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P40976

- LYS2_SCHPO

UniProt

P40976 - LYS2_SCHPO

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Protein
L-aminoadipate-semialdehyde dehydrogenase
Gene
lys1, SPAP7G5.04c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH.

Catalytic activityi

(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.

Cofactori

Binds 1 phosphopantetheine covalently Reviewed prediction.

Pathwayi

GO - Molecular functioni

  1. L-aminoadipate-semialdehyde dehydrogenase activity Source: PomBase
  2. fatty-acyl-CoA binding Source: PomBase
  3. phosphopantetheine binding Source: InterPro

GO - Biological processi

  1. lysine biosynthetic process Source: PomBase
  2. lysine biosynthetic process via aminoadipic acid Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00033; UER00032.

Names & Taxonomyi

Protein namesi
Recommended name:
L-aminoadipate-semialdehyde dehydrogenase (EC:1.2.1.31)
Alternative name(s):
Alpha-aminoadipate reductase
Short name:
Alpha-AR
Gene namesi
Name:lys1
ORF Names:SPAP7G5.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAP7G5.04c.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi913 – 9131G → A: No activity. 1 Publication
Mutagenesisi916 – 9161S → A or T: No activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14191419L-aminoadipate-semialdehyde dehydrogenase
PRO_0000193152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei916 – 9161O-(pantetheine 4'-phosphoryl)serine Reviewed prediction

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

MaxQBiP40976.
PaxDbiP40976.

Interactioni

Protein-protein interaction databases

BioGridi278556. 3 interactions.
MINTiMINT-4689880.
STRINGi4896.SPAP7G5.04c-1.

Structurei

3D structure databases

ProteinModelPortaliP40976.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini885 – 95369Acyl carrier
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3320.
HOGENOMiHOG000191209.
KOiK00143.
OMAiDRFTMLS.
OrthoDBiEOG74TX6Z.
PhylomeDBiP40976.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR010071. AA_adenyl_domain.
IPR009081. Acyl_carrier_prot-like.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR014397. L-NH2adipate-semiAld_DH_lsu.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR006162. PPantetheine_attach_site.
IPR010080. Thioester_reductase-like_dom.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PF07993. NAD_binding_4. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
PIRSFiPIRSF001617. Alpha-AR. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
TIGR03443. alpha_am_amid. 1 hit.
TIGR01746. Thioester-redct. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00455. AMP_BINDING. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40976-1 [UniParc]FASTAAdd to Basket

« Hide

MSQTAPSDTE YNQRLERWSE RLKSQTISHL PTDYSRPVPS RLVEAVFERT     50
LPEDAKTALI KVYVAAQAKG ILVTPFNILL TIFIILVSRM TGDEDISIGT 100
SSENAIPFVL RTFIQPSDSF LDLLAKVCDL EKEGSSDAVD FSDLINFLNA 150
KLSKKDDPRK TLVHLRFYNA PDAPSENFLS TTGLDVDLTV LVSVKKPSDQ 200
LTSLRSQFTF PDLQLKLIYN QLLFSESRVN IVADQLLKLV VSASKDVTGP 250
IGALDLMTPT QMNVLPDPTV DLDWSGYRGA IQDIFASNAA KFPDRECIVV 300
TPSVTIDAPV TSYTYRQIDE SSNILAHHLV KNGIERGDVV MVYAYRGVDL 350
VVAVMGVLKA GATFSVIDPA YPPARQIIYL SVAKPRALVV LEDAGVLSPT 400
VVEYVEKSLE LKTYVPALKL AKDGSLTGGS VSKGADDILQ HVLHLKSEQT 450
GVVVGPDSTP TLSFTSGSEG IPKGVKGRHF SLAYYFDWMA QEFNLSESDR 500
FTMLSGIAHD PIQRDIFTPL FLGASLIVPT AEDIGTPGQL AQWANKYKVT 550
VTHLTPAMGQ LLAAQADEPI PSLHHAFFVG DILTKRDCLR LQVLANNVNV 600
VNMYGTTETQ RSVSYFVVPA RSQDQTFLES QKDVIPAGRG MKNVQLLVIN 650
RFDTNKICGI GEVGEIYLRA GGLAEGYLGN DELTSKKFLK SWFADPSKFV 700
DRTPENAPWK PYWFGIRDRM YRSGDLGRYL PTGNVECSGR ADDQIKIRGF 750
RIELGEINTH LSRHPNVREN ITLVRRDKDE EPTLVAYIVP QGLNKDDFDS 800
ATESEDIVVN GLKKYRKLIH DIREYLKTKL PSYAIPSVIV PLHKMPLNPN 850
GKIDKPALPF PDTSQLAAAS RSHSKHGVDE TLTATERDIR DIWLRIIPHA 900
TDVNKKASFF DIGGHSILAT RLIFELRKKF AVNVPLGLVF SEPTIEGLAK 950
EIERMKSGEM ISVMDIGKEE TREPEIEYGK DALDLVDLIP KEFPTSKDLG 1000
IDEPKTVFLT GANGYLGVFI LRDLMTRSSN LKVIALVRAS SEEHGLKRLK 1050
DSCTAYGVWD ESWAQKISVV NGDLALENWG IEERKWNKLT EVVDYVIHNG 1100
ALVHWVYPYS KLRGPNVMGT ITALKLCSLG KGKSLSFVSS TSTVDTEYYV 1150
NLSNEITSKG GNGIPESDPL QGSSKDLHTG YGQSKWVSEY LVRQAGLRGL 1200
RGVVVRPGYI LGDSKSGAIN TDDFLVRMVK GCIELGLYPN INNTVNMVPA 1250
DHVARVVTAS AFHPEQGVIV AHVTSHPRLR FNQFLGTLST FGFNTKLSEY 1300
VNWRIALERF VINESHDSAL YPLLHFVLDN LPANTKAPEL DDTNTREILK 1350
RDASWTNVDV SNGAAILEHE MGLYLSYLVA IGFLPKPTLE GKKLPEVKIN 1400
EATLEKLASA GGRGGAPTH 1419
Length:1,419
Mass (Da):156,894
Last modified:February 21, 2001 - v3
Checksum:i09AFBEFE09F21A0C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 912MT → IA in AAC15909. 1 Publication
Sequence conflicti196 – 1961Missing in AAC15909. 1 Publication
Sequence conflicti487 – 4871D → DG in AAC15909. 1 Publication
Sequence conflicti500 – 5001R → G in AAC15909. 1 Publication
Sequence conflicti600 – 6023Missing in AAC15909. 1 Publication
Sequence conflicti620 – 6212AR → GP in AAC15909. 1 Publication
Sequence conflicti712 – 7121Y → S in AAC15909. 1 Publication
Sequence conflicti926 – 9283LRK → PSQ in AAC15909. 1 Publication
Sequence conflicti1203 – 12053VVV → AAA in AAC15909. 1 Publication
Sequence conflicti1225 – 12284LVRM → WSK in AAC15909. 1 Publication
Sequence conflicti1239 – 12391P → A in AAC15909. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15923 Genomic DNA. Translation: AAC15909.1.
CU329670 Genomic DNA. Translation: CAB88271.1.
PIRiS57264.
RefSeqiNP_594314.1. NM_001019737.2.

