Reviewed, UniProtKB/Swiss-Prot P40908 (GAL7_CRYNE)

Names and origin

Protein names

Recommended name:
    Galactose-1-phosphate uridylyltransferase
      Short name=Gal-1-P uridylyltransferase
    EC=2.7.7.12
Alternative name(s):
    UDP-glucose--hexose-1-phosphate uridylyltransferase

Gene names

Name:	GAL7
Ordered Locus Names:	CNM00620, CNBM0540

Organism

Cryptococcus neoformans (Filobasidiella neoformans) [Complete proteome]

Taxonomic identifier

5207 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Tremellaceae › Filobasidiella › Filobasidiella/Cryptococcus neoformans species complex

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Pathway	Carbohydrate metabolism; galactose metabolism.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Ligand	Iron Metal-binding Zinc
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	Galactose-1-phosphate uridylyltransferase		PRO_0000169888
Sites
	Active site	188	1	Tele-UMP-histidine intermediate By similarity
	Metal binding	65	1	Zinc By similarity
	Metal binding	68	1	Zinc By similarity
	Metal binding	131	1	Zinc By similarity
	Metal binding	186	1	Zinc By similarity
	Metal binding	204	1	Iron By similarity
	Metal binding	306	1	Iron By similarity
	Metal binding	323	1	Iron By similarity
	Metal binding	325	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	P40908-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 49119349C24A4463	FASTA	381	43,032
	10 20 30 40 50 60 MTATHTHSNG SNDFTPVSIN DHVHRRFNPL LGKHVLVSPH RSLRPWNGQK ETPAIPVETP 70 80 90 100 110 120 HDSKCYLCPG NKRTTGQHNP DYKGIYVFEN DFPALLPDPL AVGTNKISDD PLFQSEPVRG 130 140 150 160 170 180 RCKVICFHPR HDLTMAAMRI SEINHVLDGW KDVYAEEGKI MQEESSDGCV QIFENRGAMM 190 200 210 220 230 240 GCSAPHPHGQ VWTTSFVPDE PATEIENFVR YASGRSGSHM LLDYALREVK ARERVVTLHE 250 260 270 280 290 300 SGWVAVVPYW AAWPFEILLM PYKRHIPSIL QLTAEEQTGL ATILKDVLSR YDNLFSCPFP 310 320 330 340 350 360 YSMGLHQSPL PPTDPTSNSA QVHFHFYPPL LRSATVRKFM VGFELLGEAQ RDIVPEQAAV 370 380 RLRESLPHKR ATLSNDKPYN P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Cryptococcus neoformans GAL7 gene and its use as an inducible promoter." Wickes B.L., Edman J.C. Mol. Microbiol. 16:1099-1109(1995) [PubMed: 8577246] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans." Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S. , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W. Science 307:1321-1324(2005) [PubMed: 15653466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B-3501A and JEC21.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U16994 Genomic DNA. Translation: AAA92683.1. AE017353 Genomic DNA. Translation: AAW46832.1. AAEY01000061 Genomic DNA. Translation: EAL17574.1.
PIR	S69795.
RefSeq	XP_568349.1. XP_772221.1.
UniGene	Fne.7433
3D structure databases
SMR	P40908. Positions 17-369.
ModBase	Search...
Protein-protein interaction databases
STRING	P40908.
Genome annotation databases
GeneID	3255268. 4939414.
GenomeReviews	Gene locus CNM00620 in contig AE017353_GR.
KEGG	cnb:CNBM0540. cne:CNM00620.
Phylogenomic databases
eggNOG	fuNOG06817.
HOGENOM	HBG600409.
OMA	HRRLNPL.
OrthoDB	EOG9Q2FXT.
PhylomeDB	P40908.
Enzyme and pathway databases
BRENDA	2.7.7.12. 2772.
Family and domain databases
InterPro	IPR001937. GalP_UDPtransf1. IPR019779. GalP_UDPtransf1_His-AS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. IPR011146. His_triad-like_motif. IPR011151. His_triad_motif. [Graphical view]
Gene3D	G3DSA:3.30.428.10. His_triad_motif. 2 hits.
PANTHER	PTHR11943. GalP_UDPtransf1. 1 hit.
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000808. GalT. 1 hit.
TIGRFAMs	TIGR00209. galT_1. 1 hit.
PROSITE	PS00117. GAL_P_UDP_TRANSF_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL7_CRYNE

Accession

Primary (citable) accession number: P40908
Secondary accession number(s): Q55IG6, Q5K807

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	February 9, 2010
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)