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P41034 (TTPA_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alpha-tocopherol transfer protein
Short name=Alpha-TTP
Gene names
Name:Ttpa
Synonyms:Tpp1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds alpha-tocopherol and enhances its transfer between separate membranes.

Subcellular location

Cytoplasm.

Tissue specificity

Liver.

Sequence similarities

Contains 1 CRAL-TRIO domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Alpha-tocopherol transfer protein
PRO_0000210766

Regions

Domain88 – 253166CRAL-TRIO

Sequences

Sequence LengthMass (Da)Tools
P41034 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 96F16E3F227F140C

FASTA27831,846
        10         20         30         40         50         60 
MAEMRPGPVV GKQLNEQPDH SPLVQPGLAE LRRRAQEEGV PETPQPLTDA FLLRFLRARD 

        70         80         90        100        110        120 
FDLDLAWRLM KNYYKWRAEC PELSADLHPR SILGLLKAGY HGVLRSRDPT GSRVLIYRIS 

       130        140        150        160        170        180 
YWDPKVFTAY DVFRVSLITS ELIVQEVETQ RNGVKAIFDL EGWQISHAFQ ITPSVAKKIA 

       190        200        210        220        230        240 
AVVTDSFPLK VRGIHLINEP VIFHAVFSMI KPFLTEKIKG RIHLHGNNYK SSLLQHFPDI 

       250        260        270 
LPLEYGGNES SMEDICQEWT NFIMKSEDYL SSISETIQ

« Hide

References

[1]"Primary structure of alpha-tocopherol transfer protein from rat liver. Homology with cellular retinaldehyde-binding protein."
Sato Y., Arai H., Miyata A., Tokita S., Yamamoto K., Tanabe T., Inoue K.
J. Biol. Chem. 268:17705-17710(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 77-87; 156-165; 178-182 AND 212-216.
Strain: Sprague-Dawley.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D16339 mRNA. Translation: BAA03843.1.
IPIIPI00189415.
PIRA47404.
RefSeqNP_037180.1. NM_013048.2.
UniGeneRn.228762.

3D structure databases

ProteinModelPortalP41034.
SMRP41034. Positions 11-274.
ModBaseSearch...

Protein-protein interaction databases

IntActP41034. 1 interaction.
STRING10116.ENSRNOP00000009611.

Proteomic databases

PRIDEP41034.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000009611; ENSRNOP00000009611; ENSRNOG00000007139.
GeneID25571.
KEGGrno:25571.
UCSCRGD:3915. rat.

Organism-specific databases

CTD7274.
RGD3915. Ttpa.

Phylogenomic databases

eggNOGNOG250577.
GeneTreeENSGT00550000074253.
HOGENOMHOG000231534.
HOVERGENHBG018009.
InParanoidP41034.
OMAYRIAHWD.
OrthoDBEOG42JNSF.

Gene expression databases

GenevestigatorP41034.
GermOnlineENSRNOG00000007139. Rattus norvegicus.

Family and domain databases

Gene3D3.40.525.10. 1 hit.
InterProIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view]
PfamPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSPR00180. CRETINALDHBP.
SMARTSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMSSF52087. CRAL_TRIO_C. 1 hit.
SSF46938. Sec14p_like_N. 1 hit.
PROSITEPS50191. CRAL_TRIO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio607189.

Entry information

Entry nameTTPA_RAT
AccessionPrimary (citable) accession number: P41034
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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