P40975 (PMP2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plasma membrane ATPase proteolipid 2

Gene names

Name:	PMP2
Ordered Locus Names:	YEL017C-A
ORF Names:	YEL017BC

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	43 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Monomer and homodimer. Associated with the 100 kDa subunit of the plasma membrane H+-ATPase.
Subcellular location	Cell membrane.
Miscellaneous	Present with 74700 molecules/cell in log phase SD medium.
Caution	It is uncertain whether Met-1 or Met-3 is the initiator.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cation transport Inferred from genetic interaction Ref.1. Source: SGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from direct assay Ref.1. Source: SGD plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 5	5			PRO_0000022073
	Chain	6 – 43	38	Plasma membrane ATPase proteolipid 2		PRO_0000022074
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Topological domain	30 – 43	14	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	P40975 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: F02403E502225434	FASTA	43	4,848
	10 20 30 40 MLMSTLPGGV ILVFILVGLA CIAIISTIIY RKWQARQRGL QRF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two distinct genes encode small isoproteolipids affecting plasma membrane H(+)-ATPase activity of Saccharomyces cerevisiae." Navarre C., Catty P., Leterme S., Dietrich F.S., Goffeau A. J. Biol. Chem. 269:21262-21268(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 6-43. Strain: ATCC 201238 / W303-1B.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X79370 Genomic DNA. Translation: CAA55915.1. U18530 Genomic DNA. Translation: AAB64509.1. AY692935 Genomic DNA. Translation: AAT92954.1. BK006939 Genomic DNA. Translation: DAA07636.1.
PIR	A53927.
RefSeq	NP_010898.1. NM_001180029.1.
3D structure databases
ProteinModelPortal	P40975.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-7629N.
MINT	MINT-1354820.
STRING	4932.YEL017C-A.
Proteomic databases
PaxDb	P40975.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YEL017C-A; YEL017C-A; YEL017C-A.
GeneID	856697.
KEGG	sce:YEL017C-A.
Organism-specific databases
CYGD	YEL017c-a.
SGD	S000002103. PMP2.
Phylogenomic databases
eggNOG	NOG237445.
GeneTree	ENSGT00390000006089.
HOGENOM	HOG000000839.
OrthoDB	EOG42C1KH.
Gene expression databases
Genevestigator	P40975.
GermOnline	YEL017C-A. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR012589. ATPase_proteolipid. [Graphical view]
Pfam	PF08114. PMP1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	982754.

Entry information

Entry name

PMP2_YEAST

Accession

Primary (citable) accession number: P40975
Secondary accession number(s): D3DLN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program