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P40890

- VTH2_YEAST

UniProt

P40890 - VTH2_YEAST

Protein

VPS10 homolog 2

Gene

VTH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.2 Publications

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. signal sequence binding Source: SGD

    GO - Biological processi

    1. Golgi to vacuole transport Source: SGD
    2. protein targeting to vacuole Source: SGD

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31644-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    VPS10 homolog 2
    Alternative name(s):
    Sortilin VTH2
    Gene namesi
    Name:VTH2
    Ordered Locus Names:YJL222W
    ORF Names:HRC1549, J0213
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL222w.
    SGDiS000003758. VTH2.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 15491528VPS10 homolog 2PRO_0000014331Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi479 – 4791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi769 – 7691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi986 – 9861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP40890.
    PaxDbiP40890.

    Expressioni

    Gene expression databases

    GenevestigatoriP40890.

    Interactioni

    Protein-protein interaction databases

    BioGridi33560. 12 interactions.
    DIPiDIP-6665N.
    IntActiP40890. 1 interaction.
    MINTiMINT-636859.
    STRINGi4932.YJL222W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40890.
    SMRiP40890. Positions 898-1343.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 13691348LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1391 – 1549159CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1370 – 139021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati57 – 6812BNR 1Add
    BLAST
    Repeati101 – 11212BNR 2Add
    BLAST
    Repeati159 – 17012BNR 3Add
    BLAST
    Repeati228 – 23912BNR 4Add
    BLAST
    Repeati393 – 40412BNR 5Add
    BLAST
    Repeati465 – 47612BNR 6Add
    BLAST
    Repeati511 – 52212BNR 7Add
    BLAST
    Repeati740 – 75112BNR 8Add
    BLAST
    Repeati837 – 84812BNR 9Add
    BLAST
    Repeati1040 – 105112BNR 10Add
    BLAST
    Repeati1119 – 113012BNR 11Add
    BLAST
    Repeati1160 – 117112BNR 12Add
    BLAST

    Sequence similaritiesi

    Belongs to the VPS10-related sortilin family.Curated
    Contains 12 BNR repeats.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG281049.
    GeneTreeiENSGT00510000046443.
    HOGENOMiHOG000169063.
    OMAiCHERERV.
    OrthoDBiEOG7DVDKD.

    Family and domain databases

    Gene3Di2.120.10.10. 2 hits.
    InterProiIPR011040. Sialidases.
    IPR006581. VPS10.
    [Graphical view]
    SMARTiSM00602. VPS10. 2 hits.
    [Graphical view]
    SUPFAMiSSF50939. SSF50939. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P40890-1 [UniParc]FASTAAdd to Basket

