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Protein

VPS10 homolog 2

Gene

VTH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.2 Publications

GO - Molecular functioni

  • nucleotide binding Source: UniProtKB-KW
  • signal sequence binding Source: SGD

GO - Biological processi

  • Golgi to vacuole transport Source: SGD
  • protein targeting to vacuole Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31644-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
VPS10 homolog 2
Alternative name(s):
Sortilin VTH2
Gene namesi
Name:VTH2
Ordered Locus Names:YJL222W
ORF Names:HRC1549, J0213
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL222W.
SGDiS000003758. VTH2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 1369LumenalSequence analysisAdd BLAST1348
Transmembranei1370 – 1390HelicalSequence analysisAdd BLAST21
Topological domaini1391 – 1549CytoplasmicSequence analysisAdd BLAST159

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001433122 – 1549VPS10 homolog 2Add BLAST1528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi479N-linked (GlcNAc...)Sequence analysis1
Glycosylationi769N-linked (GlcNAc...)Sequence analysis1
Glycosylationi986N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP40890.
PRIDEiP40890.

Interactioni

Protein-protein interaction databases

BioGridi33560. 11 interactors.
DIPiDIP-6665N.
IntActiP40890. 1 interactor.
MINTiMINT-636859.

Structurei

3D structure databases

ProteinModelPortaliP40890.
SMRiP40890.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati57 – 68BNR 1Add BLAST12
Repeati101 – 112BNR 2Add BLAST12
Repeati159 – 170BNR 3Add BLAST12
Repeati228 – 239BNR 4Add BLAST12
Repeati393 – 404BNR 5Add BLAST12
Repeati465 – 476BNR 6Add BLAST12
Repeati511 – 522BNR 7Add BLAST12
Repeati740 – 751BNR 8Add BLAST12
Repeati837 – 848BNR 9Add BLAST12
Repeati1040 – 1051BNR 10Add BLAST12
Repeati1119 – 1130BNR 11Add BLAST12
Repeati1160 – 1171BNR 12Add BLAST12

