Reviewed,
UniProtKB/Swiss-Prot P41080 (GYRA_RICPR)
Last modified
November 3, 2009.
Version 55.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: DNA gyrase subunit A EC=5.99.1.3 | ||||
| Gene names |
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| Organism | Rickettsia prowazekii [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 782 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group |
Protein attributes
| Sequence length | 905 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA. |
| Subunit structure | Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer. |
| Sequence similarities | Belongs to the topoisomerase gyrA/parC subunit family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding DNA-binding Nucleotide-binding |
| Molecular function | Isomerase Topoisomerase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA topological change Inferred from electronic annotation. Source: InterPro |
| Cellular component | chromosome Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA topoisomerase (ATP-hydrolyzing) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence analysis of the Rickettsia prowazekii gyrA gene." Wood D.O., Waite R.T. Gene 151:191-196(1994) [PubMed: 7828873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Madrid E. |
| [2] | "The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E. |
Cross-references
Sequence databases | |
|---|---|
| U02931 Genomic DNA. Translation: AAA68146.1. AJ235270 Genomic DNA. Translation: CAA14671.1. | |
| PIR | H71731. |
| RefSeq | NP_220594.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AB4 based on UniProtKB P09097. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 883928. |
| GenomeReviews | Gene locus RP206 in contig AJ235269_GR. |
| KEGG | rpr:RP206. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P41080. |
| OMA | ELGNDWN. |
Enzyme and pathway databases | |
| BioCyc | RPRO272947:RP206-MON. |
| BRENDA | 5.99.1.3. 141977. |
Family and domain databases | |
| InterPro | IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. [Graphical view] |
| Gene3D | G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit. |
| Pfam | PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view] |
| ProDom | PD000742. DNA_topoisoIV. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00434. TOP4c. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01063. gyrA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | GYRA_RICPR | ||||||||
| Accession | Primary (citable) accession number: P41080 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Rickettsia prowazekii Rickettsia prowazekii (strain Madrid E): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


