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P41145

- OPRK_HUMAN

UniProt

P41145 - OPRK_HUMAN

Protein

Kappa-type opioid receptor

Gene

OPRK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.4 Publications

    GO - Molecular functioni

    1. dynorphin receptor activity Source: UniProtKB
    2. opioid receptor activity Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: ProtInc
    2. adenylate cyclase-inhibiting opioid receptor signaling pathway Source: UniProtKB
    3. behavior Source: ProtInc
    4. defense response to virus Source: UniProtKB
    5. immune response Source: UniProtKB
    6. locomotory behavior Source: UniProtKB
    7. opioid receptor signaling pathway Source: UniProtKB
    8. phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    9. regulation of saliva secretion Source: UniProtKB
    10. sensory perception Source: ProtInc
    11. sensory perception of pain Source: UniProtKB
    12. synaptic transmission Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Behavior

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.
    SignaLinkiP41145.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kappa-type opioid receptor
    Short name:
    K-OR-1
    Short name:
    KOR-1
    Gene namesi
    Name:OPRK1
    Synonyms:OPRK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:8154. OPRK1.

    Subcellular locationi

    Cell membrane 4 Publications; Multi-pass membrane protein 4 Publications

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. integral component of plasma membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31943.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380Kappa-type opioid receptorPRO_0000069967Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...)1 Publication
    Glycosylationi39 – 391N-linked (GlcNAc...)1 Publication
    Disulfide bondi131 ↔ 2101 PublicationPROSITE-ProRule annotation
    Lipidationi345 – 3451S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP41145.
    PRIDEiP41145.

    PTM databases

    PhosphoSiteiP41145.

    Expressioni

    Tissue specificityi

    Detected in brain and placenta.2 Publications

    Gene expression databases

    ArrayExpressiP41145.
    BgeeiP41145.
    CleanExiHS_OPRK1.
    GenevestigatoriP41145.

    Organism-specific databases

    HPAiCAB022595.

    Interactioni

    Subunit structurei

    Interacts with SLC9A3R1. Interacts with GABARAPL1.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GABARAPL1Q9H0R85EBI-925028,EBI-3464833

    Protein-protein interaction databases

    BioGridi111031. 3 interactions.
    IntActiP41145. 9 interactions.
    MINTiMINT-236997.
    STRINGi9606.ENSP00000265572.

    Structurei

    Secondary structure

    1
    380
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi57 – 8630
    Helixi88 – 903
    Helixi93 – 10917
    Helixi112 – 12110
    Helixi127 – 15933
    Turni163 – 1664
    Beta strandi167 – 1693
    Helixi170 – 19627
    Beta strandi197 – 2015
    Beta strandi203 – 2064
    Beta strandi208 – 2125
    Beta strandi215 – 2173
    Helixi219 – 23315
    Helixi236 – 25924
    Helixi267 – 29933
    Helixi309 – 33325
    Helixi335 – 34511

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2A0Dmodel-A1-380[»]
    2IQNmodel-A55-348[»]
    4DJHX-ray2.90A/B43-358[»]
    ProteinModelPortaliP41145.
    SMRiP41145. Positions 40-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5757ExtracellularAdd
    BLAST
    Topological domaini86 – 9510Cytoplasmic
    Topological domaini120 – 13213ExtracellularAdd
    BLAST
    Topological domaini155 – 17319CytoplasmicAdd
    BLAST
    Topological domaini197 – 22226ExtracellularAdd
    BLAST
    Topological domaini248 – 27427CytoplasmicAdd
    BLAST
    Topological domaini297 – 31115ExtracellularAdd
    BLAST
    Topological domaini334 – 38047CytoplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei58 – 8528Helical; Name=1Add
    BLAST
    Transmembranei96 – 11924Helical; Name=2Add
    BLAST
    Transmembranei133 – 15422Helical; Name=3Add
    BLAST
    Transmembranei174 – 19623Helical; Name=4Add
    BLAST
    Transmembranei223 – 24725Helical; Name=5Add
    BLAST
    Transmembranei275 – 29622Helical; Name=6Add
    BLAST
    Transmembranei312 – 33322Helical; Name=7Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG317066.
    HOGENOMiHOG000230486.
    HOVERGENiHBG106919.
    InParanoidiP41145.
    KOiK04214.
    OMAiPFQSTEY.
    OrthoDBiEOG7BKCVQ.
    PhylomeDBiP41145.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000452. Kappa_opi_rcpt.
    IPR001418. Opioid_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00532. KAPPAOPIOIDR.
    PR00384. OPIOIDR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P41145-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDSPIQIFRG EPGPTCAPSA CLPPNSSAWF PGWAEPDSNG SAGSEDAQLE    50
    PAHISPAIPV IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN 100
    LALADALVTT TMPFQSTVYL MNSWPFGDVL CKIVISIDYY NMFTSIFTLT 150
    MMSVDRYIAV CHPVKALDFR TPLKAKIINI CIWLLSSSVG ISAIVLGGTK 200
    VREDVDVIEC SLQFPDDDYS WWDLFMKICV FIFAFVIPVL IIIVCYTLMI 250
    LRLKSVRLLS GSREKDRNLR RITRLVLVVV AVFVVCWTPI HIFILVEALG 300
    STSHSTAALS SYYFCIALGY TNSSLNPILY AFLDENFKRC FRDFCFPLKM 350
    RMERQSTSRV RNTVQDPAYL RDIDGMNKPV 380
    Length:380
    Mass (Da):42,645
    Last modified:October 17, 2006 - v2
    Checksum:i3DA6E9F90FB48825
    GO
    Isoform 2 (identifier: P41145-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-89: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:291
    Mass (Da):33,319
    Checksum:i86448C346FF7E35A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21D → E in AAA20985. (PubMed:8060324)Curated
    Sequence conflicti2 – 21D → E in AAM21070. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti374 – 3741D → N.
    Corresponds to variant rs9282808 [ dbSNP | Ensembl ].
    VAR_028067

