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P41145

- OPRK_HUMAN

UniProt

P41145 - OPRK_HUMAN

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Protein

Kappa-type opioid receptor

Gene
OPRK1, OPRK
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.4 Publications

GO - Molecular functioni

  1. dynorphin receptor activity Source: UniProtKB
  2. opioid receptor activity Source: UniProtKB
  3. protein binding Source: IntAct

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: ProtInc
  2. adenylate cyclase-inhibiting opioid receptor signaling pathway Source: UniProtKB
  3. behavior Source: ProtInc
  4. defense response to virus Source: UniProtKB
  5. immune response Source: UniProtKB
  6. locomotory behavior Source: UniProtKB
  7. opioid receptor signaling pathway Source: UniProtKB
  8. phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  9. regulation of saliva secretion Source: UniProtKB
  10. sensory perception Source: ProtInc
  11. sensory perception of pain Source: UniProtKB
  12. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinkiP41145.

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-type opioid receptor
Short name:
K-OR-1
Short name:
KOR-1
Gene namesi
Name:OPRK1
Synonyms:OPRK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:8154. OPRK1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 4 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757ExtracellularAdd
BLAST
Transmembranei58 – 8528Helical; Name=1Add
BLAST
Topological domaini86 – 9510Cytoplasmic
Transmembranei96 – 11924Helical; Name=2Add
BLAST
Topological domaini120 – 13213ExtracellularAdd
BLAST
Transmembranei133 – 15422Helical; Name=3Add
BLAST
Topological domaini155 – 17319CytoplasmicAdd
BLAST
Transmembranei174 – 19623Helical; Name=4Add
BLAST
Topological domaini197 – 22226ExtracellularAdd
BLAST
Transmembranei223 – 24725Helical; Name=5Add
BLAST
Topological domaini248 – 27427CytoplasmicAdd
BLAST
Transmembranei275 – 29622Helical; Name=6Add
BLAST
Topological domaini297 – 31115ExtracellularAdd
BLAST
Transmembranei312 – 33322Helical; Name=7Add
BLAST
Topological domaini334 – 38047CytoplasmicAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. integral component of plasma membrane Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31943.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Kappa-type opioid receptorPRO_0000069967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)1 Publication
Glycosylationi39 – 391N-linked (GlcNAc...)1 Publication
Disulfide bondi131 ↔ 2101 Publication
Lipidationi345 – 3451S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP41145.
PRIDEiP41145.

PTM databases

PhosphoSiteiP41145.

Expressioni

Tissue specificityi

Detected in brain and placenta.2 Publications

Gene expression databases

ArrayExpressiP41145.
BgeeiP41145.
CleanExiHS_OPRK1.
GenevestigatoriP41145.

Organism-specific databases

HPAiCAB022595.

Interactioni

Subunit structurei

Interacts with SLC9A3R1. Interacts with GABARAPL1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPL1Q9H0R85EBI-925028,EBI-3464833

Protein-protein interaction databases

BioGridi111031. 3 interactions.
IntActiP41145. 9 interactions.
MINTiMINT-236997.
STRINGi9606.ENSP00000265572.

Structurei

Secondary structure

1
380
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi57 – 8630
Helixi88 – 903
Helixi93 – 10917
Helixi112 – 12110
Helixi127 – 15933
Turni163 – 1664
Beta strandi167 – 1693
Helixi170 – 19627
Beta strandi197 – 2015
Beta strandi203 – 2064
Beta strandi208 – 2125
Beta strandi215 – 2173
Helixi219 – 23315
Helixi236 – 25924
Helixi267 – 29933
Helixi309 – 33325
Helixi335 – 34511

