Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA-binding protein inhibitor ID-3

Gene

Id3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).By similarity

GO - Molecular functioni

  • bHLH transcription factor binding Source: RGD
  • DNA binding transcription factor activity Source: Ensembl
  • leptomycin B binding Source: Ensembl
  • protein dimerization activity Source: InterPro
  • protein domain specific binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processBiological rhythms, Myogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein inhibitor ID-3
Alternative name(s):
Inhibitor of DNA binding 3
Inhibitor of differentiation 3
Gene namesi
Name:Id3
Synonyms:Id-3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2860 Id3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272491 – 119DNA-binding protein inhibitor ID-3Add BLAST119

Post-translational modificationi

Phosphorylated in vitro by CDC2 and PKC.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP41138
PRIDEiP41138

PTM databases

PhosphoSitePlusiP41138

Expressioni

Gene expression databases

BgeeiENSRNOG00000026124
GenevisibleiP41138 RN

Interactioni

Subunit structurei

Homodimer, and heterodimer with other HLH proteins. Interacts with COPS5 and COPS7A. Interacts with IFI204. Interacts with GATA4 and NKX2-5. Interacts with ANKRD2; both proteins cooperate in myoblast differentiation. Interacts with CLOCK and ARNTL/BMAL1 (By similarity).By similarity

GO - Molecular functioni

  • bHLH transcription factor binding Source: RGD
  • protein dimerization activity Source: InterPro
  • protein domain specific binding Source: RGD

Protein-protein interaction databases

BioGridi247615, 2 interactors
STRINGi10116.ENSRNOP00000035270

Structurei

3D structure databases

ProteinModelPortaliP41138
SMRiP41138
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 80bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiENOG410IYKY Eukaryota
ENOG4112051 LUCA
GeneTreeiENSGT00390000000908
HOGENOMiHOG000234788
HOVERGENiHBG009009
InParanoidiP41138
KOiK17694
OMAiLYDMNDC
OrthoDBiEOG091G0VHR
PhylomeDBiP41138
TreeFamiTF326217

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR026052 DNA-bd_prot-inh
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR11723 PTHR11723, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P41138-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALSPVRGC YEAVCCLSER SLAIARGRGK SPSAEEPLSL LDDMNHCYSR
60 70 80 90 100
LRELVPGVPR GTQLSQVEIL QRVIDYILDL QVVLAEPAPG PPDGPHLPIQ
110
TAELTPELVI SKDKRSFCH
Length:119
Mass (Da):13,059
Last modified:February 1, 1995 - v1
Checksum:iA8B6AC04D2C9A5A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10864 mRNA Translation: BAA01635.1
BC064658 mRNA Translation: AAH64658.1
PIRiJC2113
RefSeqiNP_037190.1, NM_013058.2
UniGeneiRn.2760

Genome annotation databases

EnsembliENSRNOT00000035788; ENSRNOP00000035270; ENSRNOG00000026124
GeneIDi25585
KEGGirno:25585
UCSCiRGD:2860 rat

Similar proteinsi

Entry informationi

Entry nameiID3_RAT
AccessioniPrimary (citable) accession number: P41138
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health