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Protein

Protein scd2/ral3

Gene

scd2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for mating and morphogenesis. Interacts directly with scd1 and with cdc42. May bridge and facilitate scd1 and cdc42 interactions.

GO - Molecular functioni

GO - Biological processi

  • Cdc42 protein signal transduction Source: PomBase
  • cell morphogenesis Source: InterPro
  • conjugation with cellular fusion Source: PomBase
  • positive regulation of conjugation with cellular fusion Source: PomBase
  • regulation of establishment or maintenance of cell polarity regulating cell shape Source: PomBase
  • signal transduction involved in positive regulation of conjugation with cellular fusion Source: PomBase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein scd2/ral3
Gene namesi
Name:scd2
Synonyms:ral3
ORF Names:SPAC22H10.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC22H10.07
PomBaseiSPAC22H10.07 scd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976201 – 536Protein scd2/ral3Add BLAST536

Proteomic databases

MaxQBiP40996
PaxDbiP40996
PRIDEiP40996

PTM databases

iPTMnetiP40996

Interactioni

Subunit structurei

Scd1, scd2, cdc42, and ras1, in its GTP-bound state, act cooperatively to form a protein complex.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi278220, 10 interactors
IntActiP40996, 2 interactors
MINTiP40996
STRINGi4896.SPAC22H10.07.1

Structurei

3D structure databases

ProteinModelPortaliP40996
SMRiP40996
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 86SH3 1PROSITE-ProRule annotationAdd BLAST63
Domaini123 – 185SH3 2PROSITE-ProRule annotationAdd BLAST63
Domaini293 – 413PXPROSITE-ProRule annotationAdd BLAST121
Domaini459 – 533PB1PROSITE-ProRule annotationAdd BLAST75

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

HOGENOMiHOG000170685
InParanoidiP40996
KOiK11237
OMAiKRIMPYI
OrthoDBiEOG092C1KS9
PhylomeDBiP40996

Family and domain databases

CDDicd06890 PX_Bem1p, 1 hit
cd11878 SH3_Bem1p_1, 1 hit
cd11879 SH3_Bem1p_2, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR030507 Bem1/Scd2
IPR035550 Bem1/Scd2_PX
IPR035548 Bem1/Scd2_SH3_1
IPR035549 Bem1/Scd2_SH3_2
IPR000270 PB1_dom
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR45397 PTHR45397, 2 hits
PfamiView protein in Pfam
PF00564 PB1, 1 hit
PF00787 PX, 1 hit
PF00018 SH3_1, 2 hits
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00312 PX, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 2 hits
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50195 PX, 1 hit
PS50002 SH3, 2 hits

Sequencei

Sequence statusi: Complete.

P40996-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIKRTWKT HSRILDKDPF SIEPPRKVIR ALYDYTARKA TEVSFAKGDF
60 70 80 90 100
FHVIGRENDK AWYEVCNPAA GTRGFVPVSH FEEIGKTVKS ERDSDGSGQI
110 120 130 140 150
SFTDLTTNSS TTRSSISELH SGSQPLFGIV QFDFAAERPD ELEAKAGEAI
160 170 180 190 200
IIIARSNHEW LVAKPIGRLG GPGLIPLSFI QLRDLKTGAV IKDVSEAVLR
210 220 230 240 250
ISCIPRVEDW KRAAADYKKS SIPLGKFSDG ETQTMPSLSP STENLQINND
260 270 280 290 300
VTYQAATDNS STFPGSVANE LTPLQTLESR TASIASKNKK DMSSEPTVVA
310 320 330 340 350
AMVENYMIRD DQYWYLVRAV MSDGKHRNLC RYYEDFFNFQ TKFLELFPNE
360 370 380 390 400
AGRGDERRVI PYMPGPVDDV NELISSQRAM DLDVYLKEMC RLPARLLENE
410 420 430 440 450
LVKLFFLPLD GDVESPHPTS TMPEALPREP LSFSLPEKAP EKATNISIPE
460 470 480 490 500
SAPTTAGSTC KVKVRLGDET FALRVPSDIS FEDFCERLTN KLGECEHLSY
510 520 530
RDTNANKVLP LNNVDDLRKA CSQESGVLLF AERRRF
Length:536
Mass (Da):60,043
Last modified:February 1, 1995 - v1
Checksum:i7B86BA8CB32D1762
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12539 Genomic DNA Translation: AAA50557.1
CU329670 Genomic DNA Translation: CAA93608.1
PIRiT38210
RefSeqiNP_593744.1, NM_001019175.2

Genome annotation databases

EnsemblFungiiSPAC22H10.07.1; SPAC22H10.07.1:pep; SPAC22H10.07
GeneIDi2541726
KEGGispo:SPAC22H10.07

Similar proteinsi

Entry informationi

Entry nameiSCD2_SCHPO
AccessioniPrimary (citable) accession number: P40996
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 25, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health