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P41139 (ID4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA-binding protein inhibitor ID-4
Alternative name(s):
Inhibitor of DNA binding 4
Gene names
Name:Id4
Synonyms:Id-4, Idb4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length161 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding.

Subunit structure

Heterodimer with other HLH proteins.

Subcellular location

Nucleus.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
   Cellular componentNucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG1/S transition of mitotic cell cycle

Inferred from mutant phenotype PubMed 15469968. Source: MGI

brain development

Inferred from mutant phenotype PubMed 15469968. Source: MGI

cell proliferation

Inferred from mutant phenotype PubMed 15469968. Source: MGI

cellular protein localization

Inferred from mutant phenotype PubMed 16862533. Source: MGI

central nervous system myelination

Inferred from mutant phenotype PubMed 16862533. Source: MGI

cerebral cortex neuron differentiation

Inferred from mutant phenotype PubMed 15469968. Source: MGI

fat cell differentiation

Inferred from mutant phenotype PubMed 20460371. Source: MGI

hippocampus development

Inferred from mutant phenotype PubMed 15469968. Source: MGI

negative regulation of astrocyte differentiation

Inferred from genetic interaction PubMed 15882580. Source: MGI

negative regulation of fat cell differentiation

Inferred from mutant phenotype PubMed 20628571. Source: MGI

negative regulation of neuron differentiation

Inferred from mutant phenotype PubMed 15882580. Source: MGI

negative regulation of oligodendrocyte differentiation

Inferred from mutant phenotype PubMed 16862533. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16862533. Source: MGI

neuroblast proliferation

Inferred from mutant phenotype PubMed 15882580. Source: MGI

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 15882580. Source: MGI

positive regulation of osteoblast differentiation

Inferred from mutant phenotype PubMed 20628571. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 20628571. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 9418957. Source: MGI

nucleus

Inferred from direct assay PubMed 9418957. Source: MGI

   Molecular_functionRNA polymerase II transcription factor binding

Inferred from physical interaction PubMed 20628571. Source: MGI

protein binding

Inferred from physical interaction PubMed 15280210. Source: IntAct

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 161161DNA-binding protein inhibitor ID-4
PRO_0000127251

Regions

Domain52 – 10453bHLH
Compositional bias39 – 4810Poly-Ala
Compositional bias118 – 1247Poly-Pro

Sequences

Sequence LengthMass (Da)Tools
P41139 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 2DCFF47AF7EE7EED

FASTA16116,596
        10         20         30         40         50         60 
MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC KAAEAAADEP 

        70         80         90        100        110        120 
ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY ILDLQLALET HPALLRQPPP 

       130        140        150        160 
PAPPLHPAGA CPVAPPRTPL TALNTDPAGA VNKQGDSILC R 

« Hide

References

[1]"The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3."
Riechmann V., van Cruechten I., Sablitzky F.
Nucleic Acids Res. 22:749-755(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Bone marrow.
[2]"Structure, chromosomal localisation and expression of the murine dominant negative helix-loop-helix Id4 gene."
van Cruechten I., Cinato E., Fox M., King E.R., Newton J.S., Riechmann V., Sablitzky F.
Biochim. Biophys. Acta 1443:55-64(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The mouse Id2 and Id4 genes: structural organization and chromosomal localization."
Mantani A., Hernandez M.-C., Kuo W.-L., Israel M.A.
Gene 222:229-235(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X75018 mRNA. Translation: CAA52926.1.
AJ001972 Genomic DNA. Translation: CAA05120.1.
AF077859 Genomic DNA. Translation: AAD05213.1.
CCDSCCDS26492.1.
PIRS43260.
RefSeqNP_112443.1. NM_031166.2.
UniGeneMm.458006.

3D structure databases

ProteinModelPortalP41139.
SMRP41139. Positions 67-111.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200508. 2 interactions.
IntActP41139. 2 interactions.
STRING10090.ENSMUSP00000021810.

Proteomic databases

PRIDEP41139.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021810; ENSMUSP00000021810; ENSMUSG00000021379.
GeneID15904.
KEGGmmu:15904.
UCSCuc007qid.1. mouse.

Organism-specific databases

CTD3400.
MGIMGI:99414. Id4.

Phylogenomic databases

eggNOGNOG74134.
HOGENOMHOG000234788.
HOVERGENHBG009009.
InParanoidP41139.
KOK17695.
OMAGACPVAP.
OrthoDBEOG7X9G8G.
PhylomeDBP41139.
TreeFamTF326217.

Gene expression databases

ArrayExpressP41139.
BgeeP41139.
CleanExMM_ID4.
GenevestigatorP41139.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
IPR026052. DNA-bd_prot-inh.
[Graphical view]
PANTHERPTHR11723. PTHR11723. 1 hit.
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288632.
PROP41139.
SOURCESearch...

Entry information

Entry nameID4_MOUSE
AccessionPrimary (citable) accession number: P41139
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot