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P41057

- RS29A_YEAST

UniProt

P41057 - RS29A_YEAST

Protein

40S ribosomal protein S29-A

Gene

RPS29A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cofactori

    Binds 1 zinc ion per subunit.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi21 – 211ZincSequence Analysis
    Metal bindingi24 – 241ZincSequence Analysis
    Metal bindingi39 – 391ZincSequence Analysis
    Metal bindingi42 – 421ZincSequence Analysis

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32454-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S29-A
    Alternative name(s):
    S36
    YS29
    Gene namesi
    Name:RPS29A
    Synonyms:RPS36A, YS29A
    Ordered Locus Names:YLR388W
    ORF Names:L8084.11
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    SGDiS000004380. RPS29A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic small ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 565540S ribosomal protein S29-APRO_0000131032Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP41057.
    PeptideAtlasiP41057.
    PRIDEiP41057.

    Expressioni

    Gene expression databases

    GenevestigatoriP41057.

    Interactioni

    Subunit structurei

    Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi31647. 49 interactions.
    DIPiDIP-4643N.
    IntActiP41057. 4 interactions.
    MINTiMINT-475802.

    Structurei

    Secondary structure

    1
    56
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 83
    Beta strandi13 – 153
    Helixi16 – 183
    Turni22 – 243
    Beta strandi28 – 314
    Helixi33 – 353
    Helixi40 – 5011

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VW9electron microscopy6.10e1-56[»]
    1VWVelectron microscopy6.10e1-56[»]
    3IZBelectron microscopy-N1-56[»]
    3O2ZX-ray4.00S1-56[»]
    3O30X-ray4.00S1-56[»]
    3U5CX-ray3.00d1-56[»]
    3U5GX-ray3.00d1-56[»]
    4BYLelectron microscopy4.3031-56[»]
    4BYTelectron microscopy6.6031-56[»]
    ProteinModelPortaliP41057.
    SMRiP41057. Positions 4-56.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S14P family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00390000005814.
    HOGENOMiHOG000231300.
    KOiK02980.
    OMAiCFREKAA.
    OrthoDBiEOG7SV17Z.

    Family and domain databases

    InterProiIPR001209. Ribosomal_S14.
    IPR018271. Ribosomal_S14_CS.
    [Graphical view]
    PfamiPF00253. Ribosomal_S14. 1 hit.
    [Graphical view]
    PROSITEiPS00527. RIBOSOMAL_S14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P41057-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHENVWFSH PRRYGKGSRQ CRVCSSHTGL IRKYGLNICR QCFREKANDI   50
    GFNKFR 56
    Length:56
    Mass (Da):6,661
    Last modified:January 23, 2007 - v3
    Checksum:iF1A6900EE27748C2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71W → G AA sequence (PubMed:18782943)Curated
    Sequence conflicti14 – 141Y → F in ABM97475. (PubMed:17244705)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14676 Genomic DNA. Translation: BAA03507.1.
    U19729 Genomic DNA. Translation: AAB82350.1.
    EF123131 mRNA. Translation: ABM97475.1.
    BK006945 Genomic DNA. Translation: DAA09689.1.
    PIRiS48503.
    RefSeqiNP_013492.3. NM_001182277.3.

    Genome annotation databases

    EnsemblFungiiYLR388W; YLR388W; YLR388W.
    GeneIDi851104.
    KEGGisce:YLR388W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14676 Genomic DNA. Translation: BAA03507.1 .
    U19729 Genomic DNA. Translation: AAB82350.1 .
    EF123131 mRNA. Translation: ABM97475.1 .
    BK006945 Genomic DNA. Translation: DAA09689.1 .
    PIRi S48503.
    RefSeqi NP_013492.3. NM_001182277.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VW9 electron microscopy 6.10 e 1-56 [» ]
    1VWV electron microscopy 6.10 e 1-56 [» ]
    3IZB electron microscopy - N 1-56 [» ]
    3O2Z X-ray 4.00 S 1-56 [» ]
    3O30 X-ray 4.00 S 1-56 [» ]
    3U5C X-ray 3.00 d 1-56 [» ]
    3U5G X-ray 3.00 d 1-56 [» ]
    4BYL electron microscopy 4.30 3 1-56 [» ]
    4BYT electron microscopy 6.60 3 1-56 [» ]
    ProteinModelPortali P41057.
    SMRi P41057. Positions 4-56.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31647. 49 interactions.
    DIPi DIP-4643N.
    IntActi P41057. 4 interactions.
    MINTi MINT-475802.

    Proteomic databases

    MaxQBi P41057.
    PeptideAtlasi P41057.
    PRIDEi P41057.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR388W ; YLR388W ; YLR388W .
    GeneIDi 851104.
    KEGGi sce:YLR388W.

    Organism-specific databases

    SGDi S000004380. RPS29A.

    Phylogenomic databases

    GeneTreei ENSGT00390000005814.
    HOGENOMi HOG000231300.
    KOi K02980.
    OMAi CFREKAA.
    OrthoDBi EOG7SV17Z.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32454-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    NextBioi 967800.

    Gene expression databases

    Genevestigatori P41057.

    Family and domain databases

    InterProi IPR001209. Ribosomal_S14.
    IPR018271. Ribosomal_S14_CS.
    [Graphical view ]
    Pfami PF00253. Ribosomal_S14. 1 hit.
    [Graphical view ]
    PROSITEi PS00527. RIBOSOMAL_S14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "S.cerevisiae YS29A gene for ribosomal protein YS29."
      Suzuki K., Otaka E.
      Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing."
      Juneau K., Palm C., Miranda M., Davis R.W.
      Proc. Natl. Acad. Sci. U.S.A. 104:1522-1527(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-20.
      Strain: ATCC 201390 / BY4743.
    5. "Yeast ribosomal proteins. VIII. Isolation of two proteins and sequence characterization of twenty-four proteins from cytoplasmic ribosomes."
      Otaka E., Higo K., Itoh T.
      Mol. Gen. Genet. 195:544-546(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-10, CLEAVAGE OF INITIATOR METHIONINE.
    6. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    7. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE.
    8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    10. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRS29A_YEAST
    AccessioniPrimary (citable) accession number: P41057
    Secondary accession number(s): A2TBM8, D6VZ23, P05761
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 113 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 6490 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for S29 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3