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UniProtKB - P41143 (OPRD_HUMAN)

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Protein

Delta-type opioid receptor

Gene

OPRD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.3 Publications

GO - Molecular functioni

  • enkephalin receptor activity Source: UniProtKB
  • neuropeptide binding Source: GO_Central
  • opioid receptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  • adult locomotory behavior Source: Ensembl
  • cellular response to growth factor stimulus Source: Ensembl
  • cellular response to hypoxia Source: ParkinsonsUK-UCL
  • cellular response to toxic substance Source: ParkinsonsUK-UCL
  • chemical synaptic transmission Source: GO_Central
  • eating behavior Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • immune response Source: ProtInc
  • negative regulation of gene expression Source: ParkinsonsUK-UCL
  • negative regulation of protein oligomerization Source: ParkinsonsUK-UCL
  • neuropeptide signaling pathway Source: GO_Central
  • opioid receptor signaling pathway Source: UniProtKB
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • positive regulation of CREB transcription factor activity Source: ParkinsonsUK-UCL
  • positive regulation of peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
  • protein import into nucleus, translocation Source: UniProtKB
  • regulation of calcium ion transport Source: Ensembl
  • regulation of mitochondrial membrane potential Source: ParkinsonsUK-UCL
  • regulation of sensory perception of pain Source: Ensembl
  • sensory perception of pain Source: GO_Central
Complete GO annotation...

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-6785807. Interleukin-4 and 13 signaling.
SignaLinkiP41143.
SIGNORiP41143.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-type opioid receptor
Short name:
D-OR-1
Short name:
DOR-1
Gene namesi
Name:OPRD1
Synonyms:OPRD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8153. OPRD1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularBy similarityAdd BLAST47
Transmembranei48 – 75Helical; Name=1By similarityAdd BLAST28
Topological domaini76 – 85CytoplasmicBy similarity10
Transmembranei86 – 110Helical; Name=2By similarityAdd BLAST25
Topological domaini111 – 122ExtracellularBy similarityAdd BLAST12
Transmembranei123 – 144Helical; Name=3By similarityAdd BLAST22
Topological domaini145 – 163CytoplasmicBy similarityAdd BLAST19
Transmembranei164 – 186Helical; Name=4By similarityAdd BLAST23
Topological domaini187 – 206ExtracellularBy similarityAdd BLAST20
Transmembranei207 – 238Helical; Name=5By similarityAdd BLAST32
Topological domaini239 – 261CytoplasmicBy similarityAdd BLAST23
Transmembranei262 – 284Helical; Name=6By similarityAdd BLAST23
Topological domaini285 – 299ExtracellularBy similarityAdd BLAST15
Transmembranei300 – 321Helical; Name=7By similarityAdd BLAST22
Topological domaini322 – 372CytoplasmicBy similarityAdd BLAST51

GO - Cellular componenti

  • axon terminus Source: Ensembl
  • cytoplasm Source: Ensembl
  • dendrite membrane Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • intrinsic component of plasma membrane Source: UniProtKB
  • membrane raft Source: Ensembl
  • neuron projection Source: GO_Central
  • plasma membrane Source: Reactome
  • postsynaptic membrane Source: Ensembl
  • vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4985.
OpenTargetsiENSG00000116329.
PharmGKBiPA31942.

Chemistry databases

ChEMBLiCHEMBL236.
DrugBankiDB01571. 3-Methylfentanyl.
DB01439. 3-Methylthiofentanyl.
DB05050. ADL5859.
DB06274. Alvimopan.
DB00321. Amitriptyline.
DB00921. Buprenorphine.
DB00611. Butorphanol.
DB01535. Carfentanil.
DB00318. Codeine.
DB00514. Dextromethorphan.
DB00647. Dextropropoxyphene.
DB01565. Dihydromorphine.
DB01444. Dimethylthiambutene.
DB01081. Diphenoxylate.
DB01548. Diprenorphine.
DB09272. Eluxadoline.
DB01497. Etorphine.
DB00813. Fentanyl.
DB01452. Heroin.
DB00956. Hydrocodone.
DB00327. Hydromorphone.
DB01221. Ketamine.
DB06738. Ketobemidone.
DB00854. Levorphanol.
DB00836. Loperamide.
DB00333. Methadone.
DB00295. Morphine.
DB00844. Nalbuphine.
DB01183. Naloxone.
DB00704. Naltrexone.
DB00497. Oxycodone.
DB01192. Oxymorphone.
DB09396. Propoxyphene napsylate.
DB00899. Remifentanil.
DB00708. Sufentanil.
DB06204. Tapentadol.
DB00193. Tramadol.
GuidetoPHARMACOLOGYi317.

