Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P40890 (VTH2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
VPS10 homolog 2
Alternative name(s):
Sortilin VTH2
Gene names
Name:VTH2
Ordered Locus Names:YJL222W
ORF Names:HRC1549, J0213
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length1549 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Ref.4 Ref.5

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Miscellaneous

Present with 279 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the VPS10-related sortilin family.

Contains 12 BNR repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 15491528VPS10 homolog 2
PRO_0000014331

Regions

Topological domain22 – 13691348Lumenal Potential
Transmembrane1370 – 139021Helical; Potential
Topological domain1391 – 1549159Cytoplasmic Potential
Repeat57 – 6812BNR 1
Repeat101 – 11212BNR 2
Repeat159 – 17012BNR 3
Repeat228 – 23912BNR 4
Repeat393 – 40412BNR 5
Repeat465 – 47612BNR 6
Repeat511 – 52212BNR 7
Repeat740 – 75112BNR 8
Repeat837 – 84812BNR 9
Repeat1040 – 105112BNR 10
Repeat1119 – 113012BNR 11
Repeat1160 – 117112BNR 12

Amino acid modifications

Glycosylation4791N-linked (GlcNAc...) Potential
Glycosylation7691N-linked (GlcNAc...) Potential
Glycosylation9861N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P40890 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: B260CF7C927B4E4F

FASTA1,549174,402
        10         20         30         40         50         60 
MALFRALYII WVFLLIPLSN AEEFTPKVTR TLSRYVFDIV NFDDSNTLIR AEEDSVEISF 

        70         80         90        100        110        120 
DAGENWKTID EIEEPIESFV VDPFRGHDRA FAFVKTAPKF YVTDDQGKSW RPLTIPISEK 

       130        140        150        160        170        180 
ASNYFCDVTT HPIKKKHLII RCDLLTIKNS GLMYVGREIY TTNDGVSFSQ VKPSFGKIDG 

       190        200        210        220        230        240 
HISTARCDFI KSSEDSDLGG NDASILCLFR NTEYIESTGS TIDKSELILS ADGGETFKEL 

       250        260        270        280        290        300 
VQFKDKVVSR YEILKHHVIV LTQDDMYNEM SSTNIWISND VSTFQVARTP TKIRHVNMGQ 

       310        320        330        340        350        360 
IHEDSIGRIV LPVSRERDDE DSNQPGAAEV LISDSEGLKF LPINWIPNNQ FGYINVAYPG 

       370        380        390        400        410        420 
FLKGTFFGSF HPFIEYSDRK RKYSRQKVRE ETKVSVDNGL TWTNLKVVDR ENVDLFGCDV 

       430        440        450        460        470        480 
TKPERCSLQT HFYDLRNLNP SAGIMMISGI VGDGSAYNWK EEKTFISRDS GLTWRLVHNS 

       490        500        510        520        530        540 
TGLYTTGDLG NIIMYIPYRS NENGDVPSKF YYSLDQGKTW GEYDLIMPIY PYRLVSTISD 

       550        560        570        580        590        600 
GSGSKFILTG TSITEDPIFI TYSIDFSAVF DYKSCEEGDF EDWNLADGKC VNGAKYKYRR 

       610        620        630        640        650        660 
RKQDAQCLVK KAFKDLSLDE TPCNSCTGSD YECSFEFVRD AKGDCIPDYN LIALSDICDK 

       670        680        690        700        710        720 
SKGKSVLVKP LQLIKGDKCK TPMKIESVDI PCDEIPKEGS SDKEIVTTEN KFDFEIKFYQ 

       730        740        750        760        770        780 
YFDTVADESL VMLNSIGDAY ISHDGGQTIK RFDTDGEKIV EIVFNPYFNS SAYLFGSKGN 

       790        800        810        820        830        840 
IFLTHDRGYS FMIAKLPEAR QLGMPLDFSA KAQDTFIYYG GKNCESILSP ECHAVAYLTK 

       850        860        870        880        890        900 
DGGETFTEML DNAIHCEFAG TLFKYPSNDD MVMCQVKEKF SQTRSLVSST DFFQDDRKTV 

