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P41158

- ELK4_MOUSE

UniProt

P41158 - ELK4_MOUSE

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Protein

ETS domain-containing protein Elk-4

Gene

Elk4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi5 – 8581ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

GO - Biological processi

  1. cell differentiation Source: RefGenome
  2. histone H3 deacetylation Source: UniProtKB
  3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  5. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS domain-containing protein Elk-4
Alternative name(s):
Serum response factor accessory protein 1
Short name:
SAP-1
Short name:
SRF accessory protein 1
Gene namesi
Name:Elk4
Synonyms:Sap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:102853. Elk4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430ETS domain-containing protein Elk-4PRO_0000204100Add
BLAST

Proteomic databases

PRIDEiP41158.

PTM databases

PhosphoSiteiP41158.

Expressioni

Tissue specificityi

Lung and liver.

Gene expression databases

BgeeiP41158.
CleanExiMM_ELK4.
ExpressionAtlasiP41158. baseline and differential.
GenevestigatoriP41158.

Interactioni

Subunit structurei

Interacts with SIRT7.By similarity

Structurei

3D structure databases

ProteinModelPortaliP41158.
SMRiP41158. Positions 2-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG317055.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000237332.
HOVERGENiHBG004344.
InParanoidiP41158.
KOiK04376.
OMAiICWTSNN.
OrthoDBiEOG7NPFTD.
TreeFamiTF317732.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41158-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSAITLWQF LLQLLQEPQN EHMICWTSNN GEFKLLQAEE VARLWGIRKN
60 70 80 90 100
KPNMNYDKLS RALRYYYVKN IIKKVNGQKF VYKFVSYPEI LKMDPLTVGR
110 120 130 140 150
IEGDCEALNS IETSSSKDVE YGGKERPPQP GAKTSSRNDY IHSGLYSSFT
160 170 180 190 200
LNSLNTSNKK LFKSIKIENP AEKLAEKKAQ EPTPSVIKFV TTPAKKPPIE
210 220 230 240 250
PVAAAFATSP SLSPSSEETI QALETLVSPT LPSLETPASI SILATTFNPT
260 270 280 290 300
PPVPSTPLPL KEPPRTPSPP LSSNPDIDTD IESVASQPME LPENLSLEPK
310 320 330 340 350
NEDSALPEKD KTNNSSRSKK PKGLELTPAL VVTGSDPSPL GILSPSLPTA
360 370 380 390 400
SLTPALFSQT PILLTPSPLL SSIHFWSTLS PFAPLSPARL QGANTLFQFP
410 420 430
SVLNSHGPFT LSGLDGPSTP GPFSPDLQKT
Length:430
Mass (Da):46,826
Last modified:July 27, 2011 - v2
Checksum:i76CF28AB7627AB5F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991G → A in CAA85358. (PubMed:7958835)Curated
Sequence conflicti206 – 2061F → C in CAA85358. (PubMed:7958835)Curated
Sequence conflicti228 – 2281S → F in CAA85358. (PubMed:7958835)Curated
Sequence conflicti307 – 3071P → A in CAA85358. (PubMed:7958835)Curated
Sequence conflicti340 – 3401L → S in CAA85358. (PubMed:7958835)Curated
Sequence conflicti395 – 3951T → M in CAA85358. (PubMed:7958835)Curated
Sequence conflicti409 – 4091F → L in CAA85358. (PubMed:7958835)Curated
Sequence conflicti415 – 4151D → E in CAA85358. (PubMed:7958835)Curated
Sequence conflicti419 – 4191T → L in CAA85358. (PubMed:7958835)Curated
Sequence conflicti426 – 4261D → R in CAA85358. (PubMed:7958835)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36885 mRNA. Translation: CAA85358.1.
CH466520 Genomic DNA. Translation: EDL39692.1.
BC144844 mRNA. Translation: AAI44845.1.
BC145795 mRNA. Translation: AAI45796.1.
CCDSiCCDS35704.1.
PIRiI48755.
RefSeqiNP_031949.2. NM_007923.2.
XP_006529189.1. XM_006529126.1.
XP_006529190.1. XM_006529127.1.
XP_006529191.1. XM_006529128.1.
XP_006529192.1. XM_006529129.1.
XP_006529193.1. XM_006529130.1.
UniGeneiMm.254233.
Mm.482266.

Genome annotation databases

EnsembliENSMUST00000027696; ENSMUSP00000027696; ENSMUSG00000026436.
ENSMUST00000086556; ENSMUSP00000083743; ENSMUSG00000026436.
GeneIDi13714.
KEGGimmu:13714.
UCSCiuc007cob.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36885 mRNA. Translation: CAA85358.1 .
CH466520 Genomic DNA. Translation: EDL39692.1 .
BC144844 mRNA. Translation: AAI44845.1 .
BC145795 mRNA. Translation: AAI45796.1 .
CCDSi CCDS35704.1.
PIRi I48755.
RefSeqi NP_031949.2. NM_007923.2.
XP_006529189.1. XM_006529126.1.
XP_006529190.1. XM_006529127.1.
XP_006529191.1. XM_006529128.1.
XP_006529192.1. XM_006529129.1.
XP_006529193.1. XM_006529130.1.
UniGenei Mm.254233.
Mm.482266.

3D structure databases

ProteinModelPortali P41158.
SMRi P41158. Positions 2-155.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P41158.

Proteomic databases

PRIDEi P41158.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027696 ; ENSMUSP00000027696 ; ENSMUSG00000026436 .
ENSMUST00000086556 ; ENSMUSP00000083743 ; ENSMUSG00000026436 .
GeneIDi 13714.
KEGGi mmu:13714.
UCSCi uc007cob.1. mouse.

Organism-specific databases

CTDi 2005.
MGIi MGI:102853. Elk4.

Phylogenomic databases

eggNOGi NOG317055.
GeneTreei ENSGT00760000118996.
HOGENOMi HOG000237332.
HOVERGENi HBG004344.
InParanoidi P41158.
KOi K04376.
OMAi ICWTSNN.
OrthoDBi EOG7NPFTD.
TreeFami TF317732.

Miscellaneous databases

NextBioi 284492.
PROi P41158.
SOURCEi Search...

Gene expression databases

Bgeei P41158.
CleanExi MM_ELK4.
ExpressionAtlasi P41158. baseline and differential.
Genevestigatori P41158.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
[Graphical view ]
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Net, a new ets transcription factor that is activated by Ras."
    Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B.
    Genes Dev. 8:1502-1513(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiELK4_MOUSE
AccessioniPrimary (citable) accession number: P41158
Secondary accession number(s): A6H693
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3