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P41155

- TNFC_MOUSE

UniProt

P41155 - TNFC_MOUSE

Protein

Lymphotoxin-beta

Gene

Ltb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface.

    GO - Biological processi

    1. gene expression Source: MGI
    2. immune response Source: InterPro
    3. lymph node development Source: MGI
    4. positive regulation of interleukin-12 biosynthetic process Source: UniProtKB
    5. skin development Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lymphotoxin-beta
    Short name:
    LT-beta
    Alternative name(s):
    Tumor necrosis factor C
    Short name:
    TNF-C
    Tumor necrosis factor ligand superfamily member 3
    Gene namesi
    Name:Ltb
    Synonyms:Tnfc, Tnfsf3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:104796. Ltb.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306Lymphotoxin-betaPRO_0000185490Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP41155.

    Expressioni

    Gene expression databases

    ArrayExpressiP41155.
    BgeeiP41155.
    CleanExiMM_LTB.
    GenevestigatoriP41155.

    Interactioni

    Subunit structurei

    Heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.By similarity

    Protein-protein interaction databases

    BioGridi201218. 2 interactions.
    IntActiP41155. 1 interaction.
    MINTiMINT-1573434.

    Structurei

    3D structure databases

    ProteinModelPortaliP41155.
    SMRiP41155. Positions 153-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini49 – 306258ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44178.
    GeneTreeiENSGT00390000007066.
    HOGENOMiHOG000273916.
    HOVERGENiHBG000209.
    InParanoidiP41155.
    KOiK03157.
    OMAiREYGPLW.
    OrthoDBiEOG7V4B0Q.
    PhylomeDBiP41155.
    TreeFamiTF337780.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR006053. TNF.
    IPR002961. TNF_C.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    PRINTSiPR01234. TNECROSISFCT.
    PR01237. TNFC.
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41155-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTRGLQGLG GRPQGRGCLL LAVAGATSLV TLLLAVPITV LAVLALVPQD    50
    QGRRVEKIIG SGAQAQKRLD DSKPSCILPS PSSLSETPDP RLHPQRSNAS 100
    RNLASTSQGP VAQSSREASA WMTILSPAAD STPDPGVQQL PKGEPETDLN 150
    PELPAAHLIG AWMSGQGLSW EASQEEAFLR SGAQFSPTHG LALPQDGVYY 200
    LYCHVGYRGR TPPAGRSRAR SLTLRSALYR AGGAYGRGSP ELLLEGAETV 250
    TPVVDPIGYG SLWYTSVGFG GLAQLRSGER VYVNISHPDM VDYRRGKTFF 300
    GAVMVG 306
    Length:306
    Mass (Da):32,329
    Last modified:February 1, 1995 - v1
    Checksum:iB7D276AB84A22549
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12029 Genomic DNA. Translation: AAA67716.1.
    U16984 Genomic DNA. Translation: AAB60493.1.
    U16985 mRNA. Translation: AAA70089.1.
    U06950 Unassigned DNA. Translation: AAA18592.1.
    AF109719 Genomic DNA. Translation: AAC82483.1.
    CCDSiCCDS28690.1.
    PIRiI49139.
    RefSeqiNP_032544.1. NM_008518.2.
    UniGeneiMm.1715.

    Genome annotation databases

    EnsembliENSMUST00000025262; ENSMUSP00000025262; ENSMUSG00000024399.
    GeneIDi16994.
    KEGGimmu:16994.
    UCSCiuc008cgp.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12029 Genomic DNA. Translation: AAA67716.1 .
    U16984 Genomic DNA. Translation: AAB60493.1 .
    U16985 mRNA. Translation: AAA70089.1 .
    U06950 Unassigned DNA. Translation: AAA18592.1 .
    AF109719 Genomic DNA. Translation: AAC82483.1 .
    CCDSi CCDS28690.1.
    PIRi I49139.
    RefSeqi NP_032544.1. NM_008518.2.
    UniGenei Mm.1715.

    3D structure databases

    ProteinModelPortali P41155.
    SMRi P41155. Positions 153-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201218. 2 interactions.
    IntActi P41155. 1 interaction.
    MINTi MINT-1573434.

    Proteomic databases

    PRIDEi P41155.

    Protocols and materials databases

    DNASUi 16994.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025262 ; ENSMUSP00000025262 ; ENSMUSG00000024399 .
    GeneIDi 16994.
    KEGGi mmu:16994.
    UCSCi uc008cgp.2. mouse.

    Organism-specific databases

    CTDi 4050.
    MGIi MGI:104796. Ltb.

    Phylogenomic databases

    eggNOGi NOG44178.
    GeneTreei ENSGT00390000007066.
    HOGENOMi HOG000273916.
    HOVERGENi HBG000209.
    InParanoidi P41155.
    KOi K03157.
    OMAi REYGPLW.
    OrthoDBi EOG7V4B0Q.
    PhylomeDBi P41155.
    TreeFami TF337780.

    Miscellaneous databases

    NextBioi 291092.
    PROi P41155.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41155.
    Bgeei P41155.
    CleanExi MM_LTB.
    Genevestigatori P41155.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR006053. TNF.
    IPR002961. TNF_C.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01234. TNECROSISFCT.
    PR01237. TNFC.
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6.
    2. "Characterization of the mouse lymphotoxin-beta gene."
      Lawton P., Nelson J., Tizard R., Browning J.L.
      J. Immunol. 154:239-246(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: C57BL/6.
      Tissue: Spleen.
    3. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 129.

    Entry informationi

    Entry nameiTNFC_MOUSE
    AccessioniPrimary (citable) accession number: P41155
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3