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Protein

ETS domain-containing protein Elk-4

Gene

Elk4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 85ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
ETS domain-containing protein Elk-4
Alternative name(s):
Serum response factor accessory protein 1
Short name:
SAP-1
Short name:
SRF accessory protein 1
Gene namesi
Name:Elk4
Synonyms:Sap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:102853 Elk4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041001 – 430ETS domain-containing protein Elk-4Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki166Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP41158
MaxQBiP41158
PaxDbiP41158
PRIDEiP41158

PTM databases

iPTMnetiP41158
PhosphoSitePlusiP41158

Expressioni

Tissue specificityi

Lung and liver.

Gene expression databases

BgeeiENSMUSG00000026436
CleanExiMM_ELK4
ExpressionAtlasiP41158 baseline and differential
GenevisibleiP41158 MM

Interactioni

Subunit structurei

Interacts with SIRT7.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027696

Structurei

3D structure databases

ProteinModelPortaliP41158
SMRiP41158
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000237332
HOVERGENiHBG004344
InParanoidiP41158
KOiK04376
OMAiICWTSNN
OrthoDBiEOG091G0COO
TreeFamiTF317732

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequencei

Sequence statusi: Complete.

P41158-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSAITLWQF LLQLLQEPQN EHMICWTSNN GEFKLLQAEE VARLWGIRKN
60 70 80 90 100
KPNMNYDKLS RALRYYYVKN IIKKVNGQKF VYKFVSYPEI LKMDPLTVGR
110 120 130 140 150
IEGDCEALNS IETSSSKDVE YGGKERPPQP GAKTSSRNDY IHSGLYSSFT
160 170 180 190 200
LNSLNTSNKK LFKSIKIENP AEKLAEKKAQ EPTPSVIKFV TTPAKKPPIE
210 220 230 240 250
PVAAAFATSP SLSPSSEETI QALETLVSPT LPSLETPASI SILATTFNPT
260 270 280 290 300
PPVPSTPLPL KEPPRTPSPP LSSNPDIDTD IESVASQPME LPENLSLEPK
310 320 330 340 350
NEDSALPEKD KTNNSSRSKK PKGLELTPAL VVTGSDPSPL GILSPSLPTA
360 370 380 390 400
SLTPALFSQT PILLTPSPLL SSIHFWSTLS PFAPLSPARL QGANTLFQFP
410 420 430
SVLNSHGPFT LSGLDGPSTP GPFSPDLQKT
Length:430
Mass (Da):46,826
Last modified:July 27, 2011 - v2
Checksum:i76CF28AB7627AB5F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99G → A in CAA85358 (PubMed:7958835).Curated1
Sequence conflicti206F → C in CAA85358 (PubMed:7958835).Curated1
Sequence conflicti228S → F in CAA85358 (PubMed:7958835).Curated1
Sequence conflicti307P → A in CAA85358 (PubMed:7958835).Curated1
Sequence conflicti340L → S in CAA85358 (PubMed:7958835).Curated1
Sequence conflicti395T → M in CAA85358 (PubMed:7958835).Curated1
Sequence conflicti409F → L in CAA85358 (PubMed:7958835).Curated1
Sequence conflicti415D → E in CAA85358 (PubMed:7958835).Curated1
Sequence conflicti419T → L in CAA85358 (PubMed:7958835).Curated1
Sequence conflicti426D → R in CAA85358 (PubMed:7958835).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36885 mRNA Translation: CAA85358.1
CH466520 Genomic DNA Translation: EDL39692.1
BC144844 mRNA Translation: AAI44845.1
BC145795 mRNA Translation: AAI45796.1
CCDSiCCDS35704.1
PIRiI48755
RefSeqiNP_031949.2, NM_007923.2
XP_006529189.1, XM_006529126.3
XP_006529190.1, XM_006529127.3
XP_006529191.1, XM_006529128.3
XP_006529192.1, XM_006529129.3
XP_006529193.1, XM_006529130.3
UniGeneiMm.254233
Mm.482266

Genome annotation databases

EnsembliENSMUST00000027696; ENSMUSP00000027696; ENSMUSG00000026436
ENSMUST00000086556; ENSMUSP00000083743; ENSMUSG00000026436
GeneIDi13714
KEGGimmu:13714
UCSCiuc007cob.1 mouse

Similar proteinsi

Entry informationi

Entry nameiELK4_MOUSE
AccessioniPrimary (citable) accession number: P41158
Secondary accession number(s): A6H693
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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