ID   TNFC_MOUSE              Reviewed;         306 AA.
AC   P41155;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   24-JAN-2024, entry version 153.
DE   RecName: Full=Lymphotoxin-beta;
DE            Short=LT-beta;
DE   AltName: Full=Tumor necrosis factor C;
DE            Short=TNF-C;
DE   AltName: Full=Tumor necrosis factor ligand superfamily member 3;
GN   Name=Ltb; Synonyms=Tnfc, Tnfsf3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=7846035; DOI=10.1073/pnas.92.3.674;
RA   Pokholok D.K., Maroulakou I.G., Kuprash D.V., Alimzhanov M.B., Kozlov S.V.,
RA   Novobrantseva T.I., Turetskaya R.L., Green J.E., Nedospasov S.A.;
RT   "Cloning and expression analysis of the murine lymphotoxin beta gene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:674-678(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Spleen;
RX   PubMed=7995944;
RA   Lawton P., Nelson J., Tizard R., Browning J.L.;
RT   "Characterization of the mouse lymphotoxin-beta gene.";
RL   J. Immunol. 154:239-246(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=129;
RX   PubMed=14656967; DOI=10.1101/gr.1736803;
RA   Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA   Hood L.;
RT   "Analysis of the gene-dense major histocompatibility complex class III
RT   region and its comparison to mouse.";
RL   Genome Res. 13:2621-2636(2003).
CC   -!- FUNCTION: Cytokine that binds to LTBR/TNFRSF3. May play a specific role
CC       in immune response regulation. Provides the membrane anchor for the
CC       attachment of the heterotrimeric complex to the cell surface.
CC   -!- SUBUNIT: Heterotrimer of either two LTB and one LTA subunits or (less
CC       prevalent) two LTA and one LTB subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR   EMBL; U12029; AAA67716.1; -; Genomic_DNA.
DR   EMBL; U16984; AAB60493.1; -; Genomic_DNA.
DR   EMBL; U16985; AAA70089.1; -; mRNA.
DR   EMBL; U06950; AAA18592.1; -; Unassigned_DNA.
DR   EMBL; AF109719; AAC82483.1; -; Genomic_DNA.
DR   CCDS; CCDS28690.1; -.
DR   PIR; I49139; I49139.
DR   RefSeq; NP_032544.1; NM_008518.2.
DR   AlphaFoldDB; P41155; -.
DR   SMR; P41155; -.
DR   BioGRID; 201218; 2.
DR   IntAct; P41155; 1.
DR   STRING; 10090.ENSMUSP00000025262; -.
DR   GlyCosmos; P41155; 2 sites, No reported glycans.
DR   GlyGen; P41155; 2 sites.
DR   iPTMnet; P41155; -.
DR   PhosphoSitePlus; P41155; -.
DR   EPD; P41155; -.
DR   PaxDb; 10090-ENSMUSP00000025262; -.
DR   ProteomicsDB; 258790; -.
DR   Antibodypedia; 27204; 250 antibodies from 25 providers.
DR   DNASU; 16994; -.
DR   Ensembl; ENSMUST00000025262.6; ENSMUSP00000025262.6; ENSMUSG00000024399.6.
DR   GeneID; 16994; -.
DR   KEGG; mmu:16994; -.
DR   UCSC; uc008cgp.2; mouse.
DR   AGR; MGI:104796; -.
DR   CTD; 4050; -.
DR   MGI; MGI:104796; Ltb.
DR   VEuPathDB; HostDB:ENSMUSG00000024399; -.
DR   eggNOG; ENOG502SMSQ; Eukaryota.
DR   GeneTree; ENSGT01060000248544; -.
DR   InParanoid; P41155; -.
DR   OMA; GAWMKGQ; -.
DR   OrthoDB; 5319639at2759; -.
DR   PhylomeDB; P41155; -.
DR   TreeFam; TF337780; -.
DR   Reactome; R-MMU-5668541; TNFR2 non-canonical NF-kB pathway.
DR   Reactome; R-MMU-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
DR   BioGRID-ORCS; 16994; 3 hits in 79 CRISPR screens.
DR   PRO; PR:P41155; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; P41155; Protein.
DR   Bgee; ENSMUSG00000024399; Expressed in spleen and 52 other cell types or tissues.
DR   ExpressionAtlas; P41155; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:MGI.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR   GO; GO:0010467; P:gene expression; IMP:MGI.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0048535; P:lymph node development; IMP:MGI.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR   GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:0032735; P:positive regulation of interleukin-12 production; IMP:UniProtKB.
DR   GO; GO:0043588; P:skin development; IMP:MGI.
DR   CDD; cd00184; TNF; 1.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR006053; TNF.
DR   InterPro; IPR002961; TNF_C.
DR   InterPro; IPR021184; TNF_CS.
DR   InterPro; IPR006052; TNF_dom.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR11471:SF29; LYMPHOTOXIN-BETA; 1.
DR   PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR   Pfam; PF00229; TNF; 1.
DR   PRINTS; PR01234; TNECROSISFCT.
DR   PRINTS; PR01237; TNFC.
DR   SMART; SM00207; TNF; 1.
DR   SUPFAM; SSF49842; TNF-like; 1.
DR   PROSITE; PS00251; TNF_1; 1.
DR   PROSITE; PS50049; TNF_2; 1.
DR   Genevisible; P41155; MM.
PE   2: Evidence at transcript level;
KW   Cytokine; Glycoprotein; Membrane; Reference proteome; Signal-anchor;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..306
FT                   /note="Lymphotoxin-beta"
FT                   /id="PRO_0000185490"
FT   TOPO_DOM        1..27
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..306
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          63..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          127..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..112
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        98
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        284
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   306 AA;  32329 MW;  B7D276AB84A22549 CRC64;
     MGTRGLQGLG GRPQGRGCLL LAVAGATSLV TLLLAVPITV LAVLALVPQD QGRRVEKIIG
     SGAQAQKRLD DSKPSCILPS PSSLSETPDP RLHPQRSNAS RNLASTSQGP VAQSSREASA
     WMTILSPAAD STPDPGVQQL PKGEPETDLN PELPAAHLIG AWMSGQGLSW EASQEEAFLR
     SGAQFSPTHG LALPQDGVYY LYCHVGYRGR TPPAGRSRAR SLTLRSALYR AGGAYGRGSP
     ELLLEGAETV TPVVDPIGYG SLWYTSVGFG GLAQLRSGER VYVNISHPDM VDYRRGKTFF
     GAVMVG
//