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Protein

60S ribosomal protein L13

Gene

Rpl13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: GO_Central
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • liver regeneration Source: RGD
  • translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L13
Gene namesi
Name:Rpl13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621179. Rpl13.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21121160S ribosomal protein L13PRO_0000192921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161N6-acetyllysineBy similarity
Modified residuei52 – 521PhosphoserineBy similarity
Modified residuei77 – 771PhosphoserineBy similarity
Modified residuei106 – 1061PhosphoserineBy similarity
Cross-linki174 – 174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei177 – 1771N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP41123.
PRIDEiP41123.

PTM databases

iPTMnetiP41123.

Expressioni

Gene expression databases

GenevisibleiP41123. RN.

Interactioni

Protein-protein interaction databases

IntActiP41123. 3 interactions.
MINTiMINT-4565131.
STRINGi10116.ENSRNOP00000020635.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L13e family.Curated

Phylogenomic databases

eggNOGiKOG3295. Eukaryota.
COG4352. LUCA.
GeneTreeiENSGT00390000007818.
HOGENOMiHOG000170452.
HOVERGENiHBG001156.
InParanoidiP41123.
KOiK02873.
OMAiECKGRIL.
OrthoDBiEOG74TX1G.
PhylomeDBiP41123.
TreeFamiTF300073.

Family and domain databases

InterProiIPR001380. Ribosomal_L13e.
IPR018256. Ribosomal_L13e_CS.
[Graphical view]
PANTHERiPTHR11722. PTHR11722. 1 hit.
PfamiPF01294. Ribosomal_L13e. 1 hit.
[Graphical view]
PROSITEiPS01104. RIBOSOMAL_L13E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41123-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSRNGMIL KPHFHKDWQQ RVDTWFNQPA RKIRRRKARQ AKARRIAPRP
60 70 80 90 100
ASGPIRPIVR CPTVRYHTKV RAGRGFSLEE LRVAGIHKKM ARTIGISVDP
110 120 130 140 150
RRRNKSTESL QANVQRLKEY RSKLILFPRK PSAPKKGDSS AEELKLATQL
160 170 180 190 200
TGPVMPIRNV YKKEKARAIT EEEKNFKAFA SLRMARANAR LFGIRAKRAK
210
EAAEQDVEKK K
Length:211
Mass (Da):24,309
Last modified:January 23, 2007 - v2
Checksum:i27BE84B1D810206F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561R → S in CAA55130 (PubMed:8198561).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78327 mRNA. Translation: CAA55130.1.
BC058143 mRNA. Translation: AAH58143.1.
PIRiJC2368.
RefSeqiNP_112363.1. NM_031101.1.
XP_008764125.1. XM_008765903.1.
XP_008774860.1. XM_008776638.1.
UniGeneiRn.156566.
Rn.908.

Genome annotation databases

EnsembliENSRNOT00000020635; ENSRNOP00000020635; ENSRNOG00000015335.
GeneIDi100359922.
81765.
KEGGirno:100359922.
rno:81765.
UCSCiRGD:621179. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78327 mRNA. Translation: CAA55130.1.
BC058143 mRNA. Translation: AAH58143.1.
PIRiJC2368.
RefSeqiNP_112363.1. NM_031101.1.
XP_008764125.1. XM_008765903.1.
XP_008774860.1. XM_008776638.1.
UniGeneiRn.156566.
Rn.908.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP41123. 3 interactions.
MINTiMINT-4565131.
STRINGi10116.ENSRNOP00000020635.

PTM databases

iPTMnetiP41123.

Proteomic databases

PaxDbiP41123.
PRIDEiP41123.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020635; ENSRNOP00000020635; ENSRNOG00000015335.
GeneIDi100359922.
81765.
KEGGirno:100359922.
rno:81765.
UCSCiRGD:621179. rat.

Organism-specific databases

CTDi6137.
RGDi621179. Rpl13.

Phylogenomic databases

eggNOGiKOG3295. Eukaryota.
COG4352. LUCA.
GeneTreeiENSGT00390000007818.
HOGENOMiHOG000170452.
HOVERGENiHBG001156.
InParanoidiP41123.
KOiK02873.
OMAiECKGRIL.
OrthoDBiEOG74TX1G.
PhylomeDBiP41123.
TreeFamiTF300073.

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP41123.

Gene expression databases

GenevisibleiP41123. RN.

Family and domain databases

InterProiIPR001380. Ribosomal_L13e.
IPR018256. Ribosomal_L13e_CS.
[Graphical view]
PANTHERiPTHR11722. PTHR11722. 1 hit.
PfamiPF01294. Ribosomal_L13e. 1 hit.
[Graphical view]
PROSITEiPS01104. RIBOSOMAL_L13E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of rat ribosomal protein L13."
    Olvera J., Wool I.G.
    Biochem. Biophys. Res. Commun. 201:102-107(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiRL13_RAT
AccessioniPrimary (citable) accession number: P41123
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.