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P41146

- OPRX_HUMAN

UniProt

P41146 - OPRX_HUMAN

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Protein
Nociceptin receptor
Gene
OPRL1, OOR, ORL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.5 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei110 – 1101Important for G protein-mediated signaling
Sitei130 – 1301Important for G protein-mediated signaling

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB
  2. nociceptin receptor activity Source: UniProtKB
  3. protein binding Source: IntAct

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
  2. behavior Source: UniProtKB-KW
  3. opioid receptor signaling pathway Source: GOC
  4. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  5. sensory perception Source: ProtInc
  6. sensory perception of pain Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Nociceptin receptor
Alternative name(s):
Kappa-type 3 opioid receptor
Short name:
KOR-3
Orphanin FQ receptor
Gene namesi
Name:OPRL1
Synonyms:OOR, ORL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:8155. OPRL1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle
Note: Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane.4 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848Extracellular1 Publication
Add
BLAST
Transmembranei49 – 7426Helical; Name=1
Add
BLAST
Topological domaini75 – 8713Cytoplasmic1 Publication
Add
BLAST
Transmembranei88 – 10922Helical; Name=2
Add
BLAST
Topological domaini110 – 12415Extracellular1 Publication
Add
BLAST
Transmembranei125 – 14622Helical; Name=3
Add
BLAST
Topological domaini147 – 16519Cytoplasmic1 Publication
Add
BLAST
Transmembranei166 – 18823Helical; Name=4
Add
BLAST
Topological domaini189 – 21123Extracellular1 Publication
Add
BLAST
Transmembranei212 – 23625Helical; Name=5
Add
BLAST
Topological domaini237 – 26428Cytoplasmic1 Publication
Add
BLAST
Transmembranei265 – 28521Helical; Name=6
Add
BLAST
Topological domaini286 – 30015Extracellular1 Publication
Add
BLAST
Transmembranei301 – 32222Helical; Name=7
Add
BLAST
Topological domaini323 – 37048Cytoplasmic1 Publication
Add
BLAST

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi107 – 1071Q → A: Impairs G protein-mediated inhibition of adenylate cyclase. 1 Publication
Mutagenesisi110 – 1101D → A: Abolishes G protein-mediated inhibition of adenylate cyclase. No effect on antagonist-mediated inhibition of G protein-mediated signaling. 1 Publication
Mutagenesisi130 – 1301D → A: Abolishes G protein-mediated inhibition of adenylate cyclase. Abolishes antagonist-mediated inhibition of G protein-mediated signaling. 1 Publication
Mutagenesisi131 – 1311Y → A: Impairs G protein-mediated inhibition of adenylate cyclase. 1 Publication
Mutagenesisi280 – 2801Q → A: Impairs G protein-mediated inhibition of adenylate cyclase. 1 Publication
Mutagenesisi309 – 3091Y → A: Mildly impairs G protein-mediated inhibition of adenylate cyclase. Abolishes antagonist-mediated inhibition of G protein-mediated signaling. 1 Publication
Mutagenesisi337 – 3371S → A: No effect on ligand-mediated internalization; when associated with A-346 and A-351. 1 Publication
Mutagenesisi346 – 3461S → A: No effect on ligand-mediated internalization; when associated with A-337 and A-351. 1 Publication
Mutagenesisi351 – 3511S → A: No effect on ligand-mediated internalization; when associated with A-337 and A-346. 1 Publication
Mutagenesisi363 – 3631S → A: Impairs ligand-mediated internalization. 1 Publication

Organism-specific databases

PharmGKBiPA31944.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Nociceptin receptor
PRO_0000069980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi28 – 281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi39 – 391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi123 ↔ 2001 Publication
Lipidationi334 – 3341S-palmitoyl cysteine Reviewed prediction
Modified residuei363 – 3631Phosphoserine Inferred

Post-translational modificationi

Phosphorylation at Ser-363 requires ADRBK2.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP41146.

PTM databases

PhosphoSiteiP41146.

Expressioni

Tissue specificityi

Detected in blood leukocytes.1 Publication

Inductioni

By phytohemagglutinin (PHA).1 Publication

Gene expression databases

BgeeiP41146.
CleanExiHS_OPRL1.
GenevestigatoriP41146.

