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Protein

Sorting nexin MVP1

Gene

MVP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for vacuolar protein sorting.1 Publication

Miscellaneous

Present with 2210 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei172Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei174Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei198Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei213Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: SGD

GO - Biological processi

  • endocytosis Source: GO_Central
  • plasma membrane tubulation Source: SGD
  • protein targeting to vacuole Source: SGD
  • retrograde transport, endosome to Golgi Source: SGD
  • vesicle organization Source: GO_Central

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32715-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin MVP1
Gene namesi
Name:MVP1
Ordered Locus Names:YMR004W
ORF Names:YM8270.06
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR004W
SGDiS000004606 MVP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138021 – 511Sorting nexin MVP1Add BLAST511

Proteomic databases

MaxQBiP40959
PaxDbiP40959
PRIDEiP40959

PTM databases

iPTMnetiP40959

Interactioni

Subunit structurei

Interacts with VPS1.1 Publication

Protein-protein interaction databases

BioGridi35174, 133 interactors
DIPiDIP-1764N
IntActiP40959, 14 interactors
MINTiP40959
STRINGi4932.YMR004W

Structurei

3D structure databases

ProteinModelPortaliP40959
SMRiP40959
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 247PXPROSITE-ProRule annotationAdd BLAST120

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

GeneTreeiENSGT00460000041594
HOGENOMiHOG000000751
InParanoidiP40959
KOiK17922
OMAiTIFQETQ
OrthoDBiEOG092C4ZGK

Family and domain databases

CDDicd06866 PX_SNX8_Mvp1p_like, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR028662 SNX8/Mvp1
IPR035704 SNX8/Mvp1_PX
PANTHERiPTHR10555:SF203 PTHR10555:SF203, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

P40959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNYEGSDPW NTSSNAWTKD DDHVVSTTNS EPSLNGISGE FNTLNFSTPL
60 70 80 90 100
DTNEEDTGFL PTNDVLEESI WDDSRNPLGA TGMSQTPNIA ANETVIDKND
110 120 130 140 150
ARDQNIEESE ADLLDWTNNV RKTYRPLDAD IIIIEEIPER EGLLFKHANY
160 170 180 190 200
LVKHLIALPS TSPSEERTVV RRYSDFLWLR EILLKRYPFR MIPELPPKRI
210 220 230 240 250
GSQNADQLFL KKRRIGLSRF INLVMKHPKL SNDDLVLTFL TVRTDLTSWR
260 270 280 290 300
KQATYDTSNE FADKKISQEF MKMWKKEFAE QWNQAASCID TSMELWYRIT
310 320 330 340 350
LLLERHEKRI MQMVHERNFF ETLVDNFSEV TPKLYPVQQN DTILDINNNL
360 370 380 390 400
SIIKKHLETT SSICKQETEE ISGTLSPKFK IFTDILLSLR SLFERYKIMA
410 420 430 440 450
ANNVVELQRH VELNKEKLES MKGKPDVSGA EYDRIKKIIQ KDRRSIIEQS
460 470 480 490 500
NRAWLIRQCI LEEFTIFQET QFLITRAFQD WAKLNSNHAG LKLNEWEKLV
510
TSIMDMPISR E
Length:511
Mass (Da):59,657
Last modified:October 1, 1996 - v2
Checksum:i0EBB10FBCBB1DD78
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85Q → N in AAA67884 (PubMed:7862158).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16137 Genomic DNA Translation: AAA67884.1
Z48613 Genomic DNA Translation: CAA88519.1
BK006946 Genomic DNA Translation: DAA09903.1
PIRiS53033
RefSeqiNP_013717.1, NM_001182500.1

Genome annotation databases

EnsemblFungiiYMR004W; YMR004W; YMR004W
GeneIDi855016
KEGGisce:YMR004W

Similar proteinsi

Entry informationi

Entry nameiMVP1_YEAST
AccessioniPrimary (citable) accession number: P40959
Secondary accession number(s): D6VZH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

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