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P41160

- LEP_MOUSE

UniProt

P41160 - LEP_MOUSE

Protein

Leptin

Gene

Lep

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.

    GO - Molecular functioni

    1. growth factor activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. adipose tissue development Source: MGI
    2. adult feeding behavior Source: HGNC
    3. bile acid metabolic process Source: MGI
    4. bone mineralization involved in bone maturation Source: Ensembl
    5. cellular response to L-ascorbic acid Source: Ensembl
    6. cellular response to retinoic acid Source: Ensembl
    7. central nervous system neuron development Source: MGI
    8. cholesterol metabolic process Source: MGI
    9. circadian rhythm Source: Ensembl
    10. eating behavior Source: MGI
    11. energy reserve metabolic process Source: Ensembl
    12. fatty acid beta-oxidation Source: MGI
    13. female pregnancy Source: Ensembl
    14. glucose homeostasis Source: MGI
    15. glucose metabolic process Source: MGI
    16. glycerol biosynthetic process Source: Ensembl
    17. hormone metabolic process Source: MGI
    18. insulin secretion Source: MGI
    19. leptin-mediated signaling pathway Source: Ensembl
    20. leukocyte tethering or rolling Source: Ensembl
    21. lipid metabolic process Source: MGI
    22. negative regulation of apoptotic process Source: Ensembl
    23. negative regulation of appetite Source: HGNC
    24. negative regulation of cartilage development Source: Ensembl
    25. negative regulation of glucagon secretion Source: BHF-UCL
    26. negative regulation of glutamine transport Source: Ensembl
    27. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    28. negative regulation of vasoconstriction Source: Ensembl
    29. ovulation from ovarian follicle Source: Ensembl
    30. placenta development Source: Ensembl
    31. positive regulation of cell proliferation Source: Ensembl
    32. positive regulation of cytokine production Source: Ensembl
    33. positive regulation of developmental growth Source: Ensembl
    34. positive regulation of follicle-stimulating hormone secretion Source: Ensembl
    35. positive regulation of hepatic stellate cell activation Source: Ensembl
    36. positive regulation of insulin receptor signaling pathway Source: Ensembl
    37. positive regulation of ion transport Source: Ensembl
    38. positive regulation of JAK-STAT cascade Source: BHF-UCL
    39. positive regulation of luteinizing hormone secretion Source: Ensembl
    40. positive regulation of MAPK cascade Source: Ensembl
    41. positive regulation of myeloid cell differentiation Source: MGI
    42. positive regulation of protein import into nucleus Source: BHF-UCL
    43. positive regulation of STAT protein import into nucleus Source: BHF-UCL
    44. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
    45. regulation of blood pressure Source: Ensembl
    46. regulation of fat cell differentiation Source: MGI
    47. regulation of gluconeogenesis Source: MGI
    48. regulation of insulin secretion Source: MGI
    49. regulation of intestinal cholesterol absorption Source: MGI
    50. regulation of lipoprotein lipid oxidation Source: Ensembl
    51. regulation of metabolic process Source: MGI
    52. regulation of protein localization to nucleus Source: MGI
    53. regulation of protein phosphorylation Source: BHF-UCL
    54. regulation of steroid biosynthetic process Source: MGI
    55. response to dietary excess Source: MGI
    56. response to hypoxia Source: Ensembl
    57. response to insulin Source: MGI
    58. response to vitamin E Source: Ensembl
    59. tyrosine phosphorylation of STAT protein Source: BHF-UCL

    Enzyme and pathway databases

    ReactomeiREACT_169390. Signaling by Leptin.
    REACT_188529. Signaling by Leptin.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leptin
    Alternative name(s):
    Obesity factor
    Gene namesi
    Name:Lep
    Synonyms:Ob
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:104663. Lep.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. extracellular region Source: Reactome
    3. extracellular space Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Lep are the cause of profound obesity and type II diabetes.

    Keywords - Diseasei

    Diabetes mellitus, Obesity

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 167146LeptinPRO_0000017687Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi117 ↔ 167By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP41160.

    PTM databases

    PhosphoSiteiP41160.

