true
1995-02-01
2024-03-27
176
GSTS1_DROME
Isolation of a Drosophila gene encoding glutathione S-transferase.
Beall C.
Fyrberg C.
Song S.
Fyrberg E.
doi:10.1007/bf01037590
1992
Biochem. Genet.
30
515-527
NUCLEOTIDE SEQUENCE [MRNA]
FUNCTION
DEVELOPMENTAL STAGE
The genome sequence of Drosophila melanogaster.
Adams M.D.
Celniker S.E.
Holt R.A.
Evans C.A.
Gocayne J.D.
Amanatides P.G.
Scherer S.E.
Li P.W.
Hoskins R.A.
Galle R.F.
George R.A.
Lewis S.E.
Richards S.
Ashburner M.
Henderson S.N.
Sutton G.G.
Wortman J.R.
Yandell M.D.
Zhang Q.
Chen L.X.
Brandon R.C.
Rogers Y.-H.C.
Blazej R.G.
Champe M.
Pfeiffer B.D.
Wan K.H.
Doyle C.
Baxter E.G.
Helt G.
Nelson C.R.
Miklos G.L.G.
Abril J.F.
Agbayani A.
An H.-J.
Andrews-Pfannkoch C.
Baldwin D.
Ballew R.M.
Basu A.
Baxendale J.
Bayraktaroglu L.
Beasley E.M.
Beeson K.Y.
Benos P.V.
Berman B.P.
Bhandari D.
Bolshakov S.
Borkova D.
Botchan M.R.
Bouck J.
Brokstein P.
Brottier P.
Burtis K.C.
Busam D.A.
Butler H.
Cadieu E.
Center A.
Chandra I.
Cherry J.M.
Cawley S.
Dahlke C.
Davenport L.B.
Davies P.
de Pablos B.
Delcher A.
Deng Z.
Mays A.D.
Dew I.
Dietz S.M.
Dodson K.
Doup L.E.
Downes M.
Dugan-Rocha S.
Dunkov B.C.
Dunn P.
Durbin K.J.
Evangelista C.C.
Ferraz C.
Ferriera S.
Fleischmann W.
Fosler C.
Gabrielian A.E.
Garg N.S.
Gelbart W.M.
Glasser K.
Glodek A.
Gong F.
Gorrell J.H.
Gu Z.
Guan P.
Harris M.
Harris N.L.
Harvey D.A.
Heiman T.J.
Hernandez J.R.
Houck J.
Hostin D.
Houston K.A.
Howland T.J.
Wei M.-H.
Ibegwam C.
Jalali M.
Kalush F.
Karpen G.H.
Ke Z.
Kennison J.A.
Ketchum K.A.
Kimmel B.E.
Kodira C.D.
Kraft C.L.
Kravitz S.
Kulp D.
Lai Z.
Lasko P.
Lei Y.
Levitsky A.A.
Li J.H.
Li Z.
Liang Y.
Lin X.
Liu X.
Mattei B.
McIntosh T.C.
McLeod M.P.
McPherson D.
Merkulov G.
Milshina N.V.
Mobarry C.
Morris J.
Moshrefi A.
Mount S.M.
Moy M.
Murphy B.
Murphy L.
Muzny D.M.
Nelson D.L.
Nelson D.R.
Nelson K.A.
Nixon K.
Nusskern D.R.
Pacleb J.M.
Palazzolo M.
Pittman G.S.
Pan S.
Pollard J.
Puri V.
Reese M.G.
Reinert K.
Remington K.
Saunders R.D.C.
Scheeler F.
Shen H.
Shue B.C.
Siden-Kiamos I.
Simpson M.
Skupski M.P.
Smith T.J.
Spier E.
Spradling A.C.
Stapleton M.
Strong R.
Sun E.
Svirskas R.
Tector C.
Turner R.
Venter E.
Wang A.H.
Wang X.
Wang Z.-Y.
Wassarman D.A.
Weinstock G.M.
Weissenbach J.
Williams S.M.
Woodage T.
Worley K.C.
Wu D.
Yang S.
Yao Q.A.
Ye J.
Yeh R.-F.
Zaveri J.S.
Zhan M.
Zhang G.
Zhao Q.
Zheng L.
Zheng X.H.
Zhong F.N.
Zhong W.
Zhou X.
Zhu S.C.
Zhu X.
Smith H.O.
Gibbs R.A.
Myers E.W.
Rubin G.M.
Venter J.C.
doi:10.1126/science.287.5461.2185
2000
Science
287
2185-2195
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
Berkeley
Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.
Misra S.
Crosby M.A.
Mungall C.J.
Matthews B.B.
Campbell K.S.
Hradecky P.
Huang Y.
Kaminker J.S.
Millburn G.H.
Prochnik S.E.
Smith C.D.
Tupy J.L.
Whitfield E.J.
Bayraktaroglu L.
Berman B.P.
Bettencourt B.R.
Celniker S.E.
de Grey A.D.N.J.
Drysdale R.A.
Harris N.L.
Richter J.
Russo S.
Schroeder A.J.
Shu S.Q.
Stapleton M.
Yamada C.
Ashburner M.
Gelbart W.M.
Rubin G.M.
Lewis S.E.
doi:10.1186/gb-2002-3-12-research0083
2002
Genome Biol.
3
RESEARCH0083.1-RESEARCH0083.22
GENOME REANNOTATION
A Drosophila full-length cDNA resource.
Stapleton M.
Carlson J.W.
Brokstein P.
Yu C.
Champe M.
George R.A.
Guarin H.
Kronmiller B.
Pacleb J.M.
Park S.
Wan K.H.
Rubin G.M.
Celniker S.E.
doi:10.1186/gb-2002-3-12-research0080
2002
Genome Biol.
3
RESEARCH0080.1-RESEARCH0080.8
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
Embryo
A preliminary characterization of the cytosolic glutathione transferase proteome from Drosophila melanogaster.
Saisawang C.
Wongsantichon J.
Ketterman A.J.
doi:10.1042/bj20111747
2012
Biochem. J.
442
181-190
FUNCTION
CATALYTIC ACTIVITY
BIOPHYSICOCHEMICAL PROPERTIES
Structure of a Drosophila sigma class glutathione S-transferase reveals a novel active site topography suited for lipid peroxidation products.
Agianian B.
Tucker P.A.
Schouten A.
Leonard K.
Bullard B.
Gros P.
doi:10.1016/s0022-2836(02)01327-x
2003
J. Mol. Biol.
326
151-165
X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE
FUNCTION
SUBUNIT
CATALYTIC ACTIVITY
1.75
A/B=1-249
33
1
GstS1
Eukaryota
Glutathione conjugation
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
0 hits in 3 CRISPR screens
fly
Expressed in testis and 51 other cell types or tissues
baseline and differential
GST_C_Sigma_like
GST_N_Sigma_like
Glutaredoxin
Glutathione-S-Trfase_C-like
Glutathione-S-Trfase_C_sf
Glutathione_S-Trfase
Glutathione_S-Trfase_N
GST_C
Thioredoxin-like_sf
GLUTATHIONE S-TRANSFERASE
GLUTATHIONE S-TRANSFERASE S1
GST_C_3
GST_N
AMPS.1
Glutathione_Transferase_(cytos
GST C-terminal domain-like
Thioredoxin-like
GST_CTER
GST_NTER
DM
Glutathione S-transferase S1
2.5.1.18
GST class-sigma 1
Glutathione S-transferase 2
GstS1
GST2
GSTS1-1
CG8938
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in the detoxification of metabolites produced during cellular division and morphogenesis (PubMed:1445191, PubMed:12547198).
0.52 mM for glutathione
1.24 mM for 1-chloro-2,4-dinitrobenzene
4.53 umol/min/mg enzyme with 1-chloro-2,4-dinitrobenzene as substrate
2.81 umol/min/mg enzyme with 4-hydroxy-2-nonenal as substrate
84.3 nmol/min/mg enzyme with adrenochrome as substrate
0.112 umol/min/mg enzyme with phenethyl isothiocyanate as substrate
Homodimer.
Expressed throughout development with highest levels being observed in nonfeeding stages, i.e. during embryonic and pupal development.
Belongs to the GST superfamily. Sigma family.
Glutathione S-transferase S1
27614
1
249
GST N-terminal
48
125
GST C-terminal
127
Disordered
42
54
85
89
96
97
109
110
PSPCATCSD
61
70
AHPRRV
79
V
224
50
58
59
62
71
76
80
82
84
88
91
93
95
99
102
105
108
121
128
152
157
169
171
185
188
191
197
213
217
220
222
232
235
243
2003-01-27
2
27614
310597df1275e46a7e40d804373f88e1
MADEAQAPPAEGAPPAEGEAPPPAEGAEGAVEGGEAAPPAEPAEPIKHSYTLFYFNVKALAEPLRYLFAYGNQEYEDVRVTRDEWPALKPTMPMGQMPVLEVDGKRVHQSISMARFLAKTVGLCGATPWEDLQIDIVVDTINDFRLKIAVVSYEPEDEIKEKKLVTLNAEVIPFYLEKLEQTVKDNDGHLALGKLTWADVYFAGITDYMNYMVKRDLLEPYPALRGVVDAVNALEPIKAWIEKRPVTEV
true
true
true
true
true
true
true
true
true
true