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    MALFRALYII WVFLLIPLSN AEEFTPKVTR TLSRYVFDIV NFDDSNTLIR     50
    AEEDSVEISF DAGENWKTID EIEEPIESFV VDPFRGHDRA FAFVKTAPKF 100
    YVTDDQGKSW RPLTIPISEK ASNYFCDVTT HPIKKKHLII RCDLLTIKNS 150
    GLMYVGREIY TTNDGVSFSQ VKPSFGKIDG HISTARCDFI KSSEDSDLGG 200
    NDASILCLFR NTEYIESTGS TIDKSELILS ADGGETFKEL VQFKDKVVSR 250
    YEILKHHVIV LTQDDMYNEM SSTNIWISND VSTFQVARTP TKIRHVNMGQ 300
    IHEDSIGRIV LPVSRERDDE DSNQPGAAEV LISDSEGLKF LPINWIPNNQ 350
    FGYINVAYPG FLKGTFFGSF HPFIEYSDRK RKYSRQKVRE ETKVSVDNGL 400
    TWTNLKVVDR ENVDLFGCDV TKPERCSLQT HFYDLRNLNP SAGIMMISGI 450
    VGDGSAYNWK EEKTFISRDS GLTWRLVHNS TGLYTTGDLG NIIMYIPYRS 500
    NENGDVPSKF YYSLDQGKTW GEYDLIMPIY PYRLVSTISD GSGSKFILTG 550
    TSITEDPIFI TYSIDFSAVF DYKSCEEGDF EDWNLADGKC VNGAKYKYRR 600
    RKQDAQCLVK KAFKDLSLDE TPCNSCTGSD YECSFEFVRD AKGDCIPDYN 650
    LIALSDICDK SKGKSVLVKP LQLIKGDKCK TPMKIESVDI PCDEIPKEGS 700
    SDKEIVTTEN KFDFEIKFYQ YFDTVADESL VMLNSIGDAY ISHDGGQTIK 750
    RFDTDGEKIV EIVFNPYFNS SAYLFGSKGN IFLTHDRGYS FMIAKLPEAR 800
    QLGMPLDFSA KAQDTFIYYG GKNCESILSP ECHAVAYLTK DGGETFTEML 850
    DNAIHCEFAG TLFKYPSNDD MVMCQVKEKF SQTRSLVSST DFFQDDRKTV 900
    FENIIGYLST GGYIIVAVPH EDNELRAYVT NDGAEFTEAK FPYDEDIGKQ 950
    DAFTILGSEE GSIFLHLATN LESGHDFGNL LKSNSNGTSF VTLEHAVNRN 1000
    TFGYVDFEKV QGLEGIIITN IVSNSEKVGE NKEDEQLKTK ITFNDGSDWN 1050
    FLKPPKKDSE GKKFPCDSVS LDKCSLHLHG YTERKDIRDT YSSGSALGMM 1100
    FGVGNVGDRL LPYEECSTFL TTDGGETWTE VKKGPHQWEY GDHGGVLVLV 1150
    PENAETDSIS YSTDFGKTWK DYKFCGDKVL VKDIITVPRD SALRFLLFGE 1200
    AKNMGSGSFR TYTIDFRNIF ERQCEFDITG RKRADFKYSP LGSRTGCLFG 1250
    HKTEFLRKTD EKCFIGNIPL SEFSRNVKNC PCTRQDFECD YNFYKASDGT 1300
    CKLVKGLSSA NGADICKKEP DLIEYYDSSG YRKIPLSTCK GGLKLDAHLA 1350
    PHPCPGKEKA FREKYSINTG AYALVFVTIL LVIFFVAWFV YDRGIRRNGG 1400
    FSRFEEIRLG DDGLIENNRT DRVVNIIVRL GLCISLITKS AFQRAKAGTA 1450
    QLSSKFRARF GNKKGATYSS LLHDQLSDEP DGFHEDSNDL SSFRGQGSNS 1500
    EIEQEDVDTS QQEHTSRTDL LGASNIPDAL PARSASHESD LAAARSEDK 1549
    Length:1,549
    Mass (Da):174,402
    Last modified:February 1, 1995 - v1
    Checksum:iB260CF7C927B4E4F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z34098 Genomic DNA. Translation: CAA83988.1.
    Z49497 Genomic DNA. Translation: CAA89519.1.
    BK006943 Genomic DNA. Translation: DAA08591.1.
    PIRiS50705.
    RefSeqiNP_012313.1. NM_001181655.1.

    Genome annotation databases

    EnsemblFungiiYJL222W; YJL222W; YJL222W.
    GeneIDi853233.
    KEGGisce:YJL222W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z34098 Genomic DNA. Translation: CAA83988.1 .
    Z49497 Genomic DNA. Translation: CAA89519.1 .
    BK006943 Genomic DNA. Translation: DAA08591.1 .
    PIRi S50705.
    RefSeqi NP_012313.1. NM_001181655.1.

    3D structure databases

    ProteinModelPortali P40890.
    SMRi P40890. Positions 898-1343.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33560. 12 interactions.
    DIPi DIP-6665N.
    IntActi P40890. 1 interaction.
    MINTi MINT-636859.
    STRINGi 4932.YJL222W.

    Proteomic databases

    MaxQBi P40890.
    PaxDbi P40890.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL222W ; YJL222W ; YJL222W .
    GeneIDi 853233.
    KEGGi sce:YJL222W.

    Organism-specific databases

    CYGDi YJL222w.
    SGDi S000003758. VTH2.

    Phylogenomic databases

    eggNOGi NOG281049.
    GeneTreei ENSGT00510000046443.
    HOGENOMi HOG000169063.
    OMAi CHERERV.
    OrthoDBi EOG7DVDKD.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31644-MONOMER.

    Miscellaneous databases

    NextBioi 973452.

    Gene expression databases

    Genevestigatori P40890.

    Family and domain databases

    Gene3Di 2.120.10.10. 2 hits.
    InterProi IPR011040. Sialidases.
    IPR006581. VPS10.
    [Graphical view ]
    SMARTi SM00602. VPS10. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50939. SSF50939. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X."
      Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F.
      Yeast 10:1657-1662(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: FUNCTION.
    5. "Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases."
      Cooper A.A., Stevens T.H.
      J. Cell Biol. 133:529-541(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVTH2_YEAST
    AccessioniPrimary (citable) accession number: P40890
    Secondary accession number(s): D6VVX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 279 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3