P40889 (YJW5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Y' element ATP-dependent helicase YJL225C
EC=3.6.4.12

Gene names

Ordered Locus Names:	YJL225C
ORF Names:	HRF393/HRD1054, HRF393/HRD732, J0202

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	1758 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance. Ref.4
Catalytic activity	ATP + H2O = ADP + phosphate.
Induction	Induced in absence of telomerase TLC1. Ref.4
Sequence similarities	Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.

Ontologies

Keywords
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro helicase activity Inferred from sequence or structural similarity Ref.4. Source: SGD nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1758	1758	Y' element ATP-dependent helicase YJL225C		PRO_0000102208
Regions
	Domain	668 – 845	178	Helicase ATP-binding
	Domain	900 – 1051	152	Helicase C-terminal
	Nucleotide binding	681 – 688	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P40889 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 7E1D052AF97F8CA0	FASTA	1,758	197,565
	10 20 30 40 50 60 MKVSDRRKFE KANFDEFESA LNNKNDLVHC PSITLFESIP TEVRSFYEDE KSGLIKVVKF 70 80 90 100 110 120 RTGAMDRKRS FEKVVISVMV GKNVKKFLTF VEDEPDFQGG PIPSKYLIPK KINLMVYTLF 130 140 150 160 170 180 QVHTLKFNRK DYDTLSLFYL NRGYYNELSF RVLERCHEIA SARPNDSSTM RTFTDFVSGA 190 200 210 220 230 240 PIVRSLQKST IRKYGYNLAP YMFLLLHVDE LSIFSAYQAS LPGEKKVDTE RLKRDLCPRK 250 260 270 280 290 300 PIEIKYFSQI CNDMMNKKDR LGDILHIILR ACALNFGAGP RGGAGDEEDR SITNEEPIIP 310 320 330 340 350 360 SVDEHGLKVC KLRSPNTPRR LRKTLDAVKA LLVSSCACTA RDLDIFDDNN GVAMWKWIKI 370 380 390 400 410 420 LYHEVAQETT LKDSYRITLV PSSDGISLLA FAGPQRNVYV DDTTRRIQLY TDYNKNGSSE 430 440 450 460 470 480 PRLKTLDGLT SDYVFYFVTV LRQMQICALG NSYDAFNHDP WMDVVGFEDP NQVTNRDISR 490 500 510 520 530 540 IVLYSYMFLN TAKGCLVEYA TFRQYMRELP KNAPQKLNFR EMRQGLIALG RHCVGSRFET 550 560 570 580 590 600 DLYESATSEL MANHSVQTGR NIYGVDSFSL TSVSGTTATL LQERASERWI QWLGLESDYH 610 620 630 640 650 660 CSFSSTRNAE DVVAGEAASS NHHQKISRVT RKRPREPKST NDILVAGQKL FGSSFEFRDL 670 680 690 700 710 720 HQLRLCYEIY MADTPSVAVQ APPGYGKTEL FHLPLIALAS KGDVEYVSFL FVPYTVLLAN 730 740 750 760 770 780 CMIRLGRRGC LNVAPVRNFI EEGYDGVTDL YVGIYDDLAS TNFTDRIAAW ENIVECTFRT 790 800 810 820 830 840 NNVKLGYLIV DEFHNFETEV YRQSQFGGIT NLDFDAFEKA IFLSGTAPEA VADAALQRIG 850 860 870 880 890 900 LTGLAKKSMD INELKRSEDL SRGLSSYPTR MFNLIKEKSE VPLGHVHKIR KKVESQPEEA 910 920 930 940 950 960 LKLLLALFES EPESKAIVVA STTNEVEELA CSWRKYFRVV WIHGKLGAAE KVSRTKEFVT 970 980 990 1000 1010 1020 DGSMQVLIGT KLVTEGIDIK QLMMVIMLDN RLNIIELIQG VGRLRDGGLC YLLSRKNSWA 1030 1040 1050 1060 1070 1080 ARNRKGELPP IKEGCITEQV REFYGLESKK GKKGQHVGCC GSRTDLSADT VELIERMDRL 1090 1100 1110 1120 1130 1140 AEKQATASMS IVALPSSFQE SNSSDRYRKY CSSDEDSNTC IHGSANASTN ASTNAITTAS 1150 1160 1170 1180 1190 1200 TNVRTNATTN ASTNATTNAS TNASTNATTN ASTNATTNSS TNATTTASTN VRTSATTTAS 1210 1220 1230 1240 1250 1260 INVRTSATTT ESTNSSTNAT TTESTNSSTN ATTTESTNSN TSATTTASIN VRTSATTTES 1270 1280 1290 1300 1310 1320 TNSSTSATTT ASINVRTSAT TTKSINSSTN ATTTESTNSN TNATTTESTN SSTNATTTES 1330 1340 1350 1360 1370 1380 TNSSTNATTT ESTNSNTSAA TTESTNSNTS ATTTESTNAS AKEDANKDGN AEDNRFHPVT 1390 1400 1410 1420 1430 1440 DINKESYKRK GSQMVLLERK KLKAQFPNTS ENMNVLQFLG FRSDEIKHLF LYGIDIYFCP 1450 1460 1470 1480 1490 1500 EGVFTQYGLC KGCQKMFELC VCWAGQKVSY RRIAWEALAV ERMLRNDEEY KEYLEDIEPY 1510 1520 1530 1540 1550 1560 HGDPVGYLKY FSVKRREIYS QIQRNYAWYL AITRRRETIS VLDSTRGKQG SQVFRMSGRQ 1570 1580 1590 1600 1610 1620 IKELYFKVWS NLRESKTEVL QYFLNWDEKK CQEEWEAKDD TVVVEALEKG GVFQRLRSMT 1630 1640 1650 1660 1670 1680 SAGLQGPQYV KLQFSRHHRQ LRSRYELSLG MHLRDQIALG VTPSKVPHWT AFLSMLIGLF 1690 1700 1710 1720 1730 1740 YNKTFRQKLE YLLEQISEVW LLPHWLDLAN VEVLAADDTR VPLYMLMVAV HKELDSDDVP 1750 DGRFDILLCR DSSREVGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X." Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F. Yeast 10:1657-1662(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE. Strain: ATCC 204508 / S288c.
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase." Yamada M., Hayatsu N., Matsuura A., Ishikawa F. J. Biol. Chem. 273:33360-33366(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z48148 Genomic DNA. Translation: CAA88141.1. Sequence problems. Z48148 Genomic DNA. Translation: CAA88142.1. Sequence problems. Z34098 Genomic DNA. Translation: CAA83986.1. Sequence problems. Z34098 Genomic DNA. Translation: CAA83985.1. Sequence problems. Z49498 Genomic DNA. Translation: CAA89520.1. Z49500 Genomic DNA. Translation: CAA89522.1. BK006943 Genomic DNA. Translation: DAA08589.1.
PIR	S57015.
RefSeq	NP_012311.1. NM_001181657.1.
3D structure databases
ProteinModelPortal	P40889.
SMR	P40889. Positions 657-719, 770-1003.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4705N.
MINT	MINT-488832.
STRING	4932.YJL225C.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YJL225C; YJL225C; YJL225C.
GeneID	853231.
KEGG	sce:YJL225C.
Organism-specific databases
CYGD	YJL225c.
SGD	S000003760. YJL225C.
Phylogenomic databases
GeneTree	ENSGT00440000033744.
HOGENOM	HOG000155528.
OrthoDB	EOG4V9Z0T.
Gene expression databases
Genevestigator	P40889.
GermOnline	YJL225C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. [Graphical view]
Pfam	PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
PROSITE	PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	973446.

Entry information

Entry name

YJW5_YEAST

Accession

Primary (citable) accession number: P40889
Secondary accession number(s): D6VVX3 , P40887, Q05371, Q9UQW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program