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Protein

60S ribosomal protein L18a

Gene

RpL18A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • centrosome duplication Source: FlyBase
  • cytoplasmic translation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L18a
Gene namesi
Name:RpL18A
ORF Names:CG6510
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010409. RpL18A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139321 – 17760S ribosomal protein L18aAdd BLAST177

Proteomic databases

PaxDbiP41093.
PRIDEiP41093.

Expressioni

Gene expression databases

BgeeiFBgn0010409.
GenevisibleiP41093. DM.

Interactioni

Protein-protein interaction databases

BioGridi62674. 16 interactors.
DIPiDIP-19043N.
IntActiP41093. 9 interactors.
MINTiMINT-321854.
STRINGi7227.FBpp0086103.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CS1-177[»]
ProteinModelPortaliP41093.
SMRiP41093.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0829. Eukaryota.
COG2157. LUCA.
GeneTreeiENSGT00390000015797.
InParanoidiP41093.
KOiK02882.
OMAiCRRPAIK.
OrthoDBiEOG091G0LX4.
PhylomeDBiP41093.

Family and domain databases

HAMAPiMF_00273. Ribosomal_L18Ae. 1 hit.
InterProiView protein in InterPro
IPR028877. 50S_L18Ae/Ribosomal_L18a/L20.
IPR023573. Ribosomal_L18a//L18Ae/LX.
IPR021138. Ribosomal_L18a/L20_eukaryotes.
PfamiView protein in Pfam
PF01775. Ribosomal_L18A. 1 hit.
PIRSFiPIRSF002190. Ribosomal_L18a. 1 hit.

Sequencei

Sequence statusi: Complete.

P41093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAKGLLKEY EVVGRKLPSE KEPQTPLYKM RIFAPDNIVA KSRFWYFLRQ
60 70 80 90 100
LKKFKKTTGE IVSIKQVYET SPVKIKNFGI WLRYDSRSGT HNMYREYRDL
110 120 130 140 150
TVGGAVTQCY RDMGARHRAR AHSIQIIKVD SIPAAKTRRV HVKQFHDSKI
160 170
KFPLVQRVHH KGNRKLFSFR KPRTYFQ
Length:177
Mass (Da):21,030
Last modified:February 1, 1995 - v1
Checksum:i4BD5E9A9F0799FA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75339 mRNA. Translation: CAA53089.1.
AE013599 Genomic DNA. Translation: AAF57838.1.
AY071222 mRNA. Translation: AAL48844.1.
PIRiS45364.
RefSeqiNP_523774.1. NM_079050.3.
UniGeneiDm.669.

Genome annotation databases

EnsemblMetazoaiFBtr0086947; FBpp0086103; FBgn0010409.
GeneIDi36985.
KEGGidme:Dmel_CG6510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75339 mRNA. Translation: CAA53089.1.
AE013599 Genomic DNA. Translation: AAF57838.1.
AY071222 mRNA. Translation: AAL48844.1.
PIRiS45364.
RefSeqiNP_523774.1. NM_079050.3.
UniGeneiDm.669.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CS1-177[»]
ProteinModelPortaliP41093.
SMRiP41093.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi62674. 16 interactors.
DIPiDIP-19043N.
IntActiP41093. 9 interactors.
MINTiMINT-321854.
STRINGi7227.FBpp0086103.

Proteomic databases

PaxDbiP41093.
PRIDEiP41093.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0086947; FBpp0086103; FBgn0010409.
GeneIDi36985.
KEGGidme:Dmel_CG6510.

Organism-specific databases

CTDi6142.
FlyBaseiFBgn0010409. RpL18A.

Phylogenomic databases

eggNOGiKOG0829. Eukaryota.
COG2157. LUCA.
GeneTreeiENSGT00390000015797.
InParanoidiP41093.
KOiK02882.
OMAiCRRPAIK.
OrthoDBiEOG091G0LX4.
PhylomeDBiP41093.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpL18A. fly.
GenomeRNAii36985.
PROiPR:P41093.

Gene expression databases

BgeeiFBgn0010409.
GenevisibleiP41093. DM.

Family and domain databases

HAMAPiMF_00273. Ribosomal_L18Ae. 1 hit.
InterProiView protein in InterPro
IPR028877. 50S_L18Ae/Ribosomal_L18a/L20.
IPR023573. Ribosomal_L18a//L18Ae/LX.
IPR021138. Ribosomal_L18a/L20_eukaryotes.
PfamiView protein in Pfam
PF01775. Ribosomal_L18A. 1 hit.
PIRSFiPIRSF002190. Ribosomal_L18a. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRL18A_DROME
AccessioniPrimary (citable) accession number: P41093
Secondary accession number(s): Q9V840
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 7, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.