Reviewed,
UniProtKB/Swiss-Prot P40908 (GAL7_CRYNE)
Last modified
February 9, 2010.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Galactose-1-phosphate uridylyltransferase Short name=Gal-1-P uridylyltransferase EC=2.7.7.12 Alternative name(s): UDP-glucose--hexose-1-phosphate uridylyltransferase | ||||
| Gene names |
| ||||
| Organism | Cryptococcus neoformans (Filobasidiella neoformans) [Complete proteome] | ||||
| Taxonomic identifier | 5207 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Tremellaceae › Filobasidiella › Filobasidiella/Cryptococcus neoformans species complex |
Protein attributes
| Sequence length | 381 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose. |
| Cofactor | Binds 1 iron ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity. |
| Pathway | |
| Sequence similarities | Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carbohydrate metabolism Galactose metabolism |
| Ligand | Iron Metal-binding Zinc |
| Molecular function | Nucleotidyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 381 | 381 | Galactose-1-phosphate uridylyltransferase | PRO_0000169888 | |||||
Sites | |||||||||
| Active site | 188 | 1 | Tele-UMP-histidine intermediate By similarity | ||||||
| Metal binding | 65 | 1 | Zinc By similarity | ||||||
| Metal binding | 68 | 1 | Zinc By similarity | ||||||
| Metal binding | 131 | 1 | Zinc By similarity | ||||||
| Metal binding | 186 | 1 | Zinc By similarity | ||||||
| Metal binding | 204 | 1 | Iron By similarity | ||||||
| Metal binding | 306 | 1 | Iron By similarity | ||||||
| Metal binding | 323 | 1 | Iron By similarity | ||||||
| Metal binding | 325 | 1 | Iron By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The Cryptococcus neoformans GAL7 gene and its use as an inducible promoter." Wickes B.L., Edman J.C. Mol. Microbiol. 16:1099-1109(1995) [PubMed: 8577246] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans." Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S. Hyman R.W.Science 307:1321-1324(2005) [PubMed: 15653466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B-3501A and JEC21. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U16994 Genomic DNA. Translation: AAA92683.1. AE017353 Genomic DNA. Translation: AAW46832.1. AAEY01000061 Genomic DNA. Translation: EAL17574.1. |
| PIR | S69795. |
| RefSeq | XP_568349.1. XP_772221.1. |
| UniGene | Fne.7433 |
3D structure databases | |
| SMR | P40908. Positions 17-369. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P40908. |
Genome annotation databases | |
| GeneID | 3255268. 4939414. |
| GenomeReviews | Gene locus CNM00620 in contig AE017353_GR. |
| KEGG | cnb:CNBM0540. cne:CNM00620. |
Phylogenomic databases | |
| eggNOG | fuNOG06817. |
| HOGENOM | HBG600409. |
| OMA | HRRLNPL. |
| OrthoDB | EOG9Q2FXT. |
| PhylomeDB | P40908. |
Enzyme and pathway databases | |
| BRENDA | 2.7.7.12. 2772. |
Family and domain databases | |
| InterPro | IPR001937. GalP_UDPtransf1. IPR019779. GalP_UDPtransf1_His-AS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. IPR011146. His_triad-like_motif. IPR011151. His_triad_motif. [Graphical view] |
| Gene3D | G3DSA:3.30.428.10. His_triad_motif. 2 hits. |
| PANTHER | PTHR11943. GalP_UDPtransf1. 1 hit. |
| Pfam | PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view] |
| PIRSF | PIRSF000808. GalT. 1 hit. |
| TIGRFAMs | TIGR00209. galT_1. 1 hit. |
| PROSITE | PS00117. GAL_P_UDP_TRANSF_I. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GAL7_CRYNE | ||||||||
| Accession | Primary (citable) accession number: P40908 Secondary accession number(s): Q55IG6, Q5K807 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


