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P41143

- OPRD_HUMAN

UniProt

P41143 - OPRD_HUMAN

Protein

Delta-type opioid receptor

Gene

OPRD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 4 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.3 Publications

    GO - Molecular functioni

    1. enkephalin receptor activity Source: UniProtKB
    2. opioid receptor activity Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
    2. adult locomotory behavior Source: Ensembl
    3. cellular response to growth factor stimulus Source: Ensembl
    4. G-protein coupled receptor signaling pathway Source: UniProtKB
    5. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
    6. immune response Source: ProtInc
    7. neuropeptide signaling pathway Source: Ensembl
    8. opioid receptor signaling pathway Source: UniProtKB
    9. phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    10. protein import into nucleus, translocation Source: UniProtKB
    11. regulation of calcium ion transport Source: Ensembl
    12. regulation of sensory perception of pain Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.
    SignaLinkiP41143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Delta-type opioid receptor
    Short name:
    D-OR-1
    Short name:
    DOR-1
    Gene namesi
    Name:OPRD1
    Synonyms:OPRD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8153. OPRD1.

    Subcellular locationi

    Cell membrane 3 Publications; Multi-pass membrane protein 3 Publications

    GO - Cellular componenti

    1. axon terminus Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. dendrite membrane Source: Ensembl
    4. integral component of plasma membrane Source: ProtInc
    5. intrinsic component of plasma membrane Source: UniProtKB
    6. membrane raft Source: Ensembl
    7. plasma membrane Source: Reactome
    8. postsynaptic membrane Source: Ensembl
    9. vesicle Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31942.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Delta-type opioid receptorPRO_0000069962Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi121 ↔ 198PROSITE-ProRule annotation
    Lipidationi333 – 3331S-palmitoyl cysteineSequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP41143.
    PRIDEiP41143.

    PTM databases

    PhosphoSiteiP41143.

    Expressioni

    Tissue specificityi

    Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.2 Publications

    Gene expression databases

    BgeeiP41143.
    CleanExiHS_OPRD1.
    GenevestigatoriP41143.

    Organism-specific databases

    HPAiHPA013744.

    Interactioni

    Subunit structurei

    May form homooligomers. Interacts with GPRASP1.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATP2A2P116072EBI-2624456,EBI-8004986From a different organism.
    ATP2A2P166153EBI-2624456,EBI-358933
    CANXP278242EBI-2624456,EBI-355947
    GPRASP1Q5JY772EBI-2624456,EBI-2514717

    Protein-protein interaction databases

    BioGridi111030. 11 interactions.
    IntActiP41143. 4 interactions.
    MINTiMINT-7889289.
    STRINGi9606.ENSP00000234961.

    Structurei

    Secondary structure

    1
    372
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi40 – 7637
    Helixi78 – 803
    Helixi83 – 10018
    Helixi102 – 11110
    Helixi118 – 15134
    Turni153 – 1553
    Helixi156 – 1594
    Helixi162 – 18625
    Beta strandi187 – 1926
    Beta strandi195 – 2006
    Beta strandi203 – 2053
    Helixi206 – 22015
    Helixi223 – 24220
    Beta strandi246 – 2494
    Helixi250 – 28637
    Helixi294 – 32128
    Helixi323 – 33412

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OZCmodel-A1-372[»]
    2IQMmodel-A45-336[»]
    4N6HX-ray1.80A36-338[»]
    ProteinModelPortaliP41143.
    SMRiP41143. Positions 36-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4747ExtracellularBy similarityAdd
    BLAST
    Topological domaini76 – 8510CytoplasmicBy similarity
    Topological domaini111 – 12212ExtracellularBy similarityAdd
    BLAST
    Topological domaini145 – 16319CytoplasmicBy similarityAdd
    BLAST
    Topological domaini187 – 20620ExtracellularBy similarityAdd
    BLAST
    Topological domaini239 – 26123CytoplasmicBy similarityAdd
    BLAST
    Topological domaini285 – 29915ExtracellularBy similarityAdd
    BLAST
    Topological domaini322 – 37251CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 7528Helical; Name=1By similarityAdd
    BLAST
    Transmembranei86 – 11025Helical; Name=2By similarityAdd
    BLAST
    Transmembranei123 – 14422Helical; Name=3By similarityAdd
    BLAST
    Transmembranei164 – 18623Helical; Name=4By similarityAdd
    BLAST
    Transmembranei207 – 23832Helical; Name=5By similarityAdd
    BLAST
    Transmembranei262 – 28423Helical; Name=6By similarityAdd
    BLAST
    Transmembranei300 – 32122Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG241795.
    HOGENOMiHOG000230486.
    HOVERGENiHBG106919.
    InParanoidiP41143.
    KOiK04213.
    OMAiLCRKPCG.
    OrthoDBiEOG7BKCVQ.
    PhylomeDBiP41143.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000321. Delta_opi_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001418. Opioid_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00525. DELTAOPIOIDR.
    PR00237. GPCRRHODOPSN.
    PR00384. OPIOIDR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41143-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPAPSAGAE LQPPLFANAS DAYPSACPSA GANASGPPGA RSASSLALAI    50
    AITALYSAVC AVGLLGNVLV MFGIVRYTKM KTATNIYIFN LALADALATS 100
    TLPFQSAKYL METWPFGELL CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV 150
    CHPVKALDFR TPAKAKLINI CIWVLASGVG VPIMVMAVTR PRDGAVVCML 200
    QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL RSVRLLSGSK 250
    EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDID RRDPLVVAAL 300
    HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRKPCGRP DPSSFSRARE 350
    ATARERVTAC TPSDGPGGGA AA 372
    Length:372
    Mass (Da):40,369
    Last modified:November 2, 2010 - v4
    Checksum:i9D483FC39BA2BAE4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271C → F Improved maturation and increased expression at the cell surface. 3 Publications
    Corresponds to variant rs1042114 [ dbSNP | Ensembl ].
    VAR_012083

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07882 mRNA. Translation: AAA18789.2.
    U10504 mRNA. Translation: AAA83426.1.
    EU883570 mRNA. Translation: ACG60644.1.
    AL009181 Genomic DNA. Translation: CAA15671.1.
    CCDSiCCDS329.1.
    PIRiI38532.
    RefSeqiNP_000902.3. NM_000911.3.
    UniGeneiHs.372.

    Genome annotation databases

    EnsembliENST00000234961; ENSP00000234961; ENSG00000116329.
    GeneIDi4985.
    KEGGihsa:4985.
    UCSCiuc001brf.1. human.

    Polymorphism databases

    DMDMi311033488.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Delta opioid receptor entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07882 mRNA. Translation: AAA18789.2 .
    U10504 mRNA. Translation: AAA83426.1 .
    EU883570 mRNA. Translation: ACG60644.1 .
    AL009181 Genomic DNA. Translation: CAA15671.1 .
    CCDSi CCDS329.1.
    PIRi I38532.
    RefSeqi NP_000902.3. NM_000911.3.
    UniGenei Hs.372.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OZC model - A 1-372 [» ]
    2IQM model - A 45-336 [» ]
    4N6H X-ray 1.80 A 36-338 [» ]
    ProteinModelPortali P41143.
    SMRi P41143. Positions 36-338.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111030. 11 interactions.
    IntActi P41143. 4 interactions.
    MINTi MINT-7889289.
    STRINGi 9606.ENSP00000234961.

    Chemistry

    BindingDBi P41143.
    ChEMBLi CHEMBL2095149.
    DrugBanki DB00611. Butorphanol.
    DB00318. Codeine.
    DB00813. Fentanyl.
    DB00956. Hydrocodone.
    DB00327. Hydromorphone.
    DB00836. Loperamide.
    DB00295. Morphine.
    DB00844. Nalbuphine.
    DB01183. Naloxone.
    DB00704. Naltrexone.
    DB00497. Oxycodone.
    DB01100. Pimozide.
    DB00647. Propoxyphene.
    GuidetoPHARMACOLOGYi 317.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P41143.

    Polymorphism databases

    DMDMi 311033488.

    Proteomic databases

    PaxDbi P41143.
    PRIDEi P41143.

    Protocols and materials databases

    DNASUi 4985.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000234961 ; ENSP00000234961 ; ENSG00000116329 .
    GeneIDi 4985.
    KEGGi hsa:4985.
    UCSCi uc001brf.1. human.

    Organism-specific databases

    CTDi 4985.
    GeneCardsi GC01P029144.
    HGNCi HGNC:8153. OPRD1.
    HPAi HPA013744.
    MIMi 165195. gene.
    neXtProti NX_P41143.
    PharmGKBi PA31942.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241795.
    HOGENOMi HOG000230486.
    HOVERGENi HBG106919.
    InParanoidi P41143.
    KOi K04213.
    OMAi LCRKPCG.
    OrthoDBi EOG7BKCVQ.
    PhylomeDBi P41143.
    TreeFami TF315737.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.
    SignaLinki P41143.

    Miscellaneous databases

    GeneWikii %CE%94-opioid_receptor.
    GenomeRNAii 4985.
    NextBioi 19190.
    PROi P41143.
    SOURCEi Search...

    Gene expression databases

    Bgeei P41143.
    CleanExi HS_OPRD1.
    Genevestigatori P41143.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000321. Delta_opi_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001418. Opioid_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00525. DELTAOPIOIDR.
    PR00237. GPCRRHODOPSN.
    PR00384. OPIOIDR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, VARIANT PHE-27.
      Tissue: Brain cortex and Corpus striatum.
    2. Knapp R.J.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 40-41; 348 AND 370.
    3. "The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain."
      Simonin F., Befort K., Gaveriaux-Ruff C., Matthes H., Nappey V., Lannes B., Micheletti G., Kieffer B.
      Mol. Pharmacol. 46:1015-1021(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    4. "Isolation of cDNA coding for human opioid receptor, delta 1 (OPRD1)."
      Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-27.
      Tissue: Kidney.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Modulation of postendocytic sorting of G protein-coupled receptors."
      Whistler J.L., Enquist J., Marley A., Fong J., Gladher F., Tsuruda P., Murray S.R., Von Zastrow M.
      Science 297:615-620(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GPRASP1.
    7. "Identification of a novel family of G protein-coupled receptor associated sorting proteins."
      Simonin F., Karcher P., Boeuf J.J.-M., Matifas A., Kieffer B.L.
      J. Neurochem. 89:766-775(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GPRASP1.
    8. "Cys-27 variant of human delta-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization."
      Leskela T.T., Lackman J.J., Vierimaa M.M., Kobayashi H., Bouvier M., Petaja-Repo U.E.
      J. Biol. Chem. 287:5008-5020(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, SUBUNIT, CHARACTERIZATION OF VARIANT PHE-27.
    9. "Expression and localization of opioid receptors during the maturation of human oocytes."
      Agirregoitia E., Peralta L., Mendoza R., Exposito A., Ereno E.D., Matorras R., Agirregoitia N.
      Reprod. BioMed. Online 24:550-557(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    10. "Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence."
      Gelernter J., Kranzler H.R.
      Hum. Genet. 107:86-88(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT PHE-27.
    11. "Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation."
      Decaillot F.M., Befort K., Filliol D., Yue S., Walker P., Kieffer B.L.
      Nat. Struct. Biol. 10:629-636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING.

    Entry informationi

    Entry nameiOPRD_HUMAN
    AccessioniPrimary (citable) accession number: P41143
    Secondary accession number(s): B5B0B8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 135 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3