beta-oxidation Source: MGI
  • female pregnancy Source: Ensembl
  • glucose homeostasis Source: MGI
  • glucose metabolic process Source: MGI
  • glycerol biosynthetic process Source: Ensembl
  • hormone metabolic process Source: MGI
  • insulin secretion Source: MGI
  • leptin-mediated signaling pathway Source: Ensembl
  • leukocyte tethering or rolling Source: Ensembl
  • lipid metabolic process Source: MGI
  • negative regulation of apoptotic process Source: Ensembl
  • negative regulation of appetite Source: HGNC
  • negative regulation of cartilage development Source: Ensembl
  • negative regulation of glucagon secretion Source: BHF-UCL
  • negative regulation of glutamine transport Source: Ensembl
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • negative regulation of vasoconstriction Source: Ensembl
  • ovulation from ovarian follicle Source: Ensembl
  • placenta development Source: MGI
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of cytokine production Source: Ensembl
  • positive regulation of developmental growth Source: MGI
  • positive regulation of follicle-stimulating hormone secretion Source: Ensembl
  • positive regulation of hepatic stellate cell activation Source: Ensembl
  • positive regulation of insulin receptor signaling pathway Source: Ensembl
  • positive regulation of ion transport Source: Ensembl
  • positive regulation of JAK-STAT cascade Source: BHF-UCL
  • positive regulation of luteinizing hormone secretion Source: Ensembl
  • positive regulation of MAPK cascade Source: Ensembl
  • positive regulation of myeloid cell differentiation Source: MGI
  • positive regulation of protein import into nucleus Source: BHF-UCL
  • positive regulation of STAT protein import into nucleus Source: BHF-UCL
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
  • regulation of blood pressure Source: Ensembl
  • regulation of fat cell differentiation Source: MGI
  • regulation of gluconeogenesis Source: MGI
  • regulation of insulin secretion Source: MGI
  • regulation of intestinal cholesterol absorption Source: MGI
  • regulation of lipoprotein lipid oxidation Source: Ensembl
  • regulation of metabolic process Source: MGI
  • regulation of protein localization to nucleus Source: MGI
  • regulation of protein phosphorylation Source: BHF-UCL
  • regulation of steroid biosynthetic process Source: MGI
  • response to dietary excess Source: MGI
  • response to hypoxia Source: Ensembl
  • response to insulin Source: MGI
  • response to vitamin E Source: Ensembl
  • tyrosine phosphorylation of STAT protein Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_169390. Signaling by Leptin.
REACT_323806. Signaling by Leptin.
REACT_324802. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
REACT_330516. Synthesis, secretion, and deacylation of Ghrelin.

Names & Taxonomyi

Protein namesi
Recommended name:
Leptin
Alternative name(s):
Obesity factor
Gene namesi
Name:Lep
Synonyms:Ob
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:104663. Lep.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • extracellular region Source: Reactome
  • extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Defects in Lep are the cause of profound obesity and type II diabetes.

Keywords - Diseasei

Diabetes mellitus, Obesity

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 167146LeptinPRO_0000017687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi117 ↔ 167By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP41160.

PTM databases

PhosphoSiteiP41160.

Expressioni

Gene expression databases

BgeeiP41160.
CleanExiMM_LEP.
ExpressionAtlasiP41160. baseline and differential.
GenevisibleiP41160. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-60999N.
STRINGi10090.ENSMUSP00000067046.

Structurei

3D structure databases

ProteinModelPortaliP41160.
SMRiP41160. Positions 24-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the leptin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45133.
HOGENOMiHOG000252923.
HOVERGENiHBG007860.
InParanoidiP41160.
KOiK05424.
OMAiRINDISH.
OrthoDBiEOG77Q4Z3.
PhylomeDBiP41160.
TreeFamiTF105086.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000065. Leptin.
[Graphical view]
PANTHERiPTHR11724. PTHR11724. 1 hit.
PfamiPF02024. Leptin. 1 hit.
[Graphical view]
PIRSFiPIRSF001837. Leptin. 1 hit.
PRINTSiPR00495. LEPTIN.
ProDomiPD005698. Leptin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCWRPLCRFL WLWSYLSYVQ AVPIQKVQDD TKTLIKTIVT RINDISHTQS
60 70 80 90 100
VSAKQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND
110 120 130 140 150
LENLRDLLHL LAFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL
160
QGSLQDILQQ LDVSPEC
Length:167
Mass (Da):18,709
Last modified:February 1, 1995 - v1
Checksum:iD6783E6C76FD7116
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491Missing in 30% the clones.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18812 mRNA. Translation: AAA64564.1.
U22421 Genomic DNA. Translation: AAA64213.1.
CCDSiCCDS19955.1.
PIRiS50863. LTMS.
RefSeqiNP_032519.1. NM_008493.3.
UniGeneiMm.277072.

Genome annotation databases

EnsembliENSMUST00000069789; ENSMUSP00000067046; ENSMUSG00000059201.
GeneIDi16846.
KEGGimmu:16846.
UCSCiuc009bcv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18812 mRNA. Translation: AAA64564.1.
U22421 Genomic DNA. Translation: AAA64213.1.
CCDSiCCDS19955.1.
PIRiS50863. LTMS.
RefSeqiNP_032519.1. NM_008493.3.
UniGeneiMm.277072.

3D structure databases

ProteinModelPortaliP41160.
SMRiP41160. Positions 24-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60999N.
STRINGi10090.ENSMUSP00000067046.

PTM databases

PhosphoSiteiP41160.

Proteomic databases

PRIDEiP41160.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069789; ENSMUSP00000067046; ENSMUSG00000059201.
GeneIDi16846.
KEGGimmu:16846.
UCSCiuc009bcv.1. mouse.

Organism-specific databases

CTDi3952.
MGIiMGI:104663. Lep.

Phylogenomic databases

eggNOGiNOG45133.
HOGENOMiHOG000252923.
HOVERGENiHBG007860.
InParanoidiP41160.
KOiK05424.
OMAiRINDISH.
OrthoDBiEOG77Q4Z3.
PhylomeDBiP41160.
TreeFamiTF105086.

Enzyme and pathway databases

ReactomeiREACT_169390. Signaling by Leptin.
REACT_323806. Signaling by Leptin.
REACT_324802. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
REACT_330516. Synthesis, secretion, and deacylation of Ghrelin.

Miscellaneous databases

NextBioi290772.
PROiP41160.
SOURCEiSearch...

Gene expression databases

BgeeiP41160.
CleanExiMM_LEP.
ExpressionAtlasiP41160. baseline and differential.
GenevisibleiP41160. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000065. Leptin.
[Graphical view]
PANTHERiPTHR11724. PTHR11724. 1 hit.
PfamiPF02024. Leptin. 1 hit.
[Graphical view]
PIRSFiPIRSF001837. Leptin. 1 hit.
PRINTSiPR00495. LEPTIN.
ProDomiPD005698. Leptin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Positional cloning of the mouse obese gene and its human homologue."
    Zhang Y., Proenca P., Maffei M., Barone M., Leopold L., Friedman J.M.
    Nature 372:425-432(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Erratum
    Zhang Y., Proenca P., Maffei M., Barone M., Leopold L., Friedman J.M.
    Nature 374:479-479(1995)
  3. Chehab F.F., Lim M.E.
    Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiLEP_MOUSE
AccessioniPrimary (citable) accession number: P41160
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 24, 2015
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.