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Protein

Endo-1,4-beta-xylanase A

Gene

xynA

Organism
Caldicellulosiruptor sp. (strain Rt8B.4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

Pathway:ixylan degradation

This protein is involved in the pathway xylan degradation, which is part of Glycan degradation.
View all proteins of this organism that are known to be involved in the pathway xylan degradation and in Glycan degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei490 – 4901Proton donorBy similarity
Active sitei598 – 5981NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

UniPathwayiUPA00114.

Protein family/group databases

CAZyiCBM22. Carbohydrate-Binding Module Family 22.
GH10. Glycoside Hydrolase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-1,4-beta-xylanase A (EC:3.2.1.8)
Short name:
Xylanase A
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase A
Gene namesi
Name:xynA
OrganismiCaldicellulosiruptor sp. (strain Rt8B.4)
Taxonomic identifieri28238 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 684650Endo-1,4-beta-xylanase APRO_0000007981Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP40944.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 190151CBM-cenC 1Add
BLAST
Domaini193 – 342150CBM-cenC 2Add
BLAST
Domaini350 – 678329GH10PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GH10 (glycosyl hydrolase family 10) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
3.20.20.80. 1 hit.
InterProiIPR003305. CenC_carb-bd.
IPR008979. Galactose-bd-like.
IPR001000. Glyco_hydro_10.
IPR031158. Glyco_hydro_10_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02018. CBM_4_9. 2 hits.
PF00331. Glyco_hydro_10. 1 hit.
[Graphical view]
PRINTSiPR00134. GLHYDRLASE10.
SMARTiSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00591. GH10_1. 1 hit.
PS51760. GH10_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRSLKSRKL VFILAMLFLI NAIVSLKFIT YSSANQLASK SKYIEYNFEN
60 70 80 90 100
KSVSPLAKYP SNVVLKVTNS TCAEGTFSVL VAGRKNANDG VIVDITKFLD
110 120 130 140 150
FSREYEVSFY VLQTTKKLQR ISVTLEILDS NDKNQVIAAE KVLLPNIWTK
160 170 180 190 200
VSAKVQASNY KKAKRINLIV NMPTSKSDSF YIDLFTIKDL ENAYVLKQEN
210 220 230 240 250
FENKNTGGFL PEDKNCKITL AKDRAYSSAY SLKVQPSQKT KNGKILFPIK
260 270 280 290 300
GLLQKGGTYD FSLLVYQDSS KPVNFSAGIK LNDGKSTKEI VLAKQNVAPK
310 320 330 340 350
KWTQLFATLD LDTRFSAKDV SFFVKPAAAI SYYLDLYSIS DENWGQPVPD
360 370 380 390 400
YNLPSLCEKY KNYFKIGVAV PYRALTNPVD VEVIKRHFNS ITPENEMKPE
410 420 430 440 450
SLQPYEGGFS FSIADEYVDF CKKDNISLRG HTLVWHQQTP SWFFTNPETG
460 470 480 490 500
EKLTNSEKDK EILLDRLKKH IQTVVGRYKG KVYAWDVVNE AIDENQPDGY
510 520 530 540 550
RRSDWYNILG PEYIEKAFIW AHEADPKAKL FYNDYSTEDP YKREFIYKLI
560 570 580 590 600
KNLKAKGVPV HGVGLQCHIS LDWPDVSEIE ETVKLFSRIP GLEIHFTEID
610 620 630 640 650
ISIAKNMTDD DAYNRYLLVQ QAQKLKAIFD VLKKYRNVVT SVTFWGLKDD
660 670 680
YSWLRGDMPL LSDKDYQPKF AFWSLIDPSV VPKE
Length:684
Mass (Da):78,354
Last modified:February 1, 1995 - v1
Checksum:i0AE575F4FB4BA5E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L18965 Genomic DNA. Translation: AAB42044.1.
PIRiS41788.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L18965 Genomic DNA. Translation: AAB42044.1.
PIRiS41788.

3D structure databases

ProteinModelPortaliP40944.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM22. Carbohydrate-Binding Module Family 22.
GH10. Glycoside Hydrolase Family 10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00114.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
3.20.20.80. 1 hit.
InterProiIPR003305. CenC_carb-bd.
IPR008979. Galactose-bd-like.
IPR001000. Glyco_hydro_10.
IPR031158. Glyco_hydro_10_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02018. CBM_4_9. 2 hits.
PF00331. Glyco_hydro_10. 1 hit.
[Graphical view]
PRINTSiPR00134. GLHYDRLASE10.
SMARTiSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00591. GH10_1. 1 hit.
PS51760. GH10_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, sequencing and overexpression in Escherichia coli of a xylanase gene, xynA from the thermophilic bacterium Rt8B.4 genus Caldicellulosiruptor."
    Dwivedi P.P., Gibbs M.D., Saul D.J., Bergquist P.L.
    Appl. Microbiol. Biotechnol. 45:86-93(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiXYNA_CALSR
AccessioniPrimary (citable) accession number: P40944
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 22, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.