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Protein

ADP-ribosylation factor 2

Gene

Arf102F

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • NAD(P)+-protein-arginine ADP-ribosyltransferase activity Source: FlyBase

GO - Biological processi

  • compound eye development Source: FlyBase
  • endosomal transport Source: FlyBase
  • neurotransmitter secretion Source: FlyBase
  • protein ADP-ribosylation Source: FlyBase
  • protein transport Source: UniProtKB-KW
  • small GTPase mediated signal transduction Source: InterPro
  • synaptic vesicle endocytosis Source: FlyBase

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 2
Alternative name(s):
dARF II
Gene namesi
Name:Arf102F
Synonyms:ARF2
ORF Names:CG11027
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 4

Organism-specific databases

FlyBaseiFBgn0013749. Arf102F.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074432 – 180ADP-ribosylation factor 2Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP40945.
PRIDEiP40945.

Expressioni

Tissue specificityi

Uniformly distributed throughout adults.1 Publication

Gene expression databases

BgeeiFBgn0013749.
ExpressionAtlasiP40945. differential.
GenevisibleiP40945. DM.

Interactioni

Protein-protein interaction databases

BioGridi68649. 16 interactors.
DIPiDIP-17574N.
IntActiP40945. 4 interactors.
MINTiMINT-1594103.
STRINGi7227.FBpp0088256.

Structurei

3D structure databases

ProteinModelPortaliP40945.
SMRiP40945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121855.
InParanoidiP40945.
KOiK07977.
OMAiMVQEDEL.
OrthoDBiEOG091G0S7S.
PhylomeDBiP40945.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTISSLLT RLFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
60 70 80 90 100
FNVETVEYKN ICFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRDRI
110 120 130 140 150
TEAERELQNM LQEDELRDAV LLVFANKQDL PNAMTAAELT DKLRLNQLRN
160 170 180
RHWFIQSTCA TQGHGLYEGL DWLSAELAKK
Length:180
Mass (Da):20,617
Last modified:January 23, 2007 - v2
Checksum:iEED5B56F55BB728F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25062 Genomic DNA. Translation: AAA53667.1.
AE014135 Genomic DNA. Translation: AAF59383.1.
AY071450 mRNA. Translation: AAL49072.1.
PIRiA53859.
RefSeqiNP_001259087.1. NM_001272158.1.
NP_524631.1. NM_079892.3.
UniGeneiDm.1888.

Genome annotation databases

EnsemblMetazoaiFBtr0089192; FBpp0088256; FBgn0013749.
FBtr0333699; FBpp0305852; FBgn0013749.
GeneIDi43823.
KEGGidme:Dmel_CG11027.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25062 Genomic DNA. Translation: AAA53667.1.
AE014135 Genomic DNA. Translation: AAF59383.1.
AY071450 mRNA. Translation: AAL49072.1.
PIRiA53859.
RefSeqiNP_001259087.1. NM_001272158.1.
NP_524631.1. NM_079892.3.
UniGeneiDm.1888.

3D structure databases

ProteinModelPortaliP40945.
SMRiP40945.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68649. 16 interactors.
DIPiDIP-17574N.
IntActiP40945. 4 interactors.
MINTiMINT-1594103.
STRINGi7227.FBpp0088256.

Proteomic databases

PaxDbiP40945.
PRIDEiP40945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089192; FBpp0088256; FBgn0013749.
FBtr0333699; FBpp0305852; FBgn0013749.
GeneIDi43823.
KEGGidme:Dmel_CG11027.

Organism-specific databases

CTDi43823.
FlyBaseiFBgn0013749. Arf102F.

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121855.
InParanoidiP40945.
KOiK07977.
OMAiMVQEDEL.
OrthoDBiEOG091G0S7S.
PhylomeDBiP40945.

Miscellaneous databases

GenomeRNAii43823.
PROiPR:P40945.

Gene expression databases

BgeeiFBgn0013749.
ExpressionAtlasiP40945. differential.
GenevisibleiP40945. DM.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARF2_DROME
AccessioniPrimary (citable) accession number: P40945
Secondary accession number(s): Q9V499
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.