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8989Missing in isoform 2. 1 PublicationVSP_055313Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11053 mRNA. Translation: AAA20985.1.
    U17298 mRNA. Translation: AAC50158.1.
    L37362 mRNA. Translation: AAA63906.1.
    AF498922 mRNA. Translation: AAM21070.1.
    AK310233 mRNA. No translation available.
    AC009646 Genomic DNA. No translation available.
    BC099912 mRNA. Translation: AAH99912.1.
    L36130 mRNA. Translation: AAA63646.1.
    U16860 Genomic DNA. Translation: AAA56758.1.
    CCDSiCCDS6152.1. [P41145-1]
    CCDS64895.1. [P41145-2]
    PIRiJC2338.
    RefSeqiNP_000903.2. NM_000912.3.
    NP_001269833.1. NM_001282904.1.
    UniGeneiHs.106795.

    Genome annotation databases

    EnsembliENST00000265572; ENSP00000265572; ENSG00000082556. [P41145-1]
    ENST00000520287; ENSP00000429706; ENSG00000082556. [P41145-1]
    ENST00000524278; ENSP00000430923; ENSG00000082556. [P41145-2]
    GeneIDi4986.
    KEGGihsa:4986.
    UCSCiuc003xrh.1. human. [P41145-1]

    Polymorphism databases

    DMDMi116242691.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Kappa opioid receptor entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11053 mRNA. Translation: AAA20985.1 .
    U17298 mRNA. Translation: AAC50158.1 .
    L37362 mRNA. Translation: AAA63906.1 .
    AF498922 mRNA. Translation: AAM21070.1 .
    AK310233 mRNA. No translation available.
    AC009646 Genomic DNA. No translation available.
    BC099912 mRNA. Translation: AAH99912.1 .
    L36130 mRNA. Translation: AAA63646.1 .
    U16860 Genomic DNA. Translation: AAA56758.1 .
    CCDSi CCDS6152.1. [P41145-1 ]
    CCDS64895.1. [P41145-2 ]
    PIRi JC2338.
    RefSeqi NP_000903.2. NM_000912.3.
    NP_001269833.1. NM_001282904.1.
    UniGenei Hs.106795.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2A0D model - A 1-380 [» ]
    2IQN model - A 55-348 [» ]
    4DJH X-ray 2.90 A/B 43-358 [» ]
    ProteinModelPortali P41145.
    SMRi P41145. Positions 40-347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111031. 3 interactions.
    IntActi P41145. 9 interactions.
    MINTi MINT-236997.
    STRINGi 9606.ENSP00000265572.

    Chemistry

    BindingDBi P41145.
    ChEMBLi CHEMBL2095151.
    DrugBanki DB00921. Buprenorphine.
    DB00611. Butorphanol.
    DB00907. Cocaine.
    DB00318. Codeine.
    DB01209. Dezocine.
    DB00956. Hydrocodone.
    DB00327. Hydromorphone.
    DB00454. Meperidine.
    DB00370. Mirtazapine.
    DB00295. Morphine.
    DB00844. Nalbuphine.
    DB00704. Naltrexone.
    DB00497. Oxycodone.
    DB00652. Pentazocine.
    DB00647. Propoxyphene.
    DB00193. Tramadol.
    GuidetoPHARMACOLOGYi 318.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P41145.

