Reviewed, UniProtKB/Swiss-Prot P41002 (CCNF_HUMAN)

Names and origin

Protein names

Recommended name:
    G2/mitotic-specific cyclin-F

Gene names

Name:

CCNF

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	786 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Likely to be involved in the control of the cell cycle during S phase and G2.
Subcellular location	Nucleus.
Developmental stage	G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
Sequence similarities	Belongs to the cyclin family. Cyclin AB subfamily. Contains 1 F-box domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Nucleus
Molecular function	Cyclin
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SKP1	P52286	1	EBI-1207574,EBI-4090	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 786	786	G2/mitotic-specific cyclin-F		PRO_0000080463
Regions
	Domain	29 – 76	48	F-box
Experimental info
	Sequence conflict	252	1	A → R in CAA85308. Ref.2
	Sequence conflict	324	1	K → N in CAA85308. Ref.2
	Sequence conflict	600	1	L → V in CAA85308. Ref.2
	Sequence conflict	662	1	D → A in CAA85308. Ref.2
	Sequence conflict	710	1	P → S in AAB60342. Ref.1
	Sequence conflict	731	1	D → H in CAA85308. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P41002-1 [UniParc]. Last modified April 16, 2002. Version 2. Checksum: ADB2FE41BC708898	FASTA	786	87,640
	10 20 30 40 50 60 MGSGGVVHCR CAKCFCYPTK RRIRRRPRNL TILSLPEDVL FHILKWLSVE DILAVRAVHS 70 80 90 100 110 120 QLKDLVDNHA SVWACASFQE LWPSPGNLKL FERAAEKGNF EAAVKLGIAY LYNEGLSVSD 130 140 150 160 170 180 EARAEVNGLK ASRFFSLAER LNVGAAPFIW LFIRPPWSVS GSCCKAVVHE SLRAECQLQR 190 200 210 220 230 240 THKASILHCL GRVLSLFEDE EKQQQAHDLF EEAAHQGCLT SSYLLWESDR RTDVSDPGRC 250 260 270 280 290 300 LHSFRKLRDY AAKGCWEAQL SLAKACANAN QLGLEVRASS EIVCQLFQAS QAVSKQQVFS 310 320 330 340 350 360 VQKGLNDTMR YILIDWLVEV ATMKDFTSLC LHLTVECVDR YLRRRLVPRY RLQLLGIACM 370 380 390 400 410 420 VICTRFISKE ILTIREAVWL TDNTYKYEDL VRMMGEIVSA LEGKIRVPTV VDYKEVLLTL 430 440 450 460 470 480 VPVELRTQHL CSFLCELSLL HTSLSAYAPA RLAAAALLLA RLTHGQTQPW TTQLWDLTGF 490 500 510 520 530 540 SYEDLIPCVL SLHKKCFHDD APKDYRQVSL TAVKQRFEDK RYGEISQEEV LSYSQLCAAL 550 560 570 580 590 600 GVTQDSPDPP TFLSTGEIHA FLSSPSGRRT KRKRENSLQE DRGSFVTTPT AELSSQEETL 610 620 630 640 650 660 LGSFLDWSLD CCSGYEGDQE SEGEKEGDVT APSGILDVTV VYLNPEQHCC QESSDEEACP 670 680 690 700 710 720 EDKGPQDPQA LALDTQIPAT PGPKPLVRTS REPGKDVTTS GYSSVSTASP TSSVDGGLGA 730 740 750 760 770 780 LPQPTSVLSL DSDSHTQPCH HQARKSCLQC RPPSPPESSV PQQQVKRINL CIHSEEEDMN LGLVRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human cyclin F." Bai C., Richman R., Elledge S.J. EMBO J. 13:6087-6098(1994) [PubMed: 7813445] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1)." Kraus B., Pohlschmidt M., Leung A.L.S., Germino G.G., Snarey A., Schneider M.C., Reeders S.T., Frischauf A.-M. Genomics 24:27-33(1994) [PubMed: 7896286] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U17105 mRNA. Translation: AAB60342.1. Z36714 mRNA. Translation: CAA85308.1. BC012349 mRNA. Translation: AAH12349.1.
PIR	A55501.
RefSeq	NP_001752.2.
UniGene	Hs.1973
3D structure databases
HSSP	HSSP built from PDB template 1VIN based on UniProtKB P30274.
ModBase	Search...
Protein-protein interaction databases
IntAct	P41002.
Genome annotation databases
Ensembl	ENSG00000162063. Homo sapiens. [Contig view]
GeneID	899.
KEGG	hsa:899.
Organism-specific databases
HGNC	HGNC:1591. CCNF.
MIM	600227. gene.
PharmGKB	PA26156.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P41002.
HOVERGEN	P41002.
Gene expression databases
ArrayExpress	P41002.
CleanEx	HS_CCNF.
GermOnline	ENSG00000162063. Homo sapiens.
Family and domain databases
InterPro	IPR006670. Cyclin. IPR004367. Cyclin_C. IPR006671. Cyclin_N. IPR013763. Cyclin_related. IPR001810. F-box. [Graphical view]
Gene3D	G3DSA:1.10.472.10. Cyclin_related. 1 hit.
Pfam	PF02984. Cyclin_C. 1 hit. PF00134. Cyclin_N. 1 hit. PF00646. F-box. 1 hit. [Graphical view]
SMART	SM00385. CYCLIN. 2 hits. SM00256. FBOX. 1 hit. [Graphical view]
PROSITE	PS00292. CYCLINS. 1 hit. PS50181. FBOX. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	3714.
SOURCE	Search...

Entry information

Entry name

CCNF_HUMAN

Accession

Primary (citable) accession number: P41002
Secondary accession number(s): Q96EG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	April 16, 2002
Last modified:	November 25, 2008
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)