Interactioni

Protein-protein interaction databases

BioGridi111032. 2 interactions.
IntActiP41146. 2 interactions.
STRINGi9606.ENSP00000336764.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi48 – 7730
Helixi85 – 10117
Helixi104 – 11310
Helixi119 – 15335
Helixi164 – 18825
Beta strandi189 – 1913
Beta strandi200 – 2023
Helixi208 – 22316
Helixi225 – 24218
Helixi252 – 28736
Helixi295 – 32228
Helixi324 – 3307

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EA3X-ray3.01A/B43-339[»]
ProteinModelPortaliP41146.
SMRiP41146. Positions 47-331.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299442.
HOGENOMiHOG000230486.
HOVERGENiHBG106919.
InParanoidiP41146.
KOiK04216.
OMAiVFAICIF.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP41146.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001418. Opioid_rcpt.
IPR001420. X_opioid_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00384. OPIOIDR.
PR00547. XOPIOIDR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P41146-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEPLFPAPFW EVIYGSHLQG NLSLLSPNHS LLPPHLLLNA SHGAFLPLGL    50
KVTIVGLYLA VCVGGLLGNC LVMYVILRHT KMKTATNIYI FNLALADTLV 100
LLTLPFQGTD ILLGFWPFGN ALCKTVIAID YYNMFTSTFT LTAMSVDRYV 150
AICHPIRALD VRTSSKAQAV NVAIWALASV VGVPVAIMGS AQVEDEEIEC 200
LVEIPTPQDY WGPVFAICIF LFSFIVPVLV ISVCYSLMIR RLRGVRLLSG 250
SREKDRNLRR ITRLVLVVVA VFVGCWTPVQ VFVLAQGLGV QPSSETAVAI 300
LRFCTALGYV NSCLNPILYA FLDENFKACF RKFCCASALR RDVQVSDRVR 350
SIAKDVALAC KTSETVPRPA 370
Length:370
Mass (Da):40,693
Last modified:February 1, 1995 - v1
Checksum:i613700C0B4D093BA
GO
Isoform 2 (identifier: P41146-2) [UniParc]FASTAAdd to Basket

Also known as: KOR-3D

The sequence of this isoform differs from the canonical sequence as follows:
     74-78: Missing.

Show »
Length:365
Mass (Da):40,048
Checksum:i56D4D8DF0F277242
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei74 – 785Missing in isoform 2.
VSP_001897

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77130 mRNA. Translation: CAA54386.1.
U30185 mRNA. Translation: AAA84913.1.
AF348323 mRNA. Translation: AAK11714.1.
AF126470 mRNA. Translation: AAL54890.1.
AY268428 mRNA. Translation: AAP23195.1.
CR542061 mRNA. Translation: CAG46858.1.
AL121581 Genomic DNA. Translation: CAC17003.2.
AL590548, AL121581 Genomic DNA. Translation: CAD11904.2.
BC038433 mRNA. Translation: AAH38433.1.
L40949 mRNA. Translation: AAA96251.1.
CCDSiCCDS13556.1. [P41146-1]
PIRiS43087.
RefSeqiNP_000904.1. NM_000913.4. [P41146-1]
NP_001186948.1. NM_001200019.1. [P41146-1]
NP_872588.1. NM_182647.2. [P41146-1]
XP_005260263.1. XM_005260206.1. [P41146-2]
XP_006723862.1. XM_006723799.1. [P41146-1]
UniGeneiHs.2859.
Hs.736944.

Genome annotation databases

EnsembliENST00000336866; ENSP00000336843; ENSG00000125510. [P41146-1]
ENST00000349451; ENSP00000336764; ENSG00000125510. [P41146-1]
ENST00000355631; ENSP00000347848; ENSG00000125510. [P41146-1]
GeneIDi4987.
KEGGihsa:4987.
UCSCiuc002yic.3. human. [P41146-1]
uc002yif.4. human. [P41146-2]

Polymorphism databases

DMDMi730230.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77130 mRNA. Translation: CAA54386.1 .
U30185 mRNA. Translation: AAA84913.1 .
AF348323 mRNA. Translation: AAK11714.1 .
AF126470 mRNA. Translation: AAL54890.1 .
AY268428 mRNA. Translation: AAP23195.1 .
CR542061 mRNA. Translation: CAG46858.1 .
AL121581 Genomic DNA. Translation: CAC17003.2 .
AL590548 , AL121581 Genomic DNA. Translation: CAD11904.2 .
BC038433 mRNA. Translation: AAH38433.1 .
L40949 mRNA. Translation: AAA96251.1 .
CCDSi CCDS13556.1. [P41146-1 ]
PIRi S43087.
RefSeqi NP_000904.1. NM_000913.4. [P41146-1 ]
NP_001186948.1. NM_001200019.1. [P41146-1 ]
NP_872588.1. NM_182647.2. [P41146-1 ]
XP_005260263.1. XM_005260206.1. [P41146-2 ]
XP_006723862.1. XM_006723799.1. [P41146-1 ]
UniGenei Hs.2859.
Hs.736944.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4EA3 X-ray 3.01 A/B 43-339 [» ]
ProteinModelPortali P41146.
SMRi P41146. Positions 47-331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111032. 2 interactions.
IntActi P41146. 2 interactions.
STRINGi 9606.ENSP00000336764.