Genome annotation databases

EnsemblFungiiSPAP7G5.04c.1; SPAP7G5.04c.1:pep; SPAP7G5.04c.
GeneIDi2542079.
KEGGispo:SPAP7G5.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15923 Genomic DNA. Translation: AAC15909.1 .
CU329670 Genomic DNA. Translation: CAB88271.1 .
PIRi S57264.
RefSeqi NP_594314.1. NM_001019737.2.

3D structure databases

ProteinModelPortali P40976.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278556. 3 interactions.
MINTi MINT-4689880.
STRINGi 4896.SPAP7G5.04c-1.

Proteomic databases

MaxQBi P40976.
PaxDbi P40976.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAP7G5.04c.1 ; SPAP7G5.04c.1:pep ; SPAP7G5.04c .
GeneIDi 2542079.
KEGGi spo:SPAP7G5.04c.

Organism-specific databases

PomBasei SPAP7G5.04c.

Phylogenomic databases

eggNOGi COG3320.
HOGENOMi HOG000191209.
KOi K00143.
OMAi DRFTMLS.
OrthoDBi EOG74TX6Z.
PhylomeDBi P40976.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00032 .

Miscellaneous databases

NextBioi 20803152.

Family and domain databases

Gene3Di 1.10.1200.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR010071. AA_adenyl_domain.
IPR009081. Acyl_carrier_prot-like.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR014397. L-NH2adipate-semiAld_DH_lsu.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR006162. PPantetheine_attach_site.
IPR010080. Thioester_reductase-like_dom.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PF07993. NAD_binding_4. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view ]
PIRSFi PIRSF001617. Alpha-AR. 1 hit.
SUPFAMi SSF47336. SSF47336. 1 hit.
TIGRFAMsi TIGR01733. AA-adenyl-dom. 1 hit.
TIGR03443. alpha_am_amid. 1 hit.
TIGR01746. Thioester-redct. 1 hit.
PROSITEi PS50075. ACP_DOMAIN. 1 hit.
PS00455. AMP_BINDING. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular properties of the lys1+ gene and the regulation of alpha-aminoadipate reductase in Schizosaccharomyces pombe."
    Ford R.A., Bhattacharjee J.K.
    Curr. Genet. 28:131-137(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Posttranslational activation, site-directed mutation and phylogenetic analyses of the lysine biosynthesis enzymes alpha-aminoadipate reductase Lys1p (AAR) and the phosphopantetheinyl transferase Lys7p (PPTase) from Schizosaccharomyces pombe."
    Guo S., Bhattacharjee J.K.
    Yeast 21:1279-1288(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF GLY-913 AND SER-916.
    Strain: 972 / ATCC 24843.
  4. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLYS2_SCHPO
AccessioniPrimary (citable) accession number: P40976
Secondary accession number(s): Q9P770
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 21, 2001
Last modified: May 14, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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