P40906 (ARGI_COCP7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginase
EC=3.5.3.1

Gene names

Name:	ARG
ORF Names:	CPC735_005980

Organism

Coccidioides posadasii (strain C735) (Valley fever fungus) [Complete proteome]

Taxonomic identifier

222929 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-arginine + H2O = L-ornithine + urea.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Pathway	Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
Subunit structure	Homotrimer By similarity.
Sequence similarities	Belongs to the arginase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arginase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Arginase		PRO_0000173707
Regions
	Region	143 – 147	5	Substrate binding By similarity
	Region	154 – 156	3	Substrate binding By similarity
Sites
	Metal binding	113	1	Manganese 1 By similarity
	Metal binding	141	1	Manganese 1 By similarity
	Metal binding	141	1	Manganese 2 By similarity
	Metal binding	143	1	Manganese 2 By similarity
	Metal binding	145	1	Manganese 1 By similarity
	Metal binding	247	1	Manganese 1 By similarity
	Metal binding	247	1	Manganese 2 By similarity
	Metal binding	249	1	Manganese 2 By similarity
	Binding site	200	1	Substrate By similarity
	Binding site	292	1	Substrate By similarity
Experimental info
	Sequence conflict	153	1	D → V in AAA65960. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P40906 [UniParc]. Last modified November 3, 2009. Version 2. Checksum: D382603CC361F19A	FASTA	322	35,142
	10 20 30 40 50 60 MTSPSTIKQK FIAKGHQLGV VAVGFSDGQP NQGVDPSGLI EAGLLDQLRD DLEYDIRHDG 70 80 90 100 110 120 QVHTYAEFVP EHDPNHRGMK KPRTVSAATQ QLSRQVYEHA REGRLVLTLG GDHSIAIGTI 130 140 150 160 170 180 SGTAKAIRER LGREMAVIWV DAHADINRPE DSDSGNIHGM PLAFLTGLAK DDNEDMFGWL 190 200 210 220 230 240 QPDNLISPRK LVYIGLRDVD RAEKRLLREH GIKAFSMHDI DKYGIGRVVE MALAHIGQDT 250 260 270 280 290 300 PIHLSFDVDA LDPQWAPSTG TPVRGGLTLR EGDFIAESIH ETGSLVAMDL VEVNPTLETL 310 320 GASETIRAGC SLVRSALGDT LL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of the arginase-encoding gene (arg) from Coccidioides immitis." Pan S., Zhang M., Cole G.T. Gene 154:115-118(1995) [PubMed: 7867937] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C735.
[2]	"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W. Genome Res. 19:1722-1731(2009) [PubMed: 19717792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C735.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L36550 Genomic DNA. Translation: AAA65960.1. ACFW01000030 Genomic DNA. Translation: EER26426.1.
PIR	JC4033.
RefSeq	XP_003068571.1. XM_003068525.1.
3D structure databases
ProteinModelPortal	P40906.
ModBase	Search...
Protein-protein interaction databases
STRING	P40906.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9694054.
KEGG	cpw:CPC735_005980.
Family and domain databases
InterPro	IPR014033. Arginase_subgr. IPR006035. Ureohydrolase. IPR023696. Ureohydrolase_domain. IPR020855. Ureohydrolase_Mn_BS. [Graphical view]
Gene3D	G3DSA:3.40.800.10. Ureohydrolase. 1 hit.
KO	K01476.
PANTHER	PTHR11358:SF2. Arginase_sub. 1 hit. PTHR11358. Ureohydrolase. 1 hit.
Pfam	PF00491. Arginase. 1 hit. [Graphical view]
PIRSF	PIRSF036979. Arginase. 1 hit.
PRINTS	PR00116. ARGINASE.
TIGRFAMs	TIGR01229. RocF_arginase. 1 hit.
PROSITE	PS01053. ARGINASE_1. 1 hit. PS51409. ARGINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGI_COCP7

Accession

Primary (citable) accession number: P40906
Secondary accession number(s): C5P9L4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	November 3, 2009
Last modified:	November 16, 2011
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program