Reviewed, UniProtKB/Swiss-Prot P41044 (CAB32_DROME)

Names and origin

Protein names

Recommended name:
    Calbindin-32

Gene names

Name:	Cbp53E
Synonyms:	cbn
ORF Names:	CG6702

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Expressed in a large number of neuron of the brain and the thoracic ganglion as well as in two small muscles of the thorax.
Sequence similarities	Belongs to the calbindin family. Contains 6 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	calcium ion binding Traceable author statement. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Calbindin-32		PRO_0000073477
Regions
	Domain	35 – 70	36	EF-hand 1
	Domain	84 – 120	37	EF-hand 2
	Domain	131 – 166	36	EF-hand 3
	Domain	177 – 212	36	EF-hand 4
	Domain	224 – 259	36	EF-hand 5
	Domain	269 – 304	36	EF-hand 6
	Calcium binding	48 – 59	12	1 Potential
	Calcium binding	98 – 109	12	2 Potential
	Calcium binding	144 – 155	12	3 Potential
	Calcium binding	190 – 201	12	4 Potential
	Calcium binding	237 – 248	12	5 Potential
	Compositional bias	4 – 9	6	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	P41044-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: F5B53A15816E0F02	FASTA	310	35,717
	10 20 30 40 50 60 MDSAAAAAAK RVQIEKAHNF MRQYRDPESR ELKKLSANQF MDVWAHYDKD GNGYIEGTEL 70 80 90 100 110 120 DGFLREFVSS ANATDISPEA VTDTMLEELK SCFMEAYDDN QDGKIDIREL AQLLPMEENF 130 140 150 160 170 180 LLLFRFDNPL ESSVEFMKIW REYDTDNSGY IEADELKNFL RDLLKEAKKI NDVSEDKLIE 190 200 210 220 230 240 YTDTMLQVFD ANKDGRLQLS EMAKLLPVKE NFLCRQVFKG ATKLTKEDIE KVFSLYDRDN 250 260 270 280 290 300 SGTIENEELK GFLKDLLELV KKDDYDAQDL AAFEETIMRG VGTDKHGKIS RKELTMILLT 310 LAKISPDDEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An invertebrate calcium-binding protein of the calbindin subfamily: protein structure, genomic organization, and expression pattern of the calbindin-32 gene of Drosophila." Reifegerste R., Grimm S., Albert S., Lipski N., Heimbeck G., Hofbauer A., Pflugfelder G.O., Quack D., Reichmuth C., Schug B., Zinsmaier K.E., Buchner S., Buchner E. J. Neurosci. 13:2186-2198(1993) [PubMed: 8478695] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Berlin. Tissue: Brain.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Head.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X68566 mRNA. Translation: CAA48566.1. S59242, S59190, S59191 Unassigned DNA. Translation: AAA15214.1. AE013599 Genomic DNA. Translation: AAF57925.1. AY058340 mRNA. Translation: AAL13569.1.
PIR	S37695.
RefSeq	NP_476838.1.
UniGene	Dm.4858
3D structure databases
HSSP	HSSP built from PDB template 1G33 based on UniProtKB P02625.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:754N.
Proteomic databases
PRIDE	P41044.
Genome annotation databases
Ensembl	FBgn0004580. Drosophila melanogaster. [Contig view]
GeneID	36905.
KEGG	dme:Dmel_CG6702.
NMPDR	fig|7227.3.peg.5860.
Organism-specific databases
FlyBase	FBgn0004580. Cbp53E.
Phylogenomic databases
HOGENOM	P41044.
OMA	P41044. EENFLLF.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-005064-MON.
Gene expression databases
ArrayExpress	P41044.
GermOnline	CG6702. Drosophila melanogaster.
Family and domain databases
InterPro	IPR011992. EF-Hand_type. IPR018248. EF_hand. IPR018247. EF_HAND_1. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca_bd. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 2 hits.
Pfam	PF00036. efhand. 3 hits. [Graphical view]
ProDom	PD000012. EF-hand. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00054. EFh. 5 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 5 hits. PS50222. EF_HAND_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	800960.

Entry information

Entry name

CAB32_DROME

Accession

Primary (citable) accession number: P41044
Secondary accession number(s): Q9V7W4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project