Reviewed, UniProtKB/Swiss-Prot P40954 (CHI3_CANAL)

Names and origin

Protein names

Recommended name:
    Chitinase 3
    EC=3.2.1.14

Gene names

Name:	CHT3
ORF Names:	CaO19.7586

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	567 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.
Subcellular location	Secreted Probable.
Sequence similarities	Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Chitin degradation Polysaccharide degradation
Cellular component	Secreted
Domain	Signal
Ligand	Chitin-binding
Molecular function	Glycosidase Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	chitin catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cation binding Inferred from electronic annotation. Source: InterPro chitin binding Inferred from electronic annotation. Source: UniProtKB-KW chitinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 567	551	Chitinase 3		PRO_0000011926
Regions
	Compositional bias	319 – 436	118	Ser/Thr-rich
Sites
	Active site	157	1	Proton donor By similarity
Amino acid modifications
	Glycosylation	159	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P40954-1 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: DD843126F65E22C2	FASTA	567	60,061
	10 20 30 40 50 60 MLYLLTIFSL LLPALAINAR SNSNVAVYWG QNSGGSQQRL SYYCDSDAVD IVILSFMHQF 70 80 90 100 110 120 PSPIQLNFAN ACEGTYTANG ILQCQTIAED IKYCQNKGKT ILLSLGGAAG SYGFSDDATA 130 140 150 160 170 180 KQFAHTLWDL FGNSKNLATN DRPFYDAVLD GFDFDIENNW STGYPALATE LRTLFQKDTS 190 200 210 220 230 240 KNYYLGAAPQ CPYPDASVGP LLKQSEIDFV FIQFYNNYCN LGSSSFNWDT WLNYAETDSP 250 260 270 280 290 300 NKNIKLFVGV PASSRAAGSG YNDPSAVSQY LTSDILNSKY FGGISMWDVS AGWSNTNSNG 310 320 330 340 350 360 NFVENMKAIV KKASPGEETT SSSTTTTTTT TSTTISSSSS SSKTSKTSTT STTSSSISST 370 380 390 400 410 420 TSSTTSSTSS SSTSSSTSST TSSSTTSSQI STTSTAPTSS TSLSSSTIST SASTSDTTSV 430 440 450 460 470 480 TSSETTPVVT PSSLSSAITI PGDSTTTGIS KSSSTKPATS TTSALSSSTT TVATIPDDKE 490 500 510 520 530 540 IINTPTDTET TSKPPAIITE SDATTITQNL TPSTTTKNVK TTSTNIVTEW VWAPTTLRTL 550 560 TTTYQILTTR THIETVFAEP STVVIYN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of chitinase genes from Candida albicans." McCreath K.J., Specht C.A., Robbins P.W. Proc. Natl. Acad. Sci. U.S.A. 92:2544-2548(1995) [PubMed: 7708682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 10261 / CBS 2718 / IFO 1061.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U15801 Genomic DNA. Translation: AAA68016.1. AACQ01000032 Genomic DNA. Translation: EAL00460.1.
RefSeq	XP_719348.1.
3D structure databases
HSSP	HSSP built from PDB template 2HVM based on UniProtKB P23472.
ModBase	Search...
Protein family/group databases
CAZy	GH18. Glycoside Hydrolase Family 18.
Genome annotation databases
GeneID	3638967.
KEGG	cal:CaO19.7586.
Organism-specific databases
CGD	CAL0000219. CHT3.
Phylogenomic databases
OMA	LNFANAC.
Enzyme and pathway databases
BRENDA	3.2.1.14. 1124.
Family and domain databases
InterPro	IPR001223. Glyco_hydro18cat. IPR001579. Glyco_hydro_18_chit_AS. IPR013781. Glyco_hydro_sg_catalytic. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
Pfam	PF00704. Glyco_hydro_18. 1 hit. [Graphical view]
PROSITE	PS01095. CHITINASE_18. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHI3_CANAL

Accession

Primary (citable) accession number: P40954
Secondary accession number(s): Q5ACQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)