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Protein

VPS10 homolog 2

Gene

VTH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.2 Publications

Miscellaneous

Present with 279 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • nucleotide binding Source: UniProtKB-KW
  • signal sequence binding Source: SGD

GO - Biological processi

  • Golgi to vacuole transport Source: SGD
  • protein targeting to vacuole Source: SGD

Keywordsi

Molecular functionReceptor
Biological processProtein transport, Transport
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31644-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
VPS10 homolog 2
Alternative name(s):
Sortilin VTH2
Gene namesi
Name:VTH2
Ordered Locus Names:YJL222W
ORF Names:HRC1549, J0213
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL222W
SGDiS000003758 VTH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 1369LumenalSequence analysisAdd BLAST1348
Transmembranei1370 – 1390HelicalSequence analysisAdd BLAST21
Topological domaini1391 – 1549CytoplasmicSequence analysisAdd BLAST159

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001433122 – 1549VPS10 homolog 2Add BLAST1528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi479N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi769N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi986N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP40890
PaxDbiP40890
PRIDEiP40890

Interactioni

Protein-protein interaction databases

BioGridi33560, 11 interactors
DIPiDIP-6665N
IntActiP40890, 1 interactor
STRINGi4932.YJL222W

Structurei

3D structure databases

ProteinModelPortaliP40890
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati57 – 68BNR 1Add BLAST12
Repeati101 – 112BNR 2Add BLAST12
Repeati159 – 170BNR 3Add BLAST12
Repeati228 – 239BNR 4Add BLAST12
Repeati393 – 404BNR 5Add BLAST12
Repeati465 – 476BNR 6Add BLAST12
Repeati511 – 522BNR 7Add BLAST12
Repeati740 – 751BNR 8Add BLAST12
Repeati837 – 848BNR 9Add BLAST12
Repeati1040 – 1051BNR 10Add BLAST12
Repeati1119 – 1130BNR 11Add BLAST12
Repeati1160 – 1171BNR 12Add BLAST12

Sequence similaritiesi

Belongs to the VPS10-related sortilin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000046443
HOGENOMiHOG000169063
InParanoidiP40890
OMAiNENDSEF
OrthoDBiEOG092C0D5Y

