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Protein

Endo-1,4-beta-xylanase

Gene
N/A
Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

Pathwayi: xylan degradation

This protein is involved in the pathway xylan degradation, which is part of Glycan degradation.
View all proteins of this organism that are known to be involved in the pathway xylan degradation and in Glycan degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei187Proton donorBy similarity1
Active sitei293NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

UniPathwayiUPA00114.

Protein family/group databases

CAZyiGH10. Glycoside Hydrolase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-1,4-beta-xylanase (EC:3.2.1.8)
Short name:
Xylanase
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000000796829 – 407Endo-1,4-beta-xylanaseAdd BLAST379

Expressioni

Inductioni

By xylose.

Structurei

Secondary structure

1407
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni34 – 36Combined sources3
Helixi42 – 44Combined sources3
Helixi48 – 52Combined sources5
Turni53 – 55Combined sources3
Beta strandi57 – 62Combined sources6
Helixi64 – 68Combined sources5
Helixi70 – 79Combined sources10
Beta strandi81 – 87Combined sources7
Helixi91 – 94Combined sources4
Helixi104 – 115Combined sources12
Beta strandi119 – 123Combined sources5
Beta strandi128 – 130Combined sources3
Helixi133 – 136Combined sources4
Beta strandi141 – 143Combined sources3
Helixi144 – 146Combined sources3
Helixi150 – 175Combined sources26
Turni176 – 178Combined sources3
Beta strandi181 – 187Combined sources7
Beta strandi193 – 195Combined sources3
Helixi199 – 204Combined sources6
Helixi207 – 220Combined sources14
Beta strandi224 – 231Combined sources8
Helixi238 – 251Combined sources14
Beta strandi258 – 261Combined sources4
Beta strandi267 – 270Combined sources4
Helixi272 – 284Combined sources13
Beta strandi288 – 296Combined sources9
Beta strandi306 – 308Combined sources3
Helixi309 – 311Combined sources3
Helixi314 – 333Combined sources20
Helixi335 – 337Combined sources3
Beta strandi338 – 347Combined sources10
Helixi352 – 356Combined sources5
Beta strandi359 – 361Combined sources3
Beta strandi376 – 379Combined sources4
Beta strandi388 – 390Combined sources3
Beta strandi394 – 396Combined sources3
Helixi398 – 404Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HIZX-ray2.40A29-407[»]
1R85X-ray1.45A29-407[»]
1R86X-ray1.80A29-407[»]
1R87X-ray1.67A29-407[»]
3MMDX-ray1.70A29-407[»]
4PRWX-ray1.80A29-407[»]
4PUDX-ray2.01A37-407[»]
4PUEX-ray2.20A37-407[»]
ProteinModelPortaliP40943.
SMRiP40943.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40943.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 406GH10PROSITE-ProRule annotationAdd BLAST365

Sequence similaritiesi

Contains 1 GH10 (glycosyl hydrolase family 10) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001000. GH10.
IPR031158. GH10_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00331. Glyco_hydro_10. 1 hit.
[Graphical view]
PRINTSiPR00134. GLHYDRLASE10.
SMARTiSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00591. GH10_1. 1 hit.
PS51760. GH10_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNVVRKPLT IGLALTLLLP MGMTATSAKN ADSYAKKPHI SALNAPQLDQ
60 70 80 90 100
RYKNEFTIGA AVEPYQLQNE KDVQMLKRHF NSIVAENVMK PISIQPEEGK
110 120 130 140 150
FNFEQADRIV KFAKANGMDI RFHTLVWHSQ VPQWFFLDKE GKPMVNETDP
160 170 180 190 200
VKREQNKQLL LKRLETHIKT IVERYKDDIK YWDVVNEVVG DDGKLRNSPW
210 220 230 240 250
YQIAGIDYIK VAFQAARKYG GDNIKLYMND YNTEVEPKRT ALYNLVKQLK
260 270 280 290 300
EEGVPIDGIG HQSHIQIGWP SEAEIEKTIN MFAALGLDNQ ITELDVSMYG
310 320 330 340 350
WPPRAYPTYD AIPKQKFLDQ AARYDRLFKL YEKLSDKISN VTFWGIADNH
360 370 380 390 400
TWLDSRADVY YDANGNVVVD PNAPYAKVEK GKGKDAPFVF GPDYKVKPAY

WAIIDHK
Length:407
Mass (Da):46,763
Last modified:February 1, 1995 - v1
Checksum:iAD385C90B252B82A
GO

Sequence cautioni

The sequence ABI49951 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ868502 Genomic DNA. Translation: ABI49951.1. Different initiation.
PIRiI40570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ868502 Genomic DNA. Translation: ABI49951.1. Different initiation.
PIRiI40570.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HIZX-ray2.40A29-407[»]
1R85X-ray1.45A29-407[»]
1R86X-ray1.80A29-407[»]
1R87X-ray1.67A29-407[»]
3MMDX-ray1.70A29-407[»]
4PRWX-ray1.80A29-407[»]
4PUDX-ray2.01A37-407[»]
4PUEX-ray2.20A37-407[»]
ProteinModelPortaliP40943.
SMRiP40943.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH10. Glycoside Hydrolase Family 10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00114.

Miscellaneous databases

EvolutionaryTraceiP40943.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001000. GH10.
IPR031158. GH10_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00331. Glyco_hydro_10. 1 hit.
[Graphical view]
PRINTSiPR00134. GLHYDRLASE10.
SMARTiSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00591. GH10_1. 1 hit.
PS51760. GH10_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYN1_GEOSE
AccessioniPrimary (citable) accession number: P40943
Secondary accession number(s): Q09LX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.