P41085 (DHSC_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinate dehydrogenase cytochrome b556 subunit
Short name=Cytochrome b-556

Gene names

Name:	sdhC
Ordered Locus Names:	RP126

Organism

Rickettsia prowazekii (strain Madrid E)

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Membrane-anchoring subunit of succinate dehydrogenase (SDH) By similarity.
Cofactor	Heme group. The heme is bound between the two transmembrane subunits By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Subunit structure	Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome b560 family.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane succinate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW succinate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 124	124	Succinate dehydrogenase cytochrome b556 subunit		PRO_0000203514
Regions
	Topological domain	1 – 29	29	Cytoplasmic By similarity
	Transmembrane	30 – 55	26	Helical; By similarity
	Topological domain	56 – 67	12	Periplasmic By similarity
	Transmembrane	68 – 88	21	Helical; By similarity
	Topological domain	89 – 103	15	Cytoplasmic By similarity
	Transmembrane	104 – 124	21	Helical; By similarity
Sites
	Metal binding	83	1	Iron (heme axial ligand); shared with second transmembrane subunit By similarity

Sequences

	Sequence		Length	Mass (Da)
	P41085 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 070111704551ACB6	FASTA	124	14,383
	10 20 30 40 50 60 MTKIKQEIYN KRPTSPHLTI YKPQISSTLS ILHRMTGVAL FFVVSILVWW LILSKYDNNY 70 80 90 100 110 120 LQLASCCIIK ICLVAFSYSW CYHLCNGIRH LFWDIGYGFS IKAVNITGWC VVVCSILLTM LLWV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Wood D.O. Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Madrid E.
[2]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U02603 Unassigned DNA. Translation: AAA18325.1. AJ235270 Genomic DNA. Translation: CAA14595.1.
PIR	D71722.
RefSeq	NP_220518.1. NC_000963.1.
3D structure databases
ProteinModelPortal	P41085.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	883754.
GenomeReviews	Gene locus RP126 in contig AJ235269_GR.
KEGG	rpr:RP126.
PATRIC	17900992. VBIRicPro72556_0128.
Phylogenomic databases
HOGENOM	HBG734972.
OMA	TWALMHH.
ProtClustDB	CLSK870757.
Enzyme and pathway databases
BioCyc	RPRO272947:RP126-MONOMER.
Family and domain databases
InterPro	IPR018495. Succ_DH_cyt_bsu_CS. IPR014314. Succ_DH_cytb556. IPR014361. Succ_DH_cytb560. IPR000701. Succ_DH_Fumarate_Rdtase_TM-su. [Graphical view]
KO	K00241.
Pfam	PF01127. Sdh_cyt. 1 hit. [Graphical view]
PIRSF	PIRSF000178. SDH_cyt_b560. 1 hit.
TIGRFAMs	TIGR02970. Succ_dehyd_cytB. 1 hit.
PROSITE	PS01000. SDH_CYT_1. 1 hit. PS01001. SDH_CYT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHSC_RICPR

Accession

Primary (citable) accession number: P41085

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program