Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lymphotoxin-beta

Gene

Ltb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface.

GO - Biological processi

  • gene expression Source: MGI
  • immune response Source: InterPro
  • lymph node development Source: MGI
  • positive regulation of interleukin-12 biosynthetic process Source: UniProtKB
  • skin development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphotoxin-beta
Short name:
LT-beta
Alternative name(s):
Tumor necrosis factor C
Short name:
TNF-C
Tumor necrosis factor ligand superfamily member 3
Gene namesi
Name:Ltb
Synonyms:Tnfc, Tnfsf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:104796. Ltb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei28 – 4821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini49 – 306258ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • extracellular space Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Lymphotoxin-betaPRO_0000185490Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP41155.

Expressioni

Gene expression databases

BgeeiP41155.
CleanExiMM_LTB.
ExpressionAtlasiP41155. baseline and differential.
GenevisibleiP41155. MM.

Interactioni

Subunit structurei

Heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.By similarity

Protein-protein interaction databases

BioGridi201218. 2 interactions.
IntActiP41155. 1 interaction.
MINTiMINT-1573434.
STRINGi10090.ENSMUSP00000025262.

Structurei

3D structure databases

ProteinModelPortaliP41155.
SMRiP41155. Positions 153-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44178.
GeneTreeiENSGT00390000007066.
HOGENOMiHOG000273916.
HOVERGENiHBG000209.
InParanoidiP41155.
KOiK03157.
OMAiREYGPLW.
OrthoDBiEOG7V4B0Q.
PhylomeDBiP41155.
TreeFamiTF337780.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR002961. TNF_C.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
PR01237. TNFC.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTRGLQGLG GRPQGRGCLL LAVAGATSLV TLLLAVPITV LAVLALVPQD
60 70 80 90 100
QGRRVEKIIG SGAQAQKRLD DSKPSCILPS PSSLSETPDP RLHPQRSNAS
110 120 130 140 150
RNLASTSQGP VAQSSREASA WMTILSPAAD STPDPGVQQL PKGEPETDLN
160 170 180 190 200
PELPAAHLIG AWMSGQGLSW EASQEEAFLR SGAQFSPTHG LALPQDGVYY
210 220 230 240 250
LYCHVGYRGR TPPAGRSRAR SLTLRSALYR AGGAYGRGSP ELLLEGAETV
260 270 280 290 300
TPVVDPIGYG SLWYTSVGFG GLAQLRSGER VYVNISHPDM VDYRRGKTFF

GAVMVG
Length:306
Mass (Da):32,329
Last modified:February 1, 1995 - v1
Checksum:iB7D276AB84A22549
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12029 Genomic DNA. Translation: AAA67716.1.
U16984 Genomic DNA. Translation: AAB60493.1.
U16985 mRNA. Translation: AAA70089.1.
U06950 Unassigned DNA. Translation: AAA18592.1.
AF109719 Genomic DNA. Translation: AAC82483.1.
CCDSiCCDS28690.1.
PIRiI49139.
RefSeqiNP_032544.1. NM_008518.2.
UniGeneiMm.1715.

Genome annotation databases

EnsembliENSMUST00000025262; ENSMUSP00000025262; ENSMUSG00000024399.
GeneIDi16994.
KEGGimmu:16994.
UCSCiuc008cgp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12029 Genomic DNA. Translation: AAA67716.1.
U16984 Genomic DNA. Translation: AAB60493.1.
U16985 mRNA. Translation: AAA70089.1.
U06950 Unassigned DNA. Translation: AAA18592.1.
AF109719 Genomic DNA. Translation: AAC82483.1.
CCDSiCCDS28690.1.
PIRiI49139.
RefSeqiNP_032544.1. NM_008518.2.
UniGeneiMm.1715.

3D structure databases

ProteinModelPortaliP41155.
SMRiP41155. Positions 153-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201218. 2 interactions.
IntActiP41155. 1 interaction.
MINTiMINT-1573434.
STRINGi10090.ENSMUSP00000025262.

Proteomic databases

PRIDEiP41155.

Protocols and materials databases

DNASUi16994.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025262; ENSMUSP00000025262; ENSMUSG00000024399.
GeneIDi16994.
KEGGimmu:16994.
UCSCiuc008cgp.2. mouse.

Organism-specific databases

CTDi4050.
MGIiMGI:104796. Ltb.

Phylogenomic databases

eggNOGiNOG44178.
GeneTreeiENSGT00390000007066.
HOGENOMiHOG000273916.
HOVERGENiHBG000209.
InParanoidiP41155.
KOiK03157.
OMAiREYGPLW.
OrthoDBiEOG7V4B0Q.
PhylomeDBiP41155.
TreeFamiTF337780.

Miscellaneous databases

NextBioi291092.
PROiP41155.
SOURCEiSearch...

Gene expression databases

BgeeiP41155.
CleanExiMM_LTB.
ExpressionAtlasiP41155. baseline and differential.
GenevisibleiP41155. MM.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR002961. TNF_C.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
PR01237. TNFC.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
  2. "Characterization of the mouse lymphotoxin-beta gene."
    Lawton P., Nelson J., Tizard R., Browning J.L.
    J. Immunol. 154:239-246(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: C57BL/6.
    Tissue: Spleen.
  3. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129.

Entry informationi

Entry nameiTNFC_MOUSE
AccessioniPrimary (citable) accession number: P41155
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 24, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.