Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kappa-type opioid receptor

Gene

OPRK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.4 Publications

GO - Molecular functioni

  • dynorphin receptor activity Source: UniProtKB
  • neuropeptide binding Source: GO_Central
  • opioid receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Enzyme and pathway databases

BioCyciZFISH:ENSG00000082556-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SignaLinkiP41145.
SIGNORiP41145.

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-type opioid receptor
Short name:
K-OR-1
Short name:
KOR-1
Gene namesi
Name:OPRK1
Synonyms:OPRK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:8154. OPRK1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularAdd BLAST57
Transmembranei58 – 85Helical; Name=1Add BLAST28
Topological domaini86 – 95Cytoplasmic10
Transmembranei96 – 119Helical; Name=2Add BLAST24
Topological domaini120 – 132ExtracellularAdd BLAST13
Transmembranei133 – 154Helical; Name=3Add BLAST22
Topological domaini155 – 173CytoplasmicAdd BLAST19
Transmembranei174 – 196Helical; Name=4Add BLAST23
Topological domaini197 – 222ExtracellularAdd BLAST26
Transmembranei223 – 247Helical; Name=5Add BLAST25
Topological domaini248 – 274CytoplasmicAdd BLAST27
Transmembranei275 – 296Helical; Name=6Add BLAST22
Topological domaini297 – 311ExtracellularAdd BLAST15
Transmembranei312 – 333Helical; Name=7Add BLAST22
Topological domaini334 – 380CytoplasmicAdd BLAST47

GO - Cellular componenti

  • axon terminus Source: Ensembl
  • dendrite Source: Ensembl
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • neuron projection Source: GO_Central
  • perikaryon Source: Ensembl
  • plasma membrane Source: Reactome
  • synapse Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4986.
OpenTargetsiENSG00000082556.
PharmGKBiPA31943.

Chemistry databases

ChEMBLiCHEMBL237.
DrugBankiDB06274. Alvimopan.
DB00321. Amitriptyline.
DB00921. Buprenorphine.
DB00611. Butorphanol.
DB00318. Codeine.
DB00514. Dextromethorphan.
DB00647. Dextropropoxyphene.
DB01209. Dezocine.
DB09272. Eluxadoline.
DB00813. Fentanyl.
DB01452. Heroin.
DB00327. Hydromorphone.
DB01221. Ketamine.
DB06738. Ketobemidone.
DB00854. Levorphanol.
DB00836. Loperamide.
DB00825. Menthol.
DB06800. Methylnaltrexone.
DB06148. Mianserin.
DB00370. Mirtazapine.
DB00295. Morphine.
DB00844. Nalbuphine.
DB01183. Naloxone.
DB00704. Naltrexone.
DB00497. Oxycodone.
DB00652. Pentazocine.
DB00454. Pethidine.
DB00396. Progesterone.
DB00899. Remifentanil.
DB00708. Sufentanil.
DB06204. Tapentadol.
DB00193. Tramadol.
GuidetoPHARMACOLOGYi318.

Polymorphism and mutation databases

BioMutaiOPRK1.
DMDMi116242691.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699671 – 380Kappa-type opioid receptorAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...)1 Publication1
Glycosylationi39N-linked (GlcNAc...)1 Publication1
Disulfide bondi131 ↔ 210PROSITE-ProRule annotation1 Publication
Modified residuei157PhosphotyrosineBy similarity1
Lipidationi345S-palmitoyl cysteineSequence analysis1
Modified residuei363PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP41145.
PeptideAtlasiP41145.
PRIDEiP41145.

PTM databases

iPTMnetiP41145.
PhosphoSitePlusiP41145.

Expressioni

Tissue specificityi

Detected in brain and placenta.2 Publications

Gene expression databases

BgeeiENSG00000082556.
CleanExiHS_OPRK1.
ExpressionAtlasiP41145. baseline and differential.
GenevisibleiP41145. HS.

Organism-specific databases

HPAiCAB022595.

Interactioni

Subunit structurei

Interacts with SLC9A3R1. Interacts with GABARAPL1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPL1Q9H0R85EBI-925028,EBI-746969

Protein-protein interaction databases

BioGridi111031. 9 interactors.
IntActiP41145. 9 interactors.
MINTiMINT-236997.
STRINGi9606.ENSP00000265572.

Chemistry databases

BindingDBiP41145.

Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi57 – 86Combined sources30
Helixi88 – 90Combined sources3
Helixi93 – 109Combined sources17
Helixi112 – 121Combined sources10
Helixi127 – 159Combined sources33
Turni163 – 166Combined sources4
Beta strandi167 – 169Combined sources3
Helixi170 – 196Combined sources27
Beta strandi197 – 201Combined sources5
Beta strandi203 – 206Combined sources4
Beta strandi208 – 212Combined sources5
Beta strandi215 – 217Combined sources3
Helixi219 – 233Combined sources15
Helixi236 – 259Combined sources24
Helixi267 – 299Combined sources33
Helixi309 – 333Combined sources25
Helixi335 – 345Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A0Dmodel-A1-380[»]
2IQNmodel-A55-348[»]
4DJHX-ray2.90A/B43-358[»]
ProteinModelPortaliP41145.
SMRiP41145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230486.
HOVERGENiHBG106919.
InParanoidiP41145.
KOiK04214.
OMAiPFQSTEY.
OrthoDBiEOG091G0HEN.
PhylomeDBiP41145.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000452. Kappa_opi_rcpt.
IPR001418. Opioid_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00532. KAPPAOPIOIDR.
PR00384. OPIOIDR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P41145-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSPIQIFRG EPGPTCAPSA CLPPNSSAWF PGWAEPDSNG SAGSEDAQLE
60 70 80 90 100
PAHISPAIPV IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN
110 120 130 140 150
LALADALVTT TMPFQSTVYL MNSWPFGDVL CKIVISIDYY NMFTSIFTLT
160 170 180 190 200
MMSVDRYIAV CHPVKALDFR TPLKAKIINI CIWLLSSSVG ISAIVLGGTK
210 220 230 240 250
VREDVDVIEC SLQFPDDDYS WWDLFMKICV FIFAFVIPVL IIIVCYTLMI
260 270 280 290 300
LRLKSVRLLS GSREKDRNLR RITRLVLVVV AVFVVCWTPI HIFILVEALG
310 320 330 340 350
STSHSTAALS SYYFCIALGY TNSSLNPILY AFLDENFKRC FRDFCFPLKM
360 370 380
RMERQSTSRV RNTVQDPAYL RDIDGMNKPV
Length:380
Mass (Da):42,645
Last modified:October 17, 2006 - v2
Checksum:i3DA6E9F90FB48825
GO
Isoform 2 (identifier: P41145-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Note: No experimental confirmation available.
Show »
Length:291
Mass (Da):33,319
Checksum:i86448C346FF7E35A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2D → E in AAA20985 (PubMed:8060324).Curated1
Sequence conflicti2D → E in AAM21070 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028067374D → N.Corresponds to variant rs9282808dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0553131 – 89Missing in isoform 2. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11053 mRNA. Translation: AAA20985.1.
U17298 mRNA. Translation: AAC50158.1.
L37362 mRNA. Translation: AAA63906.1.
AF498922 mRNA. Translation: AAM21070.1.
AK310233 mRNA. No translation available.
AC009646 Genomic DNA. No translation available.
BC099912 mRNA. Translation: AAH99912.1.
L36130 mRNA. Translation: AAA63646.1.
U16860 Genomic DNA. Translation: AAA56758.1.
CCDSiCCDS6152.1. [P41145-1]
CCDS64895.1. [P41145-2]
PIRiJC2338.
RefSeqiNP_000903.2. NM_000912.4. [P41145-1]
NP_001269833.1. NM_001282904.1. [P41145-2]
NP_001305426.1. NM_001318497.1.
UniGeneiHs.106795.

Genome annotation databases

EnsembliENST00000265572; ENSP00000265572; ENSG00000082556. [P41145-1]
ENST00000520287; ENSP00000429706; ENSG00000082556. [P41145-1]
ENST00000524278; ENSP00000430923; ENSG00000082556. [P41145-2]
ENST00000612786; ENSP00000483000; ENSG00000082556. [P41145-2]
GeneIDi4986.
KEGGihsa:4986.
UCSCiuc003xrh.2. human. [P41145-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Kappa opioid receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11053 mRNA. Translation: AAA20985.1.
U17298 mRNA. Translation: AAC50158.1.
L37362 mRNA. Translation: AAA63906.1.
AF498922 mRNA. Translation: AAM21070.1.
AK310233 mRNA. No translation available.
AC009646 Genomic DNA. No translation available.
BC099912 mRNA. Translation: AAH99912.1.
L36130 mRNA. Translation: AAA63646.1.
U16860 Genomic DNA. Translation: AAA56758.1.
CCDSiCCDS6152.1. [P41145-1]
CCDS64895.1. [P41145-2]
PIRiJC2338.
RefSeqiNP_000903.2. NM_000912.4. [P41145-1]
NP_001269833.1. NM_001282904.1. [P41145-2]
NP_001305426.1. NM_001318497.1.
UniGeneiHs.106795.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A0Dmodel-A1-380[»]
2IQNmodel-A55-348[»]
4DJHX-ray2.90A/B43-358[»]
ProteinModelPortaliP41145.
SMRiP41145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111031. 9 interactors.
IntActiP41145. 9 interactors.
MINTiMINT-236997.
STRINGi9606.ENSP00000265572.

Chemistry databases

BindingDBiP41145.
ChEMBLiCHEMBL237.
DrugBankiDB06274. Alvimopan.
DB00321. Amitriptyline.
DB00921. Buprenorphine.
DB00611. Butorphanol.
DB00318. Codeine.
DB00514. Dextromethorphan.
DB00647. Dextropropoxyphene.
DB01209. Dezocine.
DB09272. Eluxadoline.
DB00813. Fentanyl.
DB01452. Heroin.
DB00327. Hydromorphone.
DB01221. Ketamine.
DB06738. Ketobemidone.
DB00854. Levorphanol.
DB00836. Loperamide.
DB00825. Menthol.
DB06800. Methylnaltrexone.
DB06148. Mianserin.
DB00370. Mirtazapine.
DB00295. Morphine.
DB00844. Nalbuphine.
DB01183. Naloxone.
DB00704. Naltrexone.
DB00497. Oxycodone.
DB00652. Pentazocine.
DB00454. Pethidine.
DB00396. Progesterone.
DB00899. Remifentanil.
DB00708. Sufentanil.
DB06204. Tapentadol.
DB00193. Tramadol.
GuidetoPHARMACOLOGYi318.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP41145.
PhosphoSitePlusiP41145.

Polymorphism and mutation databases

BioMutaiOPRK1.
DMDMi116242691.

Proteomic databases

PaxDbiP41145.
PeptideAtlasiP41145.
PRIDEiP41145.

Protocols and materials databases

DNASUi4986.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265572; ENSP00000265572; ENSG00000082556. [P41145-1]
ENST00000520287; ENSP00000429706; ENSG00000082556. [P41145-1]
ENST00000524278; ENSP00000430923; ENSG00000082556. [P41145-2]
ENST00000612786; ENSP00000483000; ENSG00000082556. [P41145-2]
GeneIDi4986.
KEGGihsa:4986.
UCSCiuc003xrh.2. human. [P41145-1]

Organism-specific databases

CTDi4986.
DisGeNETi4986.
GeneCardsiOPRK1.
HGNCiHGNC:8154. OPRK1.
HPAiCAB022595.
MIMi165196. gene.
neXtProtiNX_P41145.
OpenTargetsiENSG00000082556.
PharmGKBiPA31943.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230486.
HOVERGENiHBG106919.
InParanoidiP41145.
KOiK04214.
OMAiPFQSTEY.
OrthoDBiEOG091G0HEN.
PhylomeDBiP41145.
TreeFamiTF315737.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000082556-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SignaLinkiP41145.
SIGNORiP41145.

Miscellaneous databases

GeneWikii%CE%9A-opioid_receptor.
GenomeRNAii4986.
PROiP41145.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000082556.
CleanExiHS_OPRK1.
ExpressionAtlasiP41145. baseline and differential.
GenevisibleiP41145. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000452. Kappa_opi_rcpt.
IPR001418. Opioid_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00532. KAPPAOPIOIDR.
PR00384. OPIOIDR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPRK_HUMAN
AccessioniPrimary (citable) accession number: P41145
Secondary accession number(s): E5RHC9, Q499G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.