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Protein

DNA-binding protein inhibitor ID-4

Gene

Id4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation.

GO - Molecular functioni

  • protein dimerization activity Source: InterPro
  • RNA polymerase II transcription factor binding Source: MGI

GO - Biological processi

  • brain development Source: MGI
  • cell proliferation Source: MGI
  • cellular protein localization Source: MGI
  • central nervous system myelination Source: MGI
  • cerebral cortex neuron differentiation Source: MGI
  • circadian rhythm Source: UniProtKB
  • fat cell differentiation Source: MGI
  • G1/S transition of mitotic cell cycle Source: MGI
  • hippocampus development Source: MGI
  • negative regulation of astrocyte differentiation Source: MGI
  • negative regulation of fat cell differentiation Source: MGI
  • negative regulation of neuron differentiation Source: MGI
  • negative regulation of oligodendrocyte differentiation Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • neuroblast proliferation Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • prostate gland epithelium morphogenesis Source: MGI
  • prostate gland morphogenesis Source: MGI
  • prostate gland stromal morphogenesis Source: MGI
  • seminal vesicle morphogenesis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein inhibitor ID-4
Alternative name(s):
Inhibitor of DNA binding 4
Inhibitor of differentiation 4
Gene namesi
Name:Id4
Synonyms:Id-4, Idb4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:99414 Id4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice do not exhibit a noticeable circadian phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272511 – 161DNA-binding protein inhibitor ID-4Add BLAST161

Proteomic databases

PaxDbiP41139
PeptideAtlasiP41139
PRIDEiP41139

PTM databases

PhosphoSitePlusiP41139

Expressioni

Inductioni

Expressed in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain with peak levels between CT16 and CT20.1 Publication

Gene expression databases

BgeeiENSMUSG00000021379
CleanExiMM_ID4
ExpressionAtlasiP41139 baseline and differential
GenevisibleiP41139 MM

Interactioni

Subunit structurei

Heterodimer with other HLH proteins.

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein dimerization activity Source: InterPro
  • RNA polymerase II transcription factor binding Source: MGI

Protein-protein interaction databases

BioGridi200508, 2 interactors
IntActiP41139, 2 interactors
STRINGi10090.ENSMUSP00000021810

Structurei

3D structure databases

ProteinModelPortaliP41139
SMRiP41139
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 104bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 48Poly-Ala10
Compositional biasi118 – 124Poly-Pro7

Phylogenomic databases

eggNOGiENOG410IVMK Eukaryota
ENOG4111QS6 LUCA
GeneTreeiENSGT00390000000908
HOGENOMiHOG000234788
HOVERGENiHBG009009
InParanoidiP41139
KOiK17695
OMAiHHQRTSI
OrthoDBiEOG091G0VHR
PhylomeDBiP41139
TreeFamiTF326217

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR026052 DNA-bd_prot-inh
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR11723 PTHR11723, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P41139-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC
60 70 80 90 100
KAAEAAADEP ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY
110 120 130 140 150
ILDLQLALET HPALLRQPPP PAPPLHPAGA CPVAPPRTPL TALNTDPAGA
160
VNKQGDSILC R
Length:161
Mass (Da):16,596
Last modified:February 1, 1995 - v1
Checksum:i2DCFF47AF7EE7EED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75018 mRNA Translation: CAA52926.1
AJ001972 Genomic DNA Translation: CAA05120.1
AF077859 Genomic DNA Translation: AAD05213.1
CCDSiCCDS26492.1
PIRiS43260
RefSeqiNP_112443.1, NM_031166.2
UniGeneiMm.458006

Genome annotation databases

EnsembliENSMUST00000021810; ENSMUSP00000021810; ENSMUSG00000021379
GeneIDi15904
KEGGimmu:15904
UCSCiuc007qid.1 mouse

Similar proteinsi

Entry informationi

Entry nameiID4_MOUSE
AccessioniPrimary (citable) accession number: P41139
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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