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Protein

DNA-binding protein inhibitor ID-1

Gene

ID1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-2559585. Oncogene Induced Senescence.
SIGNORiP41134.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein inhibitor ID-1
Alternative name(s):
Class B basic helix-loop-helix protein 24
Short name:
bHLHb24
Inhibitor of DNA binding 1
Inhibitor of differentiation 1
Gene namesi
Name:ID1
Synonyms:BHLHB24, ID
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:5360. ID1.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: Ensembl
  • Golgi apparatus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: GDB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29608.

Chemistry

ChEMBLiCHEMBL1075116.

Polymorphism and mutation databases

BioMutaiID1.
DMDMi21264450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155DNA-binding protein inhibitor ID-1PRO_0000127236Add
BLAST

Proteomic databases

EPDiP41134.
MaxQBiP41134.
PaxDbiP41134.
PRIDEiP41134.

PTM databases

iPTMnetiP41134.
PhosphoSiteiP41134.

Expressioni

Developmental stagei

Expression correlates with proliferation in some types of cells.

Gene expression databases

BgeeiP41134.
GenevisibleiP41134. HS.

Organism-specific databases

HPAiCAB025915.
HPA051456.

Interactioni

Subunit structurei

Heterodimer with other HLH proteins. Interacts with COPS5, IFI204, GATA4 and NKX2-5 (By similarity). Interacts with CLOCK and ARNTL/BMAL1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CASKO149363EBI-1215527,EBI-1215506
CAV1Q031356EBI-1215527,EBI-603614
TCF4P158843EBI-1215527,EBI-533224

Protein-protein interaction databases

BioGridi109623. 39 interactions.
DIPiDIP-38112N.
IntActiP41134. 27 interactions.
STRINGi9606.ENSP00000365280.

Structurei

3D structure databases

ProteinModelPortaliP41134.
SMRiP41134. Positions 65-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 10553bHLHPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi98 – 11114Nuclear export signalBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IWDR. Eukaryota.
ENOG4111VAY. LUCA.
GeneTreeiENSGT00390000000908.
HOVERGENiHBG009009.
InParanoidiP41134.
KOiK04680.
OMAiYIWDLEL.
OrthoDBiEOG7X9G8G.
PhylomeDBiP41134.
TreeFamiTF326217.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR026052. DNA-bd_prot-inh.
[Graphical view]
PANTHERiPTHR11723. PTHR11723. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform ID-A (identifier: P41134-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVASGSTAT AAAGPSCALK AGKTASGAGE VVRCLSEQSV AISRCAGGAG
60 70 80 90 100
ARLPALLDEQ QVNVLLYDMN GCYSRLKELV PTLPQNRKVS KVEILQHVID
110 120 130 140 150
YIRDLQLELN SESEVGTPGG RGLPVRAPLS TLNGEISALT AEAACVPADD

RILCR
Length:155
Mass (Da):16,133
Last modified:May 27, 2002 - v3
Checksum:i480287384B667161
GO
Isoform ID-B (identifier: P41134-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-155: AACVPADDRILCR → VRSRSDH

Show »
Length:149
Mass (Da):15,586
Checksum:iDA265F6900663BC2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161S → T in BAA02988 (PubMed:8294468).Curated
Sequence conflicti16 – 161S → T in BAA02989 (PubMed:8294468).Curated
Sequence conflicti46 – 461A → R (PubMed:8086456).Curated
Sequence conflicti46 – 461A → R (PubMed:8294468).Curated
Sequence conflicti48 – 481Missing (PubMed:8086456).Curated
Sequence conflicti48 – 481Missing (PubMed:8294468).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631N → D.
Corresponds to variant rs1802548 [ dbSNP | Ensembl ].
VAR_049544

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei143 – 15513AACVP…RILCR → VRSRSDH in isoform ID-B. 2 PublicationsVSP_002108Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77956 mRNA. Translation: CAA54920.1.
D13889 mRNA. Translation: BAA02988.1.
D13890 mRNA. Translation: BAA02989.1.
S78986 mRNA. Translation: AAB35037.1.
S78825 mRNA. Translation: AAB35038.1.
U57645 Genomic DNA. Translation: AAC13882.1.
U57645 Genomic DNA. Translation: AAC13883.1.
BT007443 mRNA. Translation: AAP36111.1.
AK291152 mRNA. Translation: BAF83841.1.
AL110115 Genomic DNA. Translation: CAC14950.2.
AL110115, AL117381 Genomic DNA. Translation: CAI20171.1.
AL117381, AL110115 Genomic DNA. Translation: CAI23029.1.
AL117381, AL110115 Genomic DNA. Translation: CAI23030.1.
CH471077 Genomic DNA. Translation: EAW76432.1.
CH471077 Genomic DNA. Translation: EAW76434.1.
BC000613 mRNA. Translation: AAH00613.1.
BC012420 mRNA. Translation: AAH12420.1.
CCDSiCCDS13185.1. [P41134-1]
CCDS13186.1. [P41134-2]
PIRiA49727.
B49727.
JC5395.
JC5396.
S47524.
RefSeqiNP_002156.2. NM_002165.3. [P41134-1]
NP_851998.1. NM_181353.2. [P41134-2]
UniGeneiHs.504609.