Polymorphism and mutation databases

BioMutaiOPRD1.
DMDMi311033488.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699621 – 372Delta-type opioid receptorAdd BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi121 ↔ 198PROSITE-ProRule annotation
Lipidationi333S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication
Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Ubl conjugation

Proteomic databases

PaxDbiP41143.
PeptideAtlasiP41143.
PRIDEiP41143.

PTM databases

iPTMnetiP41143.
PhosphoSitePlusiP41143.

Expressioni

Tissue specificityi

Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.2 Publications

Gene expression databases

BgeeiENSG00000116329.
CleanExiHS_OPRD1.
ExpressionAtlasiP41143. baseline and differential.
GenevisibleiP41143. HS.

Organism-specific databases

HPAiHPA013744.

Interactioni

Subunit structurei

May form homooligomers. Forms a heterodimer with OPRM1 (By similarity). Interacts with GPRASP1 (PubMed:12142540, PubMed:15086532). Interacts with RTP4; the interaction promotes cell surface localization of the OPRD1-OPRM1 heterodimer (By similarity).By similarity3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111030. 17 interactors.
IntActiP41143. 10 interactors.
MINTiMINT-7889289.
STRINGi9606.ENSP00000234961.

Chemistry databases

BindingDBiP41143.

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi40 – 76Combined sources37
Helixi78 – 80Combined sources3
Helixi83 – 100Combined sources18
Helixi102 – 111Combined sources10
Helixi118 – 151Combined sources34
Turni153 – 155Combined sources3
Helixi156 – 159Combined sources4
Helixi162 – 186Combined sources25
Beta strandi187 – 192Combined sources6
Beta strandi195 – 200Combined sources6
Beta strandi203 – 205Combined sources3
Helixi206 – 220Combined sources15
Helixi223 – 242Combined sources20
Beta strandi246 – 249Combined sources4
Helixi250 – 286Combined sources37
Helixi294 – 321Combined sources28
Helixi323 – 334Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OZCmodel-A1-372[»]
2IQMmodel-A45-336[»]
4N6HX-ray1.80A36-338[»]
4RWAX-ray3.28A/B39-338[»]
4RWDX-ray2.70A/B39-338[»]
ProteinModelPortaliP41143.
SMRiP41143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230486.
HOVERGENiHBG106919.
InParanoidiP41143.
KOiK04213.
OMAiLCRAPCG.
OrthoDBiEOG091G0HEN.
PhylomeDBiP41143.
TreeFamiTF315737.

Family and domain databases

InterProiView protein in InterPro
IPR000321. Delta_opi_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001418. Opioid_rcpt.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00525. DELTAOPIOIDR.
PR00237. GPCRRHODOPSN.
PR00384. OPIOIDR.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P41143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAPSAGAE LQPPLFANAS DAYPSACPSA GANASGPPGA RSASSLALAI 
        60         70         80         90        100
AITALYSAVC AVGLLGNVLV MFGIVRYTKM KTATNIYIFN LALADALATS 
       110        120        130        140        150
TLPFQSAKYL METWPFGELL CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV 
       160        170        180        190        200
CHPVKALDFR TPAKAKLINI CIWVLASGVG VPIMVMAVTR PRDGAVVCML 
       210        220        230        240        250
QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL RSVRLLSGSK 
       260        270        280        290        300
EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDID RRDPLVVAAL 
       310        320        330        340        350
HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRKPCGRP DPSSFSRARE 
       360        370 
ATARERVTAC TPSDGPGGGA AA
Length:372
Mass (Da):40,369
Last modified:November 2, 2010 - v4
Checksum:i9D483FC39BA2BAE4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01208327C → F Improved maturation and increased expression at the cell surface. 4 PublicationsCorresponds to variant dbSNP:rs1042114Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07882 mRNA. Translation: AAA18789.2.
U10504 mRNA. Translation: AAA83426.1.
EU883570 mRNA. Translation: ACG60644.1.
AL009181 Genomic DNA. No translation available.
CCDSiCCDS329.1.
PIRiI38532.
RefSeqiNP_000902.3. NM_000911.3.
UniGeneiHs.372.

Genome annotation databases

EnsembliENST00000234961; ENSP00000234961; ENSG00000116329.
GeneIDi4985.
KEGGihsa:4985.
UCSCiuc001brf.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiOPRD_HUMAN
AccessioniPrimary (citable) accession number: P41143
Secondary accession number(s): B5B0B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 2, 2010
Last modified: June 7, 2017
This is version 160 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families