    Expressioni

    Gene expression databases

    BgeeiP41160.
    CleanExiMM_LEP.
    GenevestigatoriP41160.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000067046.

    Structurei

    3D structure databases

    ProteinModelPortaliP41160.
    SMRiP41160. Positions 24-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the leptin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45133.
    HOGENOMiHOG000252923.
    HOVERGENiHBG007860.
    InParanoidiP41160.
    KOiK05424.
    OMAiTIVTRIN.
    OrthoDBiEOG77Q4Z3.
    PhylomeDBiP41160.
    TreeFamiTF105086.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000065. Leptin.
    [Graphical view]
    PANTHERiPTHR11724. PTHR11724. 1 hit.
    PfamiPF02024. Leptin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001837. Leptin. 1 hit.
    PRINTSiPR00495. LEPTIN.
    ProDomiPD005698. Leptin. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P41160-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCWRPLCRFL WLWSYLSYVQ AVPIQKVQDD TKTLIKTIVT RINDISHTQS    50
    VSAKQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND 100
    LENLRDLLHL LAFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL 150
    QGSLQDILQQ LDVSPEC 167
    Length:167
    Mass (Da):18,709
    Last modified:February 1, 1995 - v1
    Checksum:iD6783E6C76FD7116
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti49 – 491Missing in 30% the clones.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18812 mRNA. Translation: AAA64564.1.
    U22421 Genomic DNA. Translation: AAA64213.1.
    CCDSiCCDS19955.1.
    PIRiS50863. LTMS.
    RefSeqiNP_032519.1. NM_008493.3.
    UniGeneiMm.277072.

    Genome annotation databases

    EnsembliENSMUST00000069789; ENSMUSP00000067046; ENSMUSG00000059201.
    GeneIDi16846.
    KEGGimmu:16846.
    UCSCiuc009bcv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18812 mRNA. Translation: AAA64564.1 .
    U22421 Genomic DNA. Translation: AAA64213.1 .
    CCDSi CCDS19955.1.
    PIRi S50863. LTMS.
    RefSeqi NP_032519.1. NM_008493.3.
    UniGenei Mm.277072.

    3D structure databases

    ProteinModelPortali P41160.
    SMRi P41160. Positions 24-167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000067046.

    PTM databases

    PhosphoSitei P41160.

    Proteomic databases

    PRIDEi P41160.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000069789 ; ENSMUSP00000067046 ; ENSMUSG00000059201 .
    GeneIDi 16846.
    KEGGi mmu:16846.
    UCSCi uc009bcv.1. mouse.

    Organism-specific databases

    CTDi 3952.
    MGIi MGI:104663. Lep.

    Phylogenomic databases

    eggNOGi NOG45133.
    HOGENOMi HOG000252923.
    HOVERGENi HBG007860.
    InParanoidi P41160.
    KOi K05424.
    OMAi TIVTRIN.
    OrthoDBi EOG77Q4Z3.
    PhylomeDBi P41160.
    TreeFami TF105086.

    Enzyme and pathway databases

    Reactomei REACT_169390. Signaling by Leptin.
    REACT_188529. Signaling by Leptin.

    Miscellaneous databases

    NextBioi 290772.
    PROi P41160.
    SOURCEi Search...

    Gene expression databases

    Bgeei P41160.
    CleanExi MM_LEP.
    Genevestigatori P41160.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000065. Leptin.
    [Graphical view ]
    PANTHERi PTHR11724. PTHR11724. 1 hit.
    Pfami PF02024. Leptin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001837. Leptin. 1 hit.
    PRINTSi PR00495. LEPTIN.
    ProDomi PD005698. Leptin. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Positional cloning of the mouse obese gene and its human homologue."
      Zhang Y., Proenca P., Maffei M., Barone M., Leopold L., Friedman J.M.
      Nature 372:425-432(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Erratum
      Zhang Y., Proenca P., Maffei M., Barone M., Leopold L., Friedman J.M.
      Nature 374:479-479(1995)
    3. Chehab F.F., Lim M.E.
      Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiLEP_MOUSE
    AccessioniPrimary (citable) accession number: P41160
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3