Genome annotation databases

EnsembliENST00000376105; ENSP00000365273; ENSG00000125968. [P41134-2]
ENST00000376112; ENSP00000365280; ENSG00000125968. [P41134-1]
GeneIDi3397.
KEGGihsa:3397.
UCSCiuc002wwg.3. human. [P41134-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77956 mRNA. Translation: CAA54920.1.
D13889 mRNA. Translation: BAA02988.1.
D13890 mRNA. Translation: BAA02989.1.
S78986 mRNA. Translation: AAB35037.1.
S78825 mRNA. Translation: AAB35038.1.
U57645 Genomic DNA. Translation: AAC13882.1.
U57645 Genomic DNA. Translation: AAC13883.1.
BT007443 mRNA. Translation: AAP36111.1.
AK291152 mRNA. Translation: BAF83841.1.
AL110115 Genomic DNA. Translation: CAC14950.2.
AL110115, AL117381 Genomic DNA. Translation: CAI20171.1.
AL117381, AL110115 Genomic DNA. Translation: CAI23029.1.
AL117381, AL110115 Genomic DNA. Translation: CAI23030.1.
CH471077 Genomic DNA. Translation: EAW76432.1.
CH471077 Genomic DNA. Translation: EAW76434.1.
BC000613 mRNA. Translation: AAH00613.1.
BC012420 mRNA. Translation: AAH12420.1.
CCDSiCCDS13185.1. [P41134-1]
CCDS13186.1. [P41134-2]
PIRiA49727.
B49727.
JC5395.
JC5396.
S47524.
RefSeqiNP_002156.2. NM_002165.3. [P41134-1]
NP_851998.1. NM_181353.2. [P41134-2]
UniGeneiHs.504609.

3D structure databases

ProteinModelPortaliP41134.
SMRiP41134. Positions 65-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109623. 39 interactions.
DIPiDIP-38112N.
IntActiP41134. 27 interactions.
STRINGi9606.ENSP00000365280.

Chemistry

ChEMBLiCHEMBL1075116.

PTM databases

iPTMnetiP41134.
PhosphoSiteiP41134.

Polymorphism and mutation databases

BioMutaiID1.
DMDMi21264450.

Proteomic databases

EPDiP41134.
MaxQBiP41134.
PaxDbiP41134.
PRIDEiP41134.

Protocols and materials databases

DNASUi3397.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376105; ENSP00000365273; ENSG00000125968. [P41134-2]
ENST00000376112; ENSP00000365280; ENSG00000125968. [P41134-1]
GeneIDi3397.
KEGGihsa:3397.
UCSCiuc002wwg.3. human. [P41134-1]

Organism-specific databases

CTDi3397.
GeneCardsiID1.
HGNCiHGNC:5360. ID1.
HPAiCAB025915.
HPA051456.
MIMi600349. gene.
neXtProtiNX_P41134.
PharmGKBiPA29608.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWDR. Eukaryota.
ENOG4111VAY. LUCA.
GeneTreeiENSGT00390000000908.
HOVERGENiHBG009009.
InParanoidiP41134.
KOiK04680.
OMAiYIWDLEL.
OrthoDBiEOG7X9G8G.
PhylomeDBiP41134.
TreeFamiTF326217.

Enzyme and pathway databases

ReactomeiR-HSA-2559585. Oncogene Induced Senescence.
SIGNORiP41134.

Miscellaneous databases

GeneWikiiID1.
GenomeRNAii3397.
NextBioi13422.
PROiP41134.
SOURCEiSearch...

Gene expression databases

BgeeiP41134.
GenevisibleiP41134. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR026052. DNA-bd_prot-inh.
[Graphical view]
PANTHERiPTHR11723. PTHR11723. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: identification of functionally conserved residues common to Id proteins."
    Deed R.W., Jasiok M., Norton J.D.
    Biochim. Biophys. Acta 1219:160-162(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ID-A).
    Tissue: Placenta.
  2. "Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts."
    Hara E., Yamaguchi T., Nojima H., Ide T., Campisi J., Okayama H., Oda K.
    J. Biol. Chem. 269:2139-2145(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ID-A AND ID-B).
    Tissue: Lung.
  3. "Id gene expression during development and molecular cloning of the human Id-1 gene."
    Zhu W., Dahmen J., Bulfone A., Rigolet M., Hernandez M.-C., Kuo W.L., Puelles L., Rubenstein J.L.R., Israel M.A.
    Brain Res. Mol. Brain Res. 30:312-326(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ID-A AND ID-B).
  4. "Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene."
    Nehlin J.O., Hara E., Kuo W.L., Collins C., Campisi J.
    Biochem. Biophys. Res. Commun. 231:628-634(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ID-A).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ID-A).
  7. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ID-A).
    Tissue: Ovary and Skin.
  10. "The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression."
    Ward S.M., Fernando S.J., Hou T.Y., Duffield G.E.
    J. Biol. Chem. 285:38987-39000(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLOCK AND ARNTL.

Entry informationi

Entry nameiID1_HUMAN
AccessioniPrimary (citable) accession number: P41134
Secondary accession number(s): A8K537
, E1P5L4, O00651, O00652, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 27, 2002
Last modified: May 11, 2016
This is version 172 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.