Reviewed, UniProtKB/Swiss-Prot P41134 (ID1_HUMAN)

Names and origin

Protein names

Recommended name:
    DNA-binding protein inhibitor ID-1
Alternative name(s):
    Inhibitor of DNA binding 1

Gene names

Name:	ID1
Synonyms:	ID

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding.
Subunit structure	Heterodimer with other HLH proteins. Interacts with COPS5 By similarity.
Subcellular location	Nucleus.
Developmental stage	Expression correlates with proliferation in some types of cells.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from physical interaction. Source: IntAct transcription regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CASK	O14936	1	EBI-1215527,EBI-1215506
CAV1	Q03135	3	EBI-1215527,EBI-603614
PSMD4	P55036	1	EBI-1215527,EBI-359318

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Notes: Additional isoforms seem to exist.

Isoform ID-A (identifier: P41134-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform ID-B (identifier: P41134-2)

The sequence of this isoform differs from the canonical sequence as follows:
     143-155: AACVPADDRILCR → VRSRSDH

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 155	155	DNA-binding protein inhibitor ID-1		PRO_0000127236
Regions
	Domain	66 – 106	41	Helix-loop-helix motif
Natural variations
	Alternative sequence	143 – 155	13	AACVP…RILCR → VRSRSDH in isoform ID-B.		VSP_002108
Experimental info
	Sequence conflict	16	1	S → T in BAA02988 and BAA02989. Ref.2
	Sequence conflict	46	1	A → R Ref.1 Ref.2
	Sequence conflict	48	1	Missing Ref.1 Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform ID-A [UniParc]. Last modified May 27, 2002. Version 3. Checksum: 480287384B667161	FASTA	155	16,133
	10 20 30 40 50 60 MKVASGSTAT AAAGPSCALK AGKTASGAGE VVRCLSEQSV AISRCAGGAG ARLPALLDEQ 70 80 90 100 110 120 QVNVLLYDMN GCYSRLKELV PTLPQNRKVS KVEILQHVID YIRDLQLELN SESEVGTPGG 130 140 150 RGLPVRAPLS TLNGEISALT AEAACVPADD RILCR
	Isoform ID-B [UniParc]. Checksum: DA265F6900663BC2		149	15,586
	10 20 30 40 50 60 MKVASGSTAT AAAGPSCALK AGKTASGAGE VVRCLSEQSV AISRCAGGAG ARLPALLDEQ 70 80 90 100 110 120 QVNVLLYDMN GCYSRLKELV PTLPQNRKVS KVEILQHVID YIRDLQLELN SESEVGTPGG 130 140 RGLPVRAPLS TLNGEISALT AEVRSRSDH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: identification of functionally conserved residues common to Id proteins." Deed R.W., Jasiok M., Norton J.D. Biochim. Biophys. Acta 1219:160-162(1994) [PubMed: 8086456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ID-A). Tissue: Placenta.
[2]	"Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts." Hara E., Yamaguchi T., Nojima H., Ide T., Campisi J., Okayama H., Oda K. J. Biol. Chem. 269:2139-2145(1994) [PubMed: 8294468] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ID-A AND ID-B). Tissue: Lung.
[3]	"Id gene expression during development and molecular cloning of the human Id-1 gene." Zhu W., Dahmen J., Bulfone A., Rigolet M., Hernandez M.-C., Kuo W.L., Puelles L., Rubenstein J.L.R., Israel M.A. Brain Res. Mol. Brain Res. 30:312-326(1995) [PubMed: 7637581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ID-A AND ID-B).
[4]	"Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene." Nehlin J.O., Hara E., Kuo W.L., Collins C., Campisi J. Biochem. Biophys. Res. Commun. 231:628-634(1997) [PubMed: 9070860] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[5]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ID-A).
[6]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ID-A). Tissue: Ovary and Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X77956 mRNA. Translation: CAA54920.1. D13889 mRNA. Translation: BAA02988.1. D13890 mRNA. Translation: BAA02989.1. S78986 mRNA. Translation: AAB35037.1. S78825 mRNA. Translation: AAB35038.1. U57645 Genomic DNA. Translation: AAC13882.1. U57645 Genomic DNA. Translation: AAC13883.1. BT007443 mRNA. Translation: AAP36111.1. AL110115 Genomic DNA. Translation: CAC14950.2. AL110115, AL117381 Genomic DNA. Translation: CAI20171.1. AL117381, AL110115 Genomic DNA. Translation: CAI23029.1. AL117381, AL110115 Genomic DNA. Translation: CAI23030.1. BC000613 mRNA. Translation: AAH00613.1. BC012420 mRNA. Translation: AAH12420.1.
PIR	A49727. B49727. JC5395. JC5396. S47524.
RefSeq	NP_002156.2. NP_851998.1.
UniGene	Hs.504609
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P41134.
PTM databases
PhosphoSite	P41134.
Genome annotation databases
Ensembl	ENSG00000125968. Homo sapiens. [Contig view]
GeneID	3397.
KEGG	hsa:3397.
Organism-specific databases
H-InvDB	HIX0015712.
HGNC	HGNC:5360. ID1.
MIM	600349. gene.
PharmGKB	PA142672118.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	P41134.
Gene expression databases
ArrayExpress	P41134.
GermOnline	ENSG00000125968. Homo sapiens.
Family and domain databases
InterPro	IPR001092. HLH_basic. IPR011598. HLH_DNA_bd. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	P41134.
NextBio	13422.
SOURCE	Search...

Entry information

Entry name

ID1_HUMAN

Accession

Primary (citable) accession number: P41134
Secondary accession number(s): O00651 , O00652, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	May 27, 2002
Last modified:	November 25, 2008
This is version 91 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)