    Polymorphism databases

    DMDMi 116242691.

    Proteomic databases

    PaxDbi P41145.
    PRIDEi P41145.

    Protocols and materials databases

    DNASUi 4986.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265572 ; ENSP00000265572 ; ENSG00000082556 . [P41145-1 ]
    ENST00000520287 ; ENSP00000429706 ; ENSG00000082556 . [P41145-1 ]
    ENST00000524278 ; ENSP00000430923 ; ENSG00000082556 . [P41145-2 ]
    GeneIDi 4986.
    KEGGi hsa:4986.
    UCSCi uc003xrh.1. human. [P41145-1 ]

    Organism-specific databases

    CTDi 4986.
    GeneCardsi GC08M054138.
    HGNCi HGNC:8154. OPRK1.
    HPAi CAB022595.
    MIMi 165196. gene.
    neXtProti NX_P41145.
    PharmGKBi PA31943.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG317066.
    HOGENOMi HOG000230486.
    HOVERGENi HBG106919.
    InParanoidi P41145.
    KOi K04214.
    OMAi PFQSTEY.
    OrthoDBi EOG7BKCVQ.
    PhylomeDBi P41145.
    TreeFami TF315737.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.
    SignaLinki P41145.

    Miscellaneous databases

    GeneWikii %CE%9A-opioid_receptor.
    GenomeRNAii 4986.
    NextBioi 19194.
    PROi P41145.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41145.
    Bgeei P41145.
    CleanExi HS_OPRK1.
    Genevestigatori P41145.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000452. Kappa_opi_rcpt.
    IPR001418. Opioid_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00532. KAPPAOPIOIDR.
    PR00384. OPIOIDR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a human kappa opioid receptor cDNA from placenta."
      Mansson E., Bare L.A., Yang D.
      Biochem. Biophys. Res. Commun. 202:1431-1437(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Placenta.
    2. "Kappa-opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system."
      Simonin F., Gaveriaus-Ruff C., Befort K., Lannes B., Micheletti G., Mattei M.-G., Charon G., Bloch B., Kieffer B.
      Proc. Natl. Acad. Sci. U.S.A. 92:7006-7010(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Placenta.
    3. "Cloning of a human kappa opioid receptor from the brain."
      Zhu J., Chen C., Xue J.-C., Kunapuli S., Deriel J.K., Liu-Chen L.-Y.
      Life Sci. 56:PL201-PL207(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    8. "Human kappa opiate receptor second extracellular loop elevates dynorphin's affinity for human mu/kappa chimeras."
      Wang J.B., Johnson P.S., Wu J.M., Wang W.F., Uhl G.R.
      J. Biol. Chem. 269:25966-25969(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 136-279 (ISOFORMS 1/2).
      Tissue: Brain.
    9. "Mapping of the human kappa opioid receptor gene to chromosome 8q11.2-q12: no evidence for multiple kappa opioid receptor genes."
      Grandy D.K.
      Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-203 (ISOFORMS 1/2).
    10. "Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate."
      Li J.-G., Chen C., Liu-Chen L.-Y.
      J. Biol. Chem. 277:27545-27552(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SLC9A3R1, FUNCTION, SUBCELLULAR LOCATION.
    11. "GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor."
      Chen C., Li J.-G., Chen Y., Huang P., Wang Y., Liu-Chen L.-Y.
      J. Biol. Chem. 281:7983-7993(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GABARAPL1.
    12. "N-glycosylation of the human kappa opioid receptor enhances its stability but slows its trafficking along the biosynthesis pathway."
      Li J.G., Chen C., Liu-Chen L.Y.
      Biochemistry 46:10960-10970(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-25 AND ASN-39.
    13. "The role of kappa-opioid receptor activation in mediating antinociception and addiction."
      Wang Y.H., Sun J.F., Tao Y.M., Chi Z.Q., Liu J.G.
      Acta Pharmacol. Sin. 31:1065-1070(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    14. "Kinase cascades and ligand-directed signaling at the kappa opioid receptor."
      Bruchas M.R., Chavkin C.
      Psychopharmacology 210:137-147(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    15. Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 43-358 IN COMPLEX WITH ANTAGONIST, FUNCTION, SUBCELLULAR LOCATION, DISULFIDE BOND.

    Entry informationi

    Entry nameiOPRK_HUMAN
    AccessioniPrimary (citable) accession number: P41145
    Secondary accession number(s): E5RHC9, Q499G4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3