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Protein

60S ribosomal protein L27a

Gene

RpL27A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: GO_Central
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L27a
Gene namesi
Name:RpL27A
Synonyms:RpL27a2, RpL27Aa, RpL27Ab
ORF Names:CG15442
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0285948. RpL27A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001048861 – 14960S ribosomal protein L27aAdd BLAST149

Proteomic databases

PaxDbiP41092.
PRIDEiP41092.

Expressioni

Gene expression databases

BgeeiFBgn0261606.
ExpressionAtlasiP41092. differential.
GenevisibleiP41092. DM.

Interactioni

Protein-protein interaction databases

BioGridi59848. 4 interactors.
DIPiDIP-18398N.
IntActiP41092. 23 interactors.
MINTiMINT-874607.
STRINGi7227.FBpp0077142.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00Ca1-149[»]
ProteinModelPortaliP41092.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1742. Eukaryota.
COG0200. LUCA.
GeneTreeiENSGT00390000005534.
InParanoidiP41092.
KOiK02900.
OMAiGRVGQHR.
OrthoDBiEOG091G0TQF.
PhylomeDBiP41092.

Family and domain databases

HAMAPiMF_01341. Ribosomal_L15. 1 hit.
InterProiView protein in InterPro
IPR030878. Ribosomal_L15.
IPR001196. Ribosomal_L15_CS.
IPR021131. Ribosomal_L18e/L15P.
PfamiView protein in Pfam
PF00828. Ribosomal_L27A. 1 hit.
SUPFAMiSSF52080. SSF52080. 1 hit.
PROSITEiView protein in PROSITE
PS00475. RIBOSOMAL_L15. 1 hit.

Sequencei

Sequence statusi: Complete.

P41092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIKRKKTR KLRGHVSHGH GRIGKHRKHP GGRGNAGGMH HHRINFDKYH
60 70 80 90 100
PGYFGKVGMR NFHLRRQHKF RPEINLDKLW SLVGAEKFAE LEKEKSTKAP
110 120 130 140
VIDLVKFGYY KLLGRGHLPA RPVIVKAKYF SKKAEDKIKK AGGVCLLSA
Length:149
Mass (Da):17,022
Last modified:May 2, 2002 - v2
Checksum:i7777397307B89DCC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2S → R in CAA52601 (PubMed:8297386).Curated1
Sequence conflicti36A → L in CAA52601 (PubMed:8297386).Curated1
Sequence conflicti140K → E in CAA52601 (PubMed:8297386).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74484 mRNA. Translation: CAA52601.1.
U66357 Genomic DNA. Translation: AAC47475.1.
U66358 mRNA. Translation: AAC47472.1.
AE014134 Genomic DNA. Translation: AAF51006.3.
AY071144 mRNA. Translation: AAL48766.1.
PIRiJC2392.
JC6202.
RefSeqiNP_001188689.2. NM_001201760.2.
NP_001285601.1. NM_001298672.1.
NP_476963.1. NM_057615.6.
UniGeneiDm.295.

Genome annotation databases

EnsemblMetazoaiFBtr0077452; FBpp0077142; FBgn0261606.
FBtr0335136; FBpp0307135; FBgn0261606.
FBtr0345285; FBpp0311452; FBgn0261606.
GeneIDi33654.
KEGGidme:Dmel_CG15442.

Similar proteinsi

Entry informationi

Entry nameiRL27A_DROME
AccessioniPrimary (citable) accession number: P41092
Secondary accession number(s): Q94530, Q9VR02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 2, 2002
Last modified: September 27, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families