Reviewed, UniProtKB/Swiss-Prot P41077 (PNTAA_RICPR)

Names and origin

Protein names

Recommended name:
    NAD(P) transhydrogenase subunit alpha part 1
    EC=1.6.1.2
Alternative name(s):
    Nicotinamide nucleotide transhydrogenase subunit alpha 1
    Pyridine nucleotide transhydrogenase subunit alpha 1

Gene names

Name:	pntAA
Ordered Locus Names:	RP863

Organism

Rickettsia prowazekii [Complete proteome] [HAMAP]

Taxonomic identifier

782 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane By similarity.
Catalytic activity	NADPH + NAD+ = NADP+ + NADH.
Subunit structure	Complex of an alpha and a beta chain; in Rickettsia, the alpha chain seems to be made of two subunits.
Sequence similarities	Belongs to the AlaDH/PNT family.

Ontologies

Keywords
Ligand	NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD(P)+ transhydrogenase (AB-specific) activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 383	383	NAD(P) transhydrogenase subunit alpha part 1		PRO_0000199020

Sequences

	Sequence		Length	Mass (Da)
	P41077-1 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 70FC641B1F7C35C9	FASTA	383	41,638
	10 20 30 40 50 60 MKIVALKEKV KNETRTAITP EVAGLLIKKG YAVTVEKDIG LYAGFLDEEY VAVGTKISSV 70 80 90 100 110 120 PLEIISDADI ILKVQPSSVT DKYSELEFAK QGAIVVGLLS PYLNHEYIKA AAKKNLTTFA 130 140 150 160 170 180 MEFVPRITKA QNMDALSSQS NLVGYRAVIE ASYHYTKAFP MMITAAGTIS ACKTLVLGVG 190 200 210 220 230 240 VAGLQAIATA KRLGSIVAGY DVRIATKEQV ESLGAKFVSP ELQEDLEEES GYASESSADY 250 260 270 280 290 300 KAKQEKFLAK IIKGYNIVIT TAQIPGKKAP MLVTDKMIES MMYGSVIVDI STSTGGNVEG 310 320 330 340 350 360 SEPDKIVTRH GVTIIGLLNL ASKIASDSSK LYSKNLYNFL TYALQDGQFN MDDELVRDML 370 380 ITKDGKIVNY IIREKYESIT DNG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.
[2]	"Transcriptional characterization of the Rickettsia prowazekii major macromolecular synthesis operon." Shaw E.I., Marks G.L., Winkler H.H., Wood D.O. J. Bacteriol. 179:6448-6452(1997) [PubMed: 9335295] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 215-383. Strain: Madrid E.
[3]	"Codon usage and base composition in Rickettsia prowazekii." Andersson S.G.E., Sharp P.M. J. Mol. Evol. 42:525-536(1996) [PubMed: 8662004] [Abstract] Cited for: GENE NAME.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235273 Genomic DNA. Translation: CAA15287.1. U02878 Unassigned DNA. Translation: AAB81400.1.
PIR	G71648.
RefSeq	NP_221211.1.
3D structure databases
SMR	P41077. Positions 1-374.
ModBase	Search...
Genome annotation databases
GeneID	883431.
KEGG	rpr:RP863.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG289735.
OMA	GCLLSDE.
Enzyme and pathway databases
BioCyc	RPRO272947:RP863-MONOMER.
BRENDA	1.6.1.2. 141977.
Family and domain databases
InterPro	IPR007698. Ala_DH/PNT_C. IPR008142. Ala_DH/PNT_CS1. IPR007886. Ala_DH/PNT_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01262. AlaDh_PNT_C. 1 hit. PF05222. AlaDh_PNT_N. 1 hit. [Graphical view]
PROSITE	PS00836. ALADH_PNT_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PNTAA_RICPR

Accession

Primary (citable) accession number: P41077

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	May 30, 2000
Last modified:	February 9, 2010
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)