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P41158

- ELK4_MOUSE

UniProt

P41158 - ELK4_MOUSE

Protein

ETS domain-containing protein Elk-4

Gene

Elk4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi5 – 8581ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. cell differentiation Source: RefGenome
    2. histone H3 deacetylation Source: UniProtKB
    3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    5. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS domain-containing protein Elk-4
    Alternative name(s):
    Serum response factor accessory protein 1
    Short name:
    SAP-1
    Short name:
    SRF accessory protein 1
    Gene namesi
    Name:Elk4
    Synonyms:Sap1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:102853. Elk4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430ETS domain-containing protein Elk-4PRO_0000204100Add
    BLAST

    Proteomic databases

    PRIDEiP41158.

    PTM databases

    PhosphoSiteiP41158.

    Expressioni

    Tissue specificityi

    Lung and liver.

    Gene expression databases

    ArrayExpressiP41158.
    BgeeiP41158.
    CleanExiMM_ELK4.
    GenevestigatoriP41158.

    Interactioni

    Subunit structurei

    Interacts with SIRT7.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP41158.
    SMRiP41158. Positions 2-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG317055.
    GeneTreeiENSGT00750000117271.
    HOGENOMiHOG000237332.
    HOVERGENiHBG004344.
    InParanoidiA6H693.
    KOiK04376.
    OMAiICWTSNN.
    OrthoDBiEOG7NPFTD.
    TreeFamiTF317732.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    [Graphical view]
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41158-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSAITLWQF LLQLLQEPQN EHMICWTSNN GEFKLLQAEE VARLWGIRKN    50
    KPNMNYDKLS RALRYYYVKN IIKKVNGQKF VYKFVSYPEI LKMDPLTVGR 100
    IEGDCEALNS IETSSSKDVE YGGKERPPQP GAKTSSRNDY IHSGLYSSFT 150
    LNSLNTSNKK LFKSIKIENP AEKLAEKKAQ EPTPSVIKFV TTPAKKPPIE 200
    PVAAAFATSP SLSPSSEETI QALETLVSPT LPSLETPASI SILATTFNPT 250
    PPVPSTPLPL KEPPRTPSPP LSSNPDIDTD IESVASQPME LPENLSLEPK 300
    NEDSALPEKD KTNNSSRSKK PKGLELTPAL VVTGSDPSPL GILSPSLPTA 350
    SLTPALFSQT PILLTPSPLL SSIHFWSTLS PFAPLSPARL QGANTLFQFP 400
    SVLNSHGPFT LSGLDGPSTP GPFSPDLQKT 430
    Length:430
    Mass (Da):46,826
    Last modified:July 27, 2011 - v2
    Checksum:i76CF28AB7627AB5F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti99 – 991G → A in CAA85358. (PubMed:7958835)Curated
    Sequence conflicti206 – 2061F → C in CAA85358. (PubMed:7958835)Curated
    Sequence conflicti228 – 2281S → F in CAA85358. (PubMed:7958835)Curated
    Sequence conflicti307 – 3071P → A in CAA85358. (PubMed:7958835)Curated
    Sequence conflicti340 – 3401L → S in CAA85358. (PubMed:7958835)Curated
    Sequence conflicti395 – 3951T → M in CAA85358. (PubMed:7958835)Curated
    Sequence conflicti409 – 4091F → L in CAA85358. (PubMed:7958835)Curated
    Sequence conflicti415 – 4151D → E in CAA85358. (PubMed:7958835)Curated
    Sequence conflicti419 – 4191T → L in CAA85358. (PubMed:7958835)Curated
    Sequence conflicti426 – 4261D → R in CAA85358. (PubMed:7958835)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36885 mRNA. Translation: CAA85358.1.
    CH466520 Genomic DNA. Translation: EDL39692.1.
    BC144844 mRNA. Translation: AAI44845.1.
    BC145795 mRNA. Translation: AAI45796.1.
    CCDSiCCDS35704.1.
    PIRiI48755.
    RefSeqiNP_031949.2. NM_007923.2.
    XP_006529189.1. XM_006529126.1.
    XP_006529190.1. XM_006529127.1.
    XP_006529191.1. XM_006529128.1.
    XP_006529192.1. XM_006529129.1.
    XP_006529193.1. XM_006529130.1.
    UniGeneiMm.254233.
    Mm.482266.

    Genome annotation databases

    EnsembliENSMUST00000027696; ENSMUSP00000027696; ENSMUSG00000026436.
    ENSMUST00000086556; ENSMUSP00000083743; ENSMUSG00000026436.
    GeneIDi13714.
    KEGGimmu:13714.
    UCSCiuc007cob.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36885 mRNA. Translation: CAA85358.1 .
    CH466520 Genomic DNA. Translation: EDL39692.1 .
    BC144844 mRNA. Translation: AAI44845.1 .
    BC145795 mRNA. Translation: AAI45796.1 .
    CCDSi CCDS35704.1.
    PIRi I48755.
    RefSeqi NP_031949.2. NM_007923.2.
    XP_006529189.1. XM_006529126.1.
    XP_006529190.1. XM_006529127.1.
    XP_006529191.1. XM_006529128.1.
    XP_006529192.1. XM_006529129.1.
    XP_006529193.1. XM_006529130.1.
    UniGenei Mm.254233.
    Mm.482266.

    3D structure databases

    ProteinModelPortali P41158.
    SMRi P41158. Positions 2-155.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P41158.

    Proteomic databases

    PRIDEi P41158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027696 ; ENSMUSP00000027696 ; ENSMUSG00000026436 .
    ENSMUST00000086556 ; ENSMUSP00000083743 ; ENSMUSG00000026436 .
    GeneIDi 13714.
    KEGGi mmu:13714.
    UCSCi uc007cob.1. mouse.

    Organism-specific databases

    CTDi 2005.
    MGIi MGI:102853. Elk4.

    Phylogenomic databases

    eggNOGi NOG317055.
    GeneTreei ENSGT00750000117271.
    HOGENOMi HOG000237332.
    HOVERGENi HBG004344.
    InParanoidi A6H693.
    KOi K04376.
    OMAi ICWTSNN.
    OrthoDBi EOG7NPFTD.
    TreeFami TF317732.

    Miscellaneous databases

    NextBioi 284492.
    PROi P41158.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41158.
    Bgeei P41158.
    CleanExi MM_ELK4.
    Genevestigatori P41158.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    [Graphical view ]
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Net, a new ets transcription factor that is activated by Ras."
      Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B.
      Genes Dev. 8:1502-1513(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiELK4_MOUSE
    AccessioniPrimary (citable) accession number: P41158
    Secondary accession number(s): A6H693
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3