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Protein

Melanocortin receptor 5

Gene

Mc5r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocortin receptor 5
Short name:
MC5-R
Gene namesi
Name:Mc5r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:99420. Mc5r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737ExtracellularSequence analysisAdd
BLAST
Transmembranei38 – 6124Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini62 – 7312CytoplasmicSequence analysisAdd
BLAST
Transmembranei74 – 9724Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini98 – 11417ExtracellularSequence analysisAdd
BLAST
Transmembranei115 – 13824Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini139 – 15517CytoplasmicSequence analysisAdd
BLAST
Transmembranei156 – 17924Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini180 – 1867ExtracellularSequence analysis
Transmembranei187 – 21125Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini212 – 23928CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26526Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini266 – 2738ExtracellularSequence analysis
Transmembranei274 – 29724Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini298 – 32528CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4489.
GuidetoPHARMACOLOGYi286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Melanocortin receptor 5PRO_0000069729Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence analysis
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Lipidationi311 – 3111S-palmitoyl cysteineSequence analysis
Lipidationi312 – 3121S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP41149.
PRIDEiP41149.

PTM databases

iPTMnetiP41149.
PhosphoSiteiP41149.

Expressioni

Tissue specificityi

Skin, adrenal gland, skeletal muscle, bone marrow, spleen, thymus, gonads, uterus and brain.

Gene expression databases

BgeeiENSMUSG00000007480.
CleanExiMM_MC5R.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130497.

Chemistry

BindingDBiP41149.

Structurei

3D structure databases

ProteinModelPortaliP41149.
SMRiP41149. Positions 42-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG108148.
InParanoidiP41149.
PhylomeDBiP41149.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001908. Melancort_rcpt.
IPR000621. Melancort_rcpt_5.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF5. PTHR22750:SF5. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01063. MELNOCORTN5R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41149-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSSTLTVL NLTLNASEDG ILGSNVKNKS LACEEMGIAV EVFLTLGLVS
60 70 80 90 100
LLENILVIGA IVKNKNLHSP MYFFVGSLAV ADMLVSMSNA WETVTIYLLN
110 120 130 140 150
NKHLVIADTF VRHIDNVFDS MICISVVASM CSLLAIAVDR YITIFYALRY
160 170 180 190 200
HHIMTARRSG VIIACIWTFC ISCGIVFIIY YESKYVIICL ISMFFTMLFF
210 220 230 240 250
MVSLYIHMFL LARNHVKRIA ASPRYNSVRQ RTSMKGAITL TMLLGIFIVC
260 270 280 290 300
WSPFFLHLIL MISCPQNVYC SCFMSYFNMY LILIMCNSVI DPLIYALRSQ
310 320
EMRRTFKEIV CCHGFRRPCR LLGGY
Length:325
Mass (Da):36,953
Last modified:February 1, 1995 - v1
Checksum:i5A014D1C1E0157EE
GO

Sequence cautioni

The sequence AAA76585 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 741F → Y (PubMed:8185570).Curated
Sequence conflicti74 – 741F → Y (PubMed:7739752).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76295 Genomic DNA. Translation: CAA53943.1.
L22527 Genomic DNA. Translation: AAA21337.1.
U08354 mRNA. Translation: AAA76585.1. Different initiation.
PIRiI49008.
UniGeneiMm.8003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76295 Genomic DNA. Translation: CAA53943.1.
L22527 Genomic DNA. Translation: AAA21337.1.
U08354 mRNA. Translation: AAA76585.1. Different initiation.
PIRiI49008.
UniGeneiMm.8003.

3D structure databases

ProteinModelPortaliP41149.
SMRiP41149. Positions 42-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130497.

Chemistry

BindingDBiP41149.
ChEMBLiCHEMBL4489.
GuidetoPHARMACOLOGYi286.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP41149.
PhosphoSiteiP41149.

Proteomic databases

PaxDbiP41149.
PRIDEiP41149.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:99420. Mc5r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG108148.
InParanoidiP41149.
PhylomeDBiP41149.

Miscellaneous databases

PROiP41149.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007480.
CleanExiMM_MC5R.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001908. Melancort_rcpt.
IPR000621. Melancort_rcpt_5.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF5. PTHR22750:SF5. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01063. MELNOCORTN5R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMC5R_MOUSE
AccessioniPrimary (citable) accession number: P41149
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.