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Protein

ETS domain-containing protein Elk-4

Gene

Elk4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi5 – 8581ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS domain-containing protein Elk-4
Alternative name(s):
Serum response factor accessory protein 1
Short name:
SAP-1
Short name:
SRF accessory protein 1
Gene namesi
Name:Elk4
Synonyms:Sap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:102853. Elk4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430ETS domain-containing protein Elk-4PRO_0000204100Add
BLAST

Proteomic databases

PRIDEiP41158.

PTM databases

PhosphoSiteiP41158.

Expressioni

Tissue specificityi

Lung and liver.

Gene expression databases

BgeeiP41158.
CleanExiMM_ELK4.
ExpressionAtlasiP41158. baseline and differential.
GenevisibleiP41158. MM.

Interactioni

Subunit structurei

Interacts with SIRT7.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027696.

Structurei

3D structure databases

ProteinModelPortaliP41158.
SMRiP41158. Positions 2-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG317055.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000237332.
HOVERGENiHBG004344.
InParanoidiP41158.
KOiK04376.
OMAiICWTSNN.
OrthoDBiEOG7NPFTD.
TreeFamiTF317732.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41158-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSAITLWQF LLQLLQEPQN EHMICWTSNN GEFKLLQAEE VARLWGIRKN
60 70 80 90 100
KPNMNYDKLS RALRYYYVKN IIKKVNGQKF VYKFVSYPEI LKMDPLTVGR
110 120 130 140 150
IEGDCEALNS IETSSSKDVE YGGKERPPQP GAKTSSRNDY IHSGLYSSFT
160 170 180 190 200
LNSLNTSNKK LFKSIKIENP AEKLAEKKAQ EPTPSVIKFV TTPAKKPPIE
210 220 230 240 250
PVAAAFATSP SLSPSSEETI QALETLVSPT LPSLETPASI SILATTFNPT
260 270 280 290 300
PPVPSTPLPL KEPPRTPSPP LSSNPDIDTD IESVASQPME LPENLSLEPK
310 320 330 340 350
NEDSALPEKD KTNNSSRSKK PKGLELTPAL VVTGSDPSPL GILSPSLPTA
360 370 380 390 400
SLTPALFSQT PILLTPSPLL SSIHFWSTLS PFAPLSPARL QGANTLFQFP
410 420 430
SVLNSHGPFT LSGLDGPSTP GPFSPDLQKT
Length:430
Mass (Da):46,826
Last modified:July 27, 2011 - v2
Checksum:i76CF28AB7627AB5F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991G → A in CAA85358 (PubMed:7958835).Curated
Sequence conflicti206 – 2061F → C in CAA85358 (PubMed:7958835).Curated
Sequence conflicti228 – 2281S → F in CAA85358 (PubMed:7958835).Curated
Sequence conflicti307 – 3071P → A in CAA85358 (PubMed:7958835).Curated
Sequence conflicti340 – 3401L → S in CAA85358 (PubMed:7958835).Curated
Sequence conflicti395 – 3951T → M in CAA85358 (PubMed:7958835).Curated
Sequence conflicti409 – 4091F → L in CAA85358 (PubMed:7958835).Curated
Sequence conflicti415 – 4151D → E in CAA85358 (PubMed:7958835).Curated
Sequence conflicti419 – 4191T → L in CAA85358 (PubMed:7958835).Curated
Sequence conflicti426 – 4261D → R in CAA85358 (PubMed:7958835).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36885 mRNA. Translation: CAA85358.1.
CH466520 Genomic DNA. Translation: EDL39692.1.
BC144844 mRNA. Translation: AAI44845.1.
BC145795 mRNA. Translation: AAI45796.1.
CCDSiCCDS35704.1.
PIRiI48755.
RefSeqiNP_031949.2. NM_007923.2.
XP_006529189.1. XM_006529126.2.
XP_006529190.1. XM_006529127.2.
XP_006529191.1. XM_006529128.2.
XP_006529192.1. XM_006529129.2.
XP_006529193.1. XM_006529130.2.
UniGeneiMm.254233.
Mm.482266.

Genome annotation databases

EnsembliENSMUST00000027696; ENSMUSP00000027696; ENSMUSG00000026436.
ENSMUST00000086556; ENSMUSP00000083743; ENSMUSG00000026436.
GeneIDi13714.
KEGGimmu:13714.
UCSCiuc007cob.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36885 mRNA. Translation: CAA85358.1.
CH466520 Genomic DNA. Translation: EDL39692.1.
BC144844 mRNA. Translation: AAI44845.1.
BC145795 mRNA. Translation: AAI45796.1.
CCDSiCCDS35704.1.
PIRiI48755.
RefSeqiNP_031949.2. NM_007923.2.
XP_006529189.1. XM_006529126.2.
XP_006529190.1. XM_006529127.2.
XP_006529191.1. XM_006529128.2.
XP_006529192.1. XM_006529129.2.
XP_006529193.1. XM_006529130.2.
UniGeneiMm.254233.
Mm.482266.

3D structure databases

ProteinModelPortaliP41158.
SMRiP41158. Positions 2-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027696.

PTM databases

PhosphoSiteiP41158.

Proteomic databases

PRIDEiP41158.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027696; ENSMUSP00000027696; ENSMUSG00000026436.
ENSMUST00000086556; ENSMUSP00000083743; ENSMUSG00000026436.
GeneIDi13714.
KEGGimmu:13714.
UCSCiuc007cob.1. mouse.

Organism-specific databases

CTDi2005.
MGIiMGI:102853. Elk4.

Phylogenomic databases

eggNOGiNOG317055.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000237332.
HOVERGENiHBG004344.
InParanoidiP41158.
KOiK04376.
OMAiICWTSNN.
OrthoDBiEOG7NPFTD.
TreeFamiTF317732.

Miscellaneous databases

NextBioi284492.
PROiP41158.
SOURCEiSearch...

Gene expression databases

BgeeiP41158.
CleanExiMM_ELK4.
ExpressionAtlasiP41158. baseline and differential.
GenevisibleiP41158. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Net, a new ets transcription factor that is activated by Ras."
    Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B.
    Genes Dev. 8:1502-1513(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiELK4_MOUSE
AccessioniPrimary (citable) accession number: P41158
Secondary accession number(s): A6H693
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.