P41044 (CAB32_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calbindin-32

Gene names

Name:	Cbp53E
Synonyms:	cbn
ORF Names:	CG6702

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Expressed in a large number of neuron of the brain and the thoracic ganglion as well as in two small muscles of the thorax.
Sequence similarities	Belongs to the calbindin family. Contains 6 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	calcium ion binding Traceable author statement. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Calbindin-32		PRO_0000073477
Regions
	Domain	35 – 70	36	EF-hand 1
	Domain	84 – 120	37	EF-hand 2
	Domain	131 – 166	36	EF-hand 3
	Domain	177 – 212	36	EF-hand 4
	Domain	224 – 259	36	EF-hand 5
	Domain	269 – 304	36	EF-hand 6
	Calcium binding	48 – 59	12	1 Potential
	Calcium binding	98 – 109	12	2 Potential
	Calcium binding	144 – 155	12	3 Potential
	Calcium binding	190 – 201	12	4 Potential
	Calcium binding	237 – 248	12	5 Potential
	Compositional bias	4 – 9	6	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	P41044 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: F5B53A15816E0F02	FASTA	310	35,717
	10 20 30 40 50 60 MDSAAAAAAK RVQIEKAHNF MRQYRDPESR ELKKLSANQF MDVWAHYDKD GNGYIEGTEL 70 80 90 100 110 120 DGFLREFVSS ANATDISPEA VTDTMLEELK SCFMEAYDDN QDGKIDIREL AQLLPMEENF 130 140 150 160 170 180 LLLFRFDNPL ESSVEFMKIW REYDTDNSGY IEADELKNFL RDLLKEAKKI NDVSEDKLIE 190 200 210 220 230 240 YTDTMLQVFD ANKDGRLQLS EMAKLLPVKE NFLCRQVFKG ATKLTKEDIE KVFSLYDRDN 250 260 270 280 290 300 SGTIENEELK GFLKDLLELV KKDDYDAQDL AAFEETIMRG VGTDKHGKIS RKELTMILLT 310 LAKISPDDEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An invertebrate calcium-binding protein of the calbindin subfamily: protein structure, genomic organization, and expression pattern of the calbindin-32 gene of Drosophila." Reifegerste R., Grimm S., Albert S., Lipski N., Heimbeck G., Hofbauer A., Pflugfelder G.O., Quack D., Reichmuth C., Schug B., Zinsmaier K.E., Buchner S., Buchner E. J. Neurosci. 13:2186-2198(1993) [PubMed: 8478695] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Berlin. Tissue: Brain.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Head.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X68566 mRNA. Translation: CAA48566.1. S59242, S59190, S59191 Unassigned DNA. Translation: AAA15214.1. AE013599 Genomic DNA. Translation: AAF57925.1. AY058340 mRNA. Translation: AAL13569.1.
PIR	S37695.
RefSeq	NP_476838.1. NM_057490.3.
UniGene	Dm.4858.
3D structure databases
ProteinModelPortal	P41044.
SMR	P41044. Positions 32-299.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-754N.
STRING	P41044.
Proteomic databases
PRIDE	P41044.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0087056; FBpp0086204; FBgn0004580.
GeneID	36905.
KEGG	dme:Dmel_CG6702.
NMPDR	fig|7227.3.peg.5860.
Organism-specific databases
CTD	36905.
FlyBase	FBgn0004580. Cbp53E.
Phylogenomic databases
eggNOG	inNOG04104.
GeneTree	EMGT00050000016497.
InParanoid	P41044.
OMA	EENFLLF.
OrthoDB	EOG4W3R3Q.
PhylomeDB	P41044.
Gene expression databases
ArrayExpress	P41044.
Bgee	P41044.
GermOnline	CG6702. Drosophila melanogaster.
Family and domain databases
InterPro	IPR018248. EF-hand. IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca-bd. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 2 hits.
Pfam	PF00036. efhand. 2 hits. [Graphical view]
SMART	SM00054. EFh. 5 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 5 hits. PS50222. EF_HAND_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	800960.

Entry information

Entry name

CAB32_DROME

Accession

Primary (citable) accession number: P41044
Secondary accession number(s): Q9V7W4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project