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A0Dmodel-A1-380[»]
2IQNmodel-A55-348[»]
4DJHX-ray2.90A/B43-358[»]
ProteinModelPortaliP41145.
SMRiP41145. Positions 40-347.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG317066.
HOGENOMiHOG000230486.
HOVERGENiHBG106919.
InParanoidiP41145.
KOiK04214.
OMAiPFQSTEY.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP41145.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000452. Kappa_opi_rcpt.
IPR001418. Opioid_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00532. KAPPAOPIOIDR.
PR00384. OPIOIDR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P41145-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDSPIQIFRG EPGPTCAPSA CLPPNSSAWF PGWAEPDSNG SAGSEDAQLE    50
PAHISPAIPV IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN 100
LALADALVTT TMPFQSTVYL MNSWPFGDVL CKIVISIDYY NMFTSIFTLT 150
MMSVDRYIAV CHPVKALDFR TPLKAKIINI CIWLLSSSVG ISAIVLGGTK 200
VREDVDVIEC SLQFPDDDYS WWDLFMKICV FIFAFVIPVL IIIVCYTLMI 250
LRLKSVRLLS GSREKDRNLR RITRLVLVVV AVFVVCWTPI HIFILVEALG 300
STSHSTAALS SYYFCIALGY TNSSLNPILY AFLDENFKRC FRDFCFPLKM 350
RMERQSTSRV RNTVQDPAYL RDIDGMNKPV 380
Length:380
Mass (Da):42,645
Last modified:October 17, 2006 - v2
Checksum:i3DA6E9F90FB48825
GO
Isoform 2 (identifier: P41145-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Note: No experimental confirmation available.

Show »
Length:291
Mass (Da):33,319
Checksum:i86448C346FF7E35A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti374 – 3741D → N.
Corresponds to variant rs9282808 [ dbSNP | Ensembl ].
VAR_028067

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8989Missing in isoform 2. VSP_055313Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21D → E in AAA20985. 1 Publication
Sequence conflicti2 – 21D → E in AAM21070. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11053 mRNA. Translation: AAA20985.1.
U17298 mRNA. Translation: AAC50158.1.
L37362 mRNA. Translation: AAA63906.1.
AF498922 mRNA. Translation: AAM21070.1.
AK310233 mRNA. No translation available.
AC009646 Genomic DNA. No translation available.
BC099912 mRNA. Translation: AAH99912.1.
L36130 mRNA. Translation: AAA63646.1.
U16860 Genomic DNA. Translation: AAA56758.1.
CCDSiCCDS6152.1. [P41145-1]
PIRiJC2338.
RefSeqiNP_000903.2. NM_000912.3.
NP_001269833.1. NM_001282904.1.
UniGeneiHs.106795.

Genome annotation databases

EnsembliENST00000265572; ENSP00000265572; ENSG00000082556.
ENST00000520287; ENSP00000429706; ENSG00000082556.
GeneIDi4986.
KEGGihsa:4986.
UCSCiuc003xrh.1. human. [P41145-1]

Polymorphism databases

DMDMi116242691.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Kappa opioid receptor entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11053 mRNA. Translation: AAA20985.1 .
U17298 mRNA. Translation: AAC50158.1 .
L37362 mRNA. Translation: AAA63906.1 .
AF498922 mRNA. Translation: AAM21070.1 .
AK310233 mRNA. No translation available.
AC009646 Genomic DNA. No translation available.
BC099912 mRNA. Translation: AAH99912.1 .
L36130 mRNA. Translation: AAA63646.1 .
U16860 Genomic DNA. Translation: AAA56758.1 .
CCDSi CCDS6152.1. [P41145-1 ]
PIRi JC2338.
RefSeqi NP_000903.2. NM_000912.3.
NP_001269833.1. NM_001282904.1.
UniGenei Hs.106795.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2A0D model - A 1-380 [» ]
2IQN model - A 55-348 [» ]
4DJH X-ray 2.90 A/B 43-358 [» ]
ProteinModelPortali P41145.
SMRi P41145. Positions 40-347.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111031. 3 interactions.
IntActi P41145. 9 interactions.
MINTi MINT-236997.
STRINGi 9606.ENSP00000265572.

Chemistry

BindingDBi P41145.
ChEMBLi CHEMBL2095151.
DrugBanki DB00921. Buprenorphine.
DB00611. Butorphanol.
DB00907. Cocaine.
DB00318. Codeine.
DB01209. Dezocine.
DB00956. Hydrocodone.
DB00327. Hydromorphone.
DB00454. Meperidine.
DB00370. Mirtazapine.
DB00295. Morphine.
DB00844. Nalbuphine.
DB00704. Naltrexone.
DB00497. Oxycodone.
DB00652. Pentazocine.
DB00647. Propoxyphene.
DB00193. Tramadol.
GuidetoPHARMACOLOGYi 318.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P41145.

