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Protein

60S ribosomal protein L28

Gene

Rpl28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: MGI
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_231519. Eukaryotic Translation Termination.
REACT_249044. Formation of a pool of free 40S subunits.
REACT_253640. Peptide chain elongation.
REACT_259469. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_262078. GTP hydrolysis and joining of the 60S ribosomal subunit.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L28
Gene namesi
Name:Rpl28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:101839. Rpl28.

Subcellular locationi

GO - Cellular componenti

  1. cell body Source: MGI
  2. cytoplasm Source: MGI
  3. cytoplasmic ribonucleoprotein granule Source: MGI
  4. cytosolic large ribosomal subunit Source: MGI
  5. dendrite Source: MGI
  6. extracellular vesicular exosome Source: MGI
  7. membrane Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 13713660S ribosomal protein L28PRO_0000122390Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei115 – 1151PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP41105.
PaxDbiP41105.
PRIDEiP41105.

PTM databases

PhosphoSiteiP41105.

Expressioni

Gene expression databases

BgeeiP41105.
CleanExiMM_RPL28.
ExpressionAtlasiP41105. baseline and differential.
GenevestigatoriP41105.

Interactioni

Protein-protein interaction databases

BioGridi202975. 6 interactions.
DIPiDIP-59974N.
IntActiP41105. 2 interactions.
MINTiMINT-1858259.

Structurei

3D structure databases

ProteinModelPortaliP41105.
SMRiP41105. Positions 1-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L28e family.Curated

Phylogenomic databases

eggNOGiNOG148062.
HOGENOMiHOG000200513.
HOVERGENiHBG000701.
InParanoidiP41105.
KOiK02903.
OMAiNKPFSTE.
OrthoDBiEOG74N5JT.
PhylomeDBiP41105.
TreeFamiTF300173.

Family and domain databases

InterProiIPR029004. L28e/Mak16.
IPR002672. Ribosomal_L28e.
[Graphical view]
PANTHERiPTHR10544. PTHR10544. 1 hit.
PfamiPF01778. Ribosomal_L28e. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41105-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAHLQWMVV RNCSSFLIKR NKQTYSTEPN NLKARNSFRY NGLIHRKTVG
60 70 80 90 100
VEPAADGKGV VVVMKRRSGQ RKPATSYVRT TINKNARATL SSIRHMIRKN
110 120 130
KYRPDLRMAA IRRASAILRS QKPVVVKRKR TRPTKSS
Length:137
Mass (Da):15,733
Last modified:January 23, 2007 - v2
Checksum:i44D9CF515F9B687B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74856 mRNA. Translation: CAA52848.1.
AK018714 mRNA. Translation: BAB31362.1.
AK076133 mRNA. Translation: BAC36209.1.
BC024395 mRNA. Translation: AAH24395.1.
CCDSiCCDS39742.1.
PIRiI48738.
RefSeqiNP_033107.1. NM_009081.2.
UniGeneiMm.379002.

Genome annotation databases

EnsembliENSMUST00000032597; ENSMUSP00000032597; ENSMUSG00000030432.
ENSMUST00000078432; ENSMUSP00000104217; ENSMUSG00000030432.
GeneIDi19943.
KEGGimmu:19943.
UCSCiuc009eys.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74856 mRNA. Translation: CAA52848.1.
AK018714 mRNA. Translation: BAB31362.1.
AK076133 mRNA. Translation: BAC36209.1.
BC024395 mRNA. Translation: AAH24395.1.
CCDSiCCDS39742.1.
PIRiI48738.
RefSeqiNP_033107.1. NM_009081.2.
UniGeneiMm.379002.

3D structure databases

ProteinModelPortaliP41105.
SMRiP41105. Positions 1-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202975. 6 interactions.
DIPiDIP-59974N.
IntActiP41105. 2 interactions.
MINTiMINT-1858259.

PTM databases

PhosphoSiteiP41105.

Proteomic databases

MaxQBiP41105.
PaxDbiP41105.
PRIDEiP41105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032597; ENSMUSP00000032597; ENSMUSG00000030432.
ENSMUST00000078432; ENSMUSP00000104217; ENSMUSG00000030432.
GeneIDi19943.
KEGGimmu:19943.
UCSCiuc009eys.1. mouse.

Organism-specific databases

CTDi6158.
MGIiMGI:101839. Rpl28.

Phylogenomic databases

eggNOGiNOG148062.
HOGENOMiHOG000200513.
HOVERGENiHBG000701.
InParanoidiP41105.
KOiK02903.
OMAiNKPFSTE.
OrthoDBiEOG74N5JT.
PhylomeDBiP41105.
TreeFamiTF300173.

Enzyme and pathway databases

ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_231519. Eukaryotic Translation Termination.
REACT_249044. Formation of a pool of free 40S subunits.
REACT_253640. Peptide chain elongation.
REACT_259469. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_262078. GTP hydrolysis and joining of the 60S ribosomal subunit.

Miscellaneous databases

ChiTaRSiRpl28. mouse.
NextBioi297461.
PROiP41105.
SOURCEiSearch...

Gene expression databases

BgeeiP41105.
CleanExiMM_RPL28.
ExpressionAtlasiP41105. baseline and differential.
GenevestigatoriP41105.

Family and domain databases

InterProiIPR029004. L28e/Mak16.
IPR002672. Ribosomal_L28e.
[Graphical view]
PANTHERiPTHR10544. PTHR10544. 1 hit.
PfamiPF01778. Ribosomal_L28e. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and expression of a cDNA encoding the mouse homologue of the rat ribosomal protein L28."
    Burke P.S., Lium E., Lin C.S., Wolgemuth D.J.
    Gene 142:315-316(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  4. Bienvenut W.V., Sandilands E., Serrels B., Brunton V.G., Frame M.C.
    Submitted (FEB-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-20 AND 36-46, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiRL28_MOUSE
AccessioniPrimary (citable) accession number: P41105
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.