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P40915

- NDUV2_NEUCR

UniProt

P40915 - NDUV2_NEUCR

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Protein

NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial

Gene
nuo-24, 123A4.080, NCU01169
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

Binds 1 2Fe-2S cluster Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi143 – 1431Iron-sulfur (2Fe-2S) Reviewed prediction
Metal bindingi148 – 1481Iron-sulfur (2Fe-2S) Reviewed prediction
Metal bindingi186 – 1861Iron-sulfur (2Fe-2S) Reviewed prediction
Metal bindingi190 – 1901Iron-sulfur (2Fe-2S) Reviewed prediction

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. electron carrier activity Source: RefGenome
  3. metal ion binding Source: UniProtKB-KW
  4. NADH dehydrogenase (ubiquinone) activity Source: RefGenome

GO - Biological processi

  1. mitochondrial electron transport, NADH to ubiquinone Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Protein family/group databases

TCDBi3.D.1.6.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Gene namesi
Name:nuo-24
ORF Names:123A4.080, NCU01169
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 2, Linkage Group V

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial respiratory chain complex I Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4242Mitochondrion Reviewed predictionAdd
BLAST
Chaini43 – 263221NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrialPRO_0000020008Add
BLAST

Interactioni

Subunit structurei

Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

Protein-protein interaction databases

STRINGi5141.NCU01169.1.

Structurei

3D structure databases

ProteinModelPortaliP40915.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1905.
HOGENOMiHOG000257748.
KOiK03943.
OMAiVHRDTPY.
OrthoDBiEOG76HQC0.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR10371. PTHR10371. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01958. nuoE_fam. 1 hit.
PROSITEiPS01099. COMPLEX1_24K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40915-1 [UniParc]FASTAAdd to Basket

« Hide

MATKLTPFLM RTAVRAATRL STKPSTIAPV SRACLSISAR RPSDTLMVHR    50
NTPDNNPDIP FKFSADNEKV IEEIIKRYPP QYKKAAVMPL LDLGQRQHGF 100
CSISVMNEVA RLLEMPPMRV YEVASFYTMY NRTPVGKFHV QACTTTPCQL 150
GGCGSDVIVK AIKEHLGIKQ GETTPDGLFT FIEVECLGAC ANAPMVQIND 200
DYFEDLTPET IKQVLSALKE SVTDVSKAPQ PGPQSGRQTC ENAAGLTSLT 250
SEPYGPEVTR SDL 263
Length:263
Mass (Da):28,842
Last modified:February 1, 1995 - v1
Checksum:i8B06FB7DEADDA819
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78083 mRNA. Translation: CAA54990.1.
AL670009 Genomic DNA. Translation: CAD21361.1.
CM002240 Genomic DNA. Translation: EAA32299.1.
RefSeqiXP_961535.1. XM_956442.1.

Genome annotation databases

EnsemblFungiiEFNCRT00000004361; EFNCRP00000004361; EFNCRG00000004355.
GeneIDi3877731.
KEGGincr:NCU01169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78083 mRNA. Translation: CAA54990.1 .
AL670009 Genomic DNA. Translation: CAD21361.1 .
CM002240 Genomic DNA. Translation: EAA32299.1 .
RefSeqi XP_961535.1. XM_956442.1.

3D structure databases

ProteinModelPortali P40915.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU01169.1.

Protein family/group databases

TCDBi 3.D.1.6.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000004361 ; EFNCRP00000004361 ; EFNCRG00000004355 .
GeneIDi 3877731.
KEGGi ncr:NCU01169.

Phylogenomic databases

eggNOGi COG1905.
HOGENOMi HOG000257748.
KOi K03943.
OMAi VHRDTPY.
OrthoDBi EOG76HQC0.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR10371. PTHR10371. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01958. nuoE_fam. 1 hit.
PROSITEi PS01099. COMPLEX1_24K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complementary DNA sequences of the 24 kDa and 21 kDa subunits of complex I from Neurospora."
    Azevedo J.E., Duarte M., Belo J.A., Werner S., Videira A.
    Biochim. Biophys. Acta 1188:159-161(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  3. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiNDUV2_NEUCR
AccessioniPrimary (citable) accession number: P40915
Secondary accession number(s): Q7RVE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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