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Protein

Sorting nexin MVP1

Gene

MVP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for vacuolar protein sorting.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei172 – 1721Phosphatidylinositol 3-phosphateBy similarity
Binding sitei174 – 1741Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei198 – 1981Phosphatidylinositol 3-phosphateBy similarity
Binding sitei213 – 2131Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: SGD

GO - Biological processi

  • endocytosis Source: GO_Central
  • membrane tubulation Source: SGD
  • protein targeting to vacuole Source: SGD
  • retrograde transport, endosome to Golgi Source: SGD
  • vesicle organization Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32715-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin MVP1
Gene namesi
Name:MVP1
Ordered Locus Names:YMR004W
ORF Names:YM8270.06
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR004W.
SGDiS000004606. MVP1.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  • cytoplasm Source: SGD
  • cytosol Source: GOC
  • endosome Source: SGD
  • extrinsic component of membrane Source: GO_Central
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Sorting nexin MVP1PRO_0000213802Add
BLAST

Proteomic databases

MaxQBiP40959.

PTM databases

iPTMnetiP40959.

Interactioni

Subunit structurei

Interacts with VPS1.1 Publication

Protein-protein interaction databases

BioGridi35174. 76 interactions.
DIPiDIP-1764N.
IntActiP40959. 14 interactions.
MINTiMINT-397666.

Structurei

3D structure databases

ProteinModelPortaliP40959.
SMRiP40959. Positions 146-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini128 – 247120PXPROSITE-ProRule annotationAdd
BLAST

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00460000041594.
HOGENOMiHOG000000751.
InParanoidiP40959.
KOiK17922.
OMAiFTIFQET.
OrthoDBiEOG092C4ZGK.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNYEGSDPW NTSSNAWTKD DDHVVSTTNS EPSLNGISGE FNTLNFSTPL
60 70 80 90 100
DTNEEDTGFL PTNDVLEESI WDDSRNPLGA TGMSQTPNIA ANETVIDKND
110 120 130 140 150
ARDQNIEESE ADLLDWTNNV RKTYRPLDAD IIIIEEIPER EGLLFKHANY
160 170 180 190 200
LVKHLIALPS TSPSEERTVV RRYSDFLWLR EILLKRYPFR MIPELPPKRI
210 220 230 240 250
GSQNADQLFL KKRRIGLSRF INLVMKHPKL SNDDLVLTFL TVRTDLTSWR
260 270 280 290 300
KQATYDTSNE FADKKISQEF MKMWKKEFAE QWNQAASCID TSMELWYRIT
310 320 330 340 350
LLLERHEKRI MQMVHERNFF ETLVDNFSEV TPKLYPVQQN DTILDINNNL
360 370 380 390 400
SIIKKHLETT SSICKQETEE ISGTLSPKFK IFTDILLSLR SLFERYKIMA
410 420 430 440 450
ANNVVELQRH VELNKEKLES MKGKPDVSGA EYDRIKKIIQ KDRRSIIEQS
460 470 480 490 500
NRAWLIRQCI LEEFTIFQET QFLITRAFQD WAKLNSNHAG LKLNEWEKLV
510
TSIMDMPISR E
Length:511
Mass (Da):59,657
Last modified:October 1, 1996 - v2
Checksum:i0EBB10FBCBB1DD78
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851Q → N in AAA67884 (PubMed:7862158).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16137 Genomic DNA. Translation: AAA67884.1.
Z48613 Genomic DNA. Translation: CAA88519.1.
BK006946 Genomic DNA. Translation: DAA09903.1.
PIRiS53033.
RefSeqiNP_013717.1. NM_001182500.1.

Genome annotation databases

EnsemblFungiiYMR004W; YMR004W; YMR004W.
GeneIDi855016.
KEGGisce:YMR004W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16137 Genomic DNA. Translation: AAA67884.1.
Z48613 Genomic DNA. Translation: CAA88519.1.
BK006946 Genomic DNA. Translation: DAA09903.1.
PIRiS53033.
RefSeqiNP_013717.1. NM_001182500.1.

3D structure databases

ProteinModelPortaliP40959.
SMRiP40959. Positions 146-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35174. 76 interactions.
DIPiDIP-1764N.
IntActiP40959. 14 interactions.
MINTiMINT-397666.

PTM databases

iPTMnetiP40959.

Proteomic databases

MaxQBiP40959.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR004W; YMR004W; YMR004W.
GeneIDi855016.
KEGGisce:YMR004W.

Organism-specific databases

EuPathDBiFungiDB:YMR004W.
SGDiS000004606. MVP1.

Phylogenomic databases

GeneTreeiENSGT00460000041594.
HOGENOMiHOG000000751.
InParanoidiP40959.
KOiK17922.
OMAiFTIFQET.
OrthoDBiEOG092C4ZGK.

Enzyme and pathway databases

BioCyciYEAST:G3O-32715-MONOMER.

Miscellaneous databases

PROiP40959.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMVP1_YEAST
AccessioniPrimary (citable) accession number: P40959
Secondary accession number(s): D6VZH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2210 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.