ID CFI1_ARATH Reviewed; 246 AA. AC P41088; Q8W532; Q9LE13; Q9LF74; Q9LF75; DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot. DT 11-JUL-2002, sequence version 2. DT 16-JUN-2009, entry version 72. DE RecName: Full=Chalcone--flavonone isomerase 1; DE Short=Chalcone isomerase 1; DE EC=5.5.1.6; DE AltName: Full=Protein TRANSPARENT TESTA 5; GN Name=CHI1; Synonyms=CFI, TT5; OrderedLocusNames=At3g55120; GN ORFNames=T15C9_120; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; OC rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION. RC STRAIN=cv. Columbia, and cv. Landsberg erecta; RX MEDLINE=92361255; PubMed=1354004; DOI=10.1105/tpc.4.3.333; RA Shirley B.W., Hanley S., Goodman H.M.; RT "Effects of ionizing radiation on a plant genome: analysis of two RT Arabidopsis transparent testa mutations."; RL Plant Cell 4:333-347(1992). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=cv. Gr-5, cv. Ita-0, cv. Mh-0, cv. Per-1, cv. Rv-1, and RC cv. Wlp-2; RX MEDLINE=20296760; PubMed=10835405; RA Kuittinen H., Aguade M.; RT "Nucleotide variation at the chalcone isomerase locus in Arabidopsis RT thaliana."; RL Genetics 155:863-872(2000). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=cv. Gran-10, cv. Gran-2, cv. Gran-3, cv. Gran-4, cv. Gran-5, RC cv. Gran-6, cv. Gran-7, cv. Gran-8, cv. Gran-9, cv. Lu-2, cv. Lu-3, RC cv. Lu-4, cv. Lu-5, cv. Lu-6, cv. Lu-7, cv. Lu-8, cv. Rv-10, cv. Rv-2, RC cv. Rv-3, cv. Rv-4, cv. Rv-5, cv. Rv-6, cv. Rv-7, cv. Rv-8, cv. Rv-9, RC cv. Tv-10, cv. Tv-2, cv. Tv-3, cv. Tv-4, cv. Tv-5, cv. Tv-6, cv. Tv-7, RC cv. Tv-8, cv. Tv-9, cv. Wlp-10, cv. Wlp-2, cv. Wlp-3, cv. Wlp-4, RC cv. Wlp-5, cv. Wlp-6, cv. Wlp-7, cv. Wlp-8, and cv. Wlp-9; RX MEDLINE=22300337; PubMed=12411612; RA Kuittinen H., Salguero D., Aguade M.; RT "Parallel patterns of sequence variation within and between RT populations at three loci of Arabidopsis thaliana."; RL Mol. Biol. Evol. 19:2030-2034(2002). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION BY RP LIGHT. RC STRAIN=cv. Columbia; RX PubMed=15821875; DOI=10.1007/s11103-004-6910-0; RA Hartmann U., Sagasser M., Mehrtens F., Stracke R., Weisshaar B.; RT "Differential combinatorial interactions of cis-acting elements RT recognized by R2R3-MYB, BZIP, and BHLH factors control light- RT responsive and tissue-specific activation of phenylpropanoid RT biosynthesis genes."; RL Plant Mol. Biol. 57:155-171(2005). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX MEDLINE=21016720; PubMed=11130713; DOI=10.1038/35048706; RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., RA Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., RA Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., RA De Simone V., Choisne N., Artiguenave F., Robert C., Brottier P., RA Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., RA Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., RA Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., RA Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., RA Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., RA Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., RA Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., RA Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., RA Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., RA Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., RA Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., RA Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., RA Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., RA Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., RA Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., RA Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., RA Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., RA Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., RA Watanabe A., Yamada M., Yasuda M., Tabata S.; RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis RT thaliana."; RL Nature 408:820-822(2000). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX MEDLINE=22954850; PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., RA Feldmann K.A.; RT "Full-length cDNA from Arabidopsis thaliana."; RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the intramolecular cyclization of bicyclic CC chalcones into tricyclic (S)-flavanones. Responsible for the CC isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed CC chalcone) into naringenin. CC -!- CATALYTIC ACTIVITY: A chalcone = a flavanone. CC -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid CC biosynthesis. CC -!- TISSUE SPECIFICITY: Mostly expressed in siliques and flowers, and, CC to a lower extent, in leaves. CC -!- INDUCTION: By light. CC -!- MISCELLANEOUS: Part of the biosynthetic pathway for all classes of CC flavonoids, a large class of secondary plant metabolites, many of CC which are brightly colored. CC -!- SIMILARITY: Belongs to the chalcone isomerase family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M86358; AAA32766.1; -; Genomic_DNA. DR EMBL; AJ287299; CAB94969.1; -; Genomic_DNA. DR EMBL; AJ287300; CAB94970.1; -; Genomic_DNA. DR EMBL; AJ287301; CAB94971.1; -; Genomic_DNA. DR EMBL; AJ287302; CAB94972.1; -; Genomic_DNA. DR EMBL; AJ287303; CAB94973.1; -; Genomic_DNA. DR EMBL; AJ287304; CAB94974.1; -; Genomic_DNA. DR EMBL; AJ287305; CAB94975.1; -; Genomic_DNA. DR EMBL; AJ287306; CAB94976.1; -; Genomic_DNA. DR EMBL; AJ287307; CAB94977.1; -; Genomic_DNA. DR EMBL; AJ287308; CAB94978.1; -; Genomic_DNA. DR EMBL; AJ287309; CAB94979.1; -; Genomic_DNA. DR EMBL; AJ287310; CAB94980.1; -; Genomic_DNA. DR EMBL; AJ287311; CAB94981.1; -; Genomic_DNA. DR EMBL; AJ287312; CAB94982.1; -; Genomic_DNA. DR EMBL; AJ287313; CAB94983.1; -; Genomic_DNA. DR EMBL; AJ287314; CAB94984.1; -; Genomic_DNA. DR EMBL; AJ287315; CAB94985.1; -; Genomic_DNA. DR EMBL; AJ287316; CAB94986.1; -; Genomic_DNA. DR EMBL; AJ287317; CAB94987.1; -; Genomic_DNA. DR EMBL; AJ287318; CAB94988.1; -; Genomic_DNA. DR EMBL; AJ287319; CAB94989.1; -; Genomic_DNA. DR EMBL; AJ287320; CAB94990.1; -; Genomic_DNA. DR EMBL; AJ287321; CAB94991.1; -; Genomic_DNA. DR EMBL; AJ492461; CAD42187.1; -; Genomic_DNA. DR EMBL; AJ492462; CAD42188.1; -; Genomic_DNA. DR EMBL; AJ492463; CAD42189.1; -; Genomic_DNA. DR EMBL; AJ492464; CAD42190.1; -; Genomic_DNA. DR EMBL; AJ492465; CAD42191.1; -; Genomic_DNA. DR EMBL; AJ492466; CAD42192.1; -; Genomic_DNA. DR EMBL; AJ492467; CAD42193.1; -; Genomic_DNA. DR EMBL; AJ492468; CAD42194.1; -; Genomic_DNA. DR EMBL; AJ492469; CAD42195.1; -; Genomic_DNA. DR EMBL; AJ492470; CAD42196.1; -; Genomic_DNA. DR EMBL; AJ492471; CAD42197.1; -; Genomic_DNA. DR EMBL; AJ492472; CAD42198.1; -; Genomic_DNA. DR EMBL; AJ492473; CAD42199.1; -; Genomic_DNA. DR EMBL; AJ492474; CAD42200.1; -; Genomic_DNA. DR EMBL; AJ492475; CAD42201.1; -; Genomic_DNA. DR EMBL; AJ492476; CAD42202.1; -; Genomic_DNA. DR EMBL; AJ492477; CAD42203.1; -; Genomic_DNA. DR EMBL; AJ492478; CAD42204.1; -; Genomic_DNA. DR EMBL; AJ492479; CAD42205.1; -; Genomic_DNA. DR EMBL; AJ492480; CAD42206.1; -; Genomic_DNA. DR EMBL; AJ492481; CAD42207.1; -; Genomic_DNA. DR EMBL; AJ492482; CAD42208.1; -; Genomic_DNA. DR EMBL; AJ492483; CAD42209.1; -; Genomic_DNA. DR EMBL; AJ492484; CAD42210.1; -; Genomic_DNA. DR EMBL; AJ492485; CAD42211.1; -; Genomic_DNA. DR EMBL; AJ492486; CAD42212.1; -; Genomic_DNA. DR EMBL; AJ492487; CAD42213.1; -; Genomic_DNA. DR EMBL; AJ492488; CAD42214.1; -; Genomic_DNA. DR EMBL; AJ492489; CAD42215.1; -; Genomic_DNA. DR EMBL; AJ492490; CAD42216.1; -; Genomic_DNA. DR EMBL; AJ492491; CAD42217.1; -; Genomic_DNA. DR EMBL; AJ492492; CAD42218.1; -; Genomic_DNA. DR EMBL; AJ492493; CAD42219.1; -; Genomic_DNA. DR EMBL; AJ492494; CAD42220.1; -; Genomic_DNA. DR EMBL; AJ492495; CAD42221.1; -; Genomic_DNA. DR EMBL; AJ492496; CAD42222.1; -; Genomic_DNA. DR EMBL; AJ492497; CAD42223.1; -; Genomic_DNA. DR EMBL; AJ492498; CAD42224.1; -; Genomic_DNA. DR EMBL; AJ492499; CAD42225.1; -; Genomic_DNA. DR EMBL; AJ492500; CAD42226.1; -; Genomic_DNA. DR EMBL; AJ492501; CAD42227.1; -; Genomic_DNA. DR EMBL; AJ492502; CAD42228.1; -; Genomic_DNA. DR EMBL; AJ492503; CAD42229.1; -; Genomic_DNA. DR EMBL; AJ418046; CAD10782.1; -; mRNA. DR EMBL; AF439537; AAL35225.1; -; Genomic_DNA. DR EMBL; AL132970; CAB82707.2; -; Genomic_DNA. DR EMBL; BT004265; AAO42267.1; -; mRNA. DR EMBL; BT005528; AAO63948.1; -; mRNA. DR EMBL; AY086088; AAM63295.1; -; mRNA. DR IPI; IPI00534732; -. DR PIR; JQ1687; JQ1687. DR PIR; T47651; T47651. DR RefSeq; NP_191072.1; -. DR UniGene; At.27425; -. DR HSSP; P28012; 1JX1. DR IntAct; P41088; 3. DR PRIDE; P41088; -. DR GeneID; 824678; -. DR GenomeReviews; BA000014_GR; AT3G55120. DR KEGG; ath:AT3G55120; -. DR NMPDR; fig|3702.1.peg.16826; -. DR TAIR; At3g55120; -. DR OMA; P41088; VIENKLL. DR BRENDA; 5.5.1.6; 302. DR ArrayExpress; P41088; -. DR GermOnline; AT3G55120; Arabidopsis thaliana. DR GO; GO:0042406; C:extrinsic to endoplasmic reticulum membrane; IDA:TAIR. DR GO; GO:0005634; C:nucleus; IDA:TAIR. DR GO; GO:0009705; C:plant-type vacuole membrane; IDA:TAIR. DR GO; GO:0045430; F:chalcone isomerase activity; IEA:EC. DR GO; GO:0009813; P:flavonoid biosynthetic process; IMP:TAIR. DR GO; GO:0010224; P:response to UV-B; IMP:TAIR. DR InterPro; IPR016088; Chalcone_isomerase_3-sand. DR InterPro; IPR003466; Chalcone_isomerase_subgr. DR Gene3D; G3DSA:3.50.70.10; Chalcone; 1. DR Pfam; PF02431; Chalcone; 1. PE 2: Evidence at transcript level; KW Complete proteome; Flavonoid biosynthesis; Isomerase. FT CHAIN 1 246 Chalcone--flavonone isomerase 1. FT /FTId=PRO_0000166428. FT BINDING 59 59 Substrate (By similarity). FT BINDING 124 124 Substrate (By similarity). FT BINDING 201 201 Substrate (By similarity). FT SITE 117 117 Important for catalytic activity (By FT similarity). FT VARIANT 202 202 I -> V (in strain: cv. Cha-0). FT VARIANT 238 238 V -> L (in strain: cv. Gr-5, cv. Gran-2, FT cv. Gran-3, cv. Gran-5, cv. Gran-7, cv. FT Gran-8, cv. Gran-10, cv. Ita-0, cv. Ler, FT cv. Mh-0, cv. Per-1, cv. Rv-1, cv. Rv-3, FT cv. Rv-4, cv. Rv-5, cv. Rv-8, cv. Wlp-1, FT cv. Wlp-2, cv. Wlp-3, cv. Wlp-4, cv. Wlp- FT 5, cv. Wlp-6, cv. Wlp-7, cv. Wlp-8, cv. FT Wlp-9 and cv. Wlp-10). FT VARIANT 246 246 N -> NRE (in strain: cv. Rv-2, cv. Rv-9, FT cv. Rv-10, cv. Tv-1, cv. Tv-2, cv. TV-6, FT cv. Tv-7, cv. Tv-8, cv. Tv-9 and cv. Tv- FT 10). SQ SEQUENCE 246 AA; 26596 MW; 2EB68BF68D576B98 CRC64; MSSSNACASP SPFPAVTKLH VDSVTFVPSV KSPASSNPLF LGGAGVRGLD IQGKFVIFTV IGVYLEGNAV PSLSVKWKGK TTEELTESIP FFREIVTGAF EKFIKVTMKL PLTGQQYSEK VTENCVAIWK QLGLYTDCEA KAVEKFLEIF KEETFPPGSS ILFALSPTGS LTVAFSKDDS IPETGIAVIE NKLLAEAVLE SIIGKNGVSP GTRLSVAERL SQLMMKNKDE KEVSDHSVEE KLAKEN //