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P41155 (TNFC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lymphotoxin-beta

Short name=LT-beta
Alternative name(s):
Tumor necrosis factor C
Short name=TNF-C
Tumor necrosis factor ligand superfamily member 3
Gene names
Name:Ltb
Synonyms:Tnfc, Tnfsf3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface.

Subunit structure

Heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits By similarity.

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the tumor necrosis factor family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Lymphotoxin-beta
PRO_0000185490

Regions

Topological domain1 – 2727Cytoplasmic Potential
Transmembrane28 – 4821Helical; Signal-anchor for type II membrane protein; Potential
Topological domain49 – 306258Extracellular Potential

Amino acid modifications

Glycosylation981N-linked (GlcNAc...) Potential
Glycosylation2841N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P41155 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: B7D276AB84A22549

FASTA30632,329
        10         20         30         40         50         60 
MGTRGLQGLG GRPQGRGCLL LAVAGATSLV TLLLAVPITV LAVLALVPQD QGRRVEKIIG 

        70         80         90        100        110        120 
SGAQAQKRLD DSKPSCILPS PSSLSETPDP RLHPQRSNAS RNLASTSQGP VAQSSREASA 

       130        140        150        160        170        180 
WMTILSPAAD STPDPGVQQL PKGEPETDLN PELPAAHLIG AWMSGQGLSW EASQEEAFLR 

       190        200        210        220        230        240 
SGAQFSPTHG LALPQDGVYY LYCHVGYRGR TPPAGRSRAR SLTLRSALYR AGGAYGRGSP 

       250        260        270        280        290        300 
ELLLEGAETV TPVVDPIGYG SLWYTSVGFG GLAQLRSGER VYVNISHPDM VDYRRGKTFF 


GAVMVG 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression analysis of the murine lymphotoxin beta gene."
Pokholok D.K., Maroulakou I.G., Kuprash D.V., Alimzhanov M.B., Kozlov S.V., Novobrantseva T.I., Turetskaya R.L., Green J.E., Nedospasov S.A.
Proc. Natl. Acad. Sci. U.S.A. 92:674-678(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6.
[2]"Characterization of the mouse lymphotoxin-beta gene."
Lawton P., Nelson J., Tizard R., Browning J.L.
J. Immunol. 154:239-246(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: C57BL/6.
Tissue: Spleen.
[3]"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 129.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12029 Genomic DNA. Translation: AAA67716.1.
U16984 Genomic DNA. Translation: AAB60493.1.
U16985 mRNA. Translation: AAA70089.1.
U06950 Unassigned DNA. Translation: AAA18592.1.
AF109719 Genomic DNA. Translation: AAC82483.1.
PIRI49139.
RefSeqNP_032544.1. NM_008518.2.
UniGeneMm.1715.

3D structure databases

ProteinModelPortalP41155.
SMRP41155. Positions 153-305.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201218. 2 interactions.
IntActP41155. 1 interaction.
MINTMINT-1573434.

Proteomic databases

PRIDEP41155.

Protocols and materials databases

DNASU16994.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025262; ENSMUSP00000025262; ENSMUSG00000024399.
GeneID16994.
KEGGmmu:16994.
UCSCuc008cgp.2. mouse.

Organism-specific databases

CTD4050.
MGIMGI:104796. Ltb.

Phylogenomic databases

eggNOGNOG44178.
GeneTreeENSGT00390000007066.
HOGENOMHOG000273916.
HOVERGENHBG000209.
InParanoidP41155.
KOK03157.
OMAREYGPLW.
OrthoDBEOG7V4B0Q.
PhylomeDBP41155.
TreeFamTF337780.

Gene expression databases

ArrayExpressP41155.
BgeeP41155.
CleanExMM_LTB.
GenevestigatorP41155.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR006053. TNF.
IPR002961. TNF_C.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00229. TNF. 1 hit.
[Graphical view]
PRINTSPR01234. TNECROSISFCT.
PR01237. TNFC.
SMARTSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio291092.
PROP41155.
SOURCESearch...

Entry information

Entry nameTNFC_MOUSE
AccessionPrimary (citable) accession number: P41155
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot