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Protein

ADP,ATP carrier protein 2, mitochondrial

Gene

AAC2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei157NucleotideBy similarity1

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: TAIR
  • copper ion binding Source: TAIR

GO - Biological processi

  • purine nucleotide transport Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-ATH-422356. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 2, mitochondrial
Alternative name(s):
ADP/ATP translocase 2
Adenine nucleotide translocator 2
Short name:
ANT 2
Gene namesi
Name:AAC2
Synonyms:ANT2
Ordered Locus Names:At5g13490
ORF Names:T6I14_20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G13490.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei81 – 115Helical; Name=1By similarityAdd BLAST35
Transmembranei152 – 176Helical; Name=2By similarityAdd BLAST25
Transmembranei185 – 219Helical; Name=3By similarityAdd BLAST35
Transmembranei255 – 282Helical; Name=4By similarityAdd BLAST28
Transmembranei287 – 321Helical; Name=5By similarityAdd BLAST35
Transmembranei350 – 375Helical; Name=6By similarityAdd BLAST26

GO - Cellular componenti

  • chloroplast Source: TAIR
  • chloroplast envelope Source: TAIR
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: TAIR
  • mitochondrial envelope Source: TAIR
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: TAIR
  • vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 74MitochondrionSequence analysisAdd BLAST74
ChainiPRO_000001924675 – 385ADP,ATP carrier protein 2, mitochondrialAdd BLAST311

Proteomic databases

PaxDbiP40941.
PRIDEiP40941.

PTM databases

SwissPalmiP40941.

Expressioni

Gene expression databases

ExpressionAtlasiP40941. baseline and differential.
GenevisibleiP40941. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi16471. 6 interactors.
IntActiP40941. 2 interactors.
STRINGi3702.AT5G13490.1.

Structurei

3D structure databases

ProteinModelPortaliP40941.
SMRiP40941.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati82 – 175Solcar 1Add BLAST94
Repeati187 – 280Solcar 2Add BLAST94
Repeati288 – 374Solcar 3Add BLAST87

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi315 – 320Substrate recognitionBy similarity6

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
HOGENOMiHOG000165727.
InParanoidiP40941.
KOiK05863.
OMAiSTLHCWA.
OrthoDBiEOG09360DZB.
PhylomeDBiP40941.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEQTQHPTI LQKVSGQLLS SSVSQDIRGY ASASKRPATY QKHAAYGNYS
60 70 80 90 100
NAAFQYPLVA ASQIATTTSP VFVQAPGEKG FTNFAIDFMM GGVSAAVSKT
110 120 130 140 150
AAAPIERVKL LIQNQDEMLK AGRLTEPYKG IRDCFGRTIR DEGIGSLWRG
160 170 180 190 200
NTANVIRYFP TQALNFAFKD YFKRLFNFKK DKDGYWKWFA GNLASGGAAG
210 220 230 240 250
ASSLLFVYSL DYARTRLAND SKSAKKGGGE RQFNGLVDVY KKTLKSDGIA
260 270 280 290 300
GLYRGFNISC AGIIVYRGLY FGLYDSVKPV LLTGDLQDSF FASFALGWLI
310 320 330 340 350
TNGAGLASYP IDTVRRRMMM TSGEAVKYKS SFDAFSQIVK KEGAKSLFKG
360 370 380
AGANILRAVA GAGVLAGYDK LQLIVFGKKY GSGGA
Length:385
Mass (Da):41,746
Last modified:June 6, 2002 - v2
Checksum:i87ADF762213207BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228G → R in CAA48579 (PubMed:8439563).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68592 mRNA. Translation: CAA48579.1.
AL391710 Genomic DNA. Translation: CAC05426.1.
CP002688 Genomic DNA. Translation: AED91901.1.
CP002688 Genomic DNA. Translation: AED91902.1.
AY050857 mRNA. Translation: AAK92794.1.
AY079407 mRNA. Translation: AAL85138.1.
PIRiS29852.
RefSeqiNP_001031876.1. NM_001036799.2.
NP_196853.1. NM_121352.4.
UniGeneiAt.127.

Genome annotation databases

EnsemblPlantsiAT5G13490.1; AT5G13490.1; AT5G13490.
AT5G13490.2; AT5G13490.2; AT5G13490.
GeneIDi831193.
GrameneiAT5G13490.1; AT5G13490.1; AT5G13490.
AT5G13490.2; AT5G13490.2; AT5G13490.
KEGGiath:AT5G13490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68592 mRNA. Translation: CAA48579.1.
AL391710 Genomic DNA. Translation: CAC05426.1.
CP002688 Genomic DNA. Translation: AED91901.1.
CP002688 Genomic DNA. Translation: AED91902.1.
AY050857 mRNA. Translation: AAK92794.1.
AY079407 mRNA. Translation: AAL85138.1.
PIRiS29852.
RefSeqiNP_001031876.1. NM_001036799.2.
NP_196853.1. NM_121352.4.
UniGeneiAt.127.

3D structure databases

ProteinModelPortaliP40941.
SMRiP40941.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16471. 6 interactors.
IntActiP40941. 2 interactors.
STRINGi3702.AT5G13490.1.

PTM databases

SwissPalmiP40941.

Proteomic databases

PaxDbiP40941.
PRIDEiP40941.

Protocols and materials databases

DNASUi831193.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G13490.1; AT5G13490.1; AT5G13490.
AT5G13490.2; AT5G13490.2; AT5G13490.
GeneIDi831193.
GrameneiAT5G13490.1; AT5G13490.1; AT5G13490.
AT5G13490.2; AT5G13490.2; AT5G13490.
KEGGiath:AT5G13490.

Organism-specific databases

TAIRiAT5G13490.

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
HOGENOMiHOG000165727.
InParanoidiP40941.
KOiK05863.
OMAiSTLHCWA.
OrthoDBiEOG09360DZB.
PhylomeDBiP40941.

Enzyme and pathway databases

ReactomeiR-ATH-422356. Regulation of insulin secretion.

Miscellaneous databases

PROiP40941.

Gene expression databases

ExpressionAtlasiP40941. baseline and differential.
GenevisibleiP40941. AT.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADT2_ARATH
AccessioniPrimary (citable) accession number: P40941
Secondary accession number(s): Q9FY52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 6, 2002
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.