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P41143

- OPRD_HUMAN

UniProt

P41143 - OPRD_HUMAN

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Protein

Delta-type opioid receptor

Gene
OPRD1, OPRD
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.3 Publications

GO - Molecular functioni

  1. enkephalin receptor activity Source: UniProtKB
  2. opioid receptor activity Source: UniProtKB
  3. protein binding Source: IntAct

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  2. adult locomotory behavior Source: Ensembl
  3. cellular response to growth factor stimulus Source: Ensembl
  4. G-protein coupled receptor signaling pathway Source: UniProtKB
  5. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  6. immune response Source: ProtInc
  7. neuropeptide signaling pathway Source: Ensembl
  8. opioid receptor signaling pathway Source: UniProtKB
  9. phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  10. protein import into nucleus, translocation Source: UniProtKB
  11. regulation of calcium ion transport Source: Ensembl
  12. regulation of sensory perception of pain Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinkiP41143.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-type opioid receptor
Short name:
D-OR-1
Short name:
DOR-1
Gene namesi
Name:OPRD1
Synonyms:OPRD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:8153. OPRD1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747Extracellular By similarityAdd
BLAST
Transmembranei48 – 7528Helical; Name=1; By similarityAdd
BLAST
Topological domaini76 – 8510Cytoplasmic By similarity
Transmembranei86 – 11025Helical; Name=2; By similarityAdd
BLAST
Topological domaini111 – 12212Extracellular By similarityAdd
BLAST
Transmembranei123 – 14422Helical; Name=3; By similarityAdd
BLAST
Topological domaini145 – 16319Cytoplasmic By similarityAdd
BLAST
Transmembranei164 – 18623Helical; Name=4; By similarityAdd
BLAST
Topological domaini187 – 20620Extracellular By similarityAdd
BLAST
Transmembranei207 – 23832Helical; Name=5; By similarityAdd
BLAST
Topological domaini239 – 26123Cytoplasmic By similarityAdd
BLAST
Transmembranei262 – 28423Helical; Name=6; By similarityAdd
BLAST
Topological domaini285 – 29915Extracellular By similarityAdd
BLAST
Transmembranei300 – 32122Helical; Name=7; By similarityAdd
BLAST
Topological domaini322 – 37251Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. axon terminus Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. dendrite membrane Source: Ensembl
  4. integral component of plasma membrane Source: ProtInc
  5. intrinsic component of plasma membrane Source: UniProtKB
  6. membrane raft Source: Ensembl
  7. plasma membrane Source: Reactome
  8. postsynaptic membrane Source: Ensembl
  9. vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31942.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Delta-type opioid receptorPRO_0000069962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi33 – 331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi121 ↔ 198 By similarity
Lipidationi333 – 3331S-palmitoyl cysteine Reviewed prediction

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP41143.
PRIDEiP41143.

PTM databases

PhosphoSiteiP41143.

Expressioni

Tissue specificityi

Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.2 Publications

Gene expression databases

BgeeiP41143.
CleanExiHS_OPRD1.
GenevestigatoriP41143.

Organism-specific databases

HPAiHPA013744.

Interactioni

Subunit structurei

May form homooligomers. Interacts with GPRASP1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATP2A2P116072EBI-2624456,EBI-8004986From a different organism.
ATP2A2P166153EBI-2624456,EBI-358933
CANXP278242EBI-2624456,EBI-355947
GPRASP1Q5JY772EBI-2624456,EBI-2514717

Protein-protein interaction databases

BioGridi111030. 11 interactions.
IntActiP41143. 4 interactions.
MINTiMINT-7889289.
STRINGi9606.ENSP00000234961.

Structurei

Secondary structure

1
372
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi40 – 7637
Helixi78 – 803
Helixi83 – 10018
Helixi102 – 11110
Helixi118 – 15134
Turni153 – 1553
Helixi156 – 1594
Helixi162 – 18625
Beta strandi187 – 1926
Beta strandi195 – 2006
Beta strandi203 – 2053
Helixi206 – 22015
Helixi223 – 24220
Beta strandi246 – 2494
Helixi250 – 28637
Helixi294 – 32128
Helixi323 – 33412

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OZCmodel-A1-372[»]
2IQMmodel-A45-336[»]
4N6HX-ray1.80A36-338[»]
ProteinModelPortaliP41143.
SMRiP41143. Positions 36-338.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG241795.
HOGENOMiHOG000230486.
HOVERGENiHBG106919.
InParanoidiP41143.
KOiK04213.
OMAiLCRKPCG.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP41143.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000321. Delta_opi_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001418. Opioid_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00525. DELTAOPIOIDR.
PR00237. GPCRRHODOPSN.
PR00384. OPIOIDR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41143-1 [UniParc]FASTAAdd to Basket

« Hide

MEPAPSAGAE LQPPLFANAS DAYPSACPSA GANASGPPGA RSASSLALAI    50
AITALYSAVC AVGLLGNVLV MFGIVRYTKM KTATNIYIFN LALADALATS 100
TLPFQSAKYL METWPFGELL CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV 150
CHPVKALDFR TPAKAKLINI CIWVLASGVG VPIMVMAVTR PRDGAVVCML 200
QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL RSVRLLSGSK 250
EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDID RRDPLVVAAL 300
HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRKPCGRP DPSSFSRARE 350
ATARERVTAC TPSDGPGGGA AA 372
Length:372
Mass (Da):40,369
Last modified:November 2, 2010 - v4
Checksum:i9D483FC39BA2BAE4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271C → F Improved maturation and increased expression at the cell surface. 4 Publications
Corresponds to variant rs1042114 [ dbSNP | Ensembl ].
VAR_012083

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07882 mRNA. Translation: AAA18789.2.
U10504 mRNA. Translation: AAA83426.1.
EU883570 mRNA. Translation: ACG60644.1.
AL009181 Genomic DNA. Translation: CAA15671.1.
CCDSiCCDS329.1.
PIRiI38532.
RefSeqiNP_000902.3. NM_000911.3.
UniGeneiHs.372.