       910        920        930        940        950        960 
FENIIGYLST GGYIIVAVPH EDNELRAYVT NDGAEFTEAK FPYDEDIGKQ DAFTILGSEE 

       970        980        990       1000       1010       1020 
GSIFLHLATN LESGHDFGNL LKSNSNGTSF VTLEHAVNRN TFGYVDFEKV QGLEGIIITN 

      1030       1040       1050       1060       1070       1080 
IVSNSEKVGE NKEDEQLKTK ITFNDGSDWN FLKPPKKDSE GKKFPCDSVS LDKCSLHLHG 

      1090       1100       1110       1120       1130       1140 
YTERKDIRDT YSSGSALGMM FGVGNVGDRL LPYEECSTFL TTDGGETWTE VKKGPHQWEY 

      1150       1160       1170       1180       1190       1200 
GDHGGVLVLV PENAETDSIS YSTDFGKTWK DYKFCGDKVL VKDIITVPRD SALRFLLFGE 

      1210       1220       1230       1240       1250       1260 
AKNMGSGSFR TYTIDFRNIF ERQCEFDITG RKRADFKYSP LGSRTGCLFG HKTEFLRKTD 

      1270       1280       1290       1300       1310       1320 
EKCFIGNIPL SEFSRNVKNC PCTRQDFECD YNFYKASDGT CKLVKGLSSA NGADICKKEP 

      1330       1340       1350       1360       1370       1380 
DLIEYYDSSG YRKIPLSTCK GGLKLDAHLA PHPCPGKEKA FREKYSINTG AYALVFVTIL 

      1390       1400       1410       1420       1430       1440 
LVIFFVAWFV YDRGIRRNGG FSRFEEIRLG DDGLIENNRT DRVVNIIVRL GLCISLITKS 

      1450       1460       1470       1480       1490       1500 
AFQRAKAGTA QLSSKFRARF GNKKGATYSS LLHDQLSDEP DGFHEDSNDL SSFRGQGSNS 

      1510       1520       1530       1540 
EIEQEDVDTS QQEHTSRTDL LGASNIPDAL PARSASHESD LAAARSEDK 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X."
Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F.
Yeast 10:1657-1662(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Multiple pathways for vacuolar sorting of yeast proteinase A."
Westphal V., Marcusson E.G., Winther J.R., Emr S.D., van den Hazel H.B.
J. Biol. Chem. 271:11865-11870(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases."
Cooper A.A., Stevens T.H.
J. Cell Biol. 133:529-541(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z34098 Genomic DNA. Translation: CAA83988.1.
Z49497 Genomic DNA. Translation: CAA89519.1.
BK006943 Genomic DNA. Translation: DAA08591.1.
PIRS50705.
RefSeqNP_012313.1. NM_001181655.1.

3D structure databases

ProteinModelPortalP40890.
SMRP40890. Positions 44-113, 441-477, 509-541, 736-795, 898-1343.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33560. 12 interactions.
DIPDIP-6665N.
IntActP40890. 1 interaction.
MINTMINT-636859.
STRING4932.YJL222W.

Proteomic databases

PaxDbP40890.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL222W; YJL222W; YJL222W.
GeneID853233.
KEGGsce:YJL222W.

Organism-specific databases

CYGDYJL222w.
SGDS000003758. VTH2.

Phylogenomic databases

eggNOGNOG281049.
GeneTreeENSGT00510000046443.
HOGENOMHOG000169063.
OMAEHTSRTD.
OrthoDBEOG7DVDKD.

Enzyme and pathway databases

BioCycYEAST:G3O-31644-MONOMER.

Gene expression databases

GenevestigatorP40890.

Family and domain databases

Gene3D2.120.10.10. 2 hits.
InterProIPR011040. Sialidases.
IPR006581. VPS10.
[Graphical view]
SMARTSM00602. VPS10. 2 hits.
[Graphical view]
SUPFAMSSF50939. SSF50939. 3 hits.
ProtoNetSearch...

Other

NextBio973452.

Entry information

Entry nameVTH2_YEAST
AccessionPrimary (citable) accession number: P40890
Secondary accession number(s): D6VVX5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 19, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families