Reviewed, UniProtKB/Swiss-Prot P40953 (CHI2_CANAL)

Names and origin

Protein names

Recommended name:
    Chitinase 2
    EC=3.2.1.14

Gene names

Name:	CHT2
ORF Names:	CaO19.3895

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	583 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.
Subcellular location	Secreted Probable.
Sequence similarities	Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Chitin degradation Polysaccharide degradation
Cellular component	Secreted
Domain	Signal
Ligand	Chitin-binding
Molecular function	Glycosidase Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	chitin catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cation binding Inferred from electronic annotation. Source: InterPro chitin binding Inferred from electronic annotation. Source: UniProtKB-KW chitinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 583	564	Chitinase 2		PRO_0000011925
Sites
	Active site	153	1	Proton donor By similarity
Amino acid modifications
	Glycosylation	370	1	N-linked (GlcNAc...) Potential
	Glycosylation	546	1	N-linked (GlcNAc...) Potential
	Glycosylation	549	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P40953-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 113F26576340BEB5	FASTA	583	60,851
	10 20 30 40 50 60 MLSFKSLLAA AVVASSALAS ASNQVALYWG QNGAGGQERL AQYCQETDVD IVLLSFLNLF 70 80 90 100 110 120 PDPLNVNFAN QCGNTFESGL LHCSQIGADI KTCQSLGKTV LLSLGGGVGD YGFSDVASAT 130 140 150 160 170 180 KFADTLWNKF GAGEDPERPF DDAVVDGFDF DIEHGGATGY PELATALRGK FAKDTSKNYF 190 200 210 220 230 240 LSAAPQCPYP DASLGDLLSK VPLDFAFIQF YNNYCSINGQ FNYDTWSKFA DSAPNKNIKL 250 260 270 280 290 300 FVGVPATSNI AGYVDTSKLS SAIEEIKCDS HFAGVSLWDA SGAWLNTDEK GENFVVQVKN 310 320 330 340 350 360 VLNQNACVAP SSSATTQSTT TTSSAVTQST TTTSAAITQS ATTTSAAVTT KSNQIVTSSS 370 380 390 400 410 420 SSSSSIFYGN STTESSTGIA TGTVLPTGSN ENAATTGSGS NTKLAISTVT DVQKTVITIT 430 440 450 460 470 480 SCSEHKCVAT PVTTGVVVVT DIDTVYTTYC PLTNSQVYVP VQTVVCTEET CVPSPTSTAQ 490 500 510 520 530 540 KPKASTTIKG VEKGQTTSYP VVGTTEGVKK IVTTSAQTVG SSTKYVTIEL TSTITPVTYP 550 560 570 580 TSVASNGTNT TVPVFTFEGG AAVANSLNSV WFPVPFLLAA FAF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of chitinase genes from Candida albicans." McCreath K.J., Specht C.A., Robbins P.W. Proc. Natl. Acad. Sci. U.S.A. 92:2544-2548(1995) [PubMed: 7708682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 10261 / CBS 2718 / IFO 1061.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U15800 Genomic DNA. Translation: AAA68015.1. AACQ01000012 Genomic DNA. Translation: EAL03025.1.
RefSeq	XP_721807.1.
3D structure databases
HSSP	HSSP built from PDB template 2HVM based on UniProtKB P23472.
ModBase	Search...
Protein family/group databases
CAZy	GH18. Glycoside Hydrolase Family 18.
Genome annotation databases
GeneID	3636523.
KEGG	cal:CaO19.3895.
Organism-specific databases
CGD	CAL0002204. CHT2.
Phylogenomic databases
OMA	PTKGAES.
Enzyme and pathway databases
BRENDA	3.2.1.14. 1124.
Family and domain databases
InterPro	IPR001223. Glyco_hydro18cat. IPR001579. Glyco_hydro_18_chit_AS. IPR013781. Glyco_hydro_sg_catalytic. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
Pfam	PF00704. Glyco_hydro_18. 1 hit. [Graphical view]
PROSITE	PS01095. CHITINASE_18. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHI2_CANAL

Accession

Primary (citable) accession number: P40953
Secondary accession number(s): Q5AKC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 3, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)