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P40943

- XYN1_GEOSE

UniProt

P40943 - XYN1_GEOSE

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Protein
Endo-1,4-beta-xylanase
Gene
N/A
Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei187 – 1871Proton donor By similarity
Active sitei293 – 2931Nucleophile By similarity

GO - Molecular functioni

  1. endo-1,4-beta-xylanase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. xylan catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

UniPathwayiUPA00114.

Protein family/group databases

CAZyiGH10. Glycoside Hydrolase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-1,4-beta-xylanase (EC:3.2.1.8)
Short name:
Xylanase
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 Publication
Add
BLAST
Chaini29 – 407379Endo-1,4-beta-xylanase
PRO_0000007968Add
BLAST

Expressioni

Inductioni

By xylose.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni34 – 363
Helixi42 – 443
Helixi48 – 525
Turni53 – 553
Beta strandi57 – 626
Helixi64 – 685
Helixi70 – 7910
Beta strandi81 – 877
Helixi91 – 944
Helixi104 – 11512
Beta strandi119 – 1235
Beta strandi128 – 1303
Helixi133 – 1364
Beta strandi141 – 1433
Helixi144 – 1463
Helixi150 – 17526
Turni176 – 1783
Beta strandi181 – 1877
Beta strandi193 – 1953
Helixi199 – 2046
Helixi207 – 22014
Beta strandi224 – 2318
Helixi238 – 25114
Beta strandi258 – 2614
Beta strandi267 – 2704
Helixi272 – 28413
Beta strandi288 – 2969
Beta strandi306 – 3083
Helixi309 – 3113
Helixi314 – 33320
Helixi335 – 3373
Beta strandi338 – 34710
Helixi352 – 3565
Beta strandi359 – 3613
Beta strandi376 – 3794
Beta strandi388 – 3903
Beta strandi394 – 3963
Helixi398 – 4047

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HIZX-ray2.40A29-407[»]
1R85X-ray1.45A29-407[»]
1R86X-ray1.80A29-407[»]
1R87X-ray1.67A29-407[»]
3MMDX-ray1.70A29-407[»]
ProteinModelPortaliP40943.
SMRiP40943. Positions 33-407.

Miscellaneous databases

EvolutionaryTraceiP40943.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001000. Glyco_hydro_10.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00331. Glyco_hydro_10. 1 hit.
[Graphical view]
PRINTSiPR00134. GLHYDRLASE10.
SMARTiSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00591. GLYCOSYL_HYDROL_F10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40943-1 [UniParc]FASTAAdd to Basket

« Hide

MRNVVRKPLT IGLALTLLLP MGMTATSAKN ADSYAKKPHI SALNAPQLDQ    50
RYKNEFTIGA AVEPYQLQNE KDVQMLKRHF NSIVAENVMK PISIQPEEGK 100
FNFEQADRIV KFAKANGMDI RFHTLVWHSQ VPQWFFLDKE GKPMVNETDP 150
VKREQNKQLL LKRLETHIKT IVERYKDDIK YWDVVNEVVG DDGKLRNSPW 200
YQIAGIDYIK VAFQAARKYG GDNIKLYMND YNTEVEPKRT ALYNLVKQLK 250
EEGVPIDGIG HQSHIQIGWP SEAEIEKTIN MFAALGLDNQ ITELDVSMYG 300
WPPRAYPTYD AIPKQKFLDQ AARYDRLFKL YEKLSDKISN VTFWGIADNH 350
TWLDSRADVY YDANGNVVVD PNAPYAKVEK GKGKDAPFVF GPDYKVKPAY 400
WAIIDHK 407
Length:407
Mass (Da):46,763
Last modified:February 1, 1995 - v1
Checksum:iAD385C90B252B82A
GO

Sequence cautioni

The sequence ABI49951.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ868502 Genomic DNA. Translation: ABI49951.1. Different initiation.
PIRiI40570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ868502 Genomic DNA. Translation: ABI49951.1 . Different initiation.
PIRi I40570.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1HIZ X-ray 2.40 A 29-407 [» ]
1R85 X-ray 1.45 A 29-407 [» ]
1R86 X-ray 1.80 A 29-407 [» ]
1R87 X-ray 1.67 A 29-407 [» ]
3MMD X-ray 1.70 A 29-407 [» ]
ProteinModelPortali P40943.
SMRi P40943. Positions 33-407.
ModBasei Search...

Protein family/group databases

CAZyi GH10. Glycoside Hydrolase Family 10.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00114 .

Miscellaneous databases

EvolutionaryTracei P40943.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001000. Glyco_hydro_10.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00331. Glyco_hydro_10. 1 hit.
[Graphical view ]
PRINTSi PR00134. GLHYDRLASE10.
SMARTi SM00633. Glyco_10. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00591. GLYCOSYL_HYDROL_F10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and DNA sequence of the gene coding for Bacillus stearothermophilus T-6 xylanase."
    Gat O., Lapidot A., Alchanati I., Regueros C., Shoham Y.
    Appl. Environ. Microbiol. 60:1889-1896(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: T-6 / NCIMB 40221.
  2. "Purification and characterization of a thermostable xylanase from Bacillus stearothermophilus T-6."
    Khasin A., Alchanati I., Shoham Y.
    Appl. Environ. Microbiol. 59:1725-1730(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-73.
    Strain: T-6.

Entry informationi

Entry nameiXYN1_GEOSE
AccessioniPrimary (citable) accession number: P40943
Secondary accession number(s): Q09LX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 13, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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