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P40944 (XYNA_CALSR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endo-1,4-beta-xylanase A

Short name=Xylanase A
EC=3.2.1.8
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase A
Gene names
Name:xynA
OrganismCaldicellulosiruptor sp. (strain Rt8B.4)
Taxonomic identifier28238 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor

Protein attributes

Sequence length684 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

Pathway

Glycan degradation; xylan degradation.

Sequence similarities

Belongs to the glycosyl hydrolase 10 (cellulase F) family.

Contains 2 CBM-cenC (cenC-type cellulose-binding) domains.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
Xylan degradation
   DomainRepeat
Signal
   Molecular functionGlycosidase
Hydrolase
Gene Ontology (GO)
   Biological_processxylan catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionendo-1,4-beta-xylanase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 684650Endo-1,4-beta-xylanase A
PRO_0000007981

Regions

Domain40 – 190151CBM-cenC 1
Domain193 – 342150CBM-cenC 2

Sites

Active site4901Proton donor By similarity
Active site5981Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
P40944 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 0AE575F4FB4BA5E6

FASTA68478,354
        10         20         30         40         50         60 
MMRSLKSRKL VFILAMLFLI NAIVSLKFIT YSSANQLASK SKYIEYNFEN KSVSPLAKYP 

        70         80         90        100        110        120 
SNVVLKVTNS TCAEGTFSVL VAGRKNANDG VIVDITKFLD FSREYEVSFY VLQTTKKLQR 

       130        140        150        160        170        180 
ISVTLEILDS NDKNQVIAAE KVLLPNIWTK VSAKVQASNY KKAKRINLIV NMPTSKSDSF 

       190        200        210        220        230        240 
YIDLFTIKDL ENAYVLKQEN FENKNTGGFL PEDKNCKITL AKDRAYSSAY SLKVQPSQKT 

       250        260        270        280        290        300 
KNGKILFPIK GLLQKGGTYD FSLLVYQDSS KPVNFSAGIK LNDGKSTKEI VLAKQNVAPK 

       310        320        330        340        350        360 
KWTQLFATLD LDTRFSAKDV SFFVKPAAAI SYYLDLYSIS DENWGQPVPD YNLPSLCEKY 

       370        380        390        400        410        420 
KNYFKIGVAV PYRALTNPVD VEVIKRHFNS ITPENEMKPE SLQPYEGGFS FSIADEYVDF 

       430        440        450        460        470        480 
CKKDNISLRG HTLVWHQQTP SWFFTNPETG EKLTNSEKDK EILLDRLKKH IQTVVGRYKG 

       490        500        510        520        530        540 
KVYAWDVVNE AIDENQPDGY RRSDWYNILG PEYIEKAFIW AHEADPKAKL FYNDYSTEDP 

       550        560        570        580        590        600 
YKREFIYKLI KNLKAKGVPV HGVGLQCHIS LDWPDVSEIE ETVKLFSRIP GLEIHFTEID 

       610        620        630        640        650        660 
ISIAKNMTDD DAYNRYLLVQ QAQKLKAIFD VLKKYRNVVT SVTFWGLKDD YSWLRGDMPL 

       670        680 
LSDKDYQPKF AFWSLIDPSV VPKE 

« Hide

References

[1]"Cloning, sequencing and overexpression in Escherichia coli of a xylanase gene, xynA from the thermophilic bacterium Rt8B.4 genus Caldicellulosiruptor."
Dwivedi P.P., Gibbs M.D., Saul D.J., Bergquist P.L.
Appl. Microbiol. Biotechnol. 45:86-93(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L18965 Genomic DNA. Translation: AAB42044.1.
PIRS41788.

3D structure databases

ProteinModelPortalP40944.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyCBM22. Carbohydrate-Binding Module Family 22.
GH10. Glycoside Hydrolase Family 10.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00114.

Family and domain databases

Gene3D2.60.120.260. 2 hits.
3.20.20.80. 1 hit.
InterProIPR003305. CenC_carb-bd.
IPR008979. Galactose-bd-like.
IPR001000. Glyco_hydro_10.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF02018. CBM_4_9. 2 hits.
PF00331. Glyco_hydro_10. 1 hit.
[Graphical view]
PRINTSPR00134. GLHYDRLASE10.
SMARTSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMSSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEPS00591. GLYCOSYL_HYDROL_F10. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXYNA_CALSR
AccessionPrimary (citable) accession number: P40944
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 13, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries