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Reviewed, UniProtKB/Swiss-Prot P41002 (CCNF_HUMAN)

Last modified November 25, 2008. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    G2/mitotic-specific cyclin-F
Gene names
Name: CCNF
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length786 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Likely to be involved in the control of the cell cycle during S phase and G2.

Subcellular location

Nucleus.

Developmental stage

G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.

Sequence similarities

Belongs to the cyclin family. Cyclin AB subfamily.

Contains 1 F-box domain.

Ontologies

Keywords

   Biological processCell cycle
Cell division
Mitosis
   Cellular componentNucleus
   Molecular functionCyclin

Gene Ontology (GO)

   Biological processcell division

Inferred from electronic annotation. Source: UniProtKB-KW

mitosis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: InterPro

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SKP1P522861EBI-1207574,EBI-4090From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 786786G2/mitotic-specific cyclin-F
PRO_0000080463

Regions

Domain29 – 7648F-box

Experimental info

Sequence conflict2521A → R in CAA85308. Ref.2
Sequence conflict3241K → N in CAA85308. Ref.2
Sequence conflict6001L → V in CAA85308. Ref.2
Sequence conflict6621D → A in CAA85308. Ref.2
Sequence conflict7101P → S in AAB60342. Ref.1
Sequence conflict7311D → H in CAA85308. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P41002-1 [UniParc].

Last modified April 16, 2002. Version 2.
Checksum: ADB2FE41BC708898

FASTA78687,640
        10         20         30         40         50         60 
MGSGGVVHCR CAKCFCYPTK RRIRRRPRNL TILSLPEDVL FHILKWLSVE DILAVRAVHS 

        70         80         90        100        110        120 
QLKDLVDNHA SVWACASFQE LWPSPGNLKL FERAAEKGNF EAAVKLGIAY LYNEGLSVSD 

       130        140        150        160        170        180 
EARAEVNGLK ASRFFSLAER LNVGAAPFIW LFIRPPWSVS GSCCKAVVHE SLRAECQLQR 

       190        200        210        220        230        240 
THKASILHCL GRVLSLFEDE EKQQQAHDLF EEAAHQGCLT SSYLLWESDR RTDVSDPGRC 

       250        260        270        280        290        300 
LHSFRKLRDY AAKGCWEAQL SLAKACANAN QLGLEVRASS EIVCQLFQAS QAVSKQQVFS 

       310        320        330        340        350        360 
VQKGLNDTMR YILIDWLVEV ATMKDFTSLC LHLTVECVDR YLRRRLVPRY RLQLLGIACM 

       370        380        390        400        410        420 
VICTRFISKE ILTIREAVWL TDNTYKYEDL VRMMGEIVSA LEGKIRVPTV VDYKEVLLTL 

       430        440        450        460        470        480 
VPVELRTQHL CSFLCELSLL HTSLSAYAPA RLAAAALLLA RLTHGQTQPW TTQLWDLTGF 

       490        500        510        520        530        540 
SYEDLIPCVL SLHKKCFHDD APKDYRQVSL TAVKQRFEDK RYGEISQEEV LSYSQLCAAL 

       550        560        570        580        590        600 
GVTQDSPDPP TFLSTGEIHA FLSSPSGRRT KRKRENSLQE DRGSFVTTPT AELSSQEETL 

       610        620        630        640        650        660 
LGSFLDWSLD CCSGYEGDQE SEGEKEGDVT APSGILDVTV VYLNPEQHCC QESSDEEACP 

       670        680        690        700        710        720 
EDKGPQDPQA LALDTQIPAT PGPKPLVRTS REPGKDVTTS GYSSVSTASP TSSVDGGLGA 

       730        740        750        760        770        780 
LPQPTSVLSL DSDSHTQPCH HQARKSCLQC RPPSPPESSV PQQQVKRINL CIHSEEEDMN 


LGLVRL 

« Hide

References

« Hide 'large scale' references
[1]"Human cyclin F."
Bai C., Richman R., Elledge S.J.
EMBO J. 13:6087-6098(1994) [PubMed: 7813445] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1)."
Kraus B., Pohlschmidt M., Leung A.L.S., Germino G.G., Snarey A., Schneider M.C., Reeders S.T., Frischauf A.-M.
Genomics 24:27-33(1994) [PubMed: 7896286] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

U17105 mRNA. Translation: AAB60342.1.
Z36714 mRNA. Translation: CAA85308.1.
BC012349 mRNA. Translation: AAH12349.1.
PIRA55501.
RefSeqNP_001752.2.
UniGeneHs.1973

3D structure databases

HSSPHSSP built from PDB template 1VIN based on UniProtKB P30274.
ModBaseSearch...

Protein-protein interaction databases

IntActP41002.

Genome annotation databases

EnsemblENSG00000162063. Homo sapiens. [Contig view]
GeneID899.
KEGGhsa:899.

Organism-specific databases

HGNCHGNC:1591. CCNF.
MIM600227. gene.
PharmGKBPA26156.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP41002.
HOVERGENP41002.

Gene expression databases

ArrayExpressP41002.
CleanExHS_CCNF.
GermOnlineENSG00000162063. Homo sapiens.

Family and domain databases

InterProIPR006670. Cyclin.
IPR004367. Cyclin_C.
IPR006671. Cyclin_N.
IPR013763. Cyclin_related.
IPR001810. F-box.
[Graphical view]
Gene3DG3DSA:1.10.472.10. Cyclin_related. 1 hit.
PfamPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF00646. F-box. 1 hit.
[Graphical view]
SMARTSM00385. CYCLIN. 2 hits.
SM00256. FBOX. 1 hit.
[Graphical view]
PROSITEPS00292. CYCLINS. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio3714.
SOURCESearch...

Entry information

Entry nameCCNF_HUMAN
AccessionPrimary (citable) accession number: P41002
Secondary accession number(s): Q96EG9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: April 16, 2002
Last modified: November 25, 2008
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents