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Protein

40S ribosomal protein S4

Gene

RpS4

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-DME-72649 Translation initiation complex formation
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-DME-72702 Ribosomal scanning and start codon recognition
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S4
Gene namesi
Name:RpS4
Synonyms:RP4
ORF Names:CG11276
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0011284 RpS4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001308291 – 26140S ribosomal protein S4Add BLAST261

Proteomic databases

PaxDbiP41042
PRIDEiP41042

Expressioni

Gene expression databases

BgeeiFBgn0011284
ExpressionAtlasiP41042 baseline and differential
GenevisibleiP41042 DM

Interactioni

Protein-protein interaction databases

BioGridi64829, 10 interactors
IntActiP41042, 2 interactors
MINTiP41042
STRINGi7227.FBpp0075618

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AE1-261[»]
ProteinModelPortaliP41042
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 104S4 RNA-bindingAdd BLAST63

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0378 Eukaryota
COG1471 LUCA
InParanoidiP41042
KOiK02987
OMAiRKDYKFP
OrthoDBiEOG091G0MYF
PhylomeDBiP41042

Family and domain databases

CDDicd00165 S4, 1 hit
Gene3Di2.30.30.30, 1 hit
2.40.50.740, 1 hit
HAMAPiMF_00485 Ribosomal_S4e, 1 hit
InterProiView protein in InterPro
IPR032277 40S_S4_C
IPR005824 KOW
IPR014722 Rib_L2_dom2
IPR000876 Ribosomal_S4e
IPR013845 Ribosomal_S4e_central_region
IPR038237 Ribosomal_S4e_central_sf
IPR013843 Ribosomal_S4e_N
IPR018199 Ribosomal_S4e_N_CS
IPR002942 S4_RNA-bd
PANTHERiPTHR11581 PTHR11581, 1 hit
PfamiView protein in Pfam
PF16121 40S_S4_C, 1 hit
PF00467 KOW, 1 hit
PF00900 Ribosomal_S4e, 1 hit
PF08071 RS4NT, 1 hit
PF01479 S4, 1 hit
PIRSFiPIRSF002116 Ribosomal_S4, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002667 Ribosomal_S4e_central, 1 hit
PROSITEiView protein in PROSITE
PS00528 RIBOSOMAL_S4E, 1 hit
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

P41042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGPKKHLK RLAAPKAWML DKLGGVFAPR PSTGPHKLRE SLPLLIFLRN
60 70 80 90 100
RLKYALNGAE VTKIVMQRLV KVDGKVRTDP TYPAGYMDVI TLEKTGEFFR
110 120 130 140 150
LVYDVKGRFV IHRISAEEAK YKLCKVKKTQ LGAKGVPFLV THDGRTIRYP
160 170 180 190 200
DPLIHANDSV QVDIASGKIT DYIKFDSGNL CMITGGRNLG RVGTVVNRER
210 220 230 240 250
HPGSFDIVHI KDSQGHVFAT RLTNVFIIGK GNKPYISLPK GKGVKLSIAE
260
ERDKRLAAKT H
Length:261
Mass (Da):29,134
Last modified:September 27, 2005 - v2
Checksum:i9D3E3446FE5E4AE9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46I → T in BAA03786 (PubMed:8224871).Curated1
Sequence conflicti73D → Y in BAA03786 (PubMed:8224871).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16257 mRNA Translation: BAA03786.1
AE014296 Genomic DNA Translation: AAF49846.1
AE014296 Genomic DNA Translation: AAF49847.1
BT011369 mRNA Translation: AAR96161.1
PIRiJN0871
RefSeqiNP_001287055.1, NM_001300126.1
NP_524053.2, NM_079329.3
NP_729871.1, NM_168537.2
UniGeneiDm.951

Genome annotation databases

EnsemblMetazoaiFBtr0075884; FBpp0075618; FBgn0011284
FBtr0075885; FBpp0075619; FBgn0011284
FBtr0346390; FBpp0312080; FBgn0011284
GeneIDi39484
KEGGidme:Dmel_CG11276

Similar proteinsi

Entry informationi

Entry nameiRS4_DROME
AccessioniPrimary (citable) accession number: P41042
Secondary accession number(s): A4V1X0, Q9VU44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: September 27, 2005
Last modified: May 23, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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