Sequence similaritiesi

Belongs to the VPS10-related sortilin family.Curated
Contains 12 BNR repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000046443.
HOGENOMiHOG000169063.
InParanoidiP40890.
OrthoDBiEOG092C0D5Y.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
InterProiIPR011040. Sialidases.
IPR031777. Sortilin_C.
IPR031778. Sortilin_N.
IPR006581. VPS10.
[Graphical view]
PfamiPF15902. Sortilin-Vps10. 2 hits.
PF15901. Sortilin_C. 2 hits.
[Graphical view]
SMARTiSM00602. VPS10. 2 hits.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40890-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALFRALYII WVFLLIPLSN AEEFTPKVTR TLSRYVFDIV NFDDSNTLIR
60 70 80 90 100
AEEDSVEISF DAGENWKTID EIEEPIESFV VDPFRGHDRA FAFVKTAPKF
110 120 130 140 150
YVTDDQGKSW RPLTIPISEK ASNYFCDVTT HPIKKKHLII RCDLLTIKNS
160 170 180 190 200
GLMYVGREIY TTNDGVSFSQ VKPSFGKIDG HISTARCDFI KSSEDSDLGG
210 220 230 240 250
NDASILCLFR NTEYIESTGS TIDKSELILS ADGGETFKEL VQFKDKVVSR
260 270 280 290 300
YEILKHHVIV LTQDDMYNEM SSTNIWISND VSTFQVARTP TKIRHVNMGQ
310 320 330 340 350
IHEDSIGRIV LPVSRERDDE DSNQPGAAEV LISDSEGLKF LPINWIPNNQ
360 370 380 390 400
FGYINVAYPG FLKGTFFGSF HPFIEYSDRK RKYSRQKVRE ETKVSVDNGL
410 420 430 440 450
TWTNLKVVDR ENVDLFGCDV TKPERCSLQT HFYDLRNLNP SAGIMMISGI
460 470 480 490 500
VGDGSAYNWK EEKTFISRDS GLTWRLVHNS TGLYTTGDLG NIIMYIPYRS
510 520 530 540 550
NENGDVPSKF YYSLDQGKTW GEYDLIMPIY PYRLVSTISD GSGSKFILTG
560 570 580 590 600
TSITEDPIFI TYSIDFSAVF DYKSCEEGDF EDWNLADGKC VNGAKYKYRR
610 620 630 640 650
RKQDAQCLVK KAFKDLSLDE TPCNSCTGSD YECSFEFVRD AKGDCIPDYN
660 670 680 690 700
LIALSDICDK SKGKSVLVKP LQLIKGDKCK TPMKIESVDI PCDEIPKEGS
710 720 730 740 750
SDKEIVTTEN KFDFEIKFYQ YFDTVADESL VMLNSIGDAY ISHDGGQTIK
760 770 780 790 800
RFDTDGEKIV EIVFNPYFNS SAYLFGSKGN IFLTHDRGYS FMIAKLPEAR
810 820 830 840 850
QLGMPLDFSA KAQDTFIYYG GKNCESILSP ECHAVAYLTK DGGETFTEML
860 870 880 890 900
DNAIHCEFAG TLFKYPSNDD MVMCQVKEKF SQTRSLVSST DFFQDDRKTV
910 920 930 940 950
FENIIGYLST GGYIIVAVPH EDNELRAYVT NDGAEFTEAK FPYDEDIGKQ
960 970 980 990 1000
DAFTILGSEE GSIFLHLATN LESGHDFGNL LKSNSNGTSF VTLEHAVNRN
1010 1020 1030 1040 1050
TFGYVDFEKV QGLEGIIITN IVSNSEKVGE NKEDEQLKTK ITFNDGSDWN
1060 1070 1080 1090 1100
FLKPPKKDSE GKKFPCDSVS LDKCSLHLHG YTERKDIRDT YSSGSALGMM
1110 1120 1130 1140 1150
FGVGNVGDRL LPYEECSTFL TTDGGETWTE VKKGPHQWEY GDHGGVLVLV
1160 1170 1180 1190 1200
PENAETDSIS YSTDFGKTWK DYKFCGDKVL VKDIITVPRD SALRFLLFGE
1210 1220 1230 1240 1250
AKNMGSGSFR TYTIDFRNIF ERQCEFDITG RKRADFKYSP LGSRTGCLFG
1260 1270 1280 1290 1300
HKTEFLRKTD EKCFIGNIPL SEFSRNVKNC PCTRQDFECD YNFYKASDGT
1310 1320 1330 1340 1350
CKLVKGLSSA NGADICKKEP DLIEYYDSSG YRKIPLSTCK GGLKLDAHLA
1360 1370 1380 1390 1400
PHPCPGKEKA FREKYSINTG AYALVFVTIL LVIFFVAWFV YDRGIRRNGG
1410 1420 1430 1440 1450
FSRFEEIRLG DDGLIENNRT DRVVNIIVRL GLCISLITKS AFQRAKAGTA
1460 1470 1480 1490 1500
QLSSKFRARF GNKKGATYSS LLHDQLSDEP DGFHEDSNDL SSFRGQGSNS
1510 1520 1530 1540
EIEQEDVDTS QQEHTSRTDL LGASNIPDAL PARSASHESD LAAARSEDK
Length:1,549
Mass (Da):174,402
Last modified:February 1, 1995 - v1
Checksum:iB260CF7C927B4E4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34098 Genomic DNA. Translation: CAA83988.1.
Z49497 Genomic DNA. Translation: CAA89519.1.
BK006943 Genomic DNA. Translation: DAA08591.1.
PIRiS50705.
RefSeqiNP_012313.1. NM_001181655.1.

Genome annotation databases

EnsemblFungiiYJL222W; YJL222W; YJL222W.
GeneIDi853233.
KEGGisce:YJL222W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34098 Genomic DNA. Translation: CAA83988.1.
Z49497 Genomic DNA. Translation: CAA89519.1.
BK006943 Genomic DNA. Translation: DAA08591.1.
PIRiS50705.
RefSeqiNP_012313.1. NM_001181655.1.

3D structure databases

ProteinModelPortaliP40890.
SMRiP40890.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33560. 11 interactors.
DIPiDIP-6665N.
IntActiP40890. 1 interactor.
MINTiMINT-636859.

Proteomic databases

MaxQBiP40890.
PRIDEiP40890.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL222W; YJL222W; YJL222W.
GeneIDi853233.
KEGGisce:YJL222W.

Organism-specific databases

EuPathDBiFungiDB:YJL222W.
SGDiS000003758. VTH2.

Phylogenomic databases

GeneTreeiENSGT00510000046443.
HOGENOMiHOG000169063.
InParanoidiP40890.
OrthoDBiEOG092C0D5Y.

Enzyme and pathway databases

BioCyciYEAST:G3O-31644-MONOMER.

Miscellaneous databases

PROiP40890.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
InterProiIPR011040. Sialidases.
IPR031777. Sortilin_C.
IPR031778. Sortilin_N.
IPR006581. VPS10.
[Graphical view]
PfamiPF15902. Sortilin-Vps10. 2 hits.
PF15901. Sortilin_C. 2 hits.
[Graphical view]
SMARTiSM00602. VPS10. 2 hits.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiVTH2_YEAST
AccessioniPrimary (citable) accession number: P40890
Secondary accession number(s): D6VVX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 279 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.