Genome annotation databases

EnsembliENST00000234961; ENSP00000234961; ENSG00000116329.
GeneIDi4985.
KEGGihsa:4985.
UCSCiuc001brf.1. human.

Polymorphism databases

DMDMi311033488.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Delta opioid receptor entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07882 mRNA. Translation: AAA18789.2 .
U10504 mRNA. Translation: AAA83426.1 .
EU883570 mRNA. Translation: ACG60644.1 .
AL009181 Genomic DNA. Translation: CAA15671.1 .
CCDSi CCDS329.1.
PIRi I38532.
RefSeqi NP_000902.3. NM_000911.3.
UniGenei Hs.372.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OZC model - A 1-372 [» ]
2IQM model - A 45-336 [» ]
4N6H X-ray 1.80 A 36-338 [» ]
ProteinModelPortali P41143.
SMRi P41143. Positions 36-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111030. 11 interactions.
IntActi P41143. 4 interactions.
MINTi MINT-7889289.
STRINGi 9606.ENSP00000234961.

Chemistry

BindingDBi P41143.
ChEMBLi CHEMBL2095149.
DrugBanki DB00611. Butorphanol.
DB00318. Codeine.
DB00813. Fentanyl.
DB00956. Hydrocodone.
DB00327. Hydromorphone.
DB00836. Loperamide.
DB00295. Morphine.
DB00844. Nalbuphine.
DB01183. Naloxone.
DB00704. Naltrexone.
DB00497. Oxycodone.
DB01100. Pimozide.
DB00647. Propoxyphene.
GuidetoPHARMACOLOGYi 317.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P41143.

Polymorphism databases

DMDMi 311033488.

Proteomic databases

PaxDbi P41143.
PRIDEi P41143.

Protocols and materials databases

DNASUi 4985.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000234961 ; ENSP00000234961 ; ENSG00000116329 .
GeneIDi 4985.
KEGGi hsa:4985.
UCSCi uc001brf.1. human.

Organism-specific databases

CTDi 4985.
GeneCardsi GC01P029144.
HGNCi HGNC:8153. OPRD1.
HPAi HPA013744.
MIMi 165195. gene.
neXtProti NX_P41143.
PharmGKBi PA31942.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG241795.
HOGENOMi HOG000230486.
HOVERGENi HBG106919.
InParanoidi P41143.
KOi K04213.
OMAi LCRKPCG.
OrthoDBi EOG7BKCVQ.
PhylomeDBi P41143.
TreeFami TF315737.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinki P41143.

Miscellaneous databases

GeneWikii %CE%94-opioid_receptor.
GenomeRNAii 4985.
NextBioi 19190.
PROi P41143.
SOURCEi Search...

Gene expression databases

Bgeei P41143.
CleanExi HS_OPRD1.
Genevestigatori P41143.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000321. Delta_opi_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001418. Opioid_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00525. DELTAOPIOIDR.
PR00237. GPCRRHODOPSN.
PR00384. OPIOIDR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, VARIANT PHE-27.
    Tissue: Brain cortex and Corpus striatum.
  2. Knapp R.J.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 40-41; 348 AND 370.
  3. "The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain."
    Simonin F., Befort K., Gaveriaux-Ruff C., Matthes H., Nappey V., Lannes B., Micheletti G., Kieffer B.
    Mol. Pharmacol. 46:1015-1021(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "Isolation of cDNA coding for human opioid receptor, delta 1 (OPRD1)."
    Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-27.
    Tissue: Kidney.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Modulation of postendocytic sorting of G protein-coupled receptors."
    Whistler J.L., Enquist J., Marley A., Fong J., Gladher F., Tsuruda P., Murray S.R., Von Zastrow M.
    Science 297:615-620(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GPRASP1.
  7. "Identification of a novel family of G protein-coupled receptor associated sorting proteins."
    Simonin F., Karcher P., Boeuf J.J.-M., Matifas A., Kieffer B.L.
    J. Neurochem. 89:766-775(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GPRASP1.
  8. "Cys-27 variant of human delta-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization."
    Leskela T.T., Lackman J.J., Vierimaa M.M., Kobayashi H., Bouvier M., Petaja-Repo U.E.
    J. Biol. Chem. 287:5008-5020(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, SUBUNIT, CHARACTERIZATION OF VARIANT PHE-27.
  9. "Expression and localization of opioid receptors during the maturation of human oocytes."
    Agirregoitia E., Peralta L., Mendoza R., Exposito A., Ereno E.D., Matorras R., Agirregoitia N.
    Reprod. BioMed. Online 24:550-557(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. "Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence."
    Gelernter J., Kranzler H.R.
    Hum. Genet. 107:86-88(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PHE-27.
  11. "Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation."
    Decaillot F.M., Befort K., Filliol D., Yue S., Walker P., Kieffer B.L.
    Nat. Struct. Biol. 10:629-636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiOPRD_HUMAN
AccessioniPrimary (citable) accession number: P41143
Secondary accession number(s): B5B0B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 134 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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