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P41160 (LEP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leptin
Alternative name(s):
Obesity factor
Gene names
Name:Lep
Synonyms:Ob
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.

Subcellular location

Secreted Probable.

Involvement in disease

Defects in Lep are the cause of profound obesity and type II diabetes.

Sequence similarities

Belongs to the leptin family.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseDiabetes mellitus
Obesity
   DomainSignal
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadipose tissue development

Inferred from genetic interaction PubMed 10742101. Source: MGI

adult feeding behavior

Inferred from direct assay PubMed 9590691. Source: HGNC

bile acid metabolic process

Inferred from direct assay PubMed 12114517. Source: MGI

bone mineralization involved in bone maturation

Inferred from electronic annotation. Source: Ensembl

cellular response to L-ascorbic acid

Inferred from electronic annotation. Source: Ensembl

cellular response to retinoic acid

Inferred from electronic annotation. Source: Ensembl

central nervous system neuron development

Inferred from mutant phenotype PubMed 10592285. Source: MGI

cholesterol metabolic process

Inferred from genetic interaction PubMed 15995171. Source: MGI

circadian rhythm

Inferred from electronic annotation. Source: Ensembl

eating behavior

Inferred from genetic interaction PubMed 10802666. Source: MGI

energy reserve metabolic process

Inferred from electronic annotation. Source: Ensembl

fatty acid beta-oxidation

Inferred from genetic interaction PubMed 22958918. Source: MGI

female pregnancy

Inferred from electronic annotation. Source: Ensembl

glucose homeostasis

Inferred from genetic interaction PubMed 22958918. Source: MGI

glucose metabolic process

Inferred from mutant phenotype PubMed 12540600. Source: MGI

glycerol biosynthetic process

Inferred from electronic annotation. Source: Ensembl

hormone metabolic process

Inferred from mutant phenotype PubMed 16513828. Source: MGI

insulin secretion

Inferred from genetic interaction PubMed 16141392. Source: MGI

leptin-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

leukocyte tethering or rolling

Inferred from electronic annotation. Source: Ensembl

lipid metabolic process

Inferred from mutant phenotype PubMed 12815040. Source: MGI

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of appetite

Inferred from direct assay PubMed 9590691. Source: HGNC

negative regulation of cartilage development

Inferred from electronic annotation. Source: Ensembl

negative regulation of glucagon secretion

Inferred from direct assay PubMed 21234744. Source: BHF-UCL

negative regulation of glutamine transport

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 21234744. Source: BHF-UCL

negative regulation of vasoconstriction

Inferred from electronic annotation. Source: Ensembl

ovulation from ovarian follicle

Inferred from electronic annotation. Source: Ensembl

placenta development

Inferred from electronic annotation. Source: Ensembl

positive regulation of JAK-STAT cascade

Inferred from direct assay PubMed 21234744. Source: BHF-UCL

positive regulation of MAPK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of STAT protein import into nucleus

Inferred from direct assay PubMed 21234744. Source: BHF-UCL

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytokine production

Inferred from electronic annotation. Source: Ensembl

positive regulation of developmental growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of follicle-stimulating hormone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of hepatic stellate cell activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of insulin receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of ion transport

Inferred from electronic annotation. Source: Ensembl

positive regulation of luteinizing hormone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of myeloid cell differentiation

Inferred from direct assay PubMed 9057630. Source: MGI

positive regulation of protein import into nucleus

Inferred from direct assay PubMed 21234744. Source: BHF-UCL

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from electronic annotation. Source: Ensembl

regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

regulation of fat cell differentiation

Inferred from genetic interaction PubMed 22927639. Source: MGI

regulation of gluconeogenesis

Inferred from mutant phenotype PubMed 16513828. Source: MGI

regulation of insulin secretion

Inferred from mutant phenotype PubMed 16513828. Source: MGI

regulation of intestinal cholesterol absorption

Inferred from direct assay PubMed 12114517. Source: MGI

regulation of lipoprotein lipid oxidation

Inferred from electronic annotation. Source: Ensembl

regulation of metabolic process

Inferred from mutant phenotype PubMed 12925742. Source: MGI

regulation of protein phosphorylation

Inferred from direct assay PubMed 21234744. Source: BHF-UCL

regulation of steroid biosynthetic process

Inferred from mutant phenotype PubMed 16513828. Source: MGI

response to dietary excess

Inferred from mutant phenotype PubMed 16141392. Source: MGI

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to insulin

Inferred from mutant phenotype PubMed 16141392. Source: MGI

response to vitamin E

Inferred from electronic annotation. Source: Ensembl

tyrosine phosphorylation of STAT protein

Inferred from direct assay PubMed 21234744. Source: BHF-UCL

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 11387233. Source: BHF-UCL

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from direct assay PubMed 11387233. Source: BHF-UCL

   Molecular_functiongrowth factor activity

Inferred from direct assay PubMed 9057630. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 167146Leptin
PRO_0000017687

Amino acid modifications

Disulfide bond117 ↔ 167 By similarity

Natural variations

Natural variant491Missing in 30% the clones.

Sequences

Sequence LengthMass (Da)Tools
P41160 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: D6783E6C76FD7116

FASTA16718,709
        10         20         30         40         50         60 
MCWRPLCRFL WLWSYLSYVQ AVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL 

        70         80         90        100        110        120 
DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP 

       130        140        150        160 
QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC 

« Hide

References

[1]"Positional cloning of the mouse obese gene and its human homologue."
Zhang Y., Proenca P., Maffei M., Barone M., Leopold L., Friedman J.M.
Nature 372:425-432(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Erratum
Zhang Y., Proenca P., Maffei M., Barone M., Leopold L., Friedman J.M.
Nature 374:479-479(1995)
[3]Chehab F.F., Lim M.E.
Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18812 mRNA. Translation: AAA64564.1.
U22421 Genomic DNA. Translation: AAA64213.1.
PIRLTMS. S50863.
RefSeqNP_032519.1. NM_008493.3.
UniGeneMm.277072.

3D structure databases

ProteinModelPortalP41160.
SMRP41160. Positions 24-167.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000067046.

PTM databases

PhosphoSiteP41160.

Proteomic databases

PRIDEP41160.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000069789; ENSMUSP00000067046; ENSMUSG00000059201.
GeneID16846.
KEGGmmu:16846.
UCSCuc009bcv.1. mouse.

Organism-specific databases

CTD3952.
MGIMGI:104663. Lep.

Phylogenomic databases

eggNOGNOG45133.
HOGENOMHOG000252923.
HOVERGENHBG007860.
InParanoidP41160.
KOK05424.
OMAKTIVTRI.
OrthoDBEOG77Q4Z3.
PhylomeDBP41160.
TreeFamTF105086.

Enzyme and pathway databases

ReactomeREACT_169390. Signaling by Leptin.
REACT_188257. Signal Transduction.

Gene expression databases

BgeeP41160.
CleanExMM_LEP.
GenevestigatorP41160.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000065. Leptin.
[Graphical view]
PANTHERPTHR11724. PTHR11724. 1 hit.
PfamPF02024. Leptin. 1 hit.
[Graphical view]
PIRSFPIRSF001837. Leptin. 1 hit.
PRINTSPR00495. LEPTIN.
ProDomPD005698. Leptin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

NextBio290772.
PROP41160.
SOURCESearch...

Entry information

Entry nameLEP_MOUSE
AccessionPrimary (citable) accession number: P41160
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot