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P40915 (NDUV2_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Gene names
Name:nuo-24
ORF Names:123A4.080, NCU01169
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

NADH + acceptor = NAD+ + reduced acceptor.

Cofactor

Binds 1 2Fe-2S cluster Potential.

Subunit structure

Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the complex I 24 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4242Mitochondrion Potential
Chain43 – 263221NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial
PRO_0000020008

Sites

Metal binding1431Iron-sulfur (2Fe-2S) Potential
Metal binding1481Iron-sulfur (2Fe-2S) Potential
Metal binding1861Iron-sulfur (2Fe-2S) Potential
Metal binding1901Iron-sulfur (2Fe-2S) Potential

Sequences

Sequence LengthMass (Da)Tools
P40915 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 8B06FB7DEADDA819

FASTA26328,842
        10         20         30         40         50         60 
MATKLTPFLM RTAVRAATRL STKPSTIAPV SRACLSISAR RPSDTLMVHR NTPDNNPDIP 

        70         80         90        100        110        120 
FKFSADNEKV IEEIIKRYPP QYKKAAVMPL LDLGQRQHGF CSISVMNEVA RLLEMPPMRV 

       130        140        150        160        170        180 
YEVASFYTMY NRTPVGKFHV QACTTTPCQL GGCGSDVIVK AIKEHLGIKQ GETTPDGLFT 

       190        200        210        220        230        240 
FIEVECLGAC ANAPMVQIND DYFEDLTPET IKQVLSALKE SVTDVSKAPQ PGPQSGRQTC 

       250        260 
ENAAGLTSLT SEPYGPEVTR SDL 

« Hide

References

« Hide 'large scale' references
[1]"Complementary DNA sequences of the 24 kDa and 21 kDa subunits of complex I from Neurospora."
Azevedo J.E., Duarte M., Belo J.A., Werner S., Videira A.
Biochim. Biophys. Acta 1188:159-161(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78083 mRNA. Translation: CAA54990.1.
AL670009 Genomic DNA. Translation: CAD21361.1.
CM002240 Genomic DNA. Translation: EAA32299.1.
RefSeqXP_961535.1. XM_956442.1.

3D structure databases

ProteinModelPortalP40915.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU01169.1.

Protein family/group databases

TCDB3.D.1.6.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000004361; EFNCRP00000004361; EFNCRG00000004355.
GeneID3877731.
KEGGncr:NCU01169.

Phylogenomic databases

eggNOGCOG1905.
HOGENOMHOG000257748.
KOK03943.
OMAVHRDTPY.
OrthoDBEOG76HQC0.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR10371. PTHR10371. 1 hit.
SUPFAMSSF52833. SSF52833. 1 hit.
TIGRFAMsTIGR01958. nuoE_fam. 1 hit.
PROSITEPS01099. COMPLEX1_24K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUV2_NEUCR
AccessionPrimary (citable) accession number: P40915
Secondary accession number(s): Q7RVE3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families