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P40996

- SCD2_SCHPO

UniProt

P40996 - SCD2_SCHPO

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Protein

Protein scd2/ral3

Gene

scd2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Required for mating and morphogenesis. Interacts directly with scd1 and with cdc42. May bridge and facilitate scd1 and cdc42 interactions.

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor adaptor activity Source: PomBase
  2. phosphatidylinositol binding Source: PomBase

GO - Biological processi

  1. Cdc42 protein signal transduction Source: PomBase
  2. conjugation with cellular fusion Source: PomBase
  3. regulation of catalytic activity Source: GOC
  4. regulation of conjugation with cellular fusion Source: PomBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein scd2/ral3
Gene namesi
Name:scd2
Synonyms:ral3
ORF Names:SPAC22H10.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC22H10.07.

Subcellular locationi

GO - Cellular componenti

  1. Cdc42 GTPase complex Source: PomBase
  2. cell division site Source: PomBase
  3. cell tip Source: PomBase
  4. cytosol Source: PomBase
  5. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Protein scd2/ral3PRO_0000097620Add
BLAST

Proteomic databases

MaxQBiP40996.

Interactioni

Subunit structurei

Scd1, scd2, cdc42, and ras1, in its GTP-bound state, act cooperatively to form a protein complex.

Protein-protein interaction databases

BioGridi278220. 10 interactions.
MINTiMINT-111241.
STRINGi4896.SPAC22H10.07-1.

Structurei

3D structure databases

ProteinModelPortaliP40996.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 8663SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini123 – 18563SH3 2PROSITE-ProRule annotationAdd
BLAST
Domaini293 – 413121PXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG148927.
HOGENOMiHOG000170685.
InParanoidiP40996.
KOiK11237.
OMAiDDETIAW.
OrthoDBiEOG7B31WW.
PhylomeDBiP40996.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR000270. OPR_PB1.
IPR001683. Phox.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00787. PX. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00312. PX. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40996-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKIKRTWKT HSRILDKDPF SIEPPRKVIR ALYDYTARKA TEVSFAKGDF
60 70 80 90 100
FHVIGRENDK AWYEVCNPAA GTRGFVPVSH FEEIGKTVKS ERDSDGSGQI
110 120 130 140 150
SFTDLTTNSS TTRSSISELH SGSQPLFGIV QFDFAAERPD ELEAKAGEAI
160 170 180 190 200
IIIARSNHEW LVAKPIGRLG GPGLIPLSFI QLRDLKTGAV IKDVSEAVLR
210 220 230 240 250
ISCIPRVEDW KRAAADYKKS SIPLGKFSDG ETQTMPSLSP STENLQINND
260 270 280 290 300
VTYQAATDNS STFPGSVANE LTPLQTLESR TASIASKNKK DMSSEPTVVA
310 320 330 340 350
AMVENYMIRD DQYWYLVRAV MSDGKHRNLC RYYEDFFNFQ TKFLELFPNE
360 370 380 390 400
AGRGDERRVI PYMPGPVDDV NELISSQRAM DLDVYLKEMC RLPARLLENE
410 420 430 440 450
LVKLFFLPLD GDVESPHPTS TMPEALPREP LSFSLPEKAP EKATNISIPE
460 470 480 490 500
SAPTTAGSTC KVKVRLGDET FALRVPSDIS FEDFCERLTN KLGECEHLSY
510 520 530
RDTNANKVLP LNNVDDLRKA CSQESGVLLF AERRRF
Length:536
Mass (Da):60,043
Last modified:February 1, 1995 - v1
Checksum:i7B86BA8CB32D1762
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12539 Genomic DNA. Translation: AAA50557.1.
CU329670 Genomic DNA. Translation: CAA93608.1.
PIRiT38210.
RefSeqiNP_593744.1. NM_001019175.2.

Genome annotation databases

EnsemblFungiiSPAC22H10.07.1; SPAC22H10.07.1:pep; SPAC22H10.07.
GeneIDi2541726.
KEGGispo:SPAC22H10.07.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12539 Genomic DNA. Translation: AAA50557.1 .
CU329670 Genomic DNA. Translation: CAA93608.1 .
PIRi T38210.
RefSeqi NP_593744.1. NM_001019175.2.

3D structure databases

ProteinModelPortali P40996.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278220. 10 interactions.
MINTi MINT-111241.
STRINGi 4896.SPAC22H10.07-1.

Proteomic databases

MaxQBi P40996.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC22H10.07.1 ; SPAC22H10.07.1:pep ; SPAC22H10.07 .
GeneIDi 2541726.
KEGGi spo:SPAC22H10.07.

Organism-specific databases

PomBasei SPAC22H10.07.

Phylogenomic databases

eggNOGi NOG148927.
HOGENOMi HOG000170685.
InParanoidi P40996.
KOi K11237.
OMAi DDETIAW.
OrthoDBi EOG7B31WW.
PhylomeDBi P40996.

Miscellaneous databases

NextBioi 20802817.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR000270. OPR_PB1.
IPR001683. Phox.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00564. PB1. 1 hit.
PF00787. PX. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view ]
SMARTi SM00666. PB1. 1 hit.
SM00312. PX. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 2 hits.
SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cooperative interaction of S. pombe proteins required for mating and morphogenesis."
    Chang E.C., Barr M., Wang Y., Jung V., Xu H.-P., Wigler M.H.
    Cell 79:131-141(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SP870.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiSCD2_SCHPO
AccessioniPrimary (citable) accession number: P40996
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3