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Protein

Protein C-ets-1

Gene

Ets1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi335 – 415ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

  • angiogenesis involved in wound healing Source: RGD
  • cell differentiation Source: GO_Central
  • cell motility Source: Ensembl
  • cellular response to hydrogen peroxide Source: RGD
  • estrous cycle Source: RGD
  • female pregnancy Source: RGD
  • hypothalamus development Source: RGD
  • immune system process Source: UniProtKB-KW
  • negative regulation of inflammatory response Source: Ensembl
  • pituitary gland development Source: RGD
  • PML body organization Source: Ensembl
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of blood vessel endothelial cell migration Source: Ensembl
  • positive regulation of cell migration Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of endothelial cell migration Source: UniProtKB
  • positive regulation of erythrocyte differentiation Source: UniProtKB
  • positive regulation of inflammatory response Source: Ensembl
  • positive regulation of leukocyte adhesion to vascular endothelial cell Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: Ensembl
  • pri-miRNA transcription by RNA polymerase II Source: Ensembl
  • regulation of angiogenesis Source: UniProtKB
  • regulation of extracellular matrix disassembly Source: RGD
  • regulation of transcription by RNA polymerase II Source: GO_Central
  • response to estradiol Source: RGD
  • response to hypoxia Source: RGD
  • response to interleukin-1 Source: RGD
  • response to laminar fluid shear stress Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to wounding Source: RGD

Keywordsi

Molecular functionDNA-binding
Biological processImmunity, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-2559585 Oncogene Induced Senescence

Names & Taxonomyi

Protein namesi
Recommended name:
Protein C-ets-1
Alternative name(s):
p54
Gene namesi
Name:Ets1
Synonyms:Ets-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi2583 Ets1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040711 – 441Protein C-ets-1Add BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8N6-acetyllysine; alternateBy similarity1
Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei15N6-acetyllysine; alternateBy similarity1
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei38Phosphothreonine; by MAPKBy similarity1
Cross-linki138Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei223PhosphotyrosineBy similarity1
Cross-linki227Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei251PhosphoserineCombined sources1
Modified residuei254PhosphoserineBy similarity1
Modified residuei265PhosphothreonineBy similarity1
Modified residuei267PhosphoserineBy similarity1
Modified residuei270PhosphoserineBy similarity1
Modified residuei282PhosphoserineCombined sources1
Modified residuei285PhosphoserineBy similarity1
Modified residuei305N6-acetyllysineBy similarity1

Post-translational modificationi

Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity.By similarity
Ubiquitinated; which induces proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP41156
PRIDEiP41156

PTM databases

iPTMnetiP41156
PhosphoSitePlusiP41156

Expressioni

Gene expression databases

BgeeiENSRNOG00000008941
GenevisibleiP41156 RN

Interactioni

Subunit structurei

Binds DNA as a homodimer; homodimerization is required for transcription activation. Interacts with MAF and MAFB. Interacts with PAX5; the interaction alters DNA-binding properties. Interacts with DAXX. Interacts with UBE2I. Interacts with SP100; the interaction is direct and modulates ETS1 transcriptional activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

MINTiP41156
STRINGi10116.ENSRNOP00000062912

Structurei

3D structure databases

ProteinModelPortaliP41156
SMRiP41156
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 136PNTPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni130 – 243Activation domain; required for transcription activationBy similarityAdd BLAST114

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000285953
HOVERGENiHBG003088
InParanoidiP41156
KOiK02678
OMAiDEMATQE
OrthoDBiEOG091G0HJF
PhylomeDBiP41156
TreeFamiTF316214

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR016311 Transform_prot_C-ets
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PIRSFiPIRSF001698 Transforming_factor_C-ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: At least 2 isoforms are produced.
Isoform 1 (identifier: P41156-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK
60 70 80 90 100
ATFSGFTKEQ QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM
110 120 130 140 150
NGAALCALGK ECFLELAPDF VGDILWEHLE ILQKEDVKPY QVNGVNPTYP
160 170 180 190 200
ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF ITESYQTLHP ISSEELLSLK
210 220 230 240 250
YENDYPSVIL RDPLQTDTLQ TDYFAIKQEV LTPDNMCMGR ASRGKLGGQD
260 270 280 290 300
SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP
310 320 330 340 350
KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC
360 370 380 390 400
QSFISWTGDG WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN
410 420 430 440
IIHKTAGKRY VYRFVCDLQS LLGYTPEELH AMLDVKPDAD E
Length:441
Mass (Da):50,423
Last modified:February 1, 1995 - v1
Checksum:i981E029CABFBBE6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20681 mRNA Translation: AAA21093.1
BC101927 mRNA Translation: AAI01928.1
PIRiA53988
RefSeqiNP_036687.1, NM_012555.2 [P41156-1]
UniGeneiRn.88756

Genome annotation databases

EnsembliENSRNOT00000011925; ENSRNOP00000011925; ENSRNOG00000008941 [P41156-1]
GeneIDi24356
KEGGirno:24356
UCSCiRGD:2583 rat [P41156-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiETS1_RAT
AccessioniPrimary (citable) accession number: P41156
Secondary accession number(s): Q3T1H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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