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Protein

Membrane-bound lytic murein transglycosylase B

Gene

mltB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division.

Catalytic activityi

Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1621

GO - Molecular functioni

  • calcium ion binding Source: EcoCyc
  • lyase activity Source: UniProtKB-KW
  • lytic endotransglycosylase activity Source: EcoCyc
  • lytic transglycosylase activity Source: EcoCyc
  • sodium ion binding Source: EcoCyc

GO - Biological processi

  • cell wall organization Source: UniProtKB-KW
  • peptidoglycan catabolic process Source: EcoCyc

Keywordsi

Molecular functionLyase
Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciEcoCyc:G7410-MONOMER
MetaCyc:G7410-MONOMER

Protein family/group databases

CAZyiGH103 Glycoside Hydrolase Family 103

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-bound lytic murein transglycosylase B (EC:4.2.2.n1)
Alternative name(s):
35 kDa soluble lytic transglycosylase
Murein hydrolase B
Slt35
Gene namesi
Name:mltB
Ordered Locus Names:b2701, JW2671
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12699 mltB

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • outer membrane-bounded periplasmic space Source: EcoCyc

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2046262
DrugBankiDB03709 Bicine
DB02595 Bulgecin A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18CuratedAdd BLAST18
ChainiPRO_000003278419 – 361Membrane-bound lytic murein transglycosylase BAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi19N-palmitoyl cysteineCurated1
Lipidationi19S-diacylglycerol cysteineCurated1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP41052
PRIDEiP41052

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi4262079, 390 interactors
DIPiDIP-10221N
IntActiP41052, 10 interactors
STRINGi316385.ECDH10B_2869

Chemistry databases

BindingDBiP41052

Structurei

Secondary structure

1361
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni53 – 56Combined sources4
Helixi58 – 71Combined sources14
Helixi75 – 82Combined sources8
Helixi89 – 95Combined sources7
Helixi113 – 118Combined sources6
Turni119 – 121Combined sources3
Helixi124 – 136Combined sources13
Helixi138 – 148Combined sources11
Helixi152 – 163Combined sources12
Turni164 – 167Combined sources4
Beta strandi171 – 173Combined sources3
Helixi174 – 183Combined sources10
Helixi186 – 188Combined sources3
Helixi189 – 205Combined sources17
Turni210 – 212Combined sources3
Turni222 – 225Combined sources4
Helixi228 – 234Combined sources7
Beta strandi239 – 242Combined sources4
Helixi249 – 262Combined sources14
Beta strandi271 – 277Combined sources7
Beta strandi280 – 282Combined sources3
Beta strandi285 – 291Combined sources7
Helixi292 – 297Combined sources6
Beta strandi301 – 304Combined sources4
Beta strandi311 – 318Combined sources8
Beta strandi320 – 328Combined sources9
Helixi330 – 336Combined sources7
Helixi342 – 360Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D0KX-ray2.02A40-361[»]
1D0LX-ray1.97A40-361[»]
1D0MX-ray2.47A40-361[»]
1LTMX-ray1.70A42-361[»]
1QDRX-ray2.10A40-361[»]
1QDTX-ray2.10A40-361[»]
1QUSX-ray1.70A40-361[»]
1QUTX-ray2.44A40-361[»]
ProteinModelPortaliP41052
SMRiP41052
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41052

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105CVE Bacteria
COG2951 LUCA
HOGENOMiHOG000257828
InParanoidiP41052
KOiK08305
OMAiSSIRDYA
PhylomeDBiP41052

Family and domain databases

InterProiView protein in InterPro
IPR023346 Lysozyme-like_dom_sf
IPR011757 Lytic_transglycosylase_MltB
IPR031304 SLT_2
PANTHERiPTHR30163:SF0 PTHR30163:SF0, 1 hit
PfamiView protein in Pfam
PF13406 SLT_2, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
TIGRFAMsiTIGR02282 MltB, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRRYVTLL PLFVLLAACS SKPKPTETDT TTGTPSGGFL LEPQHNVMQM
60 70 80 90 100
GGDFANNPNA QQFIDKMVNK HGFDRQQLQE ILSQAKRLDS VLRLMDNQAP
110 120 130 140 150
TTSVKPPSGP NGAWLRYRKK FITPDNVQNG VVFWNQYEDA LNRAWQVYGV
160 170 180 190 200
PPEIIVGIIG VETRWGRVMG KTRILDALAT LSFNYPRRAE YFSGELETFL
210 220 230 240 250
LMARDEQDDP LNLKGSFAGA MGYGQFMPSS YKQYAVDFSG DGHINLWDPV
260 270 280 290 300
DAIGSVANYF KAHGWVKGDQ VAVMANGQAP GLPNGFKTKY SISQLAAAGL
310 320 330 340 350
TPQQPLGNHQ QASLLRLDVG TGYQYWYGLP NFYTITRYNH STHYAMAVWQ
360
LGQAVALARV Q
Length:361
Mass (Da):40,256
Last modified:February 1, 1995 - v1
Checksum:i7E98F040504F75F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18785 Genomic DNA Translation: AAB60060.1
U00096 Genomic DNA Translation: AAC75743.1
AP009048 Genomic DNA Translation: BAA16563.1
J02708 Genomic DNA No translation available.
PIRiA65050
RefSeqiNP_417181.1, NC_000913.3
WP_001295177.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75743; AAC75743; b2701
BAA16563; BAA16563; BAA16563
GeneIDi947184
KEGGiecj:JW2671
eco:b2701
PATRICifig|511145.12.peg.2792

Similar proteinsi

Entry informationi

Entry nameiMLTB_ECOLI
AccessioniPrimary (citable) accession number: P41052
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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