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Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Bacillus caldolyticus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes (Probable).Curated
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription termination

Keywords - Ligandi

RNA-binding

Protein family/group databases

MoonProtiP41007.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrR
Including the following 2 domains:
Pyrimidine operon regulatory protein
Uracil phosphoribosyltransferase (EC:2.4.2.9)
Short name:
UPRTase
Gene namesi
Name:pyrR
OrganismiBacillus caldolyticus
Taxonomic identifieri1394 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillusGeobacillus thermoleovorans group

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830281 – 179Bifunctional protein PyrRAdd BLAST179

Proteomic databases

PRIDEiP41007.

Interactioni

Subunit structurei

Homodimer and homohexamer; in equilibrium.By similarity

Structurei

Secondary structure

1179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi9 – 27Combined sources19
Beta strandi33 – 38Combined sources6
Helixi39 – 57Combined sources19
Beta strandi63 – 72Combined sources10
Beta strandi82 – 90Combined sources9
Beta strandi98 – 110Combined sources13
Helixi111 – 121Combined sources11
Beta strandi127 – 136Combined sources10
Beta strandi141 – 143Combined sources3
Beta strandi147 – 152Combined sources6
Beta strandi159 – 164Combined sources6
Helixi166 – 169Combined sources4
Beta strandi173 – 178Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NONX-ray2.40A/B/C/D1-179[»]
1XZ8X-ray2.80A/B1-179[»]
1XZNX-ray2.27A/B1-179[»]
2IGBX-ray1.68A/B1-179[»]
ProteinModelPortaliP41007.
SMRiP41007.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41007.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni40 – 41Substrate-bindingBy similarity2
Regioni104 – 112Substrate bindingBy similarity9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi100 – 112PRPP-bindingBy similarityAdd BLAST13

Sequence similaritiesi

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

P41007-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKAVVMDEQ AIRRALTRIA HEIIERNKGI DGCVLVGIKT RGIYLARRLA
60 70 80 90 100
ERIEQIEGAS VPVGELDITL YRDDLTVKTD DHEPLVKGTN VPFPVTERNV
110 120 130 140 150
ILVDDVLFTG RTVRAAMDAV MDLGRPARIQ LAVLVDRGHR ELPIRADFVG
160 170
KNVPTSRSEL IVVELSEVDG IDQVSIHEK
Length:179
Mass (Da):19,938
Last modified:February 1, 1995 - v1
Checksum:iDF889A00B239CFB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76083 Genomic DNA. Translation: CAA53696.1.
PIRiS38892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76083 Genomic DNA. Translation: CAA53696.1.
PIRiS38892.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NONX-ray2.40A/B/C/D1-179[»]
1XZ8X-ray2.80A/B1-179[»]
1XZNX-ray2.27A/B1-179[»]
2IGBX-ray1.68A/B1-179[»]
ProteinModelPortaliP41007.
SMRiP41007.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MoonProtiP41007.

Proteomic databases

PRIDEiP41007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP41007.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPYRR_BACCL
AccessioniPrimary (citable) accession number: P41007
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.