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Protein

Serine protease 2

Gene
N/A
Organism
Streptomyces fradiae (Streptomyces roseoflavus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Broad substrate specificity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35Charge relay system1
Active sitei65Charge relay system1
Active sitei147Charge relay system1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.431.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 2 (EC:3.4.21.-)
Alternative name(s):
SFase-2
OrganismiStreptomyces fradiae (Streptomyces roseoflavus)
Taxonomic identifieri1906 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938571 – 174Serine protease 2Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi15 ↔ 36
Disulfide bondi141 ↔ 168

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 9Combined sources4
Beta strandi14 – 16Combined sources3
Beta strandi19 – 23Combined sources5
Beta strandi28 – 32Combined sources5
Helixi34 – 37Combined sources4
Beta strandi41 – 46Combined sources6
Beta strandi51 – 60Combined sources10
Beta strandi62 – 64Combined sources3
Beta strandi66 – 72Combined sources7
Helixi74 – 76Combined sources3
Beta strandi79 – 82Combined sources4
Beta strandi84 – 86Combined sources3
Beta strandi88 – 90Combined sources3
Beta strandi102 – 107Combined sources6
Turni108 – 110Combined sources3
Beta strandi111 – 125Combined sources15
Beta strandi131 – 139Combined sources9
Beta strandi150 – 153Combined sources4
Beta strandi156 – 167Combined sources12
Turni168 – 170Combined sources3
Beta strandi171 – 174Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2SFAX-ray1.60A1-174[»]
ProteinModelPortaliP41140.
SMRiP41140.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41140.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S1 family.Curated

Family and domain databases

InterProiIPR001316. Pept_S1A_streptogrisin.
IPR009003. Peptidase_S1_PA.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00861. ALYTICPTASE.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IAGGEAIYAA GGGRCSLGFN VRSSSGATYA LTAGHCTEIA STWYTNSGQT
60 70 80 90 100
SLLGTRAGTS FPGNDYGLIR HSNASAADGR VYLYNGSYRD ITGAGNAYVG
110 120 130 140 150
QTVQRSGSTT GLHSGRVTGL NATVNYGGGD IVSGLIQTNV CAEPGDSGGA
160 170
LFAGSTALGL TSGGSGNCRT GGTT
Length:174
Mass (Da):17,179
Last modified:February 1, 1995 - v1
Checksum:i240BF8B84AC572EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S68947 Genomic DNA. Translation: AAB30080.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S68947 Genomic DNA. Translation: AAB30080.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2SFAX-ray1.60A1-174[»]
ProteinModelPortaliP41140.
SMRiP41140.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.431.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP41140.

Family and domain databases

InterProiIPR001316. Pept_S1A_streptogrisin.
IPR009003. Peptidase_S1_PA.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00861. ALYTICPTASE.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSFAS2_STRFR
AccessioniPrimary (citable) accession number: P41140
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.