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR036278 Sialidase_sf
IPR031777 Sortilin_C
IPR031778 Sortilin_N
IPR006581 VPS10
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF15902 Sortilin-Vps10, 2 hits
PF15901 Sortilin_C, 2 hits
SMARTiView protein in SMART
SM00602 VPS10, 2 hits
SUPFAMiSSF50939 SSF50939, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40890-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALFRALYII WVFLLIPLSN AEEFTPKVTR TLSRYVFDIV NFDDSNTLIR
60 70 80 90 100
AEEDSVEISF DAGENWKTID EIEEPIESFV VDPFRGHDRA FAFVKTAPKF
110 120 130 140 150
YVTDDQGKSW RPLTIPISEK ASNYFCDVTT HPIKKKHLII RCDLLTIKNS
160 170 180 190 200
GLMYVGREIY TTNDGVSFSQ VKPSFGKIDG HISTARCDFI KSSEDSDLGG
210 220 230 240 250
NDASILCLFR NTEYIESTGS TIDKSELILS ADGGETFKEL VQFKDKVVSR
260 270 280 290 300
YEILKHHVIV LTQDDMYNEM SSTNIWISND VSTFQVARTP TKIRHVNMGQ
310 320 330 340 350
IHEDSIGRIV LPVSRERDDE DSNQPGAAEV LISDSEGLKF LPINWIPNNQ
360 370 380 390 400
FGYINVAYPG FLKGTFFGSF HPFIEYSDRK RKYSRQKVRE ETKVSVDNGL
410 420 430 440 450
TWTNLKVVDR ENVDLFGCDV TKPERCSLQT HFYDLRNLNP SAGIMMISGI
460 470 480 490 500
VGDGSAYNWK EEKTFISRDS GLTWRLVHNS TGLYTTGDLG NIIMYIPYRS
510 520 530 540 550
NENGDVPSKF YYSLDQGKTW GEYDLIMPIY PYRLVSTISD GSGSKFILTG
560 570 580 590 600
TSITEDPIFI TYSIDFSAVF DYKSCEEGDF EDWNLADGKC VNGAKYKYRR
610 620 630 640 650
RKQDAQCLVK KAFKDLSLDE TPCNSCTGSD YECSFEFVRD AKGDCIPDYN
660 670 680 690 700
LIALSDICDK SKGKSVLVKP LQLIKGDKCK TPMKIESVDI PCDEIPKEGS
710 720 730 740 750
SDKEIVTTEN KFDFEIKFYQ YFDTVADESL VMLNSIGDAY ISHDGGQTIK
760 770 780 790 800
RFDTDGEKIV EIVFNPYFNS SAYLFGSKGN IFLTHDRGYS FMIAKLPEAR
810 820 830 840 850
QLGMPLDFSA KAQDTFIYYG GKNCESILSP ECHAVAYLTK DGGETFTEML
860 870 880 890 900
DNAIHCEFAG TLFKYPSNDD MVMCQVKEKF SQTRSLVSST DFFQDDRKTV
910 920 930 940 950
FENIIGYLST GGYIIVAVPH EDNELRAYVT NDGAEFTEAK FPYDEDIGKQ
960 970 980 990 1000
DAFTILGSEE GSIFLHLATN LESGHDFGNL LKSNSNGTSF VTLEHAVNRN
1010 1020 1030 1040 1050
TFGYVDFEKV QGLEGIIITN IVSNSEKVGE NKEDEQLKTK ITFNDGSDWN
1060 1070 1080 1090 1100
FLKPPKKDSE GKKFPCDSVS LDKCSLHLHG YTERKDIRDT YSSGSALGMM
1110 1120 1130 1140 1150
FGVGNVGDRL LPYEECSTFL TTDGGETWTE VKKGPHQWEY GDHGGVLVLV
1160 1170 1180 1190 1200
PENAETDSIS YSTDFGKTWK DYKFCGDKVL VKDIITVPRD SALRFLLFGE
1210 1220 1230 1240 1250
AKNMGSGSFR TYTIDFRNIF ERQCEFDITG RKRADFKYSP LGSRTGCLFG
1260 1270 1280 1290 1300
HKTEFLRKTD EKCFIGNIPL SEFSRNVKNC PCTRQDFECD YNFYKASDGT
1310 1320 1330 1340 1350
CKLVKGLSSA NGADICKKEP DLIEYYDSSG YRKIPLSTCK GGLKLDAHLA
1360 1370 1380 1390 1400
PHPCPGKEKA FREKYSINTG AYALVFVTIL LVIFFVAWFV YDRGIRRNGG
1410 1420 1430 1440 1450
FSRFEEIRLG DDGLIENNRT DRVVNIIVRL GLCISLITKS AFQRAKAGTA
1460 1470 1480 1490 1500
QLSSKFRARF GNKKGATYSS LLHDQLSDEP DGFHEDSNDL SSFRGQGSNS
1510 1520 1530 1540
EIEQEDVDTS QQEHTSRTDL LGASNIPDAL PARSASHESD LAAARSEDK
Length:1,549
Mass (Da):174,402
Last modified:February 1, 1995 - v1
Checksum:iB260CF7C927B4E4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34098 Genomic DNA Translation: CAA83988.1
Z49497 Genomic DNA Translation: CAA89519.1
BK006943 Genomic DNA Translation: DAA08591.1
PIRiS50705
RefSeqiNP_012313.1, NM_001181655.1

Genome annotation databases

EnsemblFungiiYJL222W; YJL222W; YJL222W
GeneIDi853233
KEGGisce:YJL222W

Similar proteinsi

Entry informationi

Entry nameiVTH2_YEAST
AccessioniPrimary (citable) accession number: P40890
Secondary accession number(s): D6VVX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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