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P41146

- OPRX_HUMAN

UniProt

P41146 - OPRX_HUMAN

Protein

Nociceptin receptor

Gene

OPRL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.5 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei110 – 1101Important for G protein-mediated signaling
    Sitei130 – 1301Important for G protein-mediated signaling

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB
    2. nociceptin receptor activity Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
    2. behavior Source: UniProtKB-KW
    3. opioid receptor signaling pathway Source: GOC
    4. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
    5. sensory perception Source: ProtInc
    6. sensory perception of pain Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Behavior

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nociceptin receptor
    Alternative name(s):
    Kappa-type 3 opioid receptor
    Short name:
    KOR-3
    Orphanin FQ receptor
    Gene namesi
    Name:OPRL1
    Synonyms:OOR, ORL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:8155. OPRL1.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle
    Note: Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane.

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi107 – 1071Q → A: Impairs G protein-mediated inhibition of adenylate cyclase. 1 Publication
    Mutagenesisi110 – 1101D → A: Abolishes G protein-mediated inhibition of adenylate cyclase. No effect on antagonist-mediated inhibition of G protein-mediated signaling. 1 Publication
    Mutagenesisi130 – 1301D → A: Abolishes G protein-mediated inhibition of adenylate cyclase. Abolishes antagonist-mediated inhibition of G protein-mediated signaling. 1 Publication
    Mutagenesisi131 – 1311Y → A: Impairs G protein-mediated inhibition of adenylate cyclase. 1 Publication
    Mutagenesisi280 – 2801Q → A: Impairs G protein-mediated inhibition of adenylate cyclase. 1 Publication
    Mutagenesisi309 – 3091Y → A: Mildly impairs G protein-mediated inhibition of adenylate cyclase. Abolishes antagonist-mediated inhibition of G protein-mediated signaling. 1 Publication
    Mutagenesisi337 – 3371S → A: No effect on ligand-mediated internalization; when associated with A-346 and A-351. 1 Publication
    Mutagenesisi346 – 3461S → A: No effect on ligand-mediated internalization; when associated with A-337 and A-351. 1 Publication
    Mutagenesisi351 – 3511S → A: No effect on ligand-mediated internalization; when associated with A-337 and A-346. 1 Publication
    Mutagenesisi363 – 3631S → A: Impairs ligand-mediated internalization. 1 Publication

    Organism-specific databases

    PharmGKBiPA31944.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Nociceptin receptorPRO_0000069980Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi123 ↔ 2001 PublicationPROSITE-ProRule annotation
    Lipidationi334 – 3341S-palmitoyl cysteineSequence Analysis
    Modified residuei363 – 3631Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation at Ser-363 requires ADRBK2.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PRIDEiP41146.

    PTM databases

    PhosphoSiteiP41146.

    Expressioni

    Tissue specificityi

    Detected in blood leukocytes.1 Publication

    Inductioni

    By phytohemagglutinin (PHA).1 Publication

    Gene expression databases

    BgeeiP41146.
    CleanExiHS_OPRL1.
    GenevestigatoriP41146.

    Interactioni

    Protein-protein interaction databases

    BioGridi111032. 2 interactions.
    IntActiP41146. 2 interactions.
    STRINGi9606.ENSP00000336764.

    Structurei

    Secondary structure

    1
    370
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi48 – 7730
    Helixi85 – 10117
    Helixi104 – 11310
    Helixi119 – 15335
    Helixi164 – 18825
    Beta strandi189 – 1913
    Beta strandi200 – 2023
    Helixi208 – 22316
    Helixi225 – 24218
    Helixi252 – 28736
    Helixi295 – 32228
    Helixi324 – 3307