Polymorphism databases

DMDMi 116242691.

Proteomic databases

PaxDbi P41145.
PRIDEi P41145.

Protocols and materials databases

DNASUi 4986.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265572 ; ENSP00000265572 ; ENSG00000082556 .
ENST00000520287 ; ENSP00000429706 ; ENSG00000082556 .
GeneIDi 4986.
KEGGi hsa:4986.
UCSCi uc003xrh.1. human. [P41145-1 ]

Organism-specific databases

CTDi 4986.
GeneCardsi GC08M054138.
HGNCi HGNC:8154. OPRK1.
HPAi CAB022595.
MIMi 165196. gene.
neXtProti NX_P41145.
PharmGKBi PA31943.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG317066.
HOGENOMi HOG000230486.
HOVERGENi HBG106919.
InParanoidi P41145.
KOi K04214.
OMAi PFQSTEY.
OrthoDBi EOG7BKCVQ.
PhylomeDBi P41145.
TreeFami TF315737.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinki P41145.

Miscellaneous databases

GeneWikii %CE%9A-opioid_receptor.
GenomeRNAii 4986.
NextBioi 19194.
PROi P41145.
SOURCEi Search...

Gene expression databases

ArrayExpressi P41145.
Bgeei P41145.
CleanExi HS_OPRK1.
Genevestigatori P41145.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000452. Kappa_opi_rcpt.
IPR001418. Opioid_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00532. KAPPAOPIOIDR.
PR00384. OPIOIDR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a human kappa opioid receptor cDNA from placenta."
    Mansson E., Bare L.A., Yang D.
    Biochem. Biophys. Res. Commun. 202:1431-1437(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. "Kappa-opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system."
    Simonin F., Gaveriaus-Ruff C., Befort K., Lannes B., Micheletti G., Mattei M.-G., Charon G., Bloch B., Kieffer B.
    Proc. Natl. Acad. Sci. U.S.A. 92:7006-7010(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  3. "Cloning of a human kappa opioid receptor from the brain."
    Zhu J., Chen C., Xue J.-C., Kunapuli S., Deriel J.K., Liu-Chen L.-Y.
    Life Sci. 56:PL201-PL207(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  8. "Human kappa opiate receptor second extracellular loop elevates dynorphin's affinity for human mu/kappa chimeras."
    Wang J.B., Johnson P.S., Wu J.M., Wang W.F., Uhl G.R.
    J. Biol. Chem. 269:25966-25969(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 136-279 (ISOFORMS 1/2).
    Tissue: Brain.
  9. "Mapping of the human kappa opioid receptor gene to chromosome 8q11.2-q12: no evidence for multiple kappa opioid receptor genes."
    Grandy D.K.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-203 (ISOFORMS 1/2).
  10. "Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate."
    Li J.-G., Chen C., Liu-Chen L.-Y.
    J. Biol. Chem. 277:27545-27552(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SLC9A3R1, FUNCTION, SUBCELLULAR LOCATION.
  11. "GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor."
    Chen C., Li J.-G., Chen Y., Huang P., Wang Y., Liu-Chen L.-Y.
    J. Biol. Chem. 281:7983-7993(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GABARAPL1.
  12. "N-glycosylation of the human kappa opioid receptor enhances its stability but slows its trafficking along the biosynthesis pathway."
    Li J.G., Chen C., Liu-Chen L.Y.
    Biochemistry 46:10960-10970(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-25 AND ASN-39.
  13. "The role of kappa-opioid receptor activation in mediating antinociception and addiction."
    Wang Y.H., Sun J.F., Tao Y.M., Chi Z.Q., Liu J.G.
    Acta Pharmacol. Sin. 31:1065-1070(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  14. "Kinase cascades and ligand-directed signaling at the kappa opioid receptor."
    Bruchas M.R., Chavkin C.
    Psychopharmacology 210:137-147(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  15. Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 43-358 IN COMPLEX WITH ANTAGONIST, FUNCTION, SUBCELLULAR LOCATION, DISULFIDE BOND.

Entry informationi

Entry nameiOPRK_HUMAN
AccessioniPrimary (citable) accession number: P41145
Secondary accession number(s): E5RHC9, Q499G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi