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P40944

- XYNA_CALSR

UniProt

P40944 - XYNA_CALSR

Protein

Endo-1,4-beta-xylanase A

Gene

xynA

Organism
Caldicellulosiruptor sp. (strain Rt8B.4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei490 – 4901Proton donorBy similarity
    Active sitei598 – 5981NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. endo-1,4-beta-xylanase activity Source: UniProtKB-EC

    GO - Biological processi

    1. xylan catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

    Enzyme and pathway databases

    UniPathwayiUPA00114.

    Protein family/group databases

    CAZyiCBM22. Carbohydrate-Binding Module Family 22.
    GH10. Glycoside Hydrolase Family 10.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endo-1,4-beta-xylanase A (EC:3.2.1.8)
    Short name:
    Xylanase A
    Alternative name(s):
    1,4-beta-D-xylan xylanohydrolase A
    Gene namesi
    Name:xynA
    OrganismiCaldicellulosiruptor sp. (strain Rt8B.4)
    Taxonomic identifieri28238 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 684650Endo-1,4-beta-xylanase APRO_0000007981Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP40944.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 190151CBM-cenC 1Add
    BLAST
    Domaini193 – 342150CBM-cenC 2Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.60.120.260. 2 hits.
    3.20.20.80. 1 hit.
    InterProiIPR003305. CenC_carb-bd.
    IPR008979. Galactose-bd-like.
    IPR001000. Glyco_hydro_10.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF02018. CBM_4_9. 2 hits.
    PF00331. Glyco_hydro_10. 1 hit.
    [Graphical view]
    PRINTSiPR00134. GLHYDRLASE10.
    SMARTiSM00633. Glyco_10. 1 hit.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.
    PROSITEiPS00591. GLYCOSYL_HYDROL_F10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P40944-1 [UniParc]FASTAAdd to Basket

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    MMRSLKSRKL VFILAMLFLI NAIVSLKFIT YSSANQLASK SKYIEYNFEN    50
    KSVSPLAKYP SNVVLKVTNS TCAEGTFSVL VAGRKNANDG VIVDITKFLD 100
    FSREYEVSFY VLQTTKKLQR ISVTLEILDS NDKNQVIAAE KVLLPNIWTK 150
    VSAKVQASNY KKAKRINLIV NMPTSKSDSF YIDLFTIKDL ENAYVLKQEN 200
    FENKNTGGFL PEDKNCKITL AKDRAYSSAY SLKVQPSQKT KNGKILFPIK 250
    GLLQKGGTYD FSLLVYQDSS KPVNFSAGIK LNDGKSTKEI VLAKQNVAPK 300
    KWTQLFATLD LDTRFSAKDV SFFVKPAAAI SYYLDLYSIS DENWGQPVPD 350
    YNLPSLCEKY KNYFKIGVAV PYRALTNPVD VEVIKRHFNS ITPENEMKPE 400
    SLQPYEGGFS FSIADEYVDF CKKDNISLRG HTLVWHQQTP SWFFTNPETG 450
    EKLTNSEKDK EILLDRLKKH IQTVVGRYKG KVYAWDVVNE AIDENQPDGY 500
    RRSDWYNILG PEYIEKAFIW AHEADPKAKL FYNDYSTEDP YKREFIYKLI 550
    KNLKAKGVPV HGVGLQCHIS LDWPDVSEIE ETVKLFSRIP GLEIHFTEID 600
    ISIAKNMTDD DAYNRYLLVQ QAQKLKAIFD VLKKYRNVVT SVTFWGLKDD 650
    YSWLRGDMPL LSDKDYQPKF AFWSLIDPSV VPKE 684
    Length:684
    Mass (Da):78,354
    Last modified:February 1, 1995 - v1
    Checksum:i0AE575F4FB4BA5E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L18965 Genomic DNA. Translation: AAB42044.1.
    PIRiS41788.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L18965 Genomic DNA. Translation: AAB42044.1 .
    PIRi S41788.

    3D structure databases

    ProteinModelPortali P40944.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi CBM22. Carbohydrate-Binding Module Family 22.
    GH10. Glycoside Hydrolase Family 10.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00114 .

    Family and domain databases

    Gene3Di 2.60.120.260. 2 hits.
    3.20.20.80. 1 hit.
    InterProi IPR003305. CenC_carb-bd.
    IPR008979. Galactose-bd-like.
    IPR001000. Glyco_hydro_10.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF02018. CBM_4_9. 2 hits.
    PF00331. Glyco_hydro_10. 1 hit.
    [Graphical view ]
    PRINTSi PR00134. GLHYDRLASE10.
    SMARTi SM00633. Glyco_10. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.
    PROSITEi PS00591. GLYCOSYL_HYDROL_F10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing and overexpression in Escherichia coli of a xylanase gene, xynA from the thermophilic bacterium Rt8B.4 genus Caldicellulosiruptor."
      Dwivedi P.P., Gibbs M.D., Saul D.J., Bergquist P.L.
      Appl. Microbiol. Biotechnol. 45:86-93(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiXYNA_CALSR
    AccessioniPrimary (citable) accession number: P40944
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3