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Protein

Translation initiation factor eIF-2B subunit delta

Gene

EIF2B4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit delta
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit delta
Gene namesi
Name:EIF2B4
Synonyms:EIF2BD
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001560692 – 523Translation initiation factor eIF-2B subunit deltaAdd BLAST522

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei85PhosphothreonineBy similarity1
Modified residuei129PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000022102.

Structurei

3D structure databases

ProteinModelPortaliP41111.
SMRiP41111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1467. Eukaryota.
COG1184. LUCA.
HOGENOMiHOG000176924.
HOVERGENiHBG051459.
InParanoidiP41111.
KOiK03680.

Family and domain databases

InterProiView protein in InterPro
IPR000649. IF-2B-related.
PfamiView protein in Pfam
PF01008. IF-2B. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVAVAVRE DSGSGMKAEL SARPGAGGKE MTQEEKLQLR KEKKQQKKKR
60 70 80 90 100
KEEKGTDVDT ASAVSAAQCP GPAREAPGPG SQSSTPGEKV PAGRTKAELR
110 120 130 140 150
AERRAKQEAE RALKQARKGE QGGPPPQASP STAGEAPAGG KRLTEHTQAD
160 170 180 190 200
DPTLLRRLVR KSERQQVPTR KDYGSKVSLF SHLPQYSRQN SLTQYMSIPS
210 220 230 240 250
SVIHPAMVRL GLQYSQGLIS GSNARCIALL RALQQVIQDY TTPPNEELSR
260 270 280 290 300
DLVNKLKPYI CFLTQCRPLS ASMYNAIKFL NKEITGVSST KREEEAKAEL
310 320 330 340 350
QAAADRYVQE KIVLAAQAIL RFASKKISNG DVILVYGCSS LVSRILQEAW
360 370 380 390 400
SEGRKFRVVV VDSRPRLEGR HMLRFLVRAG VPASYLLIPA ASYVLPEVSK
410 420 430 440 450
VLLGAHALLA NGSVMSRVGT AQLALVARAH NVPVLVCCET YKFCERVQTD
460 470 480 490 500
AFVSNELDDP DDLQCERGDH VALANWQSHP SLRLLNLVYD VTPPELVDLV
510 520
ITELGMIPCS SVPVVLRVKS SDQ
Length:523
Mass (Da):57,121
Last modified:November 1, 1997 - v2
Checksum:i057895B1E9D25558
GO

Sequence cautioni

The sequence CAA53204 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75451 mRNA. Translation: CAA53204.1. Different initiation.
PIRiS42727.
RefSeqiNP_001076241.1. NM_001082772.1.
UniGeneiOcu.2101.

Genome annotation databases

GeneIDi100009560.
KEGGiocu:100009560.

Similar proteinsi

Entry informationi

Entry nameiEI2BD_RABIT
AccessioniPrimary (citable) accession number: P41111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: March 15, 2017
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families