Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA-binding protein inhibitor ID-2

Gene

Id2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism (By similarity).By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein inhibitor ID-2
Alternative name(s):
Inhibitor of DNA binding 2
Inhibitor of differentiation 2
Gene namesi
Name:Id2
Synonyms:Id-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi2859. Id2.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

  • chromatin Source: RGD
  • cytoplasm Source: MGI
  • cytosol Source: RGD
  • nucleus Source: MGI
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 134134DNA-binding protein inhibitor ID-2PRO_0000127244Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphoserineCombined sources
Modified residuei25 – 251PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated in vitro by CDK1, PKA and PKC.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP41137.

PTM databases

iPTMnetiP41137.
PhosphoSiteiP41137.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007237.
ExpressionAtlasiP41137. baseline and differential.
GenevisibleiP41137. RN.

Interactioni

Subunit structurei

Interacts with GATA4, IFI204, NR0B2 and NKX2-5. Interacts with CLOCK and ARNTL/BMAL1 (By similarity). Heterodimer with other HLH proteins.By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009491.

Structurei

3D structure databases

ProteinModelPortaliP41137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 7553bHLHPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi106 – 11510Nuclear export signalBy similarity

Domaini

The bHLH domain is essential for its repressor activity towards the CLOCK-ARNTL/BMAL1 heterodimer.By similarity

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IVXR. Eukaryota.
ENOG4111PGK. LUCA.
GeneTreeiENSGT00390000000908.
HOGENOMiHOG000234788.
HOVERGENiHBG009009.
InParanoidiP41137.
KOiK17693.
OMAiFPSEFMS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR026052. DNA-bd_prot-inh.
[Graphical view]
PANTHERiPTHR11723. PTHR11723. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV
60 70 80 90 100
PSIPQNKKVT KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQTSR
110 120 130
TPLTTLNTDI SILSLQASEF PSELMSNDSK VLCG
Length:134
Mass (Da):14,989
Last modified:February 1, 1995 - v1
Checksum:iA0D98D54EFDEB7B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10863 mRNA. Translation: BAA01634.1.
BC086391 mRNA. Translation: AAH86391.1.
PIRiJC2112.
RefSeqiNP_037192.1. NM_013060.3.
UniGeneiRn.3272.

Genome annotation databases

EnsembliENSRNOT00000009491; ENSRNOP00000009491; ENSRNOG00000007237.
GeneIDi25587.
KEGGirno:25587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10863 mRNA. Translation: BAA01634.1.
BC086391 mRNA. Translation: AAH86391.1.
PIRiJC2112.
RefSeqiNP_037192.1. NM_013060.3.
UniGeneiRn.3272.

3D structure databases

ProteinModelPortaliP41137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009491.

PTM databases

iPTMnetiP41137.
PhosphoSiteiP41137.

Proteomic databases

PaxDbiP41137.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009491; ENSRNOP00000009491; ENSRNOG00000007237.
GeneIDi25587.
KEGGirno:25587.

Organism-specific databases

CTDi3398.
RGDi2859. Id2.

Phylogenomic databases

eggNOGiENOG410IVXR. Eukaryota.
ENOG4111PGK. LUCA.
GeneTreeiENSGT00390000000908.
HOGENOMiHOG000234788.
HOVERGENiHBG009009.
InParanoidiP41137.
KOiK17693.
OMAiFPSEFMS.

Miscellaneous databases

PROiP41137.

Gene expression databases

BgeeiENSRNOG00000007237.
ExpressionAtlasiP41137. baseline and differential.
GenevisibleiP41137. RN.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR026052. DNA-bd_prot-inh.
[Graphical view]
PANTHERiPTHR11723. PTHR11723. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiID2_RAT
AccessioniPrimary (citable) accession number: P41137
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.