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4EA3X-ray3.01A/B43-339[»]
    ProteinModelPortaliP41146.
    SMRiP41146. Positions 47-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4848Extracellular1 PublicationAdd
    BLAST
    Topological domaini75 – 8713Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini110 – 12415Extracellular1 PublicationAdd
    BLAST
    Topological domaini147 – 16519Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini189 – 21123Extracellular1 PublicationAdd
    BLAST
    Topological domaini237 – 26428Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini286 – 30015Extracellular1 PublicationAdd
    BLAST
    Topological domaini323 – 37048Cytoplasmic1 PublicationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei49 – 7426Helical; Name=1Add
    BLAST
    Transmembranei88 – 10922Helical; Name=2Add
    BLAST
    Transmembranei125 – 14622Helical; Name=3Add
    BLAST
    Transmembranei166 – 18823Helical; Name=4Add
    BLAST
    Transmembranei212 – 23625Helical; Name=5Add
    BLAST
    Transmembranei265 – 28521Helical; Name=6Add
    BLAST
    Transmembranei301 – 32222Helical; Name=7Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299442.
    HOGENOMiHOG000230486.
    HOVERGENiHBG106919.
    InParanoidiP41146.
    KOiK04216.
    OMAiVFAICIF.
    OrthoDBiEOG7BKCVQ.
    PhylomeDBiP41146.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001418. Opioid_rcpt.
    IPR001420. X_opioid_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00384. OPIOIDR.
    PR00547. XOPIOIDR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P41146-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPLFPAPFW EVIYGSHLQG NLSLLSPNHS LLPPHLLLNA SHGAFLPLGL    50
    KVTIVGLYLA VCVGGLLGNC LVMYVILRHT KMKTATNIYI FNLALADTLV 100
    LLTLPFQGTD ILLGFWPFGN ALCKTVIAID YYNMFTSTFT LTAMSVDRYV 150
    AICHPIRALD VRTSSKAQAV NVAIWALASV VGVPVAIMGS AQVEDEEIEC 200
    LVEIPTPQDY WGPVFAICIF LFSFIVPVLV ISVCYSLMIR RLRGVRLLSG 250
    SREKDRNLRR ITRLVLVVVA VFVGCWTPVQ VFVLAQGLGV QPSSETAVAI 300
    LRFCTALGYV NSCLNPILYA FLDENFKACF RKFCCASALR RDVQVSDRVR 350
    SIAKDVALAC KTSETVPRPA 370
    Length:370
    Mass (Da):40,693
    Last modified:February 1, 1995 - v1
    Checksum:i613700C0B4D093BA
    GO
    Isoform 2 (identifier: P41146-2) [UniParc]FASTAAdd to Basket

    Also known as: KOR-3D

    The sequence of this isoform differs from the canonical sequence as follows:
         74-78: Missing.

    Show »
    Length:365
    Mass (Da):40,048
    Checksum:i56D4D8DF0F277242
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei74 – 785Missing in isoform 2. 1 PublicationVSP_001897

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77130 mRNA. Translation: CAA54386.1.
    U30185 mRNA. Translation: AAA84913.1.
    AF348323 mRNA. Translation: AAK11714.1.
    AF126470 mRNA. Translation: AAL54890.1.
    AY268428 mRNA. Translation: AAP23195.1.
    CR542061 mRNA. Translation: CAG46858.1.
    AL121581 Genomic DNA. Translation: CAC17003.2.
    AL590548, AL121581 Genomic DNA. Translation: CAD11904.2.
    BC038433 mRNA. Translation: AAH38433.1.
    L40949 mRNA. Translation: AAA96251.1.
    CCDSiCCDS13556.1. [P41146-1]
    PIRiS43087.
    RefSeqiNP_000904.1. NM_000913.4. [P41146-1]
    NP_001186948.1. NM_001200019.1. [P41146-1]
    NP_872588.1. NM_182647.2. [P41146-1]
    XP_005260263.1. XM_005260206.1. [P41146-2]
    XP_006723862.1. XM_006723799.1. [P41146-1]
    UniGeneiHs.2859.
    Hs.736944.

    Genome annotation databases

    EnsembliENST00000336866; ENSP00000336843; ENSG00000125510. [P41146-1]
    ENST00000349451; ENSP00000336764; ENSG00000125510. [P41146-1]
    ENST00000355631; ENSP00000347848; ENSG00000125510. [P41146-1]
    GeneIDi4987.
    KEGGihsa:4987.
    UCSCiuc002yic.3. human. [P41146-1]
    uc002yif.4. human. [P41146-2]

    Polymorphism databases

    DMDMi730230.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77130 mRNA. Translation: CAA54386.1 .
    U30185 mRNA. Translation: AAA84913.1 .
    AF348323 mRNA. Translation: AAK11714.1 .
    AF126470 mRNA. Translation: AAL54890.1 .
    AY268428 mRNA. Translation: AAP23195.1 .
    CR542061 mRNA. Translation: CAG46858.1 .
    AL121581 Genomic DNA. Translation: CAC17003.2 .
    AL590548 , AL121581 Genomic DNA. Translation: CAD11904.2 .
    BC038433 mRNA. Translation: AAH38433.1 .
    L40949 mRNA. Translation: AAA96251.1 .
    CCDSi CCDS13556.1. [P41146-1 ]
    PIRi S43087.
    RefSeqi NP_000904.1. NM_000913.4. [P41146-1 ]
    NP_001186948.1. NM_001200019.1. [P41146-1 ]
    NP_872588.1. NM_182647.2. [P41146-1 ]
    XP_005260263.1. XM_005260206.1. [P41146-2 ]
    XP_006723862.1. XM_006723799.1. [P41146-1 ]
    UniGenei Hs.2859.
    Hs.736944.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4EA3 X-ray 3.01 A/B 43-339 [» ]
    ProteinModelPortali P41146.
    SMRi P41146. Positions 47-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111032. 2 interactions.
    IntActi P41146. 2 interactions.
    STRINGi 9606.ENSP00000336764.

    Chemistry

    BindingDBi P41146.
    ChEMBLi CHEMBL2014.
    GuidetoPHARMACOLOGYi 320.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P41146.

    Polymorphism databases

    DMDMi 730230.

    Proteomic databases

    PRIDEi P41146.

    Protocols and materials databases

    DNASUi 4987.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336866 ; ENSP00000336843 ; ENSG00000125510 . [P41146-1 ]
    ENST00000349451 ; ENSP00000336764 ; ENSG00000125510 . [P41146-1 ]
    ENST00000355631 ; ENSP00000347848 ; ENSG00000125510 . [P41146-1 ]
    GeneIDi 4987.
    KEGGi hsa:4987.
    UCSCi uc002yic.3. human. [P41146-1 ]
    uc002yif.4. human. [P41146-2 ]

    Organism-specific databases

    CTDi 4987.
    GeneCardsi GC20P062711.
    HGNCi HGNC:8155. OPRL1.
    MIMi 602548. gene.
    neXtProti NX_P41146.
    PharmGKBi PA31944.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299442.
    HOGENOMi HOG000230486.
    HOVERGENi HBG106919.
    InParanoidi P41146.
    KOi K04216.
    OMAi VFAICIF.
    OrthoDBi EOG7BKCVQ.
    PhylomeDBi P41146.
    TreeFami TF315737.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Nociceptin_receptor.
    GenomeRNAii 4987.
    NextBioi 19198.
    PROi P41146.
    SOURCEi Search...

    Gene expression databases

    Bgeei P41146.
    CleanExi HS_OPRL1.
    Genevestigatori P41146.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001418. Opioid_rcpt.
    IPR001420. X_opioid_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00384. OPIOIDR.
    PR00547. XOPIOIDR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization."
      Mollereau C., Parmentier M., Mailleux P., Butour J.-L., Moisand C., Chalon P., Caput D., Vassart G., Meunier C.
      FEBS Lett. 341:33-38(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION.
      Tissue: Brain stem.
    2. Lee P.H., Zhu J., Liu-Chen L., Chang K.
      Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Nociceptin stimulates neutrophil chemotaxis and recruitment: Inhibition by aspirin-triggered-15-Epi-lipoxin A4."
      Serhan C.N., Fierro I.M., Chiang N., Pouliot M.
      J. Immunol. 166:3650-3654(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    4. "Identification and characterization of a splice variant of human kappa3-related opioid receptor (KOR-3D) gene."
      Pan Y.-X., Xu J., Pasternak G.W.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Warren C.N., Aronstam R.S., Sharma S.V.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    9. "Expression of alternate forms of brain opioid 'orphan' receptor mRNA in activated human peripheral blood lymphocytes and lymphocytic cell lines."
      Wick M.J., Minnerath S.R., Roy S., Ramakrishnan S., Loh H.H.
      Brain Res. Mol. Brain Res. 32:342-347(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-333 (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
      Tissue: Lymphocyte.
    10. "Agonist-induced internalization and desensitization of the human nociceptin receptor expressed in CHO cells."
      Spampinato S., Di Toro R., Alessandri M., Murari G.
      Cell. Mol. Life Sci. 59:2172-2183(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    11. "Serine 363 is required for nociceptin/orphanin FQ opioid receptor (NOPR) desensitization, internalization, and arrestin signaling."
      Zhang N.R., Planer W., Siuda E.R., Zhao H.C., Stickler L., Chang S.D., Baird M.A., Cao Y.Q., Bruchas M.R.
      J. Biol. Chem. 287:42019-42030(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF SER-337; SER-346; SER-351 AND SER-363, PHOSPHORYLATION AT SER-363, SUBCELLULAR LOCATION.
    12. "Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic."
      Thompson A.A., Liu W., Chun E., Katritch V., Wu H., Vardy E., Huang X.P., Trapella C., Guerrini R., Calo G., Roth B.L., Cherezov V., Stevens R.C.
      Nature 485:395-399(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.01 ANGSTROMS) OF 43-339, FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, MUTAGENESIS OF GLN-107; ASP-110; ASP-130; TYR-131; GLN-280 AND TYR-309, DISULFIDE BOND.

    Entry informationi

    Entry nameiOPRX_HUMAN
    AccessioniPrimary (citable) accession number: P41146
    Secondary accession number(s): Q8TD34, Q8WYH9, Q9H4K4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 146 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3