Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P40996

- SCD2_SCHPO

UniProt

P40996 - SCD2_SCHPO

Protein

Protein scd2/ral3

Gene

scd2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for mating and morphogenesis. Interacts directly with scd1 and with cdc42. May bridge and facilitate scd1 and cdc42 interactions.

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor adaptor activity Source: PomBase
    2. phosphatidylinositol binding Source: PomBase
    3. protein binding Source: PomBase

    GO - Biological processi

    1. Cdc42 protein signal transduction Source: PomBase
    2. conjugation with cellular fusion Source: PomBase
    3. regulation of catalytic activity Source: GOC
    4. regulation of conjugation with cellular fusion Source: PomBase
    5. regulation of establishment or maintenance of cell polarity regulating cell shape Source: PomBase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein scd2/ral3
    Gene namesi
    Name:scd2
    Synonyms:ral3
    ORF Names:SPAC22H10.07
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC22H10.07.

    Subcellular locationi

    GO - Cellular componenti

    1. Cdc42 GTPase complex Source: PomBase
    2. cell division site Source: PomBase
    3. cell tip Source: PomBase
    4. cytosol Source: PomBase
    5. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 536536Protein scd2/ral3PRO_0000097620Add
    BLAST

    Proteomic databases

    MaxQBiP40996.

    Interactioni

    Subunit structurei

    Scd1, scd2, cdc42, and ras1, in its GTP-bound state, act cooperatively to form a protein complex.

    Protein-protein interaction databases

    BioGridi278220. 10 interactions.
    MINTiMINT-111241.
    STRINGi4896.SPAC22H10.07-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP40996.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 8663SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini123 – 18563SH3 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini293 – 413121PXPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
    Contains 2 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG148927.
    HOGENOMiHOG000170685.
    KOiK11237.
    OMAiDDETIAW.
    OrthoDBiEOG7B31WW.
    PhylomeDBiP40996.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR000270. OPR_PB1.
    IPR001683. Phox.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00564. PB1. 1 hit.
    PF00787. PX. 1 hit.
    PF00018. SH3_1. 2 hits.
    [Graphical view]
    SMARTiSM00666. PB1. 1 hit.
    SM00312. PX. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 2 hits.
    SSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    PS50002. SH3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40996-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKIKRTWKT HSRILDKDPF SIEPPRKVIR ALYDYTARKA TEVSFAKGDF    50
    FHVIGRENDK AWYEVCNPAA GTRGFVPVSH FEEIGKTVKS ERDSDGSGQI 100
    SFTDLTTNSS TTRSSISELH SGSQPLFGIV QFDFAAERPD ELEAKAGEAI 150
    IIIARSNHEW LVAKPIGRLG GPGLIPLSFI QLRDLKTGAV IKDVSEAVLR 200
    ISCIPRVEDW KRAAADYKKS SIPLGKFSDG ETQTMPSLSP STENLQINND 250
    VTYQAATDNS STFPGSVANE LTPLQTLESR TASIASKNKK DMSSEPTVVA 300
    AMVENYMIRD DQYWYLVRAV MSDGKHRNLC RYYEDFFNFQ TKFLELFPNE 350
    AGRGDERRVI PYMPGPVDDV NELISSQRAM DLDVYLKEMC RLPARLLENE 400
    LVKLFFLPLD GDVESPHPTS TMPEALPREP LSFSLPEKAP EKATNISIPE 450
    SAPTTAGSTC KVKVRLGDET FALRVPSDIS FEDFCERLTN KLGECEHLSY 500
    RDTNANKVLP LNNVDDLRKA CSQESGVLLF AERRRF 536
    Length:536
    Mass (Da):60,043
    Last modified:February 1, 1995 - v1
    Checksum:i7B86BA8CB32D1762
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12539 Genomic DNA. Translation: AAA50557.1.
    CU329670 Genomic DNA. Translation: CAA93608.1.
    PIRiT38210.
    RefSeqiNP_593744.1. NM_001019175.2.

    Genome annotation databases

    EnsemblFungiiSPAC22H10.07.1; SPAC22H10.07.1:pep; SPAC22H10.07.
    GeneIDi2541726.
    KEGGispo:SPAC22H10.07.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12539 Genomic DNA. Translation: AAA50557.1 .
    CU329670 Genomic DNA. Translation: CAA93608.1 .
    PIRi T38210.
    RefSeqi NP_593744.1. NM_001019175.2.

    3D structure databases

    ProteinModelPortali P40996.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278220. 10 interactions.
    MINTi MINT-111241.
    STRINGi 4896.SPAC22H10.07-1.

    Proteomic databases

    MaxQBi P40996.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC22H10.07.1 ; SPAC22H10.07.1:pep ; SPAC22H10.07 .
    GeneIDi 2541726.
    KEGGi spo:SPAC22H10.07.

    Organism-specific databases

    PomBasei SPAC22H10.07.

    Phylogenomic databases

    eggNOGi NOG148927.
    HOGENOMi HOG000170685.
    KOi K11237.
    OMAi DDETIAW.
    OrthoDBi EOG7B31WW.
    PhylomeDBi P40996.

    Miscellaneous databases

    NextBioi 20802817.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR000270. OPR_PB1.
    IPR001683. Phox.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00564. PB1. 1 hit.
    PF00787. PX. 1 hit.
    PF00018. SH3_1. 2 hits.
    [Graphical view ]
    SMARTi SM00666. PB1. 1 hit.
    SM00312. PX. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 2 hits.
    SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    PS50002. SH3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cooperative interaction of S. pombe proteins required for mating and morphogenesis."
      Chang E.C., Barr M., Wang Y., Jung V., Xu H.-P., Wigler M.H.
      Cell 79:131-141(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SP870.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiSCD2_SCHPO
    AccessioniPrimary (citable) accession number: P40996
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3