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Protein

60S ribosomal protein L33-B

Gene

RPL33B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 65600 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eL33 in yeast.Curated

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-33732-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L33-B1 Publication
Alternative name(s):
L37
Large ribosomal subunit protein eL33-B1 Publication
RP47
YL37
Gene namesi
Name:RPL33B1 Publication
Synonyms:RPL37B
Ordered Locus Names:YOR234C
ORF Names:O5224
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR234C.
SGDiS000005760. RPL33B.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001928082 – 10760S ribosomal protein L33-BAdd BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine; partialBy similarity1
Cross-linki47Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP41056.
PRIDEiP41056.
TopDownProteomicsiP41056.

Interactioni

Subunit structurei

Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi34627. 104 interactors.
IntActiP41056. 4 interactors.
MINTiMINT-4503399.

Structurei

3D structure databases

ProteinModelPortaliP41056.
SMRiP41056.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000016972.
HOGENOMiHOG000195636.
InParanoidiP41056.
KOiK02917.
OMAiNTRTEVD.
OrthoDBiEOG092C5MJS.

Family and domain databases

HAMAPiMF_00573. Ribosomal_L35Ae. 1 hit.
InterProiView protein in InterPro
IPR001780. Ribosomal_L35A.
IPR018266. Ribosomal_L35Ae_CS.
IPR009000. Transl_B-barrel.
PANTHERiPTHR10902. PTHR10902. 1 hit.
PfamiView protein in Pfam
PF01247. Ribosomal_L35Ae. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012670. Ribosomal_L35Ae. 1 hit.
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiView protein in PROSITE
PS01105. RIBOSOMAL_L35AE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESHRLYVK GKHLSYQRSK RVNNPNVSLI KIEGVATPQE AQFYLGKRIA
60 70 80 90 100
YVYRASKEVR GSKIRVMWGK VTRTHGNSGV VRATFRNNLP AKTFGASVRI

FLYPSNI
Length:107
Mass (Da):12,168
Last modified:January 23, 2007 - v2
Checksum:iD33E8388903B5196
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24N → D AA sequence (PubMed:18782943).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23923 Genomic DNA. Translation: AAA35006.1.
Z75142 Genomic DNA. Translation: CAA99454.1.
BK006948 Genomic DNA. Translation: DAA11004.1.
PIRiS44069.
RefSeqiNP_014877.3. NM_001183653.3.

Genome annotation databases

EnsemblFungiiYOR234C; YOR234C; YOR234C.
GeneIDi854409.
KEGGisce:YOR234C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23923 Genomic DNA. Translation: AAA35006.1.
Z75142 Genomic DNA. Translation: CAA99454.1.
BK006948 Genomic DNA. Translation: DAA11004.1.
PIRiS44069.
RefSeqiNP_014877.3. NM_001183653.3.

3D structure databases

ProteinModelPortaliP41056.
SMRiP41056.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34627. 104 interactors.
IntActiP41056. 4 interactors.
MINTiMINT-4503399.

Proteomic databases

MaxQBiP41056.
PRIDEiP41056.
TopDownProteomicsiP41056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR234C; YOR234C; YOR234C.
GeneIDi854409.
KEGGisce:YOR234C.

Organism-specific databases

EuPathDBiFungiDB:YOR234C.
SGDiS000005760. RPL33B.

Phylogenomic databases

GeneTreeiENSGT00390000016972.
HOGENOMiHOG000195636.
InParanoidiP41056.
KOiK02917.
OMAiNTRTEVD.
OrthoDBiEOG092C5MJS.

Enzyme and pathway databases

BioCyciYEAST:G3O-33732-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiPR:P41056.

Family and domain databases

HAMAPiMF_00573. Ribosomal_L35Ae. 1 hit.
InterProiView protein in InterPro
IPR001780. Ribosomal_L35A.
IPR018266. Ribosomal_L35Ae_CS.
IPR009000. Transl_B-barrel.
PANTHERiPTHR10902. PTHR10902. 1 hit.
PfamiView protein in Pfam
PF01247. Ribosomal_L35Ae. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012670. Ribosomal_L35Ae. 1 hit.
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiView protein in PROSITE
PS01105. RIBOSOMAL_L35AE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRL33B_YEAST
AccessioniPrimary (citable) accession number: P41056
Secondary accession number(s): D6W2T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.