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Protein

Protein C-ets-1

Gene

Ets1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi335 – 41581ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • angiogenesis involved in wound healing Source: RGD
  • cell differentiation Source: GO_Central
  • cell motility Source: Ensembl
  • cellular response to hydrogen peroxide Source: RGD
  • estrous cycle Source: RGD
  • female pregnancy Source: RGD
  • hypothalamus development Source: RGD
  • immune system process Source: UniProtKB-KW
  • negative regulation of cell cycle Source: Ensembl
  • negative regulation of inflammatory response Source: Ensembl
  • pituitary gland development Source: RGD
  • PML body organization Source: Ensembl
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of cell migration Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of endothelial cell migration Source: UniProtKB
  • positive regulation of erythrocyte differentiation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • regulation of angiogenesis Source: UniProtKB
  • regulation of apoptotic process Source: Ensembl
  • regulation of extracellular matrix disassembly Source: RGD
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • response to antibiotic Source: Ensembl
  • response to estradiol Source: RGD
  • response to hypoxia Source: RGD
  • response to interleukin-1 Source: RGD
  • response to laminar fluid shear stress Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to wounding Source: RGD
  • transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Immunity, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-2559585. Oncogene Induced Senescence.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein C-ets-1
Alternative name(s):
p54
Gene namesi
Name:Ets1
Synonyms:Ets-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi2583. Ets1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Protein C-ets-1PRO_0000204071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81N6-acetyllysineBy similarity
Modified residuei15 – 151N6-acetyllysine; alternateBy similarity
Cross-linki15 – 15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki15 – 15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei38 – 381Phosphothreonine; by MAPKBy similarity
Modified residuei223 – 2231PhosphotyrosineBy similarity
Cross-linki227 – 227Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei251 – 2511PhosphoserineCombined sources
Modified residuei254 – 2541PhosphoserineBy similarity
Modified residuei265 – 2651PhosphothreonineBy similarity
Modified residuei267 – 2671PhosphoserineBy similarity
Modified residuei270 – 2701PhosphoserineBy similarity
Modified residuei282 – 2821PhosphoserineCombined sources
Modified residuei285 – 2851PhosphoserineBy similarity
Modified residuei305 – 3051N6-acetyllysineBy similarity

Post-translational modificationi

Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity.By similarity
Ubiquitinated; which induces proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP41156.
PRIDEiP41156.

PTM databases

iPTMnetiP41156.
PhosphoSiteiP41156.

Expressioni

Gene expression databases

GenevisibleiP41156. RN.

Interactioni

Subunit structurei

Binds DNA as a homodimer; homodimerization is required for transcription activation. Interacts with MAF and MAFB. Interacts with PAX5; the interaction alters DNA-binding properties. Interacts with DAXX. Interacts with UBE2I. Interacts with SP100; the interaction is direct and modulates ETS1 transcriptional activity (By similarity).By similarity

GO - Molecular functioni

  • histone acetyltransferase binding Source: RGD

Protein-protein interaction databases

MINTiMINT-246872.
STRINGi10116.ENSRNOP00000062912.

Structurei

3D structure databases

ProteinModelPortaliP41156.
SMRiP41156. Positions 29-138, 297-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 13686PNTPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 243114Activation domain; required for transcription activationBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000285953.
HOVERGENiHBG003088.
InParanoidiP41156.
KOiK02678.
OMAiDEMATQE.
OrthoDBiEOG77127T.
PhylomeDBiP41156.
TreeFamiTF316214.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016311. Transform_prot_C-ets.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF001698. Transforming_factor_C-ets. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: At least 2 isoforms are produced.

Isoform 1 (identifier: P41156-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK
60 70 80 90 100
ATFSGFTKEQ QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM
110 120 130 140 150
NGAALCALGK ECFLELAPDF VGDILWEHLE ILQKEDVKPY QVNGVNPTYP
160 170 180 190 200
ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF ITESYQTLHP ISSEELLSLK
210 220 230 240 250
YENDYPSVIL RDPLQTDTLQ TDYFAIKQEV LTPDNMCMGR ASRGKLGGQD
260 270 280 290 300
SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP
310 320 330 340 350
KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC
360 370 380 390 400
QSFISWTGDG WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN
410 420 430 440
IIHKTAGKRY VYRFVCDLQS LLGYTPEELH AMLDVKPDAD E
Length:441
Mass (Da):50,423
Last modified:February 1, 1995 - v1
Checksum:i981E029CABFBBE6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20681 mRNA. Translation: AAA21093.1.
BC101927 mRNA. Translation: AAI01928.1.
PIRiA53988.
RefSeqiNP_036687.1. NM_012555.2. [P41156-1]
UniGeneiRn.88756.

Genome annotation databases

EnsembliENSRNOT00000011925; ENSRNOP00000011925; ENSRNOG00000008941. [P41156-1]
GeneIDi24356.
KEGGirno:24356.
UCSCiRGD:2583. rat. [P41156-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20681 mRNA. Translation: AAA21093.1.
BC101927 mRNA. Translation: AAI01928.1.
PIRiA53988.
RefSeqiNP_036687.1. NM_012555.2. [P41156-1]
UniGeneiRn.88756.

3D structure databases

ProteinModelPortaliP41156.
SMRiP41156. Positions 29-138, 297-441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-246872.
STRINGi10116.ENSRNOP00000062912.

PTM databases

iPTMnetiP41156.
PhosphoSiteiP41156.

Proteomic databases

PaxDbiP41156.
PRIDEiP41156.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011925; ENSRNOP00000011925; ENSRNOG00000008941. [P41156-1]
GeneIDi24356.
KEGGirno:24356.
UCSCiRGD:2583. rat. [P41156-1]

Organism-specific databases

CTDi2113.
RGDi2583. Ets1.

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000285953.
HOVERGENiHBG003088.
InParanoidiP41156.
KOiK02678.
OMAiDEMATQE.
OrthoDBiEOG77127T.
PhylomeDBiP41156.
TreeFamiTF316214.

Enzyme and pathway databases

ReactomeiR-RNO-2559585. Oncogene Induced Senescence.

Miscellaneous databases

PROiP41156.

Gene expression databases

GenevisibleiP41156. RN.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016311. Transform_prot_C-ets.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF001698. Transforming_factor_C-ets. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Effects of provirus integration in the Tpl-1/Ets-1 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas: levels of expression, polyadenylation, transcriptional initiation, and differential splicing of the Ets-1 mRNA."
    Bellacosa A., Datta K., Bear S.E., Patriotis C., Lazo P.A., Copeland N.G., Jenkins N.A., Tsichlis P.N.
    J. Virol. 68:2320-2330(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251 AND SER-282, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiETS1_RAT
AccessioniPrimary (citable) accession number: P41156
Secondary accession number(s): Q3T1H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 6, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.