Chemistry

BindingDBi P41146.
ChEMBLi CHEMBL2014.
GuidetoPHARMACOLOGYi 320.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P41146.

Polymorphism databases

DMDMi 730230.

Proteomic databases

PRIDEi P41146.

Protocols and materials databases

DNASUi 4987.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336866 ; ENSP00000336843 ; ENSG00000125510 . [P41146-1 ]
ENST00000349451 ; ENSP00000336764 ; ENSG00000125510 . [P41146-1 ]
ENST00000355631 ; ENSP00000347848 ; ENSG00000125510 . [P41146-1 ]
GeneIDi 4987.
KEGGi hsa:4987.
UCSCi uc002yic.3. human. [P41146-1 ]
uc002yif.4. human. [P41146-2 ]

Organism-specific databases

CTDi 4987.
GeneCardsi GC20P062711.
HGNCi HGNC:8155. OPRL1.
MIMi 602548. gene.
neXtProti NX_P41146.
PharmGKBi PA31944.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299442.
HOGENOMi HOG000230486.
HOVERGENi HBG106919.
InParanoidi P41146.
KOi K04216.
OMAi VFAICIF.
OrthoDBi EOG7BKCVQ.
PhylomeDBi P41146.
TreeFami TF315737.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Nociceptin_receptor.
GenomeRNAii 4987.
NextBioi 19198.
PROi P41146.
SOURCEi Search...

Gene expression databases

Bgeei P41146.
CleanExi HS_OPRL1.
Genevestigatori P41146.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001418. Opioid_rcpt.
IPR001420. X_opioid_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00384. OPIOIDR.
PR00547. XOPIOIDR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization."
    Mollereau C., Parmentier M., Mailleux P., Butour J.-L., Moisand C., Chalon P., Caput D., Vassart G., Meunier C.
    FEBS Lett. 341:33-38(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Brain stem.
  2. Lee P.H., Zhu J., Liu-Chen L., Chang K.
    Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Nociceptin stimulates neutrophil chemotaxis and recruitment: Inhibition by aspirin-triggered-15-Epi-lipoxin A4."
    Serhan C.N., Fierro I.M., Chiang N., Pouliot M.
    J. Immunol. 166:3650-3654(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
  4. "Identification and characterization of a splice variant of human kappa3-related opioid receptor (KOR-3D) gene."
    Pan Y.-X., Xu J., Pasternak G.W.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  9. "Expression of alternate forms of brain opioid 'orphan' receptor mRNA in activated human peripheral blood lymphocytes and lymphocytic cell lines."
    Wick M.J., Minnerath S.R., Roy S., Ramakrishnan S., Loh H.H.
    Brain Res. Mol. Brain Res. 32:342-347(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-333 (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
    Tissue: Lymphocyte.
  10. "Agonist-induced internalization and desensitization of the human nociceptin receptor expressed in CHO cells."
    Spampinato S., Di Toro R., Alessandri M., Murari G.
    Cell. Mol. Life Sci. 59:2172-2183(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  11. "Serine 363 is required for nociceptin/orphanin FQ opioid receptor (NOPR) desensitization, internalization, and arrestin signaling."
    Zhang N.R., Planer W., Siuda E.R., Zhao H.C., Stickler L., Chang S.D., Baird M.A., Cao Y.Q., Bruchas M.R.
    J. Biol. Chem. 287:42019-42030(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF SER-337; SER-346; SER-351 AND SER-363, PHOSPHORYLATION AT SER-363, SUBCELLULAR LOCATION.
  12. "Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic."
    Thompson A.A., Liu W., Chun E., Katritch V., Wu H., Vardy E., Huang X.P., Trapella C., Guerrini R., Calo G., Roth B.L., Cherezov V., Stevens R.C.
    Nature 485:395-399(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.01 ANGSTROMS) OF 43-339, FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, MUTAGENESIS OF GLN-107; ASP-110; ASP-130; TYR-131; GLN-280 AND TYR-309, DISULFIDE BOND.

Entry informationi

Entry nameiOPRX_HUMAN
AccessioniPrimary (citable) accession number: P41146
Secondary accession number(s): Q8TD34, Q8WYH9, Q9H4K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi