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P40996 (SCD2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein scd2/ral3
Gene names
Name:scd2
Synonyms:ral3
ORF Names:SPAC22H10.07
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for mating and morphogenesis. Interacts directly with scd1 and with cdc42. May bridge and facilitate scd1 and cdc42 interactions.

Subunit structure

Scd1, scd2, cdc42, and ras1, in its GTP-bound state, act cooperatively to form a protein complex.

Sequence similarities

Contains 1 PX (phox homology) domain.

Contains 2 SH3 domains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

shk1P505273EBI-767302,EBI-767318

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 536536Protein scd2/ral3
PRO_0000097620

Regions

Domain24 – 8663SH3 1
Domain123 – 18563SH3 2
Domain293 – 413121PX

Sequences

Sequence LengthMass (Da)Tools
P40996 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 7B86BA8CB32D1762

FASTA53660,043
        10         20         30         40         50         60 
MLKIKRTWKT HSRILDKDPF SIEPPRKVIR ALYDYTARKA TEVSFAKGDF FHVIGRENDK 

        70         80         90        100        110        120 
AWYEVCNPAA GTRGFVPVSH FEEIGKTVKS ERDSDGSGQI SFTDLTTNSS TTRSSISELH 

       130        140        150        160        170        180 
SGSQPLFGIV QFDFAAERPD ELEAKAGEAI IIIARSNHEW LVAKPIGRLG GPGLIPLSFI 

       190        200        210        220        230        240 
QLRDLKTGAV IKDVSEAVLR ISCIPRVEDW KRAAADYKKS SIPLGKFSDG ETQTMPSLSP 

       250        260        270        280        290        300 
STENLQINND VTYQAATDNS STFPGSVANE LTPLQTLESR TASIASKNKK DMSSEPTVVA 

       310        320        330        340        350        360 
AMVENYMIRD DQYWYLVRAV MSDGKHRNLC RYYEDFFNFQ TKFLELFPNE AGRGDERRVI 

       370        380        390        400        410        420 
PYMPGPVDDV NELISSQRAM DLDVYLKEMC RLPARLLENE LVKLFFLPLD GDVESPHPTS 

       430        440        450        460        470        480 
TMPEALPREP LSFSLPEKAP EKATNISIPE SAPTTAGSTC KVKVRLGDET FALRVPSDIS 

       490        500        510        520        530 
FEDFCERLTN KLGECEHLSY RDTNANKVLP LNNVDDLRKA CSQESGVLLF AERRRF

« Hide

References

« Hide 'large scale' references
[1]"Cooperative interaction of S. pombe proteins required for mating and morphogenesis."
Chang E.C., Barr M., Wang Y., Jung V., Xu H.-P., Wigler M.H.
Cell 79:131-141(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SP870.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U12539 Genomic DNA. Translation: AAA50557.1.
CU329670 Genomic DNA. Translation: CAA93608.1.
PIRT38210.
RefSeqNP_593744.1. NM_001019175.2.

3D structure databases

ProteinModelPortalP40996.
ModBaseSearch...

Protein-protein interaction databases

IntActP40996. 1 interaction.
MINTMINT-111241.
STRING4896.SPAC22H10.07-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC22H10.07.1; SPAC22H10.07.1:pep; SPAC22H10.07.
GeneID2541726.
KEGGspo:SPAC22H10.07.

Organism-specific databases

PomBaseSPAC22H10.07.

Phylogenomic databases

eggNOGNOG148927.
HOGENOMHOG000170685.
KOK11237.
OrthoDBEOG48KVMP.

Family and domain databases

Gene3D3.30.1520.10. 1 hit.
InterProIPR000270. OPR_PB1.
IPR001683. Phox.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00564. PB1. 1 hit.
PF00787. PX. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
SMARTSM00666. PB1. 1 hit.
SM00312. PX. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMSSF64268. PX. 1 hit.
SSF50044. SH3. 2 hits.
PROSITEPS50195. PX. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802817.

Entry information

Entry nameSCD2_SCHPO
AccessionPrimary (citable) accession number: P40996
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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