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P41139

- ID4_MOUSE

UniProt

P41139 - ID4_MOUSE

Protein

DNA-binding protein inhibitor ID-4

Gene

Id4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. RNA polymerase II transcription factor binding Source: MGI

    GO - Biological processi

    1. brain development Source: MGI
    2. cell proliferation Source: MGI
    3. cellular protein localization Source: MGI
    4. central nervous system myelination Source: MGI
    5. cerebral cortex neuron differentiation Source: MGI
    6. circadian rhythm Source: UniProtKB
    7. fat cell differentiation Source: MGI
    8. G1/S transition of mitotic cell cycle Source: MGI
    9. hippocampus development Source: MGI
    10. negative regulation of astrocyte differentiation Source: MGI
    11. negative regulation of fat cell differentiation Source: MGI
    12. negative regulation of neuron differentiation Source: MGI
    13. negative regulation of oligodendrocyte differentiation Source: MGI
    14. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    15. neuroblast proliferation Source: MGI
    16. positive regulation of cell proliferation Source: MGI
    17. positive regulation of osteoblast differentiation Source: MGI
    18. positive regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-binding protein inhibitor ID-4
    Alternative name(s):
    Inhibitor of DNA binding 4
    Inhibitor of differentiation 4
    Gene namesi
    Name:Id4
    Synonyms:Id-4, Idb4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:99414. Id4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice do not exhibit a noticeable circadian phenotype.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161DNA-binding protein inhibitor ID-4PRO_0000127251Add
    BLAST

    Proteomic databases

    PRIDEiP41139.

    Expressioni

    Inductioni

    Expressed in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain with peak levels between CT16 and CT20.1 Publication

    Gene expression databases

    ArrayExpressiP41139.
    BgeeiP41139.
    CleanExiMM_ID4.
    GenevestigatoriP41139.

    Interactioni

    Subunit structurei

    Heterodimer with other HLH proteins.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Olig1Q9JKN55EBI-1213725,EBI-1213712
    Olig2Q9EQW65EBI-1213725,EBI-1213740

    Protein-protein interaction databases

    BioGridi200508. 2 interactions.
    IntActiP41139. 2 interactions.
    STRINGi10090.ENSMUSP00000021810.

    Structurei

    3D structure databases

    ProteinModelPortaliP41139.
    SMRiP41139. Positions 67-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 10453bHLHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi39 – 4810Poly-Ala
    Compositional biasi118 – 1247Poly-Pro

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG74134.
    HOGENOMiHOG000234788.
    HOVERGENiHBG009009.
    InParanoidiP41139.
    KOiK17695.
    OMAiGACPVAP.
    OrthoDBiEOG7X9G8G.
    PhylomeDBiP41139.
    TreeFamiTF326217.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR026052. DNA-bd_prot-inh.
    [Graphical view]
    PANTHERiPTHR11723. PTHR11723. 1 hit.
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41139-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC    50
    KAAEAAADEP ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY 100
    ILDLQLALET HPALLRQPPP PAPPLHPAGA CPVAPPRTPL TALNTDPAGA 150
    VNKQGDSILC R 161
    Length:161
    Mass (Da):16,596
    Last modified:February 1, 1995 - v1
    Checksum:i2DCFF47AF7EE7EED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75018 mRNA. Translation: CAA52926.1.
    AJ001972 Genomic DNA. Translation: CAA05120.1.
    AF077859 Genomic DNA. Translation: AAD05213.1.
    CCDSiCCDS26492.1.
    PIRiS43260.
    RefSeqiNP_112443.1. NM_031166.2.
    UniGeneiMm.458006.

    Genome annotation databases

    EnsembliENSMUST00000021810; ENSMUSP00000021810; ENSMUSG00000021379.
    GeneIDi15904.
    KEGGimmu:15904.
    UCSCiuc007qid.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75018 mRNA. Translation: CAA52926.1 .
    AJ001972 Genomic DNA. Translation: CAA05120.1 .
    AF077859 Genomic DNA. Translation: AAD05213.1 .
    CCDSi CCDS26492.1.
    PIRi S43260.
    RefSeqi NP_112443.1. NM_031166.2.
    UniGenei Mm.458006.

    3D structure databases

    ProteinModelPortali P41139.
    SMRi P41139. Positions 67-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200508. 2 interactions.
    IntActi P41139. 2 interactions.
    STRINGi 10090.ENSMUSP00000021810.

    Proteomic databases

    PRIDEi P41139.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021810 ; ENSMUSP00000021810 ; ENSMUSG00000021379 .
    GeneIDi 15904.
    KEGGi mmu:15904.
    UCSCi uc007qid.1. mouse.

    Organism-specific databases

    CTDi 3400.
    MGIi MGI:99414. Id4.

    Phylogenomic databases

    eggNOGi NOG74134.
    HOGENOMi HOG000234788.
    HOVERGENi HBG009009.
    InParanoidi P41139.
    KOi K17695.
    OMAi GACPVAP.
    OrthoDBi EOG7X9G8G.
    PhylomeDBi P41139.
    TreeFami TF326217.

    Miscellaneous databases

    NextBioi 288632.
    PROi P41139.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41139.
    Bgeei P41139.
    CleanExi MM_ID4.
    Genevestigatori P41139.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR026052. DNA-bd_prot-inh.
    [Graphical view ]
    PANTHERi PTHR11723. PTHR11723. 1 hit.
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3."
      Riechmann V., van Cruechten I., Sablitzky F.
      Nucleic Acids Res. 22:749-755(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Bone marrow.
    2. "Structure, chromosomal localisation and expression of the murine dominant negative helix-loop-helix Id4 gene."
      van Cruechten I., Cinato E., Fox M., King E.R., Newton J.S., Riechmann V., Sablitzky F.
      Biochim. Biophys. Acta 1443:55-64(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The mouse Id2 and Id4 genes: structural organization and chromosomal localization."
      Mantani A., Hernandez M.-C., Kuo W.-L., Israel M.A.
      Gene 222:229-235(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "A role for Id2 in regulating photic entrainment of the mammalian circadian system."
      Duffield G.E., Watson N.P., Mantani A., Peirson S.N., Robles-Murguia M., Loros J.J., Israel M.A., Dunlap J.C.
      Curr. Biol. 19:297-304(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiID4_MOUSE
    AccessioniPrimary (citable) accession number: P41139
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3