P41086 (DHSD_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinate dehydrogenase hydrophobic membrane anchor subunit

Gene names

Name:	sdhD
Ordered Locus Names:	RP127

Organism

Rickettsia prowazekii (strain Madrid E)

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Membrane-anchoring subunit of succinate dehydrogenase (SDH) By similarity.
Cofactor	Heme group. The heme is bound between the two transmembrane subunits By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Subunit structure	Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, sdhC and sdhD By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro succinate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	Succinate dehydrogenase hydrophobic membrane anchor subunit		PRO_0000158678
Regions
	Topological domain	1 – 24	24	Cytoplasmic By similarity
	Transmembrane	25 – 45	21	Helical; By similarity
	Topological domain	46 – 67	22	Periplasmic By similarity
	Transmembrane	68 – 89	22	Helical; By similarity
	Topological domain	90 – 99	10	Cytoplasmic By similarity
	Transmembrane	100 – 123	24	Helical; By similarity
Sites
	Metal binding	80	1	Iron (heme axial ligand); shared with second transmembrane subunit By similarity
	Binding site	92	1	Ubiquinone By similarity

Sequences

	Sequence		Length	Mass (Da)
	P41086 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: F7E60E6A1BB455D4	FASTA	125	14,555
	10 20 30 40 50 60 MIYDFKAEII KAKNSSFSKS GSHHWLLQRV TGVILALCSF WLIYFMFTNK NNDINIIMWE 70 80 90 100 110 120 FKKPFNIVIL LITVTISLYH SVLGMRVVIE DYINCHKLRN TLIIIVKLFC ILTIVSFVVA IFYSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Wood D.O. Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Madrid E.
[2]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U02603 Unassigned DNA. Translation: AAA18326.1. AJ235270 Genomic DNA. Translation: CAA14596.1.
PIR	E71722.
RefSeq	NP_220519.1. NC_000963.1.
3D structure databases
ProteinModelPortal	P41086.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	883757.
GenomeReviews	Gene locus RP127 in contig AJ235269_GR.
KEGG	rpr:RP127.
PATRIC	17900994. VBIRicPro72556_0129.
Phylogenomic databases
HOGENOM	HBG664078.
OMA	INIIMWE.
ProtClustDB	CLSK870758.
Enzyme and pathway databases
BioCyc	RPRO272947:RP127-MONOMER.
Family and domain databases
InterPro	IPR014312. Succ_DH_anchor. IPR000701. Succ_DH_Fumarate_Rdtase_TM-su. [Graphical view]
KO	K00242.
Pfam	PF01127. Sdh_cyt. 1 hit. [Graphical view]
TIGRFAMs	TIGR02968. Succ_dehyd_anc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DHSD_RICPR

Accession

Primary (citable) accession number: P41086

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program