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Protein

Lymphotoxin-beta

Gene

Ltb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface.

GO - Molecular functioni

GO - Biological processi

  • gene expression Source: MGI
  • immune response Source: InterPro
  • lymph node development Source: MGI
  • positive regulation of interleukin-12 biosynthetic process Source: UniProtKB
  • skin development Source: MGI
  • tumor necrosis factor-mediated signaling pathway Source: Reactome

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphotoxin-beta
Short name:
LT-beta
Alternative name(s):
Tumor necrosis factor C
Short name:
TNF-C
Tumor necrosis factor ligand superfamily member 3
Gene namesi
Name:Ltb
Synonyms:Tnfc, Tnfsf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:104796. Ltb.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini49 – 306ExtracellularSequence analysisAdd BLAST258

GO - Cellular componenti

  • extracellular space Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854901 – 306Lymphotoxin-betaAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP41155.
PaxDbiP41155.
PRIDEiP41155.

PTM databases

iPTMnetiP41155.
PhosphoSitePlusiP41155.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024399.
CleanExiMM_LTB.
ExpressionAtlasiP41155. baseline and differential.
GenevisibleiP41155. MM.

Interactioni

Subunit structurei

Heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201218. 2 interactors.
IntActiP41155. 1 interactor.
MINTiMINT-1573434.
STRINGi10090.ENSMUSP00000025262.

Structurei

3D structure databases

ProteinModelPortaliP41155.
SMRiP41155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJP9. Eukaryota.
ENOG410ZHBF. LUCA.
GeneTreeiENSGT00390000007066.
HOGENOMiHOG000273916.
HOVERGENiHBG000209.
InParanoidiP41155.
KOiK03157.
OMAiYCHVGYR.
OrthoDBiEOG091G0J9M.
PhylomeDBiP41155.
TreeFamiTF337780.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR006053. TNF.
IPR002961. TNF_C.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
PfamiView protein in Pfam
PF00229. TNF. 1 hit.
PRINTSiPR01234. TNECROSISFCT.
PR01237. TNFC.
SMARTiView protein in SMART
SM00207. TNF. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P41155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTRGLQGLG GRPQGRGCLL LAVAGATSLV TLLLAVPITV LAVLALVPQD
60 70 80 90 100
QGRRVEKIIG SGAQAQKRLD DSKPSCILPS PSSLSETPDP RLHPQRSNAS
110 120 130 140 150
RNLASTSQGP VAQSSREASA WMTILSPAAD STPDPGVQQL PKGEPETDLN
160 170 180 190 200
PELPAAHLIG AWMSGQGLSW EASQEEAFLR SGAQFSPTHG LALPQDGVYY
210 220 230 240 250
LYCHVGYRGR TPPAGRSRAR SLTLRSALYR AGGAYGRGSP ELLLEGAETV
260 270 280 290 300
TPVVDPIGYG SLWYTSVGFG GLAQLRSGER VYVNISHPDM VDYRRGKTFF

GAVMVG
Length:306
Mass (Da):32,329
Last modified:February 1, 1995 - v1
Checksum:iB7D276AB84A22549
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12029 Genomic DNA. Translation: AAA67716.1.
U16984 Genomic DNA. Translation: AAB60493.1.
U16985 mRNA. Translation: AAA70089.1.
U06950 Unassigned DNA. Translation: AAA18592.1.
AF109719 Genomic DNA. Translation: AAC82483.1.
CCDSiCCDS28690.1.
PIRiI49139.
RefSeqiNP_032544.1. NM_008518.2.
UniGeneiMm.1715.

Genome annotation databases

EnsembliENSMUST00000025262; ENSMUSP00000025262; ENSMUSG00000024399.
GeneIDi16994.
KEGGimmu:16994.
UCSCiuc008cgp.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTNFC_MOUSE
AccessioniPrimary (citable) accession number: P41155
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 7, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families