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P40915

- NDUV2_NEUCR

UniProt

P40915 - NDUV2_NEUCR

Protein

NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial

Gene

nuo-24

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    Cofactori

    Binds 1 2Fe-2S cluster.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi143 – 1431Iron-sulfur (2Fe-2S)Sequence Analysis
    Metal bindingi148 – 1481Iron-sulfur (2Fe-2S)Sequence Analysis
    Metal bindingi186 – 1861Iron-sulfur (2Fe-2S)Sequence Analysis
    Metal bindingi190 – 1901Iron-sulfur (2Fe-2S)Sequence Analysis

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. electron carrier activity Source: RefGenome
    3. metal ion binding Source: UniProtKB-KW
    4. NADH dehydrogenase (ubiquinone) activity Source: RefGenome

    GO - Biological processi

    1. mitochondrial electron transport, NADH to ubiquinone Source: RefGenome

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Protein family/group databases

    TCDBi3.D.1.6.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Gene namesi
    Name:nuo-24
    ORF Names:123A4.080, NCU01169
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 2, Linkage Group V

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex I Source: RefGenome

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4242MitochondrionSequence AnalysisAdd
    BLAST
    Chaini43 – 263221NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrialPRO_0000020008Add
    BLAST

    Interactioni

    Subunit structurei

    Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

    Protein-protein interaction databases

    STRINGi5141.NCU01169.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP40915.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 24 kDa subunit family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1905.
    HOGENOMiHOG000257748.
    KOiK03943.
    OMAiVHRDTPY.
    OrthoDBiEOG76HQC0.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR002023. NuoE-like.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR10371. PTHR10371. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR01958. nuoE_fam. 1 hit.
    PROSITEiPS01099. COMPLEX1_24K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P40915-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATKLTPFLM RTAVRAATRL STKPSTIAPV SRACLSISAR RPSDTLMVHR    50
    NTPDNNPDIP FKFSADNEKV IEEIIKRYPP QYKKAAVMPL LDLGQRQHGF 100
    CSISVMNEVA RLLEMPPMRV YEVASFYTMY NRTPVGKFHV QACTTTPCQL 150
    GGCGSDVIVK AIKEHLGIKQ GETTPDGLFT FIEVECLGAC ANAPMVQIND 200
    DYFEDLTPET IKQVLSALKE SVTDVSKAPQ PGPQSGRQTC ENAAGLTSLT 250
    SEPYGPEVTR SDL 263
    Length:263
    Mass (Da):28,842
    Last modified:February 1, 1995 - v1
    Checksum:i8B06FB7DEADDA819
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78083 mRNA. Translation: CAA54990.1.
    AL670009 Genomic DNA. Translation: CAD21361.1.
    CM002240 Genomic DNA. Translation: EAA32299.1.
    RefSeqiXP_961535.1. XM_956442.1.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000004361; EFNCRP00000004361; EFNCRG00000004355.
    GeneIDi3877731.
    KEGGincr:NCU01169.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78083 mRNA. Translation: CAA54990.1 .
    AL670009 Genomic DNA. Translation: CAD21361.1 .
    CM002240 Genomic DNA. Translation: EAA32299.1 .
    RefSeqi XP_961535.1. XM_956442.1.

    3D structure databases

    ProteinModelPortali P40915.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU01169.1.

    Protein family/group databases

    TCDBi 3.D.1.6.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000004361 ; EFNCRP00000004361 ; EFNCRG00000004355 .
    GeneIDi 3877731.
    KEGGi ncr:NCU01169.

    Phylogenomic databases

    eggNOGi COG1905.
    HOGENOMi HOG000257748.
    KOi K03943.
    OMAi VHRDTPY.
    OrthoDBi EOG76HQC0.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR002023. NuoE-like.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR10371. PTHR10371. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR01958. nuoE_fam. 1 hit.
    PROSITEi PS01099. COMPLEX1_24K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complementary DNA sequences of the 24 kDa and 21 kDa subunits of complex I from Neurospora."
      Azevedo J.E., Duarte M., Belo J.A., Werner S., Videira A.
      Biochim. Biophys. Acta 1188:159-161(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
      Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
      Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    3. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiNDUV2_NEUCR
    AccessioniPrimary (citable) accession number: P40915
    Secondary accession number(s): Q7RVE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3