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Protein

NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial

Gene

nuo-24

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

[2Fe-2S] clusterCuratedNote: Binds 1 [2Fe-2S] cluster.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi143Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi148Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi186Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi190Iron-sulfur (2Fe-2S)Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Protein family/group databases

TCDBi3.D.1.6.2 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Gene namesi
Name:nuo-24
ORF Names:123A4.080, NCU01169
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 2, Linkage Group V

Organism-specific databases

EuPathDBiFungiDB:NCU01169

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42MitochondrionSequence analysisAdd BLAST42
ChainiPRO_000002000843 – 263NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrialAdd BLAST221

Interactioni

Subunit structurei

Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

Structurei

3D structure databases

ProteinModelPortaliP40915
SMRiP40915
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 24 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000257748
InParanoidiP40915
KOiK03943
OMAiNLTSEPW
OrthoDBiEOG092C3YM5

Family and domain databases

CDDicd03064 TRX_Fd_NuoE, 1 hit
InterProiView protein in InterPro
IPR002023 NuoE-like
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR10371 PTHR10371, 1 hit
PIRSFiPIRSF000216 NADH_DH_24kDa, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR01958 nuoE_fam, 1 hit
PROSITEiView protein in PROSITE
PS01099 COMPLEX1_24K, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKLTPFLM RTAVRAATRL STKPSTIAPV SRACLSISAR RPSDTLMVHR
60 70 80 90 100
NTPDNNPDIP FKFSADNEKV IEEIIKRYPP QYKKAAVMPL LDLGQRQHGF
110 120 130 140 150
CSISVMNEVA RLLEMPPMRV YEVASFYTMY NRTPVGKFHV QACTTTPCQL
160 170 180 190 200
GGCGSDVIVK AIKEHLGIKQ GETTPDGLFT FIEVECLGAC ANAPMVQIND
210 220 230 240 250
DYFEDLTPET IKQVLSALKE SVTDVSKAPQ PGPQSGRQTC ENAAGLTSLT
260
SEPYGPEVTR SDL
Length:263
Mass (Da):28,842
Last modified:February 1, 1995 - v1
Checksum:i8B06FB7DEADDA819
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78083 mRNA Translation: CAA54990.1
AL670009 Genomic DNA Translation: CAD21361.1
CM002240 Genomic DNA Translation: EAA32299.1
RefSeqiXP_961535.1, XM_956442.2

Genome annotation databases

EnsemblFungiiEAA32299; EAA32299; NCU01169
GeneIDi3877731
KEGGincr:NCU01169

Similar proteinsi

Entry informationi

Entry nameiNDUV2_NEUCR
AccessioniPrimary (citable) accession number: P40915
Secondary accession